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PMC:7647877 / 37154-40284 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T420 178-186 Body_part denotes collagen http://purl.org/sig/ont/fma/fma63891
T421 294-308 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T422 294-298 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T423 424-437 Body_part denotes keratinocytic http://purl.org/sig/ont/fma/fma62879
T424 458-463 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T425 485-495 Body_part denotes fibroblast http://purl.org/sig/ont/fma/fma63877
T426 648-659 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T427 661-670 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T428 712-722 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T429 801-821 Body_part denotes natural killer cells http://purl.org/sig/ont/fma/fma63147
T430 816-821 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T431 845-858 Body_part denotes T lymphocytes http://purl.org/sig/ont/fma/fma62870
T432 875-898 Body_part denotes cytotoxic T lymphocytes http://purl.org/sig/ont/fma/fma70573
T433 1014-1025 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T434 1031-1041 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T435 1150-1156 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T436 1278-1282 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T437 1358-1369 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T438 1799-1823 Body_part denotes respiratory and systemic http://purl.org/sig/ont/fma/fma7158
T439 1917-1922 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T440 1944-1952 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T441 2426-2449 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T102 1150-1156 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T103 1799-1823 Body_part denotes respiratory and systemic http://purl.obolibrary.org/obo/UBERON_0001004
T104 1917-1922 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T105 2426-2449 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T106 2432-2449 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T211 74-83 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T212 735-744 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T213 1042-1051 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T214 1290-1302 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T215 1466-1476 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T216 1824-1834 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T217 2101-2123 Disease denotes respiratory infections http://purl.obolibrary.org/obo/MONDO_0024355
T218 2132-2141 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T219 2215-2224 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T220 2426-2460 Disease denotes upper respiratory tract infections http://purl.obolibrary.org/obo/MONDO_0024355
T221 2474-2485 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T222 2636-2644 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T223 2761-2769 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T224 2881-2909 Disease denotes upper respiratory infections http://purl.obolibrary.org/obo/MONDO_0024355
T225 3032-3054 Disease denotes respiratory infections http://purl.obolibrary.org/obo/MONDO_0024355

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T470 84-87 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T471 178-186 http://purl.obolibrary.org/obo/CHEBI_3815 denotes collagen
T472 220-230 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T473 294-298 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T474 299-308 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T475 384-394 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T476 424-437 http://purl.obolibrary.org/obo/CL_0000312 denotes keratinocytic
T477 485-495 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblast
T478 539-540 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T479 661-670 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T480 675-685 http://purl.obolibrary.org/obo/CL_0000234 denotes phagocytes
T481 789-797 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T482 801-821 http://purl.obolibrary.org/obo/CL_0000623 denotes natural killer cells
T483 871-874 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T484 1186-1187 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T485 1376-1377 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T486 1515-1523 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T487 1524-1534 http://purl.obolibrary.org/obo/CL_0000234 denotes phagocytes
T488 1569-1570 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T489 1710-1712 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T490 1799-1823 http://purl.obolibrary.org/obo/UBERON_0001004 denotes respiratory and systemic
T491 2151-2152 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T492 2176-2177 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T493 2290-2291 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T494 2360-2363 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T495 3015-3016 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T379 0-9 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T382 0-7 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T383 22-31 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T384 22-29 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T385 121-130 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T388 121-128 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T389 336-344 Chemical denotes radicals http://purl.obolibrary.org/obo/CHEBI_26519
T390 458-463 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T391 946-955 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T394 946-953 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T395 1210-1219 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T396 1210-1217 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T397 1309-1317 Chemical denotes nutrient http://purl.obolibrary.org/obo/CHEBI_33284
T398 1548-1551 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T399 1556-1565 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T400 1556-1563 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T401 1582-1593 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T402 1659-1662 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T403 1749-1758 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T404 1749-1756 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T405 1861-1869 Chemical denotes nutrient http://purl.obolibrary.org/obo/CHEBI_33284
T406 1882-1895 Chemical denotes antimicrobial http://purl.obolibrary.org/obo/CHEBI_33281
T407 1944-1952 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T408 2033-2042 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T409 2033-2040 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T410 2230-2239 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T411 2230-2237 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T412 2319-2327 Chemical denotes nutrient http://purl.obolibrary.org/obo/CHEBI_33284
T413 2334-2343 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T416 2334-2341 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T417 2602-2611 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T418 2602-2609 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T419 2739-2748 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T420 2739-2746 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T79 56-83 Phenotype denotes susceptibility to infection http://purl.obolibrary.org/obo/HP_0002719
T80 264-280 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T81 1486-1502 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T82 2019-2042 Phenotype denotes Low levels of vitamin C http://purl.obolibrary.org/obo/HP_0100510
T83 2101-2123 Phenotype denotes respiratory infections http://purl.obolibrary.org/obo/HP_0011947
T84 2132-2141 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T85 2215-2224 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T86 2426-2460 Phenotype denotes upper respiratory tract infections http://purl.obolibrary.org/obo/HP_0002788
T87 2887-2909 Phenotype denotes respiratory infections http://purl.obolibrary.org/obo/HP_0011947
T88 3032-3054 Phenotype denotes respiratory infections http://purl.obolibrary.org/obo/HP_0011947

