PMC:7647877 / 58351-59846 JSONTXT

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    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T626","span":{"begin":10,"end":14},"obj":"Body_part"},{"id":"T627","span":{"begin":33,"end":38},"obj":"Body_part"},{"id":"T628","span":{"begin":290,"end":307},"obj":"Body_part"},{"id":"T629","span":{"begin":333,"end":338},"obj":"Body_part"},{"id":"T630","span":{"begin":344,"end":347},"obj":"Body_part"},{"id":"T631","span":{"begin":379,"end":384},"obj":"Body_part"},{"id":"T632","span":{"begin":389,"end":392},"obj":"Body_part"},{"id":"T633","span":{"begin":395,"end":400},"obj":"Body_part"},{"id":"T634","span":{"begin":406,"end":416},"obj":"Body_part"},{"id":"T635","span":{"begin":417,"end":424},"obj":"Body_part"},{"id":"T636","span":{"begin":440,"end":443},"obj":"Body_part"},{"id":"T637","span":{"begin":562,"end":576},"obj":"Body_part"},{"id":"T638","span":{"begin":624,"end":632},"obj":"Body_part"},{"id":"T639","span":{"begin":627,"end":632},"obj":"Body_part"},{"id":"T640","span":{"begin":681,"end":692},"obj":"Body_part"},{"id":"T641","span":{"begin":758,"end":762},"obj":"Body_part"},{"id":"T642","span":{"begin":758,"end":760},"obj":"Body_part"},{"id":"T643","span":{"begin":817,"end":828},"obj":"Body_part"},{"id":"T644","span":{"begin":885,"end":896},"obj":"Body_part"},{"id":"T645","span":{"begin":970,"end":979},"obj":"Body_part"},{"id":"T646","span":{"begin":974,"end":979},"obj":"Body_part"},{"id":"T647","span":{"begin":1022,"end":1027},"obj":"Body_part"},{"id":"T648","span":{"begin":1033,"end":1051},"obj":"Body_part"},{"id":"T649","span":{"begin":1046,"end":1051},"obj":"Body_part"},{"id":"T650","span":{"begin":1121,"end":1126},"obj":"Body_part"},{"id":"T651","span":{"begin":1171,"end":1180},"obj":"Body_part"},{"id":"T652","span":{"begin":1175,"end":1180},"obj":"Body_part"},{"id":"T653","span":{"begin":1199,"end":1207},"obj":"Body_part"},{"id":"T654","span":{"begin":1245,"end":1250},"obj":"Body_part"},{"id":"T655","span":{"begin":1245,"end":1247},"obj":"Body_part"},{"id":"T656","span":{"begin":1283,"end":1292},"obj":"Body_part"},{"id":"T657","span":{"begin":1287,"end":1292},"obj":"Body_part"},{"id":"T658","span":{"begin":1317,"end":1322},"obj":"Body_part"},{"id":"T659","span":{"begin":1352,"end":1360},"obj":"Body_part"},{"id":"T660","span":{"begin":1398,"end":1402},"obj":"Body_part"},{"id":"T661","span":{"begin":1412,"end":1415},"obj":"Body_part"},{"id":"T662","span":{"begin":1416,"end":1424},"obj":"Body_part"},{"id":"T663","span":{"begin":1448,"end":1462},"obj":"Body_part"}],"attributes":[{"id":"A626","pred":"fma_id","subj":"T626","obj":"http://purl.org/sig/ont/fma/fma62100"},{"id":"A627","pred":"fma_id","subj":"T627","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A628","pred":"fma_id","subj":"T628","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A629","pred":"fma_id","subj":"T629","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A630","pred":"fma_id","subj":"T630","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A631","pred":"fma_id","subj":"T631","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A632","pred":"fma_id","subj":"T632","obj":"http://purl.org/sig/ont/fma/fma62874"},{"id":"A633","pred":"fma_id","subj":"T633","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A634","pred":"fma_id","subj":"T634","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A635","pred":"fma_id","subj":"T635","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A636","pred":"fma_id","subj":"T636","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A637","pred":"fma_id","subj":"T637","obj":"http://purl.org/sig/ont/fma/fma67423"},{"id":"A638","pred":"fma_id","subj":"T638","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A639","pred":"fma_id","subj":"T639","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A640","pred":"fma_id","subj":"T640","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A641","pred":"fma_id","subj":"T641","obj":"http://purl.org/sig/ont/fma/fma84051"},{"id":"A642","pred":"fma_id","subj":"T642","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A643","pred":"fma_id","subj":"T643","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A644","pred":"fma_id","subj":"T644","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A645","pred":"fma_id","subj":"T645","obj":"http://purl.org/sig/ont/fma/fma84385"},{"id":"A646","pred":"fma_id","subj":"T646","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A647","pred":