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PMC:7647877 / 17294-28592 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T266 135-139 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T267 444-452 Body_part denotes hormones http://purl.org/sig/ont/fma/fma12278
T268 1624-1638 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T269 2059-2073 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T270 2098-2107 Body_part denotes adipocyte http://purl.org/sig/ont/fma/fma63880
T271 2230-2239 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T272 2245-2254 Body_part denotes adipocyte http://purl.org/sig/ont/fma/fma63880
T273 2358-2372 Body_part denotes Adipose tissue http://purl.org/sig/ont/fma/fma20110
T274 2397-2413 Body_part denotes endocrine system http://purl.org/sig/ont/fma/fma9668
T275 2442-2447 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T276 2460-2465 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T277 2567-2572 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T278 2612-2632 Body_part denotes extracellular matrix http://purl.org/sig/ont/fma/fma9672
T279 2644-2651 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T280 2719-2729 Body_part denotes adipocytes http://purl.org/sig/ont/fma/fma63880
T281 2772-2786 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T282 2828-2837 Body_part denotes adipocyte http://purl.org/sig/ont/fma/fma63880
T283 2851-2855 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T284 2967-2972 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T285 3040-3051 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T286 3072-3086 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T287 3254-3268 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T288 3269-3280 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T289 3369-3383 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T290 3427-3437 Body_part denotes adipocytes http://purl.org/sig/ont/fma/fma63880
T291 3492-3499 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T292 3611-3625 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T293 3654-3659 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T294 3934-3942 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T295 3970-3978 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T296 4098-4100 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T297 4127-4136 Body_part denotes adipocyte http://purl.org/sig/ont/fma/fma63880
T298 4149-4156 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T299 4236-4245 Body_part denotes adipocyte http://purl.org/sig/ont/fma/fma63880
T300 4254-4261 Body_part denotes hormone http://purl.org/sig/ont/fma/fma12278
T301 4469-4482 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T302 4581-4594 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T303 4629-4642 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T304 4643-4648 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T305 5310-5317 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T306 5350-5354 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T307 5393-5397 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T308 5636-5638 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T309 5871-5873 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T310 5940-5942 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T311 6015-6023 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T312 6071-6082 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T313 6094-6099 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T314 6190-6194 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T315 6195-6211 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T316 6206-6211 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T317 6266-6268 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T318 6286-6291 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T319 6332-6337 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T320 6358-6362 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T321 6418-6420 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T322 6470-6479 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T323 6717-6721 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T324 6822-6831 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T325 6847-6851 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T326 6847-6849 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T327 6857-6859 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T328 6912-6921 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T329 6930-6932 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T330 7331-7345 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T331 7590-7604 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T332 7658-7662 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T333 7755-7759 Body_part denotes Body http://purl.org/sig/ont/fma/fma256135
T334 8118-8122 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T335 8260-8270 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T336 8296-8299 Body_part denotes gut http://purl.org/sig/ont/fma/fma7199
T337 8537-8550 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T338 8747-8760 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T339 9277-9284 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T340 9345-9349 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T341 9836-9843 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T342 10381-10394 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T343 11037-11042 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T55 1624-1638 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T56 1632-1638 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T57 2059-2073 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T58 2067-2073 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T59 2124-2136 Body_part denotes visceral fat http://purl.obolibrary.org/obo/UBERON_0035818
T60 2358-2372 Body_part denotes Adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T61 2366-2372 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T62 2397-2413 Body_part denotes endocrine system http://purl.obolibrary.org/obo/UBERON_0000949
T63 2435-2447 Body_part denotes immune organ http://purl.obolibrary.org/obo/UBERON_0005057
T64 2442-2447 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T65 2460-2465 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T66 2772-2786 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T67 2780-2786 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T68 3072-3086 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T69 3080-3086 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T70 3254-3268 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T71 3262-3268 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T72 3369-3383 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T73 3377-3383 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T74 3611-3625 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T75 3619-3625 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T76 3654-3659 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T77 4469-4482 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T78 4581-4594 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T79 4629-4642 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T80 6190-6194 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T81 6286-6291 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T82 7331-7345 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T83 7339-7345 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T84 7590-7604 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T85 7598-7604 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T86 8537-8550 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T87 8747-8760 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T88 10381-10394 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T107 20-27 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T108 78-85 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T109 361-373 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T110 471-478 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T111 618-637 Disease denotes endocrine disorders http://purl.obolibrary.org/obo/MONDO_0005151
