PMC:7647877 / 44552-45049 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T483","span":{"begin":130,"end":138},"obj":"Body_part"},{"id":"T484","span":{"begin":133,"end":138},"obj":"Body_part"},{"id":"T485","span":{"begin":349,"end":356},"obj":"Body_part"},{"id":"T486","span":{"begin":378,"end":383},"obj":"Body_part"}],"attributes":[{"id":"A483","pred":"fma_id","subj":"T483","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A484","pred":"fma_id","subj":"T484","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A485","pred":"fma_id","subj":"T485","obj":"http://purl.org/sig/ont/fma/fma67408"},{"id":"A486","pred":"fma_id","subj":"T486","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"The immune response mechanisms in which vitamin E is involved are as follows: (i) maintains or improves the cytotoxic activity of NK cells [82] and reduces prostaglandin E2 (PGE2) production by the inhibition of cyclooxygenase-2 (COX-2) activity, mediated through decreasing of nitric oxide production [64, 112, 113]; (ii) the improvement of immune synapse formation in naive T cells, increasing the percentage of memory experienced with the antigen [112]; (iii) the modulation of Th1/Th2 balance."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T559","span":{"begin":118,"end":126},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T560","span":{"begin":130,"end":138},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T561","span":{"begin":170,"end":172},"obj":"http://purl.obolibrary.org/obo/CLO_0002860"},{"id":"T562","span":{"begin":237,"end":245},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T563","span":{"begin":370,"end":383},"obj":"http://purl.obolibrary.org/obo/CL_0000898"}],"text":"The immune response mechanisms in which vitamin E is involved are as follows: (i) maintains or improves the cytotoxic activity of NK cells [82] and reduces prostaglandin E2 (PGE2) production by the inhibition of cyclooxygenase-2 (COX-2) activity, mediated through decreasing of nitric oxide production [64, 112, 113]; (ii) the improvement of immune synapse formation in naive T cells, increasing the percentage of memory experienced with the antigen [112]; (iii) the modulation of Th1/Th2 balance."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T484","span":{"begin":40,"end":49},"obj":"Chemical"},{"id":"T485","span":{"begin":40,"end":47},"obj":"Chemical"},{"id":"T486","span":{"begin":156,"end":172},"obj":"Chemical"},{"id":"T488","span":{"begin":156,"end":169},"obj":"Chemical"},{"id":"T489","span":{"begin":174,"end":178},"obj":"Chemical"},{"id":"T490","span":{"begin":278,"end":290},"obj":"Chemical"},{"id":"T491","span":{"begin":285,"end":290},"obj":"Chemical"},{"id":"T493","span":{"begin":442,"end":449},"obj":"Chemical"}],"attributes":[{"id":"A484","pred":"chebi_id","subj":"T484","obj":"http://purl.obolibrary.org/obo/CHEBI_33234"},{"id":"A485","pred":"chebi_id","subj":"T485","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A486","pred":"chebi_id","subj":"T486","obj":"http://purl.obolibrary.org/obo/CHEBI_15551"},{"id":"A487","pred":"chebi_id","subj":"T486","obj":"http://purl.obolibrary.org/obo/CHEBI_606564"},{"id":"A488","pred":"chebi_id","subj":"T488","obj":"http://purl.obolibrary.org/obo/CHEBI_26333"},{"id":"A489","pred":"chebi_id","subj":"T489","obj":"http://purl.obolibrary.org/obo/CHEBI_15551"},{"id":"A490","pred":"chebi_id","subj":"T490","obj":"http://purl.obolibrary.org/obo/CHEBI_16480"},{"id":"A491","pred":"chebi_id","subj":"T491","obj":"http://purl.obolibrary.org/obo/CHEBI_25741"},{"id":"A492","pred":"chebi_id","subj":"T491","obj":"http://purl.obolibrary.org/obo/CHEBI_29356"},{"id":"A493","pred":"chebi_id","subj":"T493","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"}],"text":"The immune response mechanisms in which vitamin E is involved are as follows: (i) maintains or improves the cytotoxic activity of NK cells [82] and reduces prostaglandin E2 (PGE2) production by the inhibition of cyclooxygenase-2 (COX-2) activity, mediated through decreasing of nitric oxide production [64, 112, 113]; (ii) the improvement of immune synapse formation in naive T cells, increasing the percentage of memory experienced with the antigen [112]; (iii) the modulation of Th1/Th2 balance."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T184","span":{"begin":4,"end":19},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T185","span":{"begin":357,"end":366},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T186","span":{"begin":414,"end":420},"obj":"http://purl.obolibrary.org/obo/GO_0007613"}],"text":"The immune response mechanisms in which vitamin E is involved are as follows: (i) maintains or improves the cytotoxic activity of NK cells [82] and reduces prostaglandin E2 (PGE2) production by the inhibition of cyclooxygenase-2 (COX-2) activity, mediated through decreasing of nitric oxide production [64, 112, 113]; (ii) the improvement of immune synapse formation in naive T cells, increasing the percentage of memory experienced with the antigen [112]; (iii) the modulation of Th1/Th2 balance."}

{"project":"LitCovid-sentences","denotations":[{"id":"T274","span":{"begin":0,"end":497},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The immune response mechanisms in which vitamin E is involved are as follows: (i) maintains or improves the cytotoxic activity of NK cells [82] and reduces prostaglandin E2 (PGE2) production by the inhibition of cyclooxygenase-2 (COX-2) activity, mediated through decreasing of nitric oxide production [64, 112, 113]; (ii) the improvement of immune synapse formation in naive T cells, increasing the percentage of memory experienced with the antigen [112]; (iii) the modulation of Th1/Th2 balance."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1154","span":{"begin":212,"end":228},"obj":"Gene"},{"id":"1155","span":{"begin":230,"end":235},"obj":"Gene"},{"id":"1159","span":{"begin":40,"end":49},"obj":"Chemical"},{"id":"1160","span":{"begin":156,"end":172},"obj":"Chemical"},{"id":"1161","span":{"begin":174,"end":178},"obj":"Chemical"},{"id":"1162","span":{"begin":278,"end":290},"obj":"Chemical"}],"attributes":[{"id":"A1154","pred":"tao:has_database_id","subj":"1154","obj":"Gene:5743"},{"id":"A1155","pred":"tao:has_database_id","subj":"1155","obj":"Gene:5743"},{"id":"A1160","pred":"tao:has_database_id","subj":"1160","obj":"MESH:D015232"},{"id":"A1161","pred":"tao:has_database_id","subj":"1161","obj":"MESH:D015232"},{"id":"A1162","pred":"tao:has_database_id","subj":"1162","obj":"MESH:D009569"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The immune response mechanisms in which vitamin E is involved are as follows: (i) maintains or improves the cytotoxic activity of NK cells [82] and reduces prostaglandin E2 (PGE2) production by the inhibition of cyclooxygenase-2 (COX-2) activity, mediated through decreasing of nitric oxide production [64, 112, 113]; (ii) the improvement of immune synapse formation in naive T cells, increasing the percentage of memory experienced with the antigen [112]; (iii) the modulation of Th1/Th2 balance."}