PMC:7647877 / 59847-60961 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T664","span":{"begin":133,"end":141},"obj":"Body_part"},{"id":"T665","span":{"begin":165,"end":179},"obj":"Body_part"},{"id":"T666","span":{"begin":165,"end":169},"obj":"Body_part"},{"id":"T667","span":{"begin":219,"end":231},"obj":"Body_part"},{"id":"T668","span":{"begin":251,"end":256},"obj":"Body_part"},{"id":"T669","span":{"begin":270,"end":280},"obj":"Body_part"},{"id":"T670","span":{"begin":350,"end":361},"obj":"Body_part"},{"id":"T671","span":{"begin":363,"end":372},"obj":"Body_part"},{"id":"T672","span":{"begin":391,"end":398},"obj":"Body_part"},{"id":"T673","span":{"begin":394,"end":398},"obj":"Body_part"},{"id":"T674","span":{"begin":515,"end":526},"obj":"Body_part"},{"id":"T675","span":{"begin":554,"end":565},"obj":"Body_part"},{"id":"T676","span":{"begin":606,"end":612},"obj":"Body_part"},{"id":"T677","span":{"begin":647,"end":652},"obj":"Body_part"},{"id":"T678","span":{"begin":674,"end":682},"obj":"Body_part"},{"id":"T679","span":{"begin":718,"end":723},"obj":"Body_part"},{"id":"T680","span":{"begin":891,"end":899},"obj":"Body_part"},{"id":"T681","span":{"begin":917,"end":926},"obj":"Body_part"},{"id":"T682","span":{"begin":995,"end":1000},"obj":"Body_part"},{"id":"T683","span":{"begin":1015,"end":1032},"obj":"Body_part"},{"id":"T684","span":{"begin":1027,"end":1032},"obj":"Body_part"},{"id":"T685","span":{"begin":1053,"end":1064},"obj":"Body_part"}],"attributes":[{"id":"A664","pred":"fma_id","subj":"T664","obj":"http://purl.org/sig/ont/fma/fma63891"},{"id":"A665","pred":"fma_id","subj":"T665","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A666","pred":"fma_id","subj":"T666","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A667","pred":"fma_id","subj":"T667","obj":"http://purl.org/sig/ont/fma/fma62879"},{"id":"A668","pred":"fma_id","subj":"T668","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A669","pred":"fma_id","subj":"T669","obj":"http://purl.org/sig/ont/fma/fma63877"},{"id":"A670","pred":"fma_id","subj":"T670","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A671","pred":"fma_id","subj":"T671","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A672","pred":"fma_id","subj":"T672","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A673","pred":"fma_id","subj":"T673","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A674","pred":"fma_id","subj":"T674","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A675","pred":"fma_id","subj":"T675","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A676","pred":"fma_id","subj":"T676","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A677","pred":"fma_id","subj":"T677","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A678","pred":"fma_id","subj":"T678","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A679","pred":"fma_id","subj":"T679","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A680","pred":"fma_id","subj":"T680","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A681","pred":"fma_id","subj":"T681","obj":"http://purl.org/sig/ont/fma/fma61806"},{"id":"A682","pred":"fma_id","subj":"T682","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A683","pred":"fma_id","subj":"T683","obj":"http://purl.org/sig/ont/fma/fma70573"},{"id":"A684","pred":"fma_id","subj":"T684","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A685","pred":"fma_id","subj":"T685","obj":"http://purl.org/sig/ont/fma/fma62863"}],"text":"Vitamin C Oranges and orange juice, red and green peppers, strawberries, blackcurrants, kiwi, broccoli, brussels sprouts, potatoes ↑ collagen synthesis and protects cell membranes from damage caused by free radicals; ↑ keratinocyte differentiation; ↑ lipid synthesis; ↑ fibroblast proliferation and migration\nProliferation, function, and movement of neutrophils, monocytes and phagocytes; ↑ NK cell activities and chemotaxis\n↑ Phagocytosis and ROS generation; ↑ microbial killing\n↑ Apoptosis and clearance of spent neutrophils from sites of infection by macrophages\n↓ Extracellular trap (NET) formation, ↓ tissue damage\n↑ Antimicrobial effects; ↑ serum levels of complement proteins\nMaintains redox homeostasis within cells and protects against ROS and RNS during oxidative burst; regenerates other important antioxidants, such as glutathione and vitamin E, to their active state; modulates cytokine production and ↓ histamine levels\nRoles in production, differentiation, and proliferation of T cells, particularly cytotoxic T cells; ↑ proliferation of lymphocytes, ↑ generation of antibodies [79, 85, 92, 95, 120]"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T139","span":{"begin":606,"end":612},"obj":"Body_part"},{"id":"T140","span":{"begin":647,"end":652},"obj":"Body_part"}],"attributes":[{"id":"A139","pred":"uberon_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A140","pred":"uberon_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"Vitamin C Oranges and orange juice, red and green peppers, strawberries, blackcurrants, kiwi, broccoli, brussels sprouts, potatoes ↑ collagen synthesis and protects cell membranes from damage caused by free radicals; ↑ keratinocyte differentiation; ↑ lipid synthesis; ↑ fibroblast proliferation and migration\nProliferation, function, and movement of neutrophils, monocytes and phagocytes; ↑ NK cell activities and chemotaxis\n↑ Phagocytosis and ROS generation; ↑ microbial killing\n↑ Apoptosis and clearance of spent neutrophils from sites of infection by macrophages\n↓ Extracellular trap (NET) formation, ↓ tissue damage\n↑ Antimicrobial effects; ↑ serum levels of complement proteins\nMaintains redox homeostasis within cells and protects against ROS and RNS during oxidative burst; regenerates other important antioxidants, such as glutathione and vitamin E, to their active state; modulates cytokine production and ↓ histamine levels\nRoles in production, differentiation, and proliferation of T cells, particularly cytotoxic T cells; ↑ proliferation of lymphocytes, ↑ generation of antibodies [79, 85, 92, 95, 120]"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T270","span":{"begin":541,"end":550},"obj":"Disease"},{"id":"T271","span":{"begin":753,"end":756},"obj":"Disease"}],"attributes":[{"id":"A270","pred":"mondo_id","subj":"T270","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A271","pred":"mondo_id","subj":"T271","obj":"http://purl.obolibrary.org/obo/MONDO_0009821"},{"id":"A272","pred":"mondo_id","subj":"T271","obj":"http://purl.obolibrary.org/obo/MONDO_0019105"}],"text":"Vitamin C Oranges and orange juice, red and green peppers, strawberries, blackcurrants, kiwi, broccoli, brussels sprouts, potatoes ↑ collagen synthesis and protects cell membranes from damage caused by free radicals; ↑ keratinocyte differentiation; ↑ lipid synthesis; ↑ fibroblast proliferation and migration\nProliferation, function, and movement of neutrophils, monocytes and phagocytes; ↑ NK cell activities and chemotaxis\n↑ Phagocytosis and ROS generation; ↑ microbial killing\n↑ Apoptosis and clearance of spent neutrophils from sites of infection by macrophages\n↓ Extracellular trap (NET) formation, ↓ tissue damage\n↑ Antimicrobial effects; ↑ serum levels of complement proteins\nMaintains redox homeostasis within cells and protects against ROS and RNS during oxidative burst; regenerates other important antioxidants, such as glutathione and vitamin E, to their active state; modulates cytokine production and ↓ histamine levels\nRoles in production, differentiation, and proliferation of T cells, particularly cytotoxic T cells; ↑ proliferation of lymphocytes, ↑ generation of antibodies [79, 85, 92, 95, 