T112 746-753 Disease denotes Obesity http://purl.obolibrary.org/obo/MONDO_0011122
T113 773-787 Disease denotes malnutritional http://purl.obolibrary.org/obo/MONDO_0006873
T114 1153-1160 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T115 1247-1269 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T116 1274-1282 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T117 1366-1374 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T118 1377-1386 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T119 1522-1529 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T120 1811-1828 Disease denotes metabolic disease http://purl.obolibrary.org/obo/MONDO_0005066
T121 2332-2351 Disease denotes metabolic disorders http://purl.obolibrary.org/obo/MONDO_0005066
T122 2795-2802 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T123 2804-2816 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T124 3146-3153 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T125 3206-3213 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T126 3453-3465 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T127 3758-3765 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T128 3769-3777 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T129 3995-4002 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T130 4007-4015 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T131 4173-4192 Disease denotes metabolic disorders http://purl.obolibrary.org/obo/MONDO_0005066
T132 4209-4216 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T133 4725-4738 Disease denotes overnutrition http://purl.obolibrary.org/obo/MONDO_0003916
T134 4953-4965 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T135 5221-5230 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T136 5240-5248 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T137 5332-5339 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T138 5410-5419 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T139 5534-5542 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T140 5545-5554 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T141 5726-5734 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T142 5840-5847 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T143 5970-5978 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T144 6055-6067 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T145 6130-6140 Disease denotes influenzae http://purl.obolibrary.org/obo/MONDO_0005812
T146 6145-6161 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T147 6240-6248 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T148 6253-6260 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T149 6522-6530 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T150 6547-6557 Disease denotes Infectious http://purl.obolibrary.org/obo/MONDO_0005550
T151 6573-6581 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T152 7229-7237 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T153 7634-7641 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T154 7881-7888 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T155 8081-8089 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T156 8146-8153 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T157 8362-8383 Disease denotes degenerative diseases http://purl.obolibrary.org/obo/MONDO_0005559|http://purl.obolibrary.org/obo/MONDO_0024236
T159 8812-8819 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T160 8841-8848 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T161 8980-8992 Disease denotes malnourished http://purl.obolibrary.org/obo/MONDO_0006873
T162 9057-9069 Disease denotes malnutrition http://purl.obolibrary.org/obo/MONDO_0006873
T163 9105-9121 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T164 9164-9171 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T165 9226-9234 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T166 9277-9304 Disease denotes protein-energy malnutrition http://purl.obolibrary.org/obo/MONDO_0001371
T167 9292-9304 Disease denotes malnutrition http://purl.obolibrary.org/obo/MONDO_0006873
T168 9565-9572 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T169 9590-9598 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T170 9728-9736 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T171 9755-9762 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T172 9888-9900 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T173 10006-10014 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T174 10052-10064 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T175 10076-10083 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T176 10134-10146 Disease denotes malnourished http://purl.obolibrary.org/obo/MONDO_0006873
T177 10231-10241 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T178 10243-10248 Disease denotes wound http://purl.obolibrary.org/obo/MONDO_0021178
T179 10417-10429 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T180 10565-10572 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T181 10653-10661 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T182 11165-11177 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T265 58-70 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T266 100-101 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T267 140-143 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T268 282-283 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T269 303-305 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T270 331-332 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T271 482-483 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T272 639-641 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T273 771-772 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T274 1075-1076 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T275 1179-1182 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T276 1497-1500 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T277 1624-1638 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose tissue
T278 1697-1698 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T279 1905-1906 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T280 1915-1918 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T281 1978-1981 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T282 1982-1983 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T283 2031-2034 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T284 2059-2073 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose tissue
T285 2098-2107 http://purl.obolibrary.org/obo/CL_0000136 denotes adipocyte
T286 2133-2136 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T287 2245-2254 http://purl.obolibrary.org/obo/CL_0000136 denotes adipocyte
