PMC:7647877 / 7001-9871
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T120 | 19-27 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T121 | 49-61 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T122 | 49-53 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T123 | 221-228 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T124 | 307-311 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T125 | 479-483 | Body_part | denotes | IL-2 | http://purl.org/sig/ont/fma/fma84051 |
| T126 | 479-481 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T127 | 485-487 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T128 | 491-493 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T129 | 497-499 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T130 | 503-505 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T131 | 510-512 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T132 | 517-522 | Body_part | denotes | IL-12 | http://purl.org/sig/ont/fma/fma86579 |
| T133 | 517-519 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T134 | 524-526 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T135 | 531-533 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T136 | 538-540 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T137 | 545-547 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T138 | 555-557 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T139 | 571-581 | Body_part | denotes | chemokines | http://purl.org/sig/ont/fma/fma241981 |
| T140 | 619-628 | Body_part | denotes | chemokine | http://purl.org/sig/ont/fma/fma241981 |
| T141 | 686-690 | Body_part | denotes | Cell | http://purl.org/sig/ont/fma/fma68646 |
| T142 | 734-743 | Body_part | denotes | Chemokine | http://purl.org/sig/ont/fma/fma241981 |
| T143 | 774-782 | Body_part | denotes | Monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T144 | 799-806 | Body_part | denotes | Protein | http://purl.org/sig/ont/fma/fma67257 |
| T145 | 855-863 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T146 | 1075-1080 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T147 | 1156-1165 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T148 | 1187-1197 | Body_part | denotes | chemokines | http://purl.org/sig/ont/fma/fma241981 |
| T149 | 1284-1298 | Body_part | denotes | interleukins 1 | http://purl.org/sig/ont/fma/fma86583 |
| T150 | 1284-1296 | Body_part | denotes | interleukins | http://purl.org/sig/ont/fma/fma86578 |
| T151 | 1300-1304 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T152 | 1300-1302 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T153 | 1311-1313 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T154 | 1326-1331 | Body_part | denotes | IL-12 | http://purl.org/sig/ont/fma/fma86579 |
| T155 | 1326-1328 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T156 | 1742-1745 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
| T157 | 1769-1772 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T158 | 1799-1802 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T159 | 1826-1837 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T160 | 1839-1854 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
| T161 | 1849-1854 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T162 | 1856-1867 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T163 | 1869-1880 | Body_part | denotes | eosinophils | http://purl.org/sig/ont/fma/fma62861 |
| T164 | 1882-1898 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T165 | 1893-1898 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T166 | 1903-1916 | Body_part | denotes | keratinocytes | http://purl.org/sig/ont/fma/fma62879 |
| T167 | 2015-2018 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T168 | 2096-2108 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T169 | 2211-2221 | Body_part | denotes | Nucleotide | http://purl.org/sig/ont/fma/fma82740 |
| T170 | 2238-2245 | Body_part | denotes | Leucine | http://purl.org/sig/ont/fma/fma82757 |
| T171 | 2264-2272 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T172 | 2349-2356 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T173 | 2561-2573 | Body_part | denotes | B lymphocyte | http://purl.org/sig/ont/fma/fma62869 |
| T174 | 2580-2603 | Body_part | denotes | cytotoxic; T lymphocyte | http://purl.org/sig/ont/fma/fma70573 |
| T175 | 2591-2603 | Body_part | denotes | T lymphocyte | http://purl.org/sig/ont/fma/fma62870 |
| T176 | 2626-2640 | Body_part | denotes | immunoglobulin | http://purl.org/sig/ont/fma/fma62871 |
| T177 | 2642-2644 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T178 | 2646-2657 | Body_part | denotes | interleukin | http://purl.org/sig/ont/fma/fma86578 |
| T179 | 2659-2662 | Body_part | denotes | MHC | http://purl.org/sig/ont/fma/fma84079 |
| T180 | 2761-2766 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T181 | 2772-2791 | Body_part | denotes | natural killer cell | http://purl.org/sig/ont/fma/fma63147 |
| T182 | 2787-2791 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T183 | 2797-2816 | Body_part | denotes | helper T lymphocyte | http://purl.org/sig/ont/fma/fma70572 |
