PMC:7647877 / 49122-51446
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T529 | 142-155 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T530 | 364-373 | Body_part | denotes | leukocyte | http://purl.org/sig/ont/fma/fma62852 |
| T531 | 378-385 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
| T532 | 381-385 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T533 | 637-649 | Body_part | denotes | T-lymphocyte | http://purl.org/sig/ont/fma/fma62870 |
| T534 | 707-721 | Body_part | denotes | immunoglobulin | http://purl.org/sig/ont/fma/fma62871 |
| T535 | 760-764 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T536 | 785-793 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T537 | 1141-1149 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T538 | 1144-1149 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T123 | 142-155 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T250 | 903-919 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T251 | 928-937 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T252 | 1298-1307 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T253 | 1417-1426 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T254 | 1546-1562 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T624 | 59-60 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T625 | 142-155 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T626 | 303-306 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T627 | 378-385 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
| T628 | 760-764 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T629 | 1005-1006 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T630 | 1021-1026 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T631 | 1090-1096 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
| T632 | 1129-1137 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T633 | 1141-1149 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T634 | 1223-1226 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T635 | 1308-1313 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T636 | 1492-1493 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T637 | 2060-2063 | http://purl.obolibrary.org/obo/CLO_0054061 | denotes | 132 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T536 | 0-8 | Chemical | denotes | Selenium | http://purl.obolibrary.org/obo/CHEBI_27568 |
| T537 | 9-17 | Chemical | denotes | Selenium | http://purl.obolibrary.org/obo/CHEBI_27568 |
| T538 | 34-47 | Chemical | denotes | micronutrient | http://purl.obolibrary.org/obo/CHEBI_27027 |
| T539 | 189-197 | Chemical | denotes | nutrient | http://purl.obolibrary.org/obo/CHEBI_33284 |
| T540 | 320-331 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T541 | 347-350 | Chemical | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T542 | 432-443 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T543 | 526-538 | Chemical | denotes | antioxidants | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T544 | 570-573 | Chemical | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T545 | 613-621 | Chemical | denotes | Selenium | http://purl.obolibrary.org/obo/CHEBI_27568 |
| T546 | 757-759 | Chemical | denotes | Th | http://purl.obolibrary.org/obo/CHEBI_33385 |
| T38822 | 855-863 | Chemical | denotes | Selenium | http://purl.obolibrary.org/obo/CHEBI_27568 |
| T2 | 1078-1086 | Chemical | denotes | selenium | http://purl.obolibrary.org/obo/CHEBI_27568 |
| T3 | 1203-1211 | Chemical | denotes | selenium | http://purl.obolibrary.org/obo/CHEBI_27568 |
| T93088 | 1351-1359 | Chemical | denotes | selenium | http://purl.obolibrary.org/obo/CHEBI_27568 |
| T56732 | 1395-1403 | Chemical | denotes | adjuvant | http://purl.obolibrary.org/obo/CHEBI_60809 |
| T94741 | 1501-1509 | Chemical | denotes | selenium | http://purl.obolibrary.org/obo/CHEBI_27568 |
| T60507 | 1701-1712 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T43023 | 1867-1875 | Chemical | denotes | selenium | http://purl.obolibrary.org/obo/CHEBI_27568 |
| T26765 | 2114-2122 | Chemical | denotes | selenium | http://purl.obolibrary.org/obo/CHEBI_27568 |
| T56719 | 2197-2205 | Chemical | denotes | selenium | http://purl.obolibrary.org/obo/CHEBI_27568 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T99 | 590-606 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T202 | 120-136 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
| T203 | 637-663 | http://purl.obolibrary.org/obo/GO_0042098 | denotes | T-lymphocyte proliferation |
| T204 | 639-663 | http://purl.obolibrary.org/obo/GO_0046651 | denotes | lymphocyte proliferation |
| T205 | 707-732 | http://purl.obolibrary.org/obo/GO_0002377 | denotes | immunoglobulin production |
| T206 | 903-919 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
| T207 | 964-979 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immunity |
| T208 | 1332-1341 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | virulence |
| T209 | 1332-1341 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | virulence |