120]"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T745","span":{"begin":133,"end":141},"obj":"http://purl.obolibrary.org/obo/CHEBI_3815"},{"id":"T746","span":{"begin":165,"end":169},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T747","span":{"begin":170,"end":179},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T748","span":{"begin":219,"end":231},"obj":"http://purl.obolibrary.org/obo/CL_0000312"},{"id":"T749","span":{"begin":270,"end":280},"obj":"http://purl.obolibrary.org/obo/CL_0000057"},{"id":"T750","span":{"begin":363,"end":372},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T751","span":{"begin":377,"end":387},"obj":"http://purl.obolibrary.org/obo/CL_0000234"},{"id":"T752","span":{"begin":391,"end":398},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T753","span":{"begin":399,"end":409},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T754","span":{"begin":718,"end":723},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T755","span":{"begin":867,"end":873},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T756","span":{"begin":993,"end":1000},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T757","span":{"begin":1025,"end":1032},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"Vitamin C Oranges and orange juice, red and green peppers, strawberries, blackcurrants, kiwi, broccoli, brussels sprouts, potatoes ↑ collagen synthesis and protects cell membranes from damage caused by free radicals; ↑ keratinocyte differentiation; ↑ lipid synthesis; ↑ fibroblast proliferation and migration\nProliferation, function, and movement of neutrophils, monocytes and phagocytes; ↑ NK cell activities and chemotaxis\n↑ Phagocytosis and ROS generation; ↑ microbial killing\n↑ Apoptosis and clearance of spent neutrophils from sites of infection by macrophages\n↓ Extracellular trap (NET) formation, ↓ tissue damage\n↑ Antimicrobial effects; ↑ serum levels of complement proteins\nMaintains redox homeostasis within cells and protects against ROS and RNS during oxidative burst; regenerates other important antioxidants, such as glutathione and vitamin E, to their active state; modulates cytokine production and ↓ histamine levels\nRoles in production, differentiation, and proliferation of T cells, particularly cytotoxic T cells; ↑ proliferation of lymphocytes, ↑ generation of antibodies [79, 85, 92, 95, 120]"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T14758","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"T160","span":{"begin":0,"end":7},"obj":"Chemical"},{"id":"T39803","span":{"begin":207,"end":215},"obj":"Chemical"},{"id":"T162","span":{"begin":251,"end":256},"obj":"Chemical"},{"id":"T39086","span":{"begin":444,"end":447},"obj":"Chemical"},{"id":"T21541","span":{"begin":674,"end":682},"obj":"Chemical"},{"id":"T165","span":{"begin":745,"end":748},"obj":"Chemical"},{"id":"T85158","span":{"begin":753,"end":756},"obj":"Chemical"},{"id":"T45003","span":{"begin":809,"end":821},"obj":"Chemical"},{"id":"T16833","span":{"begin":831,"end":842},"obj":"Chemical"},{"id":"T171","span":{"begin":847,"end":856},"obj":"Chemical"},{"id":"T54484","span":{"begin":847,"end":854},"obj":"Chemical"},{"id":"T173","span":{"begin":917,"end":926},"obj":"Chemical"}],"attributes":[{"id":"A15564","pred":"chebi_id","subj":"T14758","obj":"http://purl.obolibrary.org/obo/CHEBI_21241"},{"id":"A41547","pred":"chebi_id","subj":"T14758","obj":"http://purl.obolibrary.org/obo/CHEBI_29073"},{"id":"A15925","pred":"chebi_id","subj":"T14758","obj":"http://purl.obolibrary.org/obo/CHEBI_38290"},{"id":"A11237","pred":"chebi_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A33063","pred":"chebi_id","subj":"T39803","obj":"http://purl.obolibrary.org/obo/CHEBI_26519"},{"id":"A64256","pred":"chebi_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A7380","pred":"chebi_id","subj":"T39086","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A95680","pred":"chebi_id","subj":"T21541","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A3279","pred":"chebi_id","subj":"T165","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A63768","pred":"chebi_id","subj":"