PMC:7652766 / 10055-10584 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T54	0-529	Sentence	denotes	Two important characteristics were described in the genome of SARS-CoV-2 that lead to alterations in the S protein: (i) receptor-binding domain (RBD), which is the most variable part of the viral genome, appears to be optimized for binding to the human ACE2 receptor, and (ii) presence of a polybasic (furin) cleavage site at the S1 and S2 boundary, via the insertion of twelve nucleotides, which allows effective cleavage by furin and other proteases and has a role in determining viral tropism, infectivity, and host range (4).

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
437	253-257	Gene	denotes	ACE2	Gene:59272
438	426-431	Gene	denotes	furin	Gene:5045
439	302-307	Gene	denotes	furin	Gene:5045
442	240-242	Gene	denotes	to	Gene:6999
443	212-214	Gene	denotes	to	Gene:6999
444	83-85	Gene	denotes	to	Gene:6999
446	62-72	Species	denotes	SARS-CoV-2	Tax:2697049
447	247-252	Species	denotes	human	Tax:9606
448	460-461	Gene	denotes	a	Gene:351
449	289-290	Gene	denotes	a	Gene:351