"fma_id","subj":"T647","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A648","pred":"fma_id","subj":"T648","obj":"http://purl.org/sig/ont/fma/fma84070"},{"id":"A649","pred":"fma_id","subj":"T649","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A650","pred":"fma_id","subj":"T650","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A651","pred":"fma_id","subj":"T651","obj":"http://purl.org/sig/ont/fma/fma84385"},{"id":"A652","pred":"fma_id","subj":"T652","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A653","pred":"fma_id","subj":"T653","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A654","pred":"fma_id","subj":"T654","obj":"http://purl.org/sig/ont/fma/fma86579"},{"id":"A655","pred":"fma_id","subj":"T655","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A656","pred":"fma_id","subj":"T656","obj":"http://purl.org/sig/ont/fma/fma84382"},{"id":"A657","pred":"fma_id","subj":"T657","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A658","pred":"fma_id","subj":"T658","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A659","pred":"fma_id","subj":"T659","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A660","pred":"fma_id","subj":"T660","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A661","pred":"fma_id","subj":"T661","obj":"http://purl.org/sig/ont/fma/fma62874"},{"id":"A662","pred":"fma_id","subj":"T662","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A663","pred":"fma_id","subj":"T663","obj":"http://purl.org/sig/ont/fma/fma82746"}],"text":"Vitamin A Milk and cheese, eggs, liver, oily fish, fortified cereals, dark orange or green vegetables (e.g., carrots, sweet potatoes, pumpkin, squash, kale, spinach, broccoli), orange fruits (e.g., apricots, peaches, papaya, mango, cantaloupe melon), tomato juice Normal differentiation of epithelial tissue; retinoic acid ↑ T and B cells with gut-homing specificity and array T cells and IgA + cells into intestinal tissues\nSupporting the gut barrier; carotenoids; ↑immunoregulatory actions including ↓ toxic effects of ROS and regulating membrane fluidity and gap-junctional communication\nRegulates number and function of NK cells,↑ to phagocytic and oxidative burst activity of macrophages\nDownregulates IFN production\nHelps to regulate the production of IL-2 and the pro-inflammatory TNF-γ, ↑ microbial action of macrophages; involved in phagocytic and oxidative burst activity of macrophages activated during inflammation\nDevelopment and differentiation of Th1 and Th2 cells; ↑ TGF- β-dependent conversion of naïve T cells into regulatory T cells; plays a role in acquisition of mucosal-homing properties by T and B cells\nDevelopment and differentiation of Th 1 and Th2 cells; maintains normal antibody-mediated Th2 response by suppressing IL-12, TNF-α, and IFN-γ production of Th1 cells\nNormal functioning of B cells, necessary for generation of antibody responses to antigen; required for B cell-mediated IgA antibody responses to bacterial polysaccharide antigens [62, 79–82, 85, 92, 95]"}

    LitCovid-PD-UBERON

    {"project":"LitCovid-PD-UBERON","denotations":[{"id":"T136","span":{"begin":10,"end":14},"obj":"Body_part"},{"id":"T137","span":{"begin":33,"end":38},"obj":"Body_part"},{"id":"T138","span":{"begin":301,"end":307},"obj":"Body_part"}],"attributes":[{"id":"A136","pred":"uberon_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/UBERON_0001913"},{"id":"A137","pred":"uberon_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A138","pred":"uberon_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Vitamin A Milk and cheese, eggs, liver, oily fish, fortified cereals, dark orange or green vegetables (e.g., carrots, sweet potatoes, pumpkin, squash, kale, spinach, broccoli), orange fruits (e.g., apricots, peaches, papaya, mango, cantaloupe melon), tomato juice Normal differentiation of epithelial tissue; retinoic acid ↑ T and B cells with gut-homing specificity and array T cells and IgA + cells into intestinal tissues\nSupporting the gut barrier; carotenoids; ↑immunoregulatory actions including ↓ toxic effects of ROS and regulating membrane fluidity and gap-junctional communication\nRegulates number and function of NK cells,↑ to phagocytic and oxidative burst activity of macrophages\nDownregulates IFN production\nHelps to regulate the production of IL-2 and the pro-inflammatory TNF-γ, ↑ microbial action of macrophages; involved in phagocytic and oxidative burst activity of macrophages activated during inflammation\nDevelopment and differentiation of Th1 and Th2 cells; ↑ TGF- β-dependent conversion of naïve T cells into regulatory T cells; plays a role in acquisition of mucosal-homing properties by T and B cells\nDevelopment and differentiation of Th 1 and Th2 cells; maintains normal antibody-mediated Th2 response by suppressing IL-12, TNF-α, and IFN-γ production of Th1 cells\nNormal functioning of B cells, necessary for generation of antibody responses to antigen; required for B cell-mediated IgA antibody responses to bacterial polysaccharide antigens [62, 79–82, 85, 92, 95]"}

    LitCovid-PD-MONDO

    {"project":"LitCovid-PD-MONDO","denotations":[{"id":"T269","span":{"begin":914,"end":926},"obj":"Disease"}],"attributes":[{"id":"A269","pred":"mondo_id","subj":"T269","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"Vitamin A Milk and cheese, eggs, liver, oily fish, fortified cereals, dark orange or green vegetables (e.g., carrots, sweet potatoes, pumpkin, squash, kale, spinach, broccoli), orange fruits (e.g., apricots, peaches, papaya, mango, cantaloupe melon), tomato juice Normal differentiation of epithelial tissue; retinoic acid ↑ T and B cells with gut-homing specificity and array T cells and IgA + cells into intestinal tissues\nSupporting the gut barrier; carotenoids; ↑immunoregulatory actions including ↓ toxic effects of ROS and regulating membrane fluidity and gap-junctional communication\nRegulates number and function of NK cells,↑ to phagocytic and oxidative burst activity of macrophages\nDownregulates IFN production\nHelps to regulate the production of IL-2 and the pro-inflammatory TNF-γ, ↑ microbial action of macrophages; involved in phagocytic and oxidative burst activity of macrophages activated during inflammation\nDevelopment and differentiation of Th1 and Th2 cells; ↑ TGF- β-dependent conversion of naïve T cells into regulatory T cells; plays a role in acquisition of mucosal-homing properties by T and B cells\nDevelopment and differentiation of Th 1 and Th2 cells; maintains normal antibody-mediated Th2 response by suppressing IL-12, TNF-α, and IFN-γ production of Th1 cells\nNormal functioning of B cells, necessary for generation of antibody responses to antigen; required for B cell-mediated IgA antibody responses to bacterial polysaccharide antigens [62, 79–82, 85, 92, 95]"}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T711","span":{"begin":8,"end":9},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T712","span":{"begin":33,"end":38},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T713","span":{"begin":33,"end":38},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T714","span":{"begin":45,"end":49},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_117565"},{"id":"T715","span":{"begin":290,"end":307},"obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"T716","span":{"begin":331,"end":338},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T717","span":{"begin":344,"end":347},"obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"T718","span":{"begin":344,"end":347},"obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"T719","span":{"begin":344,"end":347},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T720","span":{"begin":377,"end":384},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T721","span":{"begin":395,"end":400},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T722","span":{"begin":406,"end":416},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T723","span":{"begin":406,"end":416},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T724","span":{"begin":440,"end":443},"obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"T725","span":{"begin":440,"end":443},"obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"T726","span":{"begin":440,"end":443},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T727","span":{"begin":540,"end":548},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T728","span":{"begin":566,"end":576},"obj":"http://purl.obolibrary.org/obo/UBERON_0007651"},{"id":"T729","span":{"begin":624,"end":632},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T730","span":{"begin":638,"end":648},"obj":"http://purl.obolibrary.org/obo/CL_0000234"},{"id":"T731","span":{"begin":669,"end":677},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T732","span":{"begin":758,"end":762},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T733","span":{"begin":842,"end":852},"obj":"http://purl.obolibrary.org/obo/CL_0000