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PMC:7647877 / 34625-36563 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T389 295-303 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T390 298-303 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T391 370-380 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T392 423-434 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T393 476-496 Body_part denotes natural killer cells http://purl.org/sig/ont/fma/fma63147
T394 491-496 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T395 676-685 Body_part denotes Th2 cells http://purl.org/sig/ont/fma/fma84385
T396 680-685 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T397 779-788 Body_part denotes Th2 cells http://purl.org/sig/ont/fma/fma84385
T398 783-788 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T399 927-935 Body_part denotes Th1 cell http://purl.org/sig/ont/fma/fma84382
T400 931-935 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T401 1101-1106 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T402 1108-1117 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T403 1119-1127 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T404 1227-1232 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T405 1234-1243 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T406 1397-1402 Body_part denotes IL-12 http://purl.org/sig/ont/fma/fma86579
T407 1397-1399 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T408 1423-1432 Body_part denotes Th1 cells http://purl.org/sig/ont/fma/fma84382
T409 1427-1432 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T410 1510-1523 Body_part denotes T lymphocytes http://purl.org/sig/ont/fma/fma62870
T411 1671-1675 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T412 1671-1673 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T413 1767-1778 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T414 1852-1865 Body_part denotes B lymphocytes http://purl.org/sig/ont/fma/fma62869
T415 1899-1907 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T201 0-20 Disease denotes Vitamin A deficiency http://purl.obolibrary.org/obo/MONDO_0007016
T202 117-127 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T203 521-541 Disease denotes vitamin A deficiency http://purl.obolibrary.org/obo/MONDO_0007016
T204 728-748 Disease denotes vitamin A deficiency http://purl.obolibrary.org/obo/MONDO_0007016
T205 1796-1808 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T429 8-9 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T430 104-105 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T431 232-233 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T432 256-257 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T433 295-303 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T434 329-339 http://purl.obolibrary.org/obo/CL_0000234 denotes phagocytic
T435 354-362 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T436 464-472 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T437 476-496 http://purl.obolibrary.org/obo/CL_0000623 denotes natural killer cells
T438 529-530 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T439 565-566 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T440 680-685 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T441 736-737 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T442 783-788 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T443 911-912 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T444 931-935 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T445 1065-1066 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T446 1101-1106 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T447 1227-1232 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T448 1282-1288 http://purl.obolibrary.org/obo/CLO_0053477 denotes GATA-3
T449 1427-1432 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T450 1447-1448 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T451 1499-1523 http://purl.obolibrary.org/obo/CL_0000815 denotes regulatory T lymphocytes
T452 1671-1675 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T453 1714-1723 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T454 1728-1738 http://purl.obolibrary.org/obo/CL_0000234 denotes phagocytic
T455 1779-1788 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T456 1852-1853 http://purl.obolibrary.org/obo/CLO_0001021 denotes B

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T343 0-9 Chemical denotes Vitamin A http://purl.obolibrary.org/obo/CHEBI_17336
T344 0-7 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T345 224-233 Chemical denotes vitamin A http://purl.obolibrary.org/obo/CHEBI_12777
T346 224-231 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T347 248-257 Chemical denotes vitamin A http://purl.obolibrary.org/obo/CHEBI_12777
T348 248-255 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T349 521-530 Chemical denotes vitamin A http://purl.obolibrary.org/obo/CHEBI_12777
T350 521-528 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T351 557-566 Chemical denotes vitamin A http://purl.obolibrary.org/obo/CHEBI_12777
T352 557-564 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T353 728-737 Chemical denotes vitamin A http://purl.obolibrary.org/obo/CHEBI_12777
T354 728-735 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T355 903-912 Chemical denotes vitamin A http://purl.obolibrary.org/obo/CHEBI_12777
T356 903-910 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T357 1029-1042 Chemical denotes retinoic acid http://purl.obolibrary.org/obo/CHEBI_26536
T358 1038-1042 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T359 1043-1053 Chemical denotes metabolite http://purl.obolibrary.org/obo/CHEBI_25212
T360 1057-1066 Chemical denotes vitamin A http://purl.obolibrary.org/obo/CHEBI_12777
T361 1057-1064 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T362 1397-1399 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T364 1439-1448 Chemical denotes Vitamin A http://purl.obolibrary.org/obo/CHEBI_17336
T365 1439-1446 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T366 1671-1673 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T368 1925-1932 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T72 0-20 Phenotype denotes Vitamin A deficiency http://purl.obolibrary.org/obo/HP_0004905
T73 521-541 Phenotype denotes vitamin A deficiency http://purl.obolibrary.org/obo/HP_0004905
T74 728-748 Phenotype denotes vitamin A deficiency http://purl.obolibrary.org/obo/HP_0004905

