PMC:7647877 / 8090-8457 JSONTXT

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{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T38","span":{"begin":148,"end":160},"obj":"Disease"},{"id":"T39","span":{"begin":354,"end":366},"obj":"Disease"}],"attributes":[{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"NFκB is the key transcriptional regulator of many pro-inflammatory cytokines, adhesion molecules, chemokines, growth factors and other mediators of inflammation, as tumour necrosis factor (TNF), interleukins 1 (IL-1β), 6 (IL-6), and 12 (IL-12), promotes cellular proliferation and protects against apoptosis providing a mechanism that determines chronic inflammation."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T161","span":{"begin":3,"end":4},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T162","span":{"begin":195,"end":209},"obj":"http://purl.obolibrary.org/obo/PR_000001091"},{"id":"T163","span":{"begin":318,"end":319},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"NFκB is the key transcriptional regulator of many pro-inflammatory cytokines, adhesion molecules, chemokines, growth factors and other mediators of inflammation, as tumour necrosis factor (TNF), interleukins 1 (IL-1β), 6 (IL-6), and 12 (IL-12), promotes cellular proliferation and protects against apoptosis providing a mechanism that determines chronic inflammation."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T91","span":{"begin":0,"end":2},"obj":"Chemical"},{"id":"T94","span":{"begin":87,"end":96},"obj":"Chemical"},{"id":"T95","span":{"begin":195,"end":207},"obj":"Chemical"},{"id":"T96","span":{"begin":211,"end":213},"obj":"Chemical"},{"id":"T98","span":{"begin":222,"end":224},"obj":"Chemical"},{"id":"T100","span":{"begin":237,"end":239},"obj":"Chemical"}],"attributes":[{"id":"A91","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A92","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A93","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A94","pred":"chebi_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A95","pred":"chebi_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/CHEBI_52998"},{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A97","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A99","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A100","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A101","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"NFκB is the key transcriptional regulator of many pro-inflammatory cytokines, adhesion molecules, chemokines, growth factors and other mediators of inflammation, as tumour necrosis factor (TNF), interleukins 1 (IL-1β), 6 (IL-6), and 12 (IL-12), promotes cellular proliferation and protects against apoptosis providing a mechanism that determines chronic inflammation."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T8","span":{"begin":165,"end":171},"obj":"Phenotype"}],"attributes":[{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"NFκB is the key transcriptional regulator of many pro-inflammatory cytokines, adhesion molecules, chemokines, growth factors and other mediators of inflammation, as tumour necrosis factor (TNF), interleukins 1 (IL-1β), 6 (IL-6), and 12 (IL-12), promotes cellular proliferation and protects against apoptosis providing a mechanism that determines chronic inflammation."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T42","span":{"begin":16,"end":31},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T43","span":{"begin":110,"end":116},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T44","span":{"begin":148,"end":160},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T45","span":{"begin":172,"end":180},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T46","span":{"begin":172,"end":180},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T47","span":{"begin":172,"end":180},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T48","span":{"begin":172,"end":180},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T49","span":{"begin":298,"end":307},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T50","span":{"begin":298,"end":307},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T51","span":{"begin":354,"end":366},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"NFκB is the key transcriptional regulator of many pro-inflammatory cytokines, adhesion molecules, chemokines, growth factors and other mediators of inflammation, as tumour necrosis factor (TNF), interleukins 1 (IL-1β), 6 (IL-6), and 12 (IL-12), promotes cellular proliferation and protects against apoptosis providing a mechanism that determines chronic inflammation."}

{"project":"LitCovid-sentences","denotations":[{"id":"T52","span":{"begin":0,"end":367},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"NFκB is the key transcriptional regulator of many pro-inflammatory cytokines, adhesion molecules, chemokines, growth factors and other mediators of inflammation, as tumour necrosis factor (TNF), interleukins 1 (IL-1β), 6 (IL-6), and 12 (IL-12), promotes cellular proliferation and protects against apoptosis providing a mechanism that determines chronic inflammation."}

{"project":"LitCovid-PubTator","denotations":[{"id":"242","span":{"begin":0,"end":4},"obj":"Gene"},{"id":"243","span":{"begin":165,"end":187},"obj":"Gene"},{"id":"244","span":{"begin":189,"end":192},"obj":"Gene"},{"id":"245","span":{"begin":211,"end":216},"obj":"Gene"},{"id":"246","span":{"begin":222,"end":226},"obj":"Gene"},{"id":"254","span":{"begin":148,"end":160},"obj":"Disease"},{"id":"255","span":{"begin":354,"end":366},"obj":"Disease"}],"attributes":[{"id":"A242","pred":"tao:has_database_id","subj":"242","obj":"Gene:4790"},{"id":"A243","pred":"tao:has_database_id","subj":"243","obj":"Gene:7124"},{"id":"A244","pred":"tao:has_database_id","subj":"244","obj":"Gene:7124"},{"id":"A245","pred":"tao:has_database_id","subj":"245","obj":"Gene:3552"},{"id":"A246","pred":"tao:has_database_id","subj":"246","obj":"Gene:3569"},{"id":"A254","pred":"tao:has_database_id","subj":"254","obj":"MESH:D007249"},{"id":"A255","pred":"tao:has_database_id","subj":"255","obj":"MESH:D007249"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"NFκB is the key transcriptional regulator of many pro-inflammatory cytokines, adhesion molecules, chemokines, growth factors and other mediators of inflammation, as tumour necrosis factor (TNF), interleukins 1 (IL-1β), 6 (IL-6), and 12 (IL-12), promotes cellular proliferation and protects against apoptosis providing a mechanism that determines chronic inflammation."}