PMC:7652766 / 10022-10333 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"437","span":{"begin":286,"end":290},"obj":"Gene"},{"id":"442","span":{"begin":273,"end":275},"obj":"Gene"},{"id":"443","span":{"begin":245,"end":247},"obj":"Gene"},{"id":"444","span":{"begin":116,"end":118},"obj":"Gene"},{"id":"446","span":{"begin":95,"end":105},"obj":"Species"},{"id":"447","span":{"begin":280,"end":285},"obj":"Species"}],"attributes":[{"id":"A437","pred":"tao:has_database_id","subj":"437","obj":"Gene:59272"},{"id":"A442","pred":"tao:has_database_id","subj":"442","obj":"Gene:6999"},{"id":"A443","pred":"tao:has_database_id","subj":"443","obj":"Gene:6999"},{"id":"A444","pred":"tao:has_database_id","subj":"444","obj":"Gene:6999"},{"id":"A446","pred":"tao:has_database_id","subj":"446","obj":"Tax:2697049"},{"id":"A447","pred":"tao:has_database_id","subj":"447","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":" tropism, and transmission (39). Two important characteristics were described in the genome of SARS-CoV-2 that lead to alterations in the S protein: (i) receptor-binding domain (RBD), which is the most variable part of the viral genome, appears to be optimized for binding to the human ACE2 receptor, and (ii) p"}