PMC:7647877 / 38324-39172
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7647877","sourcedb":"PMC","sourceid":"7647877","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7647877","text":"Infections have a significant impact on vitamin C levels, due to the increased energy needs required by the body during inflammation. This nutrient, in fact, promotes the proliferation of lymphocytes, with a consequent increase in the generation of antibodies [79, 85, 92]. It is well known that infections increase oxidative stress and usually activate phagocytes that release ROS, so vitamin C is a well-known antioxidant that can counteract these effects by increasing phagocytosis and ROS generation and improving microbial killing [92–94]. Furthermore, supplementation with vitamin C appears to be able to prevent and treat respiratory and systemic infections [92]. High levels of this nutrient can enhance antimicrobial effects and increase serum levels of complement proteins, also playing an important role in IFN-γ production [85, 92, 95].","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T436","span":{"begin":108,"end":112},"obj":"Body_part"},{"id":"T437","span":{"begin":188,"end":199},"obj":"Body_part"},{"id":"T438","span":{"begin":629,"end":653},"obj":"Body_part"},{"id":"T439","span":{"begin":747,"end":752},"obj":"Body_part"},{"id":"T440","span":{"begin":774,"end":782},"obj":"Body_part"}],"attributes":[{"id":"A436","pred":"fma_id","subj":"T436","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A437","pred":"fma_id","subj":"T437","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A438","pred":"fma_id","subj":"T438","obj":"http://purl.org/sig/ont/fma/fma7158"},{"id":"A439","pred":"fma_id","subj":"T439","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A440","pred":"fma_id","subj":"T440","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T436","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T437","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T438","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T439","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T440","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T103","span":{"begin":629,"end":653},"obj":"Body_part"},{"id":"T104","span":{"begin":747,"end":752},"obj":"Body_part"}],"attributes":[{"id":"A103","pred":"uberon_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/UBERON_0001004"},{"id":"A104","pred":"uberon_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"subj":"T103","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T104","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T214","span":{"begin":120,"end":132},"obj":"Disease"},{"id":"T215","span":{"begin":296,"end":306},"obj":"Disease"},{"id":"T216","span":{"begin":654,"end":664},"obj":"Disease"}],"attributes":[{"id":"A214","pred":"mondo_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A215","pred":"mondo_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A216","pred":"mondo_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T214","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T215","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T216","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T484","span":{"begin":16,"end":17},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T485","span":{"begin":206,"end":207},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T486","span":{"begin":345,"end":353},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T487","span":{"begin":354,"end":364},"obj":"http://purl.obolibrary.org/obo/CL_0000234"},{"id":"T488","span":{"begin":399,"end":400},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T489","span":{"begin":540,"end":542},"obj":"http://purl.obolibrary.org/obo/CLO_0001527"},{"id":"T490","span":{"begin":629,"end":653},"obj":"http://purl.obolibrary.org/obo/UBERON_0001004"}],"attributes":[{"subj":"T484","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T485","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T486","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T487","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T488","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T489","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T490","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T395","span":{"begin":40,"end":49},"obj":"Chemical"},{"id":"T396","span":{"begin":40,"end":47},"obj":"Chemical"},{"id":"T397","span":{"begin":139,"end":147},"obj":"Chemical"},{"id":"T398","span":{"begin":378,"end":381},"obj":"Chemical"},{"id":"T399","span":{"begin":386,"end":395},"obj":"Chemical"},{"id":"T400","span":{"begin":386,"end":393},"obj":"Chemical"},{"id":"T401","span":{"begin":412,"end":423},"obj":"Chemical"},{"id":"T402","span":{"begin":489,"end":492},"obj":"Chemical"},{"id":"T403","span":{"begin":579,"end":588},"obj":"Chemical"},{"id":"T404","span":{"begin":579,"end":586},"obj":"Chemical"},{"id":"T405","span":{"begin":691,"end":699},"obj":"Chemical"},{"id":"T406","span":{"begin":712,"end":725},"obj":"Chemical"},{"id":"T407","span":{"begin":774,"end":782},"obj":"Chemical"}],"attributes":[{"id":"A395","pred":"chebi_id","subj":"T395","obj":"http://purl.obolibrary.org/obo/CHEBI_21241"},{"id":"A396","pred":"chebi_id","subj":"T396","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A397","pred":"chebi_id","subj":"T397","obj":"http://purl.obolibrary.org/obo/CHEBI_33284"},{"id":"A398","pred":"chebi_id","