PMC:7652766 / 12474-13243 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7652766","sourcedb":"PMC","sourceid":"7652766","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7652766","text":"As well as the other β-CoVs, the SARS-CoV-2 genome has a long open reading frame (ORF) 1ab region, followed by regions that encode S, E, M, and N proteins (42). Homotrimers of S proteins are present on the viral surface and are responsible for attaching to host receptors (43). The E protein plays a role in the assembly and release of the virus, in addition to being involved in viral pathogenesis (44). The M protein has three transmembrane domains and shapes the virions, promotes membrane curvature, and binds to the nucleocapsid (45, 46). Lastly, the N protein contains two domains that can bind to the RNA virus and is also an antagonist of interferon (IFN) and a virally-encoded repressor of RNA interference, which appears to benefit viral replication (47, 48).","tracks":[{"project":"LitCovid-sentences","denotations":[{"id":"T69","span":{"begin":0,"end":160},"obj":"Sentence"},{"id":"T70","span":{"begin":161,"end":277},"obj":"Sentence"},{"id":"T71","span":{"begin":278,"end":404},"obj":"Sentence"},{"id":"T72","span":{"begin":405,"end":543},"obj":"Sentence"},{"id":"T73","span":{"begin":544,"end":769},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T69","pred":"source","obj":"LitCovid-sentences"},{"subj":"T70","pred":"source","obj":"LitCovid-sentences"},{"subj":"T71","pred":"source","obj":"LitCovid-sentences"},{"subj":"T72","pred":"source","obj":"LitCovid-sentences"},{"subj":"T73","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"522","span":{"begin":144,"end":145},"obj":"Gene"},{"id":"523","span":{"begin":556,"end":557},"obj":"Gene"},{"id":"524","span":{"begin":131,"end":132},"obj":"Gene"},{"id":"525","span":{"begin":731,"end":733},"obj":"Gene"},{"id":"526","span":{"begin":601,"end":603},"obj":"Gene"},{"id":"527","span":{"begin":514,"end":516},"obj":"Gene"},{"id":"528","span":{"begin":359,"end":361},"obj":"Gene"},{"id":"529","span":{"begin":254,"end":256},"obj":"Gene"},{"id":"530","span":{"begin":23,"end":27},"obj":"Species"},{"id":"531","span":{"begin":33,"end":43},"obj":"Species"},{"id":"532","span":{"begin":668,"end":669},"obj":"Gene"},{"id":"533","span":{"begin":298,"end":299},"obj":"Gene"},{"id":"534","span":{"begin":55,"end":56},"obj":"Gene"},{"id":"535","span":{"begin":659,"end":662},"obj":"Gene"}],"attributes":[{"id":"A522","pred":"tao:has_database_id","subj":"522","obj":"Gene:43740575"},{"id":"A523","pred":"tao:has_database_id","subj":"523","obj":"Gene:43740575"},{"id":"A524","pred":"tao:has_database_id","subj":"524","obj":"Gene:43740568"},{"id":"A525","pred":"tao:has_database_id","subj":"525","obj":"Gene:6999"},{"id":"A526","pred":"tao:has_database_id","subj":"526","obj":"Gene:6999"},{"id":"A527","pred":"tao:has_database_id","subj":"527","obj":"Gene:6999"},{"id":"A528","pred":"tao:has_database_id","subj":"528","obj":"Gene:6999"},{"id":"A529","pred":"tao:has_database_id","subj":"529","obj":"Gene:6999"},{"id":"A530","pred":"tao:has_database_id","subj":"530","obj":"Tax:11118"},{"id":"A531","pred":"tao:has_database_id","subj":"531","obj":"Tax:2697049"},{"id":"A532","pred":"tao:has_database_id","subj":"532","obj":"Gene:351"},{"id":"A533","pred":"tao:has_database_id","subj":"533","obj":"Gene:351"},{"id":"A534","pred":"tao:has_database_id","subj":"534","obj":"Gene:351"},{"id":"A535","pred":"tao:has_database_id","subj":"535","obj":"Gene:3439"},{"subj":"522","pred":"source","obj":"LitCovid-PubTator"},{"subj":"523","pred":"source","obj":"LitCovid-PubTator"},{"subj":"524","pred":"source","obj":"LitCovid-PubTator"},{"subj":"525","pred":"source","obj":"LitCovid-PubTator"},{"subj":"526","pred":"source","obj":"LitCovid-PubTator"},{"subj":"527","pred":"source","obj":"LitCovid-PubTator"},{"subj":"528","pred":"source","obj":"LitCovid-PubTator"},{"subj":"529","pred":"source","obj":"LitCovid-PubTator"},{"subj":"530","pred":"source","obj":"LitCovid-PubTator"},{"subj":"531","pred":"source","obj":"LitCovid-PubTator"},{"subj":"532","pred":"source","obj":"LitCovid-PubTator"},{"subj":"533","pred":"source","obj":"LitCovid-PubTator"},{"subj":"534","pred":"source","obj":"LitCovid-PubTator"},{"subj":"535","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sentences","color":"#ec93d2","default":true},{"id":"LitCovid-PubTator","color":"#93ecec"}]}]}}