PMC:7652766 / 112477-114778 JSONTXT

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LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T159 122-160 Phenotype denotes disseminated intravascular coagulation http://purl.obolibrary.org/obo/HP_0005521
T160 165-177 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T161 199-205 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T162 210-248 Phenotype denotes disseminated intravascular coagulation http://purl.obolibrary.org/obo/HP_0005521
T163 261-275 Phenotype denotes thromboembolic http://purl.obolibrary.org/obo/HP_0001907
T164 388-397 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T165 1150-1162 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T166 1389-1395 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T167 1404-1416 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T553 0-14 Sentence denotes Anticoagulants
T554 15-184 Sentence denotes A high mortality risk in severe COVID-19 patients has been described, especially due to the development of disseminated intravascular coagulation and coagulopathy (395).
T555 185-363 Sentence denotes Patients with sepsis and disseminated intravascular coagulation may develop thromboembolic complications or microvascular clot deposition, contributing to multiple organ failure.
T556 364-646 Sentence denotes In patients with severe pneumonia, the activation of vascular endothelium, platelets, and leukocytes results in the unregulated generation of thrombin, both locally, in the lungs, and systemically, leading to fibrin deposition and subsequent tissue damage and microangiopathy (396).
T557 647-876 Sentence denotes In COVID-19 patients, severe pulmonary inflammation is believed to be associated with the regulation of pro-inflammatory cytokines, which can cause the dysfunction of endothelial cells and consequently higher thrombin production.
T558 877-969 Sentence denotes Therefore, the use of anticoagulant therapy could be beneficial for COVID-19 patients (397).
T559 970-1230 Sentence denotes In a retrospective study with 449 patients with severe COVID-19, Tang et al. (395) observed a lower mortality rate in individuals treated with prophylactic heparin associated with coagulopathy compared with those who had not been treated with an anticoagulant.
T560 1231-1451 Sentence denotes The study associated the use of thrombosis prophylaxis with lower 28-day mortality in COVID-19 patients, but only for those presenting a high value of either sepsis-induced coagulopathy score (≥4) or D-dimer (≥3.0 mg/L).
T561 1452-1697 Sentence denotes Paranjpe et al. (398) carried out a large cohort analysis with 2773 COVID-19 patients in the United States, among which 28% received anticoagulant therapy, and also found an association of anticoagulant-based treatment with lower mortality risk.
T562 1698-1868 Sentence denotes The mortality rate in patients who required mechanical ventilation and received anticoagulant therapy was lower than those who had not been treated with an anticoagulant.
T563 1869-2093 Sentence denotes It is important to highlight that heparin has an anti-inflammatory effect that can bind to inflammatory cytokines, chemokines, and proinflammatory proteins, inhibiting neutrophil chemotaxis and leukocyte migration (399–401).
T564 2094-2301 Sentence denotes In the current COVID-19 context, there are over 60 ongoing clinical trials covering the use of thromboprophylaxis, which will certainly clarify the potential role of anticoagulants in patients with COVID-19.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
4165 506-514 Gene denotes thrombin Gene:2147
4166 856-864 Gene denotes thrombin Gene:2147
4167 711-713 Gene denotes to Gene:6999
4168 570-572 Gene denotes to Gene:6999
4169 337-339 Gene denotes to Gene:6999
4170 100-102 Gene denotes to Gene:6999
4171 56-64 Species denotes patients Tax:9606
4172 185-193 Species denotes Patients Tax:9606
4173 367-375 Species denotes patients Tax:9606
4174 659-667 Species denotes patients Tax:9606
4175 954-962 Species denotes patients Tax:9606
4176 15-16 Gene denotes A Gene:351
4177 22-31 Disease denotes mortality MESH:D003643
4178 47-55 Disease denotes COVID-19 MESH:C000657245
4179 122-160 Disease denotes disseminated intravascular coagulation MESH:D004211
4180 165-177 Disease denotes coagulopathy MESH:D001778
4181 199-205 Disease denotes sepsis MESH:D018805
4182 210-248 Disease denotes disseminated intravascular coagulation MESH:D004211
4183 261-289 Disease denotes thromboembolic complications MESH:D013923
4184 340-362 Disease denotes multiple organ failure MESH:D009102
4185 388-397 Disease denotes pneumonia MESH:D011014
4186 624-639 Disease denotes microangiopathy MESH:D000783
4187 650-658 Disease denotes COVID-19 MESH:C000657245
4188 676-698 Disease denotes pulmonary inflammation MESH:D011014
4189 945-953 Disease denotes COVID-19 MESH:C000657245
4204 1004-1012 Species denotes patients Tax:9606
4205 1326-1334 Species denotes patients Tax:9606
4206 1366-1367 Gene denotes a Gene:351
4207 1062-1063 Gene denotes a Gene:351
4208 973-974 Gene denotes a Gene:351
4209 1126-1133 Chemical denotes heparin MESH:D006493
4210 1025-1033 Disease denotes COVID-19 MESH:C000657245
4211 1070-1079 Disease denotes mortality MESH:D003643
4212 1150-1162 Disease denotes coagulopathy MESH:D001778
4213 1263-1273 Disease denotes thrombosis MESH:D013927
4214 1304-1313 Disease denotes mortality MESH:D003643
4215 1317-1325 Disease denotes COVID-19 MESH:C000657245
4216 1389-1395 Disease denotes sepsis MESH:D018805
4217 1404-1416 Disease denotes coagulopathy MESH:D001778
4224 1529-1537 Species denotes patients Tax:9606
4225 1720-1728 Species denotes patients Tax:9606
4226 1486-1487 Gene denotes a Gene:351
4227 1520-1528 Disease denotes COVID-19 MESH:C000657245
4228 1682-1691 Disease denotes mortality MESH:D003643
4229 1702-1711 Disease denotes mortality MESH:D003643
4236 1957-1959 Gene denotes to Gene:6999
4237 1885-1887 Gene denotes to Gene:6999
4238 2278-2286 Species denotes patients Tax:9606
4239 1903-1910 Chemical denotes heparin MESH:D006493
4240 2109-2117 Disease denotes COVID-19 MESH:C000657245
4241 2292-2300 Disease denotes COVID-19 MESH:C000657245