PMC:7647877 / 45730-46741 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T490","span":{"begin":40,"end":44},"obj":"Body_part"},{"id":"T491","span":{"begin":102,"end":115},"obj":"Body_part"},{"id":"T492","span":{"begin":147,"end":151},"obj":"Body_part"},{"id":"T493","span":{"begin":186,"end":199},"obj":"Body_part"},{"id":"T494","span":{"begin":200,"end":205},"obj":"Body_part"},{"id":"T495","span":{"begin":436,"end":439},"obj":"Body_part"},{"id":"T496","span":{"begin":464,"end":467},"obj":"Body_part"},{"id":"T497","span":{"begin":491,"end":494},"obj":"Body_part"},{"id":"T498","span":{"begin":673,"end":684},"obj":"Body_part"},{"id":"T499","span":{"begin":728,"end":733},"obj":"Body_part"},{"id":"T500","span":{"begin":764,"end":777},"obj":"Body_part"},{"id":"T501","span":{"begin":835,"end":848},"obj":"Body_part"},{"id":"T502","span":{"begin":883,"end":887},"obj":"Body_part"},{"id":"T503","span":{"begin":925,"end":930},"obj":"Body_part"},{"id":"T504","span":{"begin":956,"end":964},"obj":"Body_part"},{"id":"T505","span":{"begin":992,"end":996},"obj":"Body_part"}],"attributes":[{"id":"A490","pred":"fma_id","subj":"T490","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A491","pred":"fma_id","subj":"T491","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A492","pred":"fma_id","subj":"T492","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A493","pred":"fma_id","subj":"T493","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A494","pred":"fma_id","subj":"T494","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A495","pred":"fma_id","subj":"T495","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A496","pred":"fma_id","subj":"T496","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A497","pred":"fma_id","subj":"T497","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A498","pred":"fma_id","subj":"T498","obj":"http://purl.org/sig/ont/fma/fma9608"},{"id":"A499","pred":"fma_id","subj":"T499","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A500","pred":"fma_id","subj":"T500","obj":"http://purl.org/sig/ont/fma/fma62869"},{"id":"A501","pred":"fma_id","subj":"T501","obj":"http://purl.org/sig/ont/fma/fma62870"},{"id":"A502","pred":"fma_id","subj":"T502","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A503","pred":"fma_id","subj":"T503","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A504","pred":"fma_id","subj":"T504","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A505","pred":"fma_id","subj":"T505","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Zinc is considered a “guardian” for the body, as it plays an essential role in the functioning of the immune system [115], plays a central role in cell growth and differentiation of the immune system cells that have rapid differentiation and turnover [116]. Most of the studies have recently reported a very interesting evaluation of the function of zinc in antiviral immunity, suggesting how it can play a role in host defense against RNA viruses, inhibiting the RNA polymerase required by RNA viruses (such as coronaviruses) to replicate [117]. The zinc-binding metallothionein seems to play an important role in antiviral defense. Zinc deficiency has a marked impact on bone marrow, decreasing the number of immune precursor cells, with reduced output of naive B lymphocytes, and causes thymic atrophy, reducing the output of naive T lymphocytes. Therefore, zinc is essential for cell growth and differentiation of immune cells, helping to modulate the cytokine release and trigger CD8+ T cell proliferation."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T119","span":{"begin":102,"end":115},"obj":"Body_part"},{"id":"T120","span":{"begin":186,"end":199},"obj":"Body_part"},{"id":"T121","span":{"begin":673,"end":684},"obj":"Body_part"}],"attributes":[{"id":"A119","pred":"uberon_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A120","pred":"uberon_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A121","pred":"uberon_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/UBERON_0002371"}],"text":"Zinc is considered a “guardian” for the body, as it plays an essential role in the functioning of the immune system [115], plays a central role in cell growth and differentiation of the immune system cells that have rapid differentiation and turnover [116]. Most of the studies have recently reported a very interesting evaluation of the function of zinc in antiviral immunity, suggesting how it can play a role in host defense against RNA viruses, inhibiting the RNA polymerase required by RNA viruses (such as coronaviruses) to replicate [117]. The zinc-binding metallothionein seems to play an important role in antiviral defense. Zinc deficiency has a marked impact on bone marrow, decreasing the number of immune precursor cells, with reduced output of naive B lymphocytes, and causes thymic atrophy, reducing the output of naive T lymphocytes. Therefore, zinc is essential for cell growth and differentiation of immune cells, helping to modulate the cytokine release and trigger CD8+ T cell proliferation."