subj":"T398","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A399","pred":"chebi_id","subj":"T399","obj":"http://purl.obolibrary.org/obo/CHEBI_21241"},{"id":"A400","pred":"chebi_id","subj":"T400","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A401","pred":"chebi_id","subj":"T401","obj":"http://purl.obolibrary.org/obo/CHEBI_22586"},{"id":"A402","pred":"chebi_id","subj":"T402","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A403","pred":"chebi_id","subj":"T403","obj":"http://purl.obolibrary.org/obo/CHEBI_21241"},{"id":"A404","pred":"chebi_id","subj":"T404","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A405","pred":"chebi_id","subj":"T405","obj":"http://purl.obolibrary.org/obo/CHEBI_33284"},{"id":"A406","pred":"chebi_id","subj":"T406","obj":"http://purl.obolibrary.org/obo/CHEBI_33281"},{"id":"A407","pred":"chebi_id","subj":"T407","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T395","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T396","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T397","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T398","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T399","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T400","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T401","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T402","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T403","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T404","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T405","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T406","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T407","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T81","span":{"begin":316,"end":332},"obj":"Phenotype"}],"attributes":[{"id":"A81","pred":"hp_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/HP_0025464"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T175","span":{"begin":120,"end":132},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T176","span":{"begin":472,"end":484},"obj":"http://purl.obolibrary.org/obo/GO_0006909"},{"id":"T177","span":{"begin":489,"end":503},"obj":"http://purl.obolibrary.org/obo/GO_1903409"}],"attributes":[{"subj":"T175","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T176","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T177","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T236","span":{"begin":0,"end":133},"obj":"Sentence"},{"id":"T237","span":{"begin":134,"end":273},"obj":"Sentence"},{"id":"T238","span":{"begin":274,"end":544},"obj":"Sentence"},{"id":"T239","span":{"begin":545,"end":670},"obj":"Sentence"},{"id":"T240","span":{"begin":671,"end":848},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T236","pred":"source","obj":"LitCovid-sentences"},{"subj":"T237","pred":"source","obj":"LitCovid-sentences"},{"subj":"T238","pred":"source","obj":"LitCovid-sentences"},{"subj":"T239","pred":"source","obj":"LitCovid-sentences"},{"subj":"T240","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1006","span":{"begin":818,"end":823},"obj":"Gene"},{"id":"1007","span":{"begin":40,"end":49},"obj":"Chemical"},{"id":"1008","span":{"begin":378,"end":381},"obj":"Chemical"},{"id":"1009","span":{"begin":386,"end":395},"obj":"Chemical"},{"id":"1010","span":{"begin":489,"end":492},"obj":"Chemical"},{"id":"1011","span":{"begin":579,"end":588},"obj":"Chemical"},{"id":"1012","span":{"begin":0,"end":10},"obj":"Disease"},{"id":"1013","span":{"begin":120,"end":132},"obj":"Disease"},{"id":"1014","span":{"begin":296,"end":306},"obj":"Disease"},{"id":"1015","span":{"begin":629,"end":664},"obj":"Disease"}],"attributes":[{"id":"A1006","pred":"tao:has_database_id","subj":"1006","obj":"Gene:3458"},{"id":"A1007","pred":"tao:has_database_id","subj":"1007","obj":"MESH:D001205"},{"id":"A1008","pred":"tao:has_database_id","subj":"1008","obj":"MESH:D017382"},{"id":"A1009","pred":"tao:has_database_id","subj":"1009","obj":"MESH:D001205"},{"id":"A1010","pred":"tao:has_database_id","subj":"1010","obj":"MESH:D017382"},{"id":"A1011","pred":"tao:has_database_id","subj":"1011","obj":"MESH:D001205"},{"id":"A1012","pred":"tao:has_database_id","subj":"1012","obj":"MESH:D007239"},{"id":"A1013","pred":"tao:has_database_id","subj":"1013","obj":"MESH:D007249"},{"id":"A1014","pred":"tao:has_database_id","subj":"1014","obj":"MESH:D007239"},{"id":"A1015","pred":"tao:has_database_id","subj":"1015","obj":"MESH:D012141"},{"subj":"1006","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1007","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1008","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1009","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1010","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1011","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1012","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1013","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1014","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1015","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#b093ec","default":true},{"id":"LitCovid-PD-UBERON","color":"#93ec96"},{"id":"LitCovid-PD-MONDO","color":"#ec93a9"},{"id":"LitCovid-PD-CLO","color":"#93c3ec"},{"id":"LitCovid-PD-CHEBI","color":"#ddec93"},{"id":"LitCovid-PD-HP","color":"#e193ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ecc6"},{"id":"LitCovid-sentences","color":"#ecac93"},{"id":"LitCovid-PubTator","color":"#9393ec"}]}]}}