T288 2358-2372 http://purl.obolibrary.org/obo/UBERON_0001013 denotes Adipose tissue
T289 2397-2413 http://purl.obolibrary.org/obo/UBERON_0000949 denotes endocrine system
T290 2397-2413 http://www.ebi.ac.uk/efo/EFO_0002969 denotes endocrine system
T291 2428-2434 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T292 2442-2447 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T293 2460-2465 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T294 2567-2572 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T295 2644-2651 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T296 2719-2729 http://purl.obolibrary.org/obo/CL_0000136 denotes adipocytes
T297 2772-2786 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose tissue
T298 2828-2837 http://purl.obolibrary.org/obo/CL_0000136 denotes adipocyte
T299 2851-2855 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T300 2967-2972 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T301 3001-3008 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose
T302 3072-3086 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose tissue
T303 3155-3157 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T304 3163-3164 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T305 3254-3268 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose tissue
T306 3320-3321 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T307 3369-3383 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose tissue
T308 3427-3437 http://purl.obolibrary.org/obo/CL_0000136 denotes adipocytes
T309 3611-3625 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose tissue
T310 3654-3659 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T311 3844-3845 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T312 3918-3928 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T313 4127-4136 http://purl.obolibrary.org/obo/CL_0000136 denotes adipocyte
T314 4149-4156 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T315 4236-4245 http://purl.obolibrary.org/obo/CL_0000136 denotes adipocyte
T316 4469-4482 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T317 4490-4491 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T318 4581-4594 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T319 4629-4642 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T320 4643-4648 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T321 4977-4987 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T322 5030-5032 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T323 5086-5087 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T324 5161-5169 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T325 5310-5317 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T326 5348-5354 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T327 5378-5379 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T328 5391-5397 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T329 6005-6006 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T330 6094-6099 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T331 6190-6211 http://purl.obolibrary.org/obo/CL_0000082 denotes lung epithelial cells
T332 6330-6337 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cells
T333 6356-6362 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T334 6542-6544 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T335 6717-6721 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T336 6847-6851 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T337 7047-7048 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T338 7071-7072 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T339 7133-7138 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T340 7218-7219 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T341 7278-7279 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T342 7310-7312 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T343 7331-7345 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose tissue
T344 7370-7371 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T345 7411-7414 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T346 7492-7494 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T347 7590-7604 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose tissue
T348 7663-7666 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T349 7812-7813 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T350 7939-7946 http://purl.obolibrary.org/obo/UBERON_0001013 denotes bodyfat
T351 8230-8233 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T352 8260-8270 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T353 8260-8270 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T354 8296-8299 http://purl.obolibrary.org/obo/UBERON_0001007 denotes gut
T355 8296-8299 http://purl.obolibrary.org/obo/UBERON_0001555 denotes gut
T356 8296-8299 http://www.ebi.ac.uk/efo/EFO_0000834 denotes gut
T357 8434-8437 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T358 8537-8550 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T359 8715-8724 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adiposity
T360 8747-8760 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T361 9345-9349 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T362 9350-9360 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T363 9491-9492 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T364 9710-9711 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T365 9740-9741 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T366 9943-9951 http://purl.obolibrary.org/obo/OBI_0100026 denotes organism
T367 9943-9951 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organism
T368 10381-10394 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T369 10767-10768 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T370 11037-11042 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T371 11109-11110 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T372 11217-11218 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T373 11291-11297 http://purl.obolibrary.org/obo/CLO_0001658 denotes active

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T192 420-429 Chemical denotes nutrients http://purl.obolibrary.org/obo/CHEBI_33284
T193 444-452 Chemical denotes hormones http://purl.obolibrary.org/obo/CHEBI_24621
T194 618-627 Chemical denotes endocrine http://purl.obolibrary.org/obo/CHEBI_24621
T195 1840-1849 Chemical denotes endocrine http://purl.obolibrary.org/obo/CHEBI_24621
T196 2397-2406 Chemical denotes endocrine http://purl.obolibrary.org/obo/CHEBI_24621
T197 2644-2651 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T198 3644-3653 Chemical denotes endocrine http://purl.obolibrary.org/obo/CHEBI_24621
T199 4077-4083 Chemical denotes Leptin http://purl.obolibrary.org/obo/CHEBI_81571
T200 4098-4100 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T202 4149-4156 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T203 4223-4229 Chemical denotes Leptin http://purl.obolibrary.org/obo/CHEBI_81571
T204 4254-4261 Chemical denotes hormone http://purl.obolibrary.org/obo/CHEBI_24621
T205 4539-4545 Chemical denotes Leptin http://purl.obolibrary.org/obo/CHEBI_81571
