PMC:7652766 / 110687-111343 JSONTXT

{"project":"LitCovid-PD-HP","denotations":[{"id":"T157","span":{"begin":467,"end":479},"obj":"Phenotype"}],"attributes":[{"id":"A157","pred":"hp_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/HP_0004395"}],"text":"According to Navarro et al. (391), no adverse effects of high doses of ivermectin have so far been demonstrated in clinical studies with patients, with only a few transient ocular events in those who experienced high doses (up to 400 μg/kg). However, Duthaler et al. (392) demonstrated that the adverse effects of ivermectin in the body can vary according to the patient’s nutritional status, and the effects of high doses can be harmful, especially in patients with malnutrition levels. The general consensus of the authors is that further studies are needed to evaluate the efficacy and safety of ivermectin administered in high doses against SARS-CoV-2."}

{"project":"LitCovid-sentences","denotations":[{"id":"T544","span":{"begin":0,"end":241},"obj":"Sentence"},{"id":"T545","span":{"begin":242,"end":487},"obj":"Sentence"},{"id":"T546","span":{"begin":488,"end":656},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"According to Navarro et al. (391), no adverse effects of high doses of ivermectin have so far been demonstrated in clinical studies with patients, with only a few transient ocular events in those who experienced high doses (up to 400 μg/kg). However, Duthaler et al. (392) demonstrated that the adverse effects of ivermectin in the body can vary according to the patient’s nutritional status, and the effects of high doses can be harmful, especially in patients with malnutrition levels. The general consensus of the authors is that further studies are needed to evaluate the efficacy and safety of ivermectin administered in high doses against SARS-CoV-2."}

{"project":"LitCovid-PubTator","denotations":[{"id":"4085","span":{"begin":560,"end":562},"obj":"Gene"},{"id":"4086","span":{"begin":356,"end":358},"obj":"Gene"},{"id":"4087","span":{"begin":227,"end":229},"obj":"Gene"},{"id":"4088","span":{"begin":10,"end":12},"obj":"Gene"},{"id":"4089","span":{"begin":137,"end":145},"obj":"Species"},{"id":"4090","span":{"begin":363,"end":370},"obj":"Species"},{"id":"4091","span":{"begin":453,"end":461},"obj":"Species"},{"id":"4092","span":{"begin":645,"end":655},"obj":"Species"},{"id":"4093","span":{"begin":157,"end":158},"obj":"Gene"},{"id":"4094","span":{"begin":71,"end":81},"obj":"Chemical"},{"id":"4095","span":{"begin":599,"end":609},"obj":"Chemical"}],"attributes":[{"id":"A4085","pred":"tao:has_database_id","subj":"4085","obj":"Gene:6999"},{"id":"A4086","pred":"tao:has_database_id","subj":"4086","obj":"Gene:6999"},{"id":"A4087","pred":"tao:has_database_id","subj":"4087","obj":"Gene:6999"},{"id":"A4088","pred":"tao:has_database_id","subj":"4088","obj":"Gene:6999"},{"id":"A4089","pred":"tao:has_database_id","subj":"4089","obj":"Tax:9606"},{"id":"A4090","pred":"tao:has_database_id","subj":"4090","obj":"Tax:9606"},{"id":"A4091","pred":"tao:has_database_id","subj":"4091","obj":"Tax:9606"},{"id":"A4092","pred":"tao:has_database_id","subj":"4092","obj":"Tax:2697049"},{"id":"A4093","pred":"tao:has_database_id","subj":"4093","obj":"Gene:351"},{"id":"A4094","pred":"tao:has_database_id","subj":"4094","obj":"MESH:D007559"},{"id":"A4095","pred":"tao:has_database_id","subj":"4095","obj":"MESH:D007559"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"According to Navarro et al. (391), no adverse effects of high doses of ivermectin have so far been demonstrated in clinical studies with patients, with only a few transient ocular events in those who experienced high doses (up to 400 μg/kg). However, Duthaler et al. (392) demonstrated that the adverse effects of ivermectin in the body can vary according to the patient’s nutritional status, and the effects of high doses can be harmful, especially in patients with malnutrition levels. The general consensus of the authors is that further studies are needed to evaluate the efficacy and safety of ivermectin administered in high doses against SARS-CoV-2."}