| T210 | 1443-1458 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T211 | 1546-1562 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
| T212 | 2114-2133 | http://purl.obolibrary.org/obo/GO_0001887 | denotes | selenium metabolism |
| T213 | 2123-2133 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T298 | 0-8 | Sentence | denotes | Selenium |
| T299 | 9-137 | Sentence | denotes | Selenium is an essential micronutrient that plays a significant role in many physiological processes including immune responses. |
| T300 | 138-290 | Sentence | denotes | The immune system needs an adequate intake of this nutrient mostly through its incorporation into selenoproteins to exerts its biological effects [126]. |
| T301 | 291-464 | Sentence | denotes | In fact, it has an important antioxidant role to quench ROS, influencing leukocyte and NK cell function and consequently modulating the host antioxidant defense system [85]. |
| T302 | 465-612 | Sentence | denotes | In fact, selenoproteins act as redox regulators and cellular antioxidants, potentially counteracting the ROS produced during oxidative stress [82]. |
| T303 | 613-739 | Sentence | denotes | Selenium is involved in T-lymphocyte proliferation and the humoral system [85], especially in immunoglobulin production [127]. |
| T304 | 740-854 | Sentence | denotes | It helps improve Th cell counts and maintain antibody levels [85] and also increases the production of IFN-γ [95]. |
| T305 | 855-1055 | Sentence | denotes | Selenium deficiencies have been associated with viral infections such as influenza, determining adaptive and innate immunity responses and leading to a high level of virus-related pathogenicity [128]. |
| T306 | 1056-1192 | Sentence | denotes | Low concentrations of selenium in humans have been linked to the reduced activity of NK cells and the increase in mycobacterial disease. |
| T307 | 1193-1342 | Sentence | denotes | Moreover, selenium deficiency has been shown to allow mutations of coxsackievirus, poliovirus and murine influenza virus, increasing their virulence. |
| T308 | 1343-1465 | Sentence | denotes | Dietary selenium supplementations were suggested as adjuvant therapies of influenza, supporting the immune response [129]. |
| T309 | 1466-1679 | Sentence | denotes | The beneficial effects of a higher selenium status have been supported for some viral infections, although there are some studies that do not conclusively demonstrate effective improvements in anti-viral immunity. |
| T310 | 1680-1819 | Sentence | denotes | On the contrary, the antioxidant properties of some selenoproteins have been suggested to contribute to boosting anti-viral immunity [129]. |
| T311 | 1820-2065 | Sentence | denotes | Currently, the recommended amounts of adequate selenium intake for adults range between 25 and 100 μg/die [130], with an average of 60 μg/die for men and 53 μg/die for women [131]; the tolerable upper intake level is set at 300–450 μg/die [132]. |
| T312 | 2066-2170 | Sentence | denotes | More research is needed to improve knowledge of selenium metabolism and requirements for optimal health. |
| T313 | 2171-2324 | Sentence | denotes | The relationships between selenium dietary intake and health status, or risk of disease, are complex and require elucidation to inform clinical practice. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1209 | 0-8 | Chemical | denotes | Selenium | MESH:D012643 |
| 1215 | 843-848 | Gene | denotes | IFN-γ | Gene:3458 |
| 1216 | 9-17 | Chemical | denotes | Selenium | MESH:D012643 |
| 1217 | 347-350 | Chemical | denotes | ROS | MESH:D017382 |
| 1218 | 570-573 | Chemical | denotes | ROS | MESH:D017382 |
| 1219 | 613-621 | Chemical | denotes | Selenium | MESH:D012643 |
| 1223 | 928-937 | Species | denotes | influenza | Tax:11320 |
| 1224 | 855-863 | Chemical | denotes | Selenium | MESH:D012643 |
| 1225 | 903-919 | Disease | denotes | viral infections | MESH:D001102 |
| 1233 | 1090-1096 | Species | denotes | humans | Tax:9606 |
| 1234 | 1260-1274 | Species | denotes | coxsackievirus | Tax:12066 |
| 1235 | 1276-1286 | Species | denotes | poliovirus | Tax:138950 |
| 1236 | 1291-1297 | Species | denotes | murine | Tax:10090 |
| 1237 | 1298-1313 | Species | denotes | influenza virus | Tax:11308 |
| 1238 | 1078-1086 | Chemical | denotes | selenium | MESH:D012643 |
| 1239 | 1203-1211 | Chemical | denotes | selenium | MESH:D012643 |
| 1242 | 1417-1426 | Species | denotes | influenza | Tax:11320 |
| 1243 | 1351-1359 | Chemical | denotes | selenium | MESH:D012643 |
| 1246 | 1501-1509 | Chemical | denotes | selenium | MESH:D012643 |
| 1247 | 1546-1562 | Disease | denotes | viral infections | MESH:D001102 |
| 1253 | 1966-1969 | Species | denotes | men | Tax:9606 |
| 1254 | 1988-1993 | Species | denotes | women | Tax:9606 |
| 1255 | 1867-1875 | Chemical | denotes | selenium | MESH:D012643 |
| 1256 | 2114-2122 | Chemical | denotes | selenium | MESH:D012643 |
| 1257 | 2197-2205 | Chemical | denotes | selenium | MESH:D012643 |