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T570","span":{"begin":19,"end":20},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T571","span":{"begin":102,"end":115},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T572","span":{"begin":129,"end":130},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T573","span":{"begin":147,"end":151},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T574","span":{"begin":186,"end":199},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T575","span":{"begin":200,"end":205},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T576","span":{"begin":252,"end":255},"obj":"http://purl.obolibrary.org/obo/CLO_0001046"},{"id":"T577","span":{"begin":301,"end":302},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T578","span":{"begin":405,"end":406},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T579","span":{"begin":440,"end":447},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T580","span":{"begin":495,"end":502},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T581","span":{"begin":650,"end":653},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T582","span":{"begin":654,"end":655},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T583","span":{"begin":673,"end":677},"obj":"http://purl.obolibrary.org/obo/UBERON_0002481"},{"id":"T584","span":{"begin":728,"end":733},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T585","span":{"begin":764,"end":765},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T586","span":{"begin":829,"end":848},"obj":"http://purl.obolibrary.org/obo/CL_0000898"},{"id":"T587","span":{"begin":883,"end":887},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T588","span":{"begin":925,"end":930},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T589","span":{"begin":985,"end":988},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T590","span":{"begin":990,"end":996},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"Zinc is considered a “guardian” for the body, as it plays an essential role in the functioning of the immune system [115], plays a central role in cell growth and differentiation of the immune system cells that have rapid differentiation and turnover [116]. Most of the studies have recently reported a very interesting evaluation of the function of zinc in antiviral immunity, suggesting how it can play a role in host defense against RNA viruses, inhibiting the RNA polymerase required by RNA viruses (such as coronaviruses) to replicate [117]. The zinc-binding metallothionein seems to play an important role in antiviral defense. Zinc deficiency has a marked impact on bone marrow, decreasing the number of immune precursor cells, with reduced output of naive B lymphocytes, and causes thymic atrophy, reducing the output of naive T lymphocytes. Therefore, zinc is essential for cell growth and differentiation of immune cells, helping to modulate the cytokine release and trigger CD8+ T cell proliferation."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T500","span":{"begin":350,"end":354},"obj":"Chemical"},{"id":"T502","span":{"begin":358,"end":367},"obj":"Chemical"},{"id":"T503","span":{"begin":551,"end":555},"obj":"Chemical"},{"id":"T505","span":{"begin":615,"end":624},"obj":"Chemical"},{"id":"T506","span":{"begin":861,"end":865},"obj":"Chemical"}],"attributes":[{"id":"A500","pred":"chebi_id","subj":"T500","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A501","pred":"chebi_id","subj":"T500","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A502","pred":"chebi_id","subj":"T502","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A503","pred":"chebi_id","subj":"T503","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A504","pred":"chebi_id","subj":"T503","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A505","pred":"chebi_id","subj":"T505","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A506","pred":"chebi_id","subj":"T506","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A507","pred":"chebi_id","subj":"T506","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"}],"text":"Zinc is considered a “guardian” for the body, as it plays an essential role in the functioning of the immune system [115], plays a central role in cell growth and differentiation of the immune system cells that have rapid differentiation and turnover [116]. Most of the studies have recently reported a very interesting evaluation of the function of zinc in antiviral immunity, suggesting how it can play a role in host defense against RNA viruses, inhibiting the RNA polymerase required by RNA viruses (such as coronaviruses) to replicate [117]. The zinc-binding metallothionein seems to play an important role in antiviral defense. Zinc deficiency has a marked impact on bone marrow, decreasing the number of immune precursor cells, with reduced output of naive B lymphocytes, and causes thymic atrophy, reducing the output of naive T lymphocytes. Therefore, zinc is essential for cell growth and differentiation of immune cells, helping to modulate the cytokine release and trigger CD8+ T cell proliferation."