234"},{"id":"T734","span":{"begin":873,"end":881},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T735","span":{"begin":897,"end":906},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T736","span":{"begin":974,"end":979},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T737","span":{"begin":1014,"end":1027},"obj":"http://purl.obolibrary.org/obo/CL_0000898"},{"id":"T738","span":{"begin":1033,"end":1051},"obj":"http://purl.obolibrary.org/obo/CL_0000815"},{"id":"T739","span":{"begin":1059,"end":1060},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T740","span":{"begin":1119,"end":1126},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T741","span":{"begin":1175,"end":1180},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T742","span":{"begin":1287,"end":1292},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T743","span":{"begin":1315,"end":1322},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T744","span":{"begin":1396,"end":1402},"obj":"http://purl.obolibrary.org/obo/CL_0000236"}],"text":"Vitamin A Milk and cheese, eggs, liver, oily fish, fortified cereals, dark orange or green vegetables (e.g., carrots, sweet potatoes, pumpkin, squash, kale, spinach, broccoli), orange fruits (e.g., apricots, peaches, papaya, mango, cantaloupe melon), tomato juice Normal differentiation of epithelial tissue; retinoic acid ↑ T and B cells with gut-homing specificity and array T cells and IgA + cells into intestinal tissues\nSupporting the gut barrier; carotenoids; ↑immunoregulatory actions including ↓ toxic effects of ROS and regulating membrane fluidity and gap-junctional communication\nRegulates number and function of NK cells,↑ to phagocytic and oxidative burst activity of macrophages\nDownregulates IFN production\nHelps to regulate the production of IL-2 and the pro-inflammatory TNF-γ, ↑ microbial action of macrophages; involved in phagocytic and oxidative burst activity of macrophages activated during inflammation\nDevelopment and differentiation of Th1 and Th2 cells; ↑ TGF- β-dependent conversion of naïve T cells into regulatory T cells; plays a role in acquisition of mucosal-homing properties by T and B cells\nDevelopment and differentiation of Th 1 and Th2 cells; maintains normal antibody-mediated Th2 response by suppressing IL-12, TNF-α, and IFN-γ production of Th1 cells\nNormal functioning of B cells, necessary for generation of antibody responses to antigen; required for B cell-mediated IgA antibody responses to bacterial polysaccharide antigens [62, 79–82, 85, 92, 95]"}

    LitCovid-PD-CHEBI

    {"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T91853","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"T144","span":{"begin":0,"end":7},"obj":"Chemical"},{"id":"T97722","span":{"begin":309,"end":322},"obj":"Chemical"},{"id":"T31821","span":{"begin":318,"end":322},"obj":"Chemical"},{"id":"T98177","span":{"begin":453,"end":464},"obj":"Chemical"},{"id":"T24485","span":{"begin":521,"end":524},"obj":"Chemical"},{"id":"T72325","span":{"begin":758,"end":760},"obj":"Chemical"},{"id":"T44807","span":{"begin":1162,"end":1164},"obj":"Chemical"},{"id":"T66751","span":{"begin":1245,"end":1247},"obj":"Chemical"},{"id":"T11555","span":{"begin":1374,"end":1381},"obj":"Chemical"},{"id":"T22298","span":{"begin":1448,"end":1462},"obj":"Chemical"},{"id":"T60345","span":{"begin":1463,"end":1471},"obj":"Chemical"}],"attributes":[{"id":"A25127","pred":"chebi_id","subj":"T91853","obj":"http://purl.obolibrary.org/obo/CHEBI_17336"},{"id":"A69014","pred":"chebi_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A50440","pred":"chebi_id","subj":"T97722","obj":"http://purl.obolibrary.org/obo/CHEBI_26536"},{"id":"A25783","pred":"chebi_id","subj":"T31821","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A36103","pred":"chebi_id","subj":"T98177","obj":"http://purl.obolibrary.org/obo/CHEBI_23044"},{"id":"A77627","pred":"chebi_id","subj":"T24485","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A15590","pred":"chebi_id","subj":"T72325","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A18440","pred":"chebi_id","subj":"T72325","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A32608","pred":"chebi_id","subj":"T44807","obj":"http://purl.obolibrary.org/obo/CHEBI_33385"},{"id":"A80066","pred":"chebi_id","subj":"T66751","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A98686","pred":"chebi_id","subj":"T66751","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A20991","pred":"chebi_id","subj":"T11555","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A37770","pred":"chebi_id","subj":"T22298","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"},{"id":"A67803","pred":"chebi_id","subj":"T60345","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"}],"text":"Vitamin