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T159 55-71 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T160 158-173 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T161 1146-1166 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T162 1146-1159 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T163 1261-1281 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T164 1261-1274 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T165 1796-1808 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T214 0-128 Sentence denotes Vitamin A deficiency impairs barrier function, impairs immune responses and increases susceptibility to a variety of infections.
T215 129-234 Sentence denotes Furthermore, many aspects of innate immunity, in addition to barrier function, are affected by vitamin A.
T216 235-459 Sentence denotes For example, vitamin A regulates the number and function of NK cells [82], contributes to the phagocytic and oxidative activity of the macrophage burst [79] and controls the maturation of neutrophils and its deficiency [83].
T217 460-542 Sentence denotes The activity of natural killer cells is therefore reduced by vitamin A deficiency.
T218 543-695 Sentence denotes The impact of vitamin A on acquired immunity is however clear since it is involved in the development and differentiation of Th1 and Th2 cells [62, 79].
T219 696-883 Sentence denotes Moreover there is evidence that vitamin A deficiency alters the balance of Th1 and Th2 cells, decreasing the Th2 response, without affecting or, in some cases, enhancing the Th1 response.
T220 884-961 Sentence denotes This suggests that vitamin A increases the Th1 cell average in immunity [84].
T221 962-1295 Sentence denotes However, studies in several experimental models have shown how the retinoic acid metabolite of vitamin A reduces the responses of Th1-type cells (cytokines, cytokine receptors and the transcription factor T-bet, which promotes Th1), improving responses to Th2-type cells (cytokines and Th2-favoring transcription factor GATA-3) [62].
T222 1296-1438 Sentence denotes Indeed, it maintains the normal Th2 response mediated by antibodies by suppressing the production of IL-12, TNF-α and IFN-γ by Th1 cells [85].
T223 1439-1634 Sentence denotes Vitamin A appears to be important in the differentiation of regulatory T lymphocytes by suppressing Th17 differentiation, which have implications for the control of adverse immune reactions [86].
T224 1635-1814 Sentence denotes It helps regulate the production of IL-2 and the pro-inflammatory TNF-γ, which activates the phagocytic and oxidative action of the macrophages activated during inflammation [79].
T225 1815-1938 Sentence denotes It ensures the normal functioning of B lymphocytes, necessary for the generation of antibody responses to the antigen [85].

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
936 1167-1172 Gene denotes T-bet Gene:30009
937 1404-1409 Gene denotes TNF-α Gene:7124
938 1414-1419 Gene denotes IFN-γ Gene:3458
939 1671-1675 Gene denotes IL-2 Gene:3558
940 0-9 Chemical denotes Vitamin A MESH:D014801
941 224-233 Chemical denotes vitamin A MESH:D014801
942 248-257 Chemical denotes vitamin A MESH:D014801
943 521-530 Chemical denotes vitamin A MESH:D014801
944 557-566 Chemical denotes vitamin A MESH:D014801
945 728-737 Chemical denotes vitamin A MESH:D014801
946 805-808 Chemical denotes Th2
947 903-912 Chemical denotes vitamin A MESH:D014801
948 1029-1042 Chemical denotes retinoic acid MESH:D014212
949 1057-1066 Chemical denotes vitamin A MESH:D014801
950 1439-1448 Chemical denotes Vitamin A MESH:D014801
951 10-28 Disease denotes deficiency impairs MESH:D060825
952 117-127 Disease denotes infections MESH:D007239
953 1796-1808 Disease denotes inflammation MESH:D007249