| T184 | 2804-2816 | Body_part | denotes | T lymphocyte | http://purl.org/sig/ont/fma/fma62870 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T37 | 373-389 | Disease | denotes | virus infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T38 | 1237-1249 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T39 | 1443-1455 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T40 | 2529-2533 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T135 | 49-53 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T136 | 71-80 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T137 | 98-104 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T138 | 137-138 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T139 | 170-171 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T140 | 301-302 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T141 | 307-311 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T142 | 373-378 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T143 | 424-434 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
| T144 | 479-483 | http://purl.obolibrary.org/obo/PR_000001379 | denotes | IL-2 |
| T145 | 485-489 | http://purl.obolibrary.org/obo/PR_000001387 | denotes | IL-3 |
| T146 | 510-515 | http://purl.obolibrary.org/obo/CLO_0053702 | denotes | IL-11 |
| T147 | 541-543 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T148 | 558-560 | http://purl.obolibrary.org/obo/CLO_0050509 | denotes | 27 |
| T149 | 609-612 | http://purl.obolibrary.org/obo/CLO_0009645 | denotes | X-C |
| T150 | 609-612 | http://purl.obolibrary.org/obo/CLO_0050824 | denotes | X-C |
| T151 | 665-675 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activation |
| T152 | 684-690 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T Cell |
| T153 | 774-782 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | Monocyte |
| T154 | 818-820 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T155 | 891-899 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T156 | 960-970 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
| T157 | 977-987 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T158 | 1063-1072 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T159 | 1073-1080 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
| T160 | 1085-1086 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T161 | 1092-1093 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T162 | 1284-1298 | http://purl.obolibrary.org/obo/PR_000001091 | denotes | interleukins 1 |
| T163 | 1407-1408 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T164 | 1657-1666 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T165 | 1839-1854 | http://purl.obolibrary.org/obo/CL_0000451 | denotes | dendritic cells |
| T166 | 1882-1892 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T167 | 1893-1898 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T168 | 1903-1916 | http://purl.obolibrary.org/obo/CL_0000312 | denotes | keratinocytes |
| T169 | 2185-2186 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T170 | 2360-2363 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T171 | 2364-2365 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T172 | 2558-2562 | http://purl.obolibrary.org/obo/CLO_0001869 | denotes | B: B |
| T173 | 2699-2700 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T174 | 2749-2758 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T175 | 2759-2766 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
| T176 | 2772-2791 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | natural killer cell |
| T177 | 2797-2816 | http://purl.obolibrary.org/obo/CL_0000912 | denotes | helper T lymphocyte |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T54 | 221-228 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T55 | 281-288 | Chemical | denotes | nucleus | http://purl.obolibrary.org/obo/CHEBI_33252 |
| T56 | 479-481 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T58 | 485-487 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T60 | 491-493 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T62 | 497-499 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T64 | 503-505 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T66 | 510-512 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T68 | 517-519 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T70 | 524-526 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T72 | 531-533 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T74 | 538-540 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T76 | 545-547 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T78 | 555-557 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T80 | 619-638 | Chemical | denotes | chemokine ligand 10 | http://purl.obolibrary.org/obo/CHEBI_138157 |
| T81 | 629-635 | Chemical | denotes | ligand | http://purl.obolibrary.org/obo/CHEBI_52214 |
| T82 | 756-762 | Chemical | denotes | ligand | http://purl.obolibrary.org/obo/CHEBI_52214 |
| T83 | 766-769 | Chemical | denotes | CCL | http://purl.obolibrary.org/obo/CHEBI_3478 |
| T84 | 799-806 | Chemical | denotes | Protein | http://purl.obolibrary.org/obo/CHEBI_16541 |
| T85 | 810-813 | Chemical | denotes | MCP | http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099 |