A Milk and cheese, eggs, liver, oily fish, fortified cereals, dark orange or green vegetables (e.g., carrots, sweet potatoes, pumpkin, squash, kale, spinach, broccoli), orange fruits (e.g., apricots, peaches, papaya, mango, cantaloupe melon), tomato juice Normal differentiation of epithelial tissue; retinoic acid ↑ T and B cells with gut-homing specificity and array T cells and IgA + cells into intestinal tissues\nSupporting the gut barrier; carotenoids; ↑immunoregulatory actions including ↓ toxic effects of ROS and regulating membrane fluidity and gap-junctional communication\nRegulates number and function of NK cells,↑ to phagocytic and oxidative burst activity of macrophages\nDownregulates IFN production\nHelps to regulate the production of IL-2 and the pro-inflammatory TNF-γ, ↑ microbial action of macrophages; involved in phagocytic and oxidative burst activity of macrophages activated during inflammation\nDevelopment and differentiation of Th1 and Th2 cells; ↑ TGF- β-dependent conversion of naïve T cells into regulatory T cells; plays a role in acquisition of mucosal-homing properties by T and B cells\nDevelopment and differentiation of Th 1 and Th2 cells; maintains normal antibody-mediated Th2 response by suppressing IL-12, TNF-α, and IFN-γ production of Th1 cells\nNormal functioning of B cells, necessary for generation of antibody responses to antigen; required for B cell-mediated IgA antibody responses to bacterial polysaccharide antigens [62, 79–82, 85, 92, 95]"}

    LitCovid-PD-GO-BP

    {"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T266","span":{"begin":653,"end":668},"obj":"http://purl.obolibrary.org/obo/GO_0045730"},{"id":"T267","span":{"begin":707,"end":721},"obj":"http://purl.obolibrary.org/obo/GO_0072647"},{"id":"T268","span":{"begin":857,"end":872},"obj":"http://purl.obolibrary.org/obo/GO_0045730"},{"id":"T269","span":{"begin":914,"end":926},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Vitamin A Milk and cheese, eggs, liver, oily fish, fortified cereals, dark orange or green vegetables (e.g., carrots, sweet potatoes, pumpkin, squash, kale, spinach, broccoli), orange fruits (e.g., apricots, peaches, papaya, mango, cantaloupe melon), tomato juice Normal differentiation of epithelial tissue; retinoic acid ↑ T and B cells with gut-homing specificity and array T cells and IgA + cells into intestinal tissues\nSupporting the gut barrier; carotenoids; ↑immunoregulatory actions including ↓ toxic effects of ROS and regulating membrane fluidity and gap-junctional communication\nRegulates number and function of NK cells,↑ to phagocytic and oxidative burst activity of macrophages\nDownregulates IFN production\nHelps to regulate the production of IL-2 and the pro-inflammatory TNF-γ, ↑ microbial action of macrophages; involved in phagocytic and oxidative burst activity of macrophages activated during inflammation\nDevelopment and differentiation of Th1 and Th2 cells; ↑ TGF- β-dependent conversion of naïve T cells into regulatory T cells; plays a role in acquisition of mucosal-homing properties by T and B cells\nDevelopment and differentiation of Th 1 and Th2 cells; maintains normal antibody-mediated Th2 response by suppressing IL-12, TNF-α, and IFN-γ production of Th1 cells\nNormal functioning of B cells, necessary for generation of antibody responses to antigen; required for B cell-mediated IgA antibody responses to bacterial polysaccharide antigens [62, 79–82, 85, 92, 95]"}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T360","span":{"begin":0,"end":424},"obj":"Sentence"},{"id":"T361","span":{"begin":425,"end":590},"obj":"Sentence"},{"id":"T362","span":{"begin":591,"end":692},"obj":"Sentence"},{"id":"T363","span":{"begin":693,"end":721},"obj":"Sentence"},{"id":"T364","span":{"begin":722,"end":926},"obj":"Sentence"},{"id":"T365","span":{"begin":927,"end":1126},"obj":"Sentence"},{"id":"T366","span":{"begin":1127,"end":1292},"obj":"Sentence"},{"id":"T367","span":{"begin":1293,"end":1495},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Vitamin A Milk and cheese, eggs, liver, oily fish, fortified cereals, dark orange or green vegetables (e.g., carrots, sweet potatoes, pumpkin, squash, kale, spinach, broccoli), orange fruits (e.g., apricots, peaches, papaya, mango, cantaloupe melon), tomato juice Normal differentiation of epithelial tissue; retinoic acid ↑ T and B cells with gut-homing specificity and array T cells and IgA + cells into intestinal tissues\nSupporting the gut barrier; carotenoids; ↑immunoregulatory actions including ↓ toxic effects of ROS and regulating membrane fluidity and gap-junctional communication\nRegulates number and function of NK cells,↑ to phagocytic and oxidative burst activity of macrophages\nDownregulates IFN production\nHelps to regulate the production of IL-2 and the pro-inflammatory TNF-γ, ↑ microbial action of macrophages; involved in phagocytic and oxidative burst activity of macrophages activated during inflammation\nDevelopment and differentiation of Th1 and Th2 cells; ↑ TGF- β-dependent conversion of naïve T cells into regulatory T cells; plays a role in acquisition of mucosal-homing properties by T and B cells\nDevelopment and differentiation of Th 1 and Th2 cells; maintains normal antibody-mediated Th2 response by suppressing IL-12, TNF-α, and IFN-γ production of Th1 cells\nNormal functioning of B cells, necessary for generation of antibody responses to antigen; required for B cell-mediated IgA antibody responses to bacterial polysaccharide antigens [62, 79–82, 85, 92, 95]"}

    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"1443","span":{"begin":707,"end":710},"obj":"Gene"},{"id":"1444","span":{"begin":758,"end":762},"obj":"Gene"},{"id":"1445","span":{"begin":1263,"end":1268},"obj":"Gene"},{"id":"1454","span":{"begin":540,"end":548},"obj":"Gene"},{"id":"1455","span":{"begin":109,"end":116},"obj":"Species"},{"id":"1456","span":{"begin":124,"end":132},"obj":"Species"},{"id":"1457","span":{"begin":157,"end":164},"obj":"Species"},{"id":"1458","span":{"begin":198,"end":206},"obj":"Species"},{"id":"1459","span":{"begin":217,"end":223},"obj":"Species"},{"id":"1460","span":{"begin":225,"end":230},"obj":"Species"},{"id":"1461","span":{"begin":251,"end":257},"obj":"Species"}],"attributes":[{"id":"A1443","pred":"tao:has_database_id","subj":"1443","obj":"Gene:3439"},{"id":"A1444","pred":"tao:has_database_id","subj":"1444","obj":"Gene:3558"},{"id":"A1445","pred":"tao:has_database_id","subj":"1445","obj":"Gene:3458"},{"id":"A1454","pred":"tao:has_database_id","subj":"1454","obj":"Gene:43740571"},{"id":"A1455","pred":"tao:has_database_id","subj":"1455","obj":"Tax:4039"},{"id":"A1456","pred":"tao:has_database_id","subj":"1456","obj":"Tax:4113"},{"id":"A1457","pred":"tao:has_database_id","subj":"1457","obj":"Tax:3562"},{"id":"A1458","pred":"tao:has_database_id","subj":"1458","obj":"Tax:36596"},{"id":"A1459","pred":"tao:has_database_id","subj":"1459","obj":"Tax:3649"},{"id":"A1460","pred":"tao:has_database_id","subj":"1460","obj":"Tax:29780"},{"id":"A1461","pred":"tao:has_database_id","subj":"1461","obj":"Tax:4081"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Vitamin A Milk and cheese, eggs, liver, oily fish, fortified cereals, dark orange or green vegetables (e.g., carrots, sweet potatoes, pumpkin, squash, kale, spinach, broccoli), orange fruits (e.g., apricots, peaches, papaya, mango, cantaloupe melon), tomato juice Normal differentiation of epithelial tissue; retinoic acid ↑ T and B cells with gut-homing specificity and array T cells and IgA + cells into intestinal tissues\nSupporting the gut barrier; carotenoids; ↑immunoregulatory actions including ↓ toxic effects of ROS and regulating membrane fluidity and gap-junctional communication\nRegulates number and function of NK cells,↑ to phagocytic and oxidative burst activity of macrophages\nDownregulates IFN production\nHelps to regulate the production of IL-2 and the pro-inflammatory TNF-γ, ↑ microbial action of macrophages; involved in phagocytic and oxidative burst activity of macrophages activated during inflammation\nDevelopment and differentiation of Th1 and Th2 cells; ↑ TGF- β-dependent conversion of naïve T cells into regulatory T cells; plays a role in acquisition of mucosal-homing properties by T and B cells\nDevelopment and differentiation of Th 1 and Th2 cells; maintains normal antibody-mediated Th2 response by suppressing IL-12, TNF-α, and IFN-γ production of Th1 cells\nNormal functioning of B cells, necessary for generation of antibody responses to antigen; required for B cell-mediated IgA antibody responses to bacterial polysaccharide antigens [62, 79–82, 85, 92, 95]"}