T206 5310-5317 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T207 5636-5638 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T209 5871-5873 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T211 5940-5942 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T213 6266-6268 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T215 6418-6420 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T217 6847-6849 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T219 6857-6859 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T221 6930-6932 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T223 7260-7264 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T224 7551-7560 Chemical denotes endocrine http://purl.obolibrary.org/obo/CHEBI_24621
T225 8931-8946 Chemical denotes food components http://purl.obolibrary.org/obo/CHEBI_78295
T226 9197-9214 Chemical denotes virulence factors http://purl.obolibrary.org/obo/CHEBI_72316
T227 9277-9284 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T228 9836-9843 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T30 20-27 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T31 78-85 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T32 471-478 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T33 746-753 Phenotype denotes Obesity http://purl.obolibrary.org/obo/HP_0001513
T34 773-787 Phenotype denotes malnutritional http://purl.obolibrary.org/obo/HP_0004395
T35 1153-1160 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T36 1247-1269 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T37 1522-1529 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T38 2098-2119 Phenotype denotes adipocyte hypertrophy http://purl.obolibrary.org/obo/HP_0030759
T39 2218-2226 Phenotype denotes plethora http://purl.obolibrary.org/obo/HP_0001050
T40 2795-2802 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T41 2828-2849 Phenotype denotes adipocyte hypertrophy http://purl.obolibrary.org/obo/HP_0030759
T42 3146-3153 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T43 3206-3213 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T44 3758-3765 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T45 3970-3984 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T46 3995-4002 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T47 4209-4216 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T48 5310-5328 Phenotype denotes insulin resistance http://purl.obolibrary.org/obo/HP_0000855
T49 5332-5339 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T50 5658-5678 Phenotype denotes acute phase response http://purl.obolibrary.org/obo/HP_0033331
T51 5840-5847 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T52 6253-6260 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T53 7634-7641 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T54 7881-7888 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T55 8014-8030 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T56 8146-8153 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T57 8812-8819 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T58 8841-8848 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T59 9057-9069 Phenotype denotes malnutrition http://purl.obolibrary.org/obo/HP_0004395
T60 9105-9121 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T61 9164-9171 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T62 9292-9304 Phenotype denotes malnutrition http://purl.obolibrary.org/obo/HP_0004395
T63 9565-9572 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T64 9755-9762 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T65 10076-10083 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T66 10565-10572 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T89 361-373 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T90 555-564 http://purl.obolibrary.org/obo/GO_0007610 denotes behaviour
T91 686-695 http://purl.obolibrary.org/obo/GO_0007610 denotes behaviour
T92 1854-1869 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T93 2502-2525 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune responses
T94 2599-2608 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T95 2665-2677 http://purl.obolibrary.org/obo/GO_0060612 denotes adipogenesis
T96 2665-2677 http://purl.obolibrary.org/obo/GO_0045444 denotes adipogenesis
T97 2679-2691 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T98 2804-2816 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T99 2851-2861 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T100 3080-3098 http://purl.obolibrary.org/obo/GO_0001894 denotes tissue homeostasis
T101 3087-3098 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T102 3334-3355 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T103 3377-3393 http://purl.obolibrary.org/obo/GO_0032941 denotes tissue secretion
T104 3384-3393 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T105 3453-3465 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T106 4137-4147 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T107 4318-4328 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T108 4450-4460 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T109 4953-4965 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T110 5107-5117 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T111 5126-5141 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T112 5467-5482 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T113 5592-5609 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T114 5592-5609 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T115 5658-5678 http://purl.obolibrary.org/obo/GO_0006953 denotes acute phase response
T116 6055-6067 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T117 6145-6161 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T118 6717-6735 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T119 6881-6890 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T120 8218-8228 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T121 8234-8241 http://purl.obolibrary.org/obo/GO_0051235 denotes storage
T122 9197-9206 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T123 9197-9206 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T124 9338-9360 http://purl.obolibrary.org/obo/GO_0045321 denotes immune cell activation
T125 9345-9360 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T126 9816-9831 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T127 9836-9853 http://purl.obolibrary.org/obo/GO_0006412 denotes protein synthesis
T128 9844-9853 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T129 9888-9900 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T130 10052-10064 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T131 10417-10429 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T132 10955-10961 http://purl.obolibrary.org/obo/GO_0007631 denotes eating
T133 11165-11177 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T104 0-27 Sentence denotes Immunonutrition and obesity
T105 28-307 Sentence denotes According to the World Health Organization (WHO), obesity is defined as a condition in which percentage of body fat (PBF) is increased to an extent in which health and well-being are impaired, and, due to the alarming prevalence increase, declared it as a “global epidemic” [35].
T106 308-453 Sentence denotes It is characterized by a state of low-grade, chronic inflammation, in addition to altered levels of circulating nutrients and metabolic hormones.
T107 454-643 Sentence denotes The condition of obesity is a multifactorial pathology that can be related to an altered nutritional behaviour or secondary to genetic, hypothalamic, iatrogenic or endocrine disorders [36].
T108 644-745 Sentence denotes Underlining the importance of nutritional behaviour, it depends directly on food nutritional quality.