| T87 | 838-845 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T88 | 1082-1084 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T91 | 1089-1091 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T94 | 1176-1185 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T95 | 1284-1296 | Chemical | denotes | interleukins | http://purl.obolibrary.org/obo/CHEBI_52998 |
| T96 | 1300-1302 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T98 | 1311-1313 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T100 | 1326-1328 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T102 | 1742-1745 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
| T103 | 1753-1772 | Chemical | denotes | double-stranded RNA | http://purl.obolibrary.org/obo/CHEBI_67208 |
| T104 | 2096-2108 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T105 | 2182-2184 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T108 | 2211-2221 | Chemical | denotes | Nucleotide | http://purl.obolibrary.org/obo/CHEBI_36976 |
| T109 | 2264-2272 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T110 | 2349-2356 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T111 | 2445-2454 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T112 | 2519-2528 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T113 | 2610-2620 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T114 | 2642-2644 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T116 | 2696-2698 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T119 | 2793-2795 | Chemical | denotes | Th | http://purl.obolibrary.org/obo/CHEBI_33385 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T8 | 1254-1260 | Phenotype | denotes | tumour | http://purl.obolibrary.org/obo/HP_0002664 |
| T9 | 2848-2854 | Phenotype | denotes | tumour | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T28 | 84-125 | http://purl.obolibrary.org/obo/GO_0035556 | denotes | intracellular signal transduction pathway |
| T29 | 98-117 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signal transduction |
| T30 | 105-117 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | transduction |
| T31 | 188-202 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylates |
| T32 | 207-220 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T33 | 312-325 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T34 | 424-443 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signalling pathways |
| T35 | 424-434 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
| T36 | 855-874 | http://purl.obolibrary.org/obo/GO_0002377 | denotes | antibody production |
| T37 | 891-915 | http://purl.obolibrary.org/obo/GO_0050766 | denotes | activity of phagocytosis |
| T38 | 903-915 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
| T39 | 960-970 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
| T40 | 991-1012 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factors |
| T41 | 991-1004 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T42 | 1105-1120 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
| T43 | 1199-1205 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T44 | 1237-1249 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T45 | 1261-1269 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T46 | 1261-1269 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T47 | 1261-1269 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T48 | 1261-1269 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T49 | 1387-1396 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T50 | 1387-1396 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T51 | 1443-1455 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T52 | 1634-1653 | http://purl.obolibrary.org/obo/GO_0006952 | denotes | defensive responses |
| T53 | 2390-2412 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune response |
| T54 | 2397-2412 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T55 | 2659-2662 | http://purl.obolibrary.org/obo/GO_0046776 | denotes | MHC |
| T56 | 2855-2863 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T57 | 2855-2863 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T58 | 2855-2863 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T59 | 2855-2863 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T47 | 0-236 | Sentence | denotes | The binding of the cytokine to its transmembrane cell surface receptor activates an intracellular signal transduction pathway, generally a Janus kinase (Jak), which, via a kinase cascade, phosphorylates its transcription protein (STAT). |
| T48 | 237-326 | Sentence | denotes | Phosphorylated STAT dimers and moves to the nucleus, initiating a new gene transcription. |
| T49 | 327-822 | Sentence | denotes | Mutation of STAT1 increases susceptibility to virus infections because it is involved in various signalling pathways, including IFN-α/β, IFN- γ, IFN-l, IL-2, IL-3, IL-6, IL-9, IL-10, IL-11, IL-12, IL-15, IL-21, IL-22, IL-26 and IL-27 [10], and chemokines of several types such as C-X-C motif chemokine ligand 10 (CXCL-10), Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted (RANTES)/Chemokine (C–C motif) ligand 5 (CCL-5), Monocyte Chemoattractant Protein-1 (MCP-1) [11]. |
| T50 | 823-916 | Sentence | denotes | IFN-γ promotes antigen-specific antibody production, increasing the activity of phagocytosis. |
| T51 | 917-1088 | Sentence | denotes | In the meantime, PRRs trigger inflammatory signalling, with activation of transcription factors like nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB). |
| T52 | 1089-1456 | Sentence | denotes | NFκB is the key transcriptional regulator of many pro-inflammatory cytokines, adhesion molecules, chemokines, growth factors and other mediators of inflammation, as tumour necrosis factor (TNF), interleukins 1 (IL-1β), 6 (IL-6), and 12 (IL-12), promotes cellular proliferation and protects against apoptosis providing a mechanism that determines chronic inflammation. |
| T53 | 1457-1564 | Sentence | denotes | The recognition of pathogens is achieved through the presence of pattern recognition receptors (PRRs) [12]. |
| T54 | 1565-1667 | Sentence | denotes | PRRs identify the microbe-associated molecular patterns (MAMPs), and defensive responses is activated. |
| T55 | 1668-1803 | Sentence | denotes | PRRs include Toll-like receptors (TLRs), that are able to recognize viral DNA, viral double-stranded RNA and viral single-stranded RNA. |
| T56 | 1804-1917 | Sentence | denotes | TLRs are expressed on macrophages, dendritic cells, neutrophils, eosinophils, epithelial cells and keratinocytes. |
| T57 | 1918-2041 | Sentence | denotes | In particular, intracellular TLR-7 and TLR-8 allow the innate recognition of the single-stranded RNA of coronaviruses [13]. |
| T58 | 2042-2200 | Sentence | denotes | Intracellular and extracellular PRRs recognized spike glycoprotein, of the coronavirus coat, starting the inflammatory process, through the NFκB pathway [14]. |
| T59 | 2201-2418 | Sentence | denotes | Moreover, Nucleotide-Binding Domain, Leucine-Rich Repeat (NLR) proteins have also been identified, and NALP3 (NACHT, LRR and PYD domains-containing protein 3) has a special function in the innate immune response [15]. |
| T60 | 2419-2483 | Sentence | denotes | The processes involved in antiviral immunity is shown in Fig. 1. |
| T61 | 2484-2557 | Sentence | denotes | Fig. 1 Graphical representation of antiviral SARS-Coronavirus 2 immunity. |
| T62 | 2558-2560 | Sentence | denotes | B: |
| T63 | 2561-2822 | Sentence | denotes | B lymphocyte; CTL: cytotoxic; T lymphocyte; IFN: interferon; Ig: immunoglobulin; IL: interleukin; MHC: major histocompatibility class; NFκB: nuclear factor kappa-light- chain- enhancer of activated B cells; NK: natural killer cell; Th: helper T lymphocyte; TLR: |
| T64 | 2823-2870 | Sentence | denotes | Toll-like receptor; TNF: tumour necrosis factor |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 176 | 2843-2846 | Gene | denotes | TNF | Gene:7124 |
| 177 | 2529-2547 | Species | denotes | SARS-Coronavirus 2 | Tax:2697049 |
| 178 | 2696-2700 | Gene | denotes | NFκB | Gene:4790 |
| 179 | 2610-2620 | Gene | denotes | interferon | Gene:3439 |
| 180 | 2605-2608 | Gene | denotes | IFN | Gene:3439 |
| 181 | 2848-2863 | Disease | denotes | tumour necrosis | MESH:D009336 |
| 219 | 339-344 | Gene | denotes | STAT1 | Gene:6772 |
| 220 | 455-462 | Gene | denotes | IFN-α/β | Gene:3440 |
| 221 | 464-470 | Gene | denotes | IFN- γ | Gene:3458 |
| 222 | 479-483 | Gene | denotes | IL-2 | Gene:3558 |
| 223 | 485-489 | Gene | denotes | IL-3 | Gene:3562 |
| 224 | 491-495 | Gene | denotes | IL-6 | Gene:3569 |
| 225 | 497-501 | Gene | denotes | IL-9 | Gene:3578 |
| 226 | 503-508 | Gene | denotes | IL-10 | Gene:3586 |
| 227 | 510-515 | Gene | denotes | IL-11 | Gene:3589 |
| 228 | 524-529 | Gene | denotes | IL-15 | Gene:3600 |
| 229 | 531-536 | Gene | denotes | IL-21 | Gene:59067 |
| 230 | 538-543 | Gene | denotes | IL-22 | Gene:50616 |
| 231 | 545-550 | Gene | denotes | IL-26 | Gene:55801 |
| 232 | 555-560 | Gene | denotes | IL-27 | Gene:246778 |
| 233 | 607-638 | Gene | denotes | C-X-C motif chemokine ligand 10 | Gene:3627 |
| 234 | 640-647 | Gene | denotes | CXCL-10 | Gene:3627 |
| 235 | 726-732 | Gene | denotes | RANTES | Gene:6352 |
| 236 | 734-764 | Gene | denotes | Chemokine (C–C motif) ligand 5 | Gene:6352 |
| 237 | 766-771 | Gene | denotes | CCL-5 | Gene:6352 |
| 238 | 774-808 | Gene | denotes | Monocyte Chemoattractant Protein-1 | Gene:6347 |
| 239 | 810-815 | Gene | denotes | MCP-1 | Gene:6347 |
| 240 | 823-828 | Gene | denotes | IFN-γ | Gene:3458 |
| 241 | 1082-1086 | Gene | denotes | NFκB | Gene:4790 |
| 242 | 1089-1093 | Gene | denotes | NFκB | Gene:4790 |
| 243 | 1254-1276 | Gene | denotes | tumour necrosis factor | Gene:7124 |
| 244 | 1278-1281 | Gene | denotes | TNF | Gene:7124 |
| 245 | 1300-1305 | Gene | denotes | IL-1β | Gene:3552 |
| 246 | 1311-1315 | Gene | denotes | IL-6 | Gene:3569 |
| 247 | 2182-2186 | Gene | denotes | NFκB | Gene:4790 |
| 248 | 2304-2309 | Gene | denotes | NALP3 | Gene:114548 |
| 249 | 2311-2358 | Gene | denotes | NACHT, LRR and PYD domains-containing protein 3 | Gene:114548 |
| 250 | 2022-2035 | Species | denotes | coronaviruses | Tax:11118 |
| 251 | 2117-2128 | Species | denotes | coronavirus | Tax:11118 |
| 252 | 2238-2245 | Chemical | denotes | Leucine | MESH:D007930 |
| 253 | 373-389 | Disease | denotes | virus infections | MESH:D001102 |
| 254 | 1237-1249 | Disease | denotes | inflammation | MESH:D007249 |
| 255 | 1443-1455 | Disease | denotes | inflammation | MESH:D007249 |