T85158","obj":"http://purl.obolibrary.org/obo/CHEBI_33697"},{"id":"A29217","pred":"chebi_id","subj":"T85158","obj":"http://purl.obolibrary.org/obo/CHEBI_62764"},{"id":"A73940","pred":"chebi_id","subj":"T45003","obj":"http://purl.obolibrary.org/obo/CHEBI_22586"},{"id":"A9968","pred":"chebi_id","subj":"T16833","obj":"http://purl.obolibrary.org/obo/CHEBI_16856"},{"id":"A5213","pred":"chebi_id","subj":"T16833","obj":"http://purl.obolibrary.org/obo/CHEBI_57925"},{"id":"A94002","pred":"chebi_id","subj":"T171","obj":"http://purl.obolibrary.org/obo/CHEBI_33234"},{"id":"A82261","pred":"chebi_id","subj":"T54484","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A74505","pred":"chebi_id","subj":"T173","obj":"http://purl.obolibrary.org/obo/CHEBI_18295"},{"id":"A93590","pred":"chebi_id","subj":"T173","obj":"http://purl.obolibrary.org/obo/CHEBI_58432"}],"text":"Vitamin C Oranges and orange juice, red and green peppers, strawberries, blackcurrants, kiwi, broccoli, brussels sprouts, potatoes ↑ collagen synthesis and protects cell membranes from damage caused by free radicals; ↑ keratinocyte differentiation; ↑ lipid synthesis; ↑ fibroblast proliferation and migration\nProliferation, function, and movement of neutrophils, monocytes and phagocytes; ↑ NK cell activities and chemotaxis\n↑ Phagocytosis and ROS generation; ↑ microbial killing\n↑ Apoptosis and clearance of spent neutrophils from sites of infection by macrophages\n↓ Extracellular trap (NET) formation, ↓ tissue damage\n↑ Antimicrobial effects; ↑ serum levels of complement proteins\nMaintains redox homeostasis within cells and protects against ROS and RNS during oxidative burst; regenerates other important antioxidants, such as glutathione and vitamin E, to their active state; modulates cytokine production and ↓ histamine levels\nRoles in production, differentiation, and proliferation of T cells, particularly cytotoxic T cells; ↑ proliferation of lymphocytes, ↑ generation of antibodies [79, 85, 92, 95, 120]"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T270","span":{"begin":133,"end":151},"obj":"http://purl.obolibrary.org/obo/GO_0032964"},{"id":"T271","span":{"begin":142,"end":151},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T272","span":{"begin":219,"end":247},"obj":"http://purl.obolibrary.org/obo/GO_0030216"},{"id":"T273","span":{"begin":251,"end":266},"obj":"http://purl.obolibrary.org/obo/GO_0008610"},{"id":"T274","span":{"begin":257,"end":266},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T275","span":{"begin":270,"end":294},"obj":"http://purl.obolibrary.org/obo/GO_0048144"},{"id":"T276","span":{"begin":414,"end":424},"obj":"http://purl.obolibrary.org/obo/GO_0006935"},{"id":"T277","span":{"begin":427,"end":439},"obj":"http://purl.obolibrary.org/obo/GO_0006909"},{"id":"T278","span":{"begin":444,"end":458},"obj":"http://purl.obolibrary.org/obo/GO_1903409"},{"id":"T279","span":{"begin":482,"end":491},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T280","span":{"begin":482,"end":491},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T281","span":{"begin":593,"end":602},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T282","span":{"begin":699,"end":710},"obj":"http://purl.obolibrary.org/obo/GO_0042592"},{"id":"T283","span":{"begin":764,"end":779},"obj":"http://purl.obolibrary.org/obo/GO_0045730"},{"id":"T284","span":{"begin":891,"end":910},"obj":"http://purl.obolibrary.org/obo/GO_0001816"},{"id":"T285","span":{"begin":1025,"end":1049},"obj":"http://purl.obolibrary.org/obo/GO_0042098"}],"text":"Vitamin C Oranges and orange juice, red and green peppers, strawberries, blackcurrants, kiwi, broccoli, brussels sprouts, potatoes ↑ collagen synthesis and protects cell membranes from damage caused by free radicals; ↑ keratinocyte differentiation; ↑ lipid synthesis; ↑ fibroblast proliferation and migration\nProliferation, function, and movement of neutrophils, monocytes and phagocytes; ↑ NK cell activities and chemotaxis\n↑ Phagocytosis and ROS generation; ↑ microbial killing\n↑ Apoptosis and clearance of spent neutrophils from sites of infection by macrophages\n↓ Extracellular trap (NET) formation, ↓ tissue damage\n↑ Antimicrobial effects; ↑ serum levels of complement proteins\nMaintains redox homeostasis within cells and protects against ROS and RNS during oxidative burst; regenerates other important antioxidants, such as glutathione and vitamin E, to their active state; modulates cytokine production and ↓ histamine levels\nRoles in production, differentiation, and proliferation of T cells, particularly cytotoxic T cells; ↑ proliferation of lymphocytes, ↑ generation of antibodies [79, 85, 92, 95, 120]"}

{"project":"LitCovid-sentences","denotations":[{"id":"T368","span":{"begin":0,"end":308},"obj":"Sentence"},{"id":"T369","span":{"begin":309,"end":424},"obj":"Sentence"},{"id":"T370","span":{"begin":425,"end":479},"obj":"Sentence"},{"id":"T371","span":{"begin":480,"end":565},"obj":"Sentence"},{"id":"T372","span":{"begin":566,"end":619},"obj":"Sentence"},{"id":"T373","span":{"begin":620,"end":682},"obj":"Sentence"},{"id":"T374","span":{"begin":683,"end":933},"obj":"Sentence"},{"id":"T375","span":{"begin":934,"end":1114},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Vitamin C Oranges and orange juice, red and green peppers, strawberries, blackcurrants, kiwi, broccoli, brussels sprouts, potatoes ↑ collagen synthesis and protects cell membranes from damage caused by free radicals; ↑ keratinocyte differentiation; ↑ lipid synthesis; ↑ fibroblast proliferation and migration\nProliferation, function, and movement of neutrophils, monocytes and phagocytes; ↑ NK cell activities and chemotaxis\n↑ Phagocytosis and ROS generation; ↑ microbial killing\n↑ Apoptosis and clearance of spent neutrophils from sites of infection by macrophages\n↓ Extracellular trap (NET) formation, ↓ tissue damage\n↑ Antimicrobial effects; ↑ serum levels of complement proteins\nMaintains redox homeostasis within cells and protects against ROS and RNS during oxidative burst; regenerates other important antioxidants, such as glutathione and vitamin E, to their active state; modulates cytokine production and ↓ histamine levels\nRoles in production, differentiation, and proliferation of T cells, particularly cytotoxic T cells; ↑ proliferation of lymphocytes, ↑ generation of antibodies [79, 85, 92, 95, 120]"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1462","span":{"begin":122,"end":130},"obj":"Species"},{"id":"1471","span":{"begin":541,"end":550},"obj":"Disease"}],"attributes":[{"id":"A1462","pred":"tao:has_database_id","subj":"1462","obj":"Tax:4113"},{"id":"A1471","pred":"tao:has_database_id","subj":"1471","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Vitamin C Oranges and orange juice, red and green peppers, strawberries, blackcurrants, kiwi, broccoli, brussels sprouts, potatoes ↑ collagen synthesis and protects cell membranes from damage caused by free radicals; ↑ keratinocyte differentiation; ↑ lipid synthesis; ↑ fibroblast proliferation and migration\nProliferation, function, and movement of neutrophils, monocytes and phagocytes; ↑ NK cell activities and chemotaxis\n↑ Phagocytosis and ROS generation; ↑ microbial killing\n↑ Apoptosis and clearance of spent neutrophils from sites of infection by macrophages\n↓ Extracellular trap (NET) formation, ↓ tissue damage\n↑ Antimicrobial effects; ↑ serum levels of complement proteins\nMaintains redox homeostasis within cells and protects against ROS and RNS during oxidative burst; regenerates other important antioxidants, such as glutathione and vitamin E, to their active state; modulates cytokine production and ↓ histamine levels\nRoles in production, differentiation, and proliferation of T cells, particularly cytotoxic T cells; ↑ proliferation of lymphocytes, ↑ generation of antibodies [79, 85, 92, 95, 120]"}