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T188","span":{"begin":147,"end":158},"obj":"http://purl.obolibrary.org/obo/GO_0016049"},{"id":"T189","span":{"begin":152,"end":158},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T190","span":{"begin":883,"end":894},"obj":"http://purl.obolibrary.org/obo/GO_0016049"},{"id":"T191","span":{"begin":888,"end":894},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T192","span":{"begin":990,"end":1010},"obj":"http://purl.obolibrary.org/obo/GO_0042098"},{"id":"T193","span":{"begin":992,"end":1010},"obj":"http://purl.obolibrary.org/obo/GO_0008283"}],"text":"Zinc is considered a “guardian” for the body, as it plays an essential role in the functioning of the immune system [115], plays a central role in cell growth and differentiation of the immune system cells that have rapid differentiation and turnover [116]. Most of the studies have recently reported a very interesting evaluation of the function of zinc in antiviral immunity, suggesting how it can play a role in host defense against RNA viruses, inhibiting the RNA polymerase required by RNA viruses (such as coronaviruses) to replicate [117]. The zinc-binding metallothionein seems to play an important role in antiviral defense. Zinc deficiency has a marked impact on bone marrow, decreasing the number of immune precursor cells, with reduced output of naive B lymphocytes, and causes thymic atrophy, reducing the output of naive T lymphocytes. Therefore, zinc is essential for cell growth and differentiation of immune cells, helping to modulate the cytokine release and trigger CD8+ T cell proliferation."}

{"project":"LitCovid-sentences","denotations":[{"id":"T280","span":{"begin":0,"end":257},"obj":"Sentence"},{"id":"T281","span":{"begin":258,"end":546},"obj":"Sentence"},{"id":"T282","span":{"begin":547,"end":633},"obj":"Sentence"},{"id":"T283","span":{"begin":634,"end":849},"obj":"Sentence"},{"id":"T284","span":{"begin":850,"end":1011},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Zinc is considered a “guardian” for the body, as it plays an essential role in the functioning of the immune system [115], plays a central role in cell growth and differentiation of the immune system cells that have rapid differentiation and turnover [116]. Most of the studies have recently reported a very interesting evaluation of the function of zinc in antiviral immunity, suggesting how it can play a role in host defense against RNA viruses, inhibiting the RNA polymerase required by RNA viruses (such as coronaviruses) to replicate [117]. The zinc-binding metallothionein seems to play an important role in antiviral defense. Zinc deficiency has a marked impact on bone marrow, decreasing the number of immune precursor cells, with reduced output of naive B lymphocytes, and causes thymic atrophy, reducing the output of naive T lymphocytes. Therefore, zinc is essential for cell growth and differentiation of immune cells, helping to modulate the cytokine release and trigger CD8+ T cell proliferation."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1171","span":{"begin":985,"end":988},"obj":"Gene"},{"id":"1172","span":{"begin":512,"end":525},"obj":"Species"},{"id":"1173","span":{"begin":790,"end":804},"obj":"Disease"}],"attributes":[{"id":"A1171","pred":"tao:has_database_id","subj":"1171","obj":"Gene:925"},{"id":"A1172","pred":"tao:has_database_id","subj":"1172","obj":"Tax:11118"},{"id":"A1173","pred":"tao:has_database_id","subj":"1173","obj":"MESH:D013953"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Zinc is considered a “guardian” for the body, as it plays an essential role in the functioning of the immune system [115], plays a central role in cell growth and differentiation of the immune system cells that have rapid differentiation and turnover [116]. Most of the studies have recently reported a very interesting evaluation of the function of zinc in antiviral immunity, suggesting how it can play a role in host defense against RNA viruses, inhibiting the RNA polymerase required by RNA viruses (such as coronaviruses) to replicate [117]. The zinc-binding metallothionein seems to play an important role in antiviral defense. Zinc deficiency has a marked impact on bone marrow, decreasing the number of immune precursor cells, with reduced output of naive B lymphocytes, and causes thymic atrophy, reducing the output of naive T lymphocytes. Therefore, zinc is essential for cell growth and differentiation of immune cells, helping to modulate the cytokine release and trigger CD8+ T cell proliferation."}