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T166 162-174 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T167 424-453 http://purl.obolibrary.org/obo/GO_0030216 denotes keratinocytic differentiation
T168 458-473 http://purl.obolibrary.org/obo/GO_0008610 denotes lipid synthesis
T169 464-473 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T170 485-509 http://purl.obolibrary.org/obo/GO_0048144 denotes fibroblast proliferation
T171 746-758 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T172 976-985 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T173 976-985 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T174 1082-1091 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T175 1290-1302 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T176 1642-1654 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T177 1659-1673 http://purl.obolibrary.org/obo/GO_1903409 denotes ROS generation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T230 0-9 Sentence denotes Vitamin C
T231 10-120 Sentence denotes The role of vitamin C in immunity and in host susceptibility to infection has been scientifically proven [92].
T232 121-281 Sentence denotes Vitamin C, in fact, is necessary for the biosynthesis of collagen and is essential for maintaining epithelial integrity and protecting against oxidative stress.
T233 282-529 Sentence denotes It protects cell membranes from damage caused by free radicals, so as to support the integrity of the epithelial barriers [79], also improves keratinocytic differentiation and lipid synthesis as well as fibroblast proliferation and migration [92].
T234 530-945 Sentence denotes It plays a role in various aspects of immunity, in fact it is involved in the proliferation, function and movement of neutrophils, monocytes and phagocytes [82] and the migration of leukocytes to sites of infection, phagocytosis and bacterial killing, in the activity of natural killer cells and in the function of T lymphocytes (especially CD8 cytotoxic T lymphocytes) and in the production of antibodies [79, 82].
T235 946-1169 Sentence denotes Vitamin C is also involved in apoptosis and elimination of depleted neutrophils from macrophage infection sites [92] and attenuates the formation of extracellular trap (NET), thus reducing the associated tissue damage [92].
T236 1170-1303 Sentence denotes Infections have a significant impact on vitamin C levels, due to the increased energy needs required by the body during inflammation.
T237 1304-1443 Sentence denotes This nutrient, in fact, promotes the proliferation of lymphocytes, with a consequent increase in the generation of antibodies [79, 85, 92].
T238 1444-1714 Sentence denotes It is well known that infections increase oxidative stress and usually activate phagocytes that release ROS, so vitamin C is a well-known antioxidant that can counteract these effects by increasing phagocytosis and ROS generation and improving microbial killing [92–94].
T239 1715-1840 Sentence denotes Furthermore, supplementation with vitamin C appears to be able to prevent and treat respiratory and systemic infections [92].
T240 1841-2018 Sentence denotes High levels of this nutrient can enhance antimicrobial effects and increase serum levels of complement proteins, also playing an important role in IFN-γ production [85, 92, 95].
T241 2019-2142 Sentence denotes Low levels of vitamin C are responsible for an increased susceptibility to severe respiratory infections such as pneumonia.
T242 2143-2333 Sentence denotes Indeed, a meta-analysis reported a significant reduction in the risk of pneumonia with vitamin C supplementation, particularly in individuals with a low dietary intake of this nutrient [96].
T243 2334-2545 Sentence denotes Vitamin C supplementation has also been demonstrated to reduce the duration and severity of upper respiratory tract infections, such as the common cold, especially in people under increased physical stress [96].
T244 2546-2650 Sentence denotes Currently, there are limited recommendations for taking vitamin C supplementation against COVID-19 [97].
T245 2651-2820 Sentence denotes Nevertheless, there is sufficient evidence to conduct several clinical trials to assess vitamin C efficacy in COVID-19 prevention and treatment (www.clinicaltrials.gov).
T246 2821-2910 Sentence denotes Previously, doses of 1–2 g/day were effective in preventing upper respiratory infections.
T247 2911-3055 Sentence denotes As those levels are not attainable through dietary sources, supplementation may be advised for those at a higher risk of respiratory infections.
T248 3056-3130 Sentence denotes Doses above 200 mg/day may not be beneficial for healthy individuals [98].

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
979 0-9 Chemical denotes Vitamin C MESH:D001205
988 871-874 Gene denotes CD8 Gene:925
989 22-31 Chemical denotes vitamin C MESH:D001205
990 121-130 Chemical denotes Vitamin C MESH:D001205
991 458-463 Chemical denotes lipid MESH:D008055
992 946-955 Chemical denotes Vitamin C MESH:D001205
993 74-83 Disease denotes infection MESH:D007239
994 735-744 Disease denotes infection MESH:D007239
995 1031-1051 Disease denotes macrophage infection MESH:D055501
1006 1988-1993 Gene denotes IFN-γ Gene:3458
1007 1210-1219 Chemical denotes vitamin C MESH:D001205
1008 1548-1551 Chemical denotes ROS MESH:D017382
1009 1556-1565 Chemical denotes vitamin C MESH:D001205
1010 1659-1662 Chemical denotes ROS MESH:D017382
1011 1749-1758 Chemical denotes vitamin C MESH:D001205
1012 1170-1180 Disease denotes Infections MESH:D007239
1013 1290-1302 Disease denotes inflammation MESH:D007249
1014 1466-1476 Disease denotes infections MESH:D007239
1015 1799-1834 Disease denotes respiratory and systemic infections MESH:D012141
1021 2033-2042 Chemical denotes vitamin C MESH:D001205
1022 2230-2239 Chemical denotes vitamin C MESH:D001205
1023 2101-2123 Disease denotes respiratory infections MESH:D012141
1024 2132-2141 Disease denotes pneumonia MESH:D011014
1025 2215-2224 Disease denotes pneumonia MESH:D011014
1030 2501-2507 Species denotes people Tax:9606
1031 2334-2343 Chemical denotes Vitamin C MESH:D001205
1032 2426-2460 Disease denotes upper respiratory tract infections MESH:D012141
1033 2474-2485 Disease denotes common cold MESH:D003139
1040 2602-2611 Chemical denotes vitamin C MESH:D001205
1041 2739-2748 Chemical denotes vitamin C MESH:D001205
1042 2636-2644 Disease denotes COVID-19 MESH:C000657245
1043 2761-2769 Disease denotes COVID-19 MESH:C000657245
1044 2881-2909 Disease denotes upper respiratory infections MESH:D012141
1045 3032-3054 Disease denotes respiratory infections MESH:D012141