T109 746-831 Sentence denotes Obesity is considered as a malnutritional status due to the poor quality of the diet.
T110 832-913 Sentence denotes The chance to get healthy foods is largely determined by one’s own profitability.
T111 914-1055 Sentence denotes Nowadays, the most vulnerable communities fight disadvantage conditions because of socioeconomic, educational, and environmental disparities.
T112 1056-1161 Sentence denotes People, who follow a poor quality of diet combined with economic disparity, are at major risk of obesity.
T113 1162-1283 Sentence denotes The expansion of fat mass, in turn, is linked to various chronic diseases, including cardiovascular disease and diabetes.
T114 1284-1462 Sentence denotes In the context of Covid-19 pandemic, these conditions affect severe outcomes from SARS-CoV-2 infection, as well as contribute to increasing the risk of mortality in general [37].
T115 1463-1540 Sentence denotes Adiposopathy, also known as “sick fat”, is at the basis of obesity condition.
T116 1541-1639 Sentence denotes It is defined as pathological dysfunction of both anatomical and functional within adipose tissue.
T117 1640-1778 Sentence denotes It is promoted by an excess of caloric energy intake and a sedentary lifestyle in genetically and environmentally susceptible individuals.
T118 1779-1870 Sentence denotes This latter may cause or worsen metabolic disease in adverse endocrine and immune response.
T119 1871-2040 Sentence denotes Modifiable lifestyle choices play a role in fat function and dysfunction, but the strong genetic component has a real chance on predisposition to dysfunctional fat [38].
T120 2041-2357 Sentence denotes The disruption of adipose tissue processes, as occurs in adipocyte hypertrophy and visceral fat accumulation, results in the production of pro-inflammatory components (like the plethora of cytokines) and adipocyte factors dysregulation, which may be both genesis and/or main contributors to metabolic disorders [39].
T121 2358-2453 Sentence denotes Adipose tissue is not only part of the endocrine system, but it is an active immune organ [40].
T122 2454-2730 Sentence denotes As an organ suitable to manage the adaptive and innate immune responses, in healthy lean individuals, its immune cells have the main role in the formation of extracellular matrix modelling, insulin sensitivity, adipogenesis, angiogenesis and clearance of apoptotic adipocytes.
T123 2731-2898 Sentence denotes On the contrary, during the expansion of adipose tissue like in obesity, inflammation results in adipocyte hypertrophy, cell death, fibrosis and metabolic dysfunction.
T124 2899-3026 Sentence denotes The inflammatory process, involving both innate and adaptive immune cells, plays an important role in adipose immunometabolism.
T125 3027-3159 Sentence denotes Among those, macrophages are fundamental for adipose tissue homeostasis and are most thoroughly studied in response to obesity [41].
T126 3160-3281 Sentence denotes As a result of the augmentation of the PBF in obesity, there is the proportional increment of adipose tissue macrophages.
T127 3282-3567 Sentence denotes Consequently, the system undergoes to a massive pro-inflammatory response resulting by adipose tissue secretion of pro-inflammatory factors, the adipocytes stimulation of inflammation-inducing factors in other tissues and the reduction of anti-inflammatory and protective factors [42].
T128 3568-3962 Sentence denotes Understanding the relationship between the adipose tissue, classified as an endocrine organ, and its immune function, the development of new therapeutic and immunonutritional strategies for obesity in COVID-19, may have important implications especially because it may act as a reservoir for more severe viral spread, with increased shedding, immune activation, and cytokine amplification [43].
T129 3963-4076 Sentence denotes In the cytokine storm milieu in obesity and COVID-19, over 50 adipokines with diverse roles have been identified.
T130 4077-4222 Sentence denotes Leptin, adiponectin, IL-6 and TNF-α mainly act in adipocyte metabolism, insulin sensitivity and metabolic disorders associated with obesity [44].
T131 4223-4398 Sentence denotes Leptin is an adipocyte-derived hormone with an important role in the central control of energy metabolism and with many pleiotropic effects in different physiological systems.
T132 4399-4538 Sentence denotes One of these is the regulatory role between energy metabolism and the immune system, being a pillar in the new concept of immunometabolism.
T133 4539-4649 Sentence denotes Leptin receptor, expressed overall in the immune system, acts in both innate and adaptive immune system cells.
T134 4650-4739 Sentence denotes As an adipokine, leptin is responsible for the inflammatory state found in overnutrition.
T135 4740-4836 Sentence denotes Moreover, in undernutrition status, it plays as crucial mediator of the immunosuppressive state.
T136 4837-5034 Sentence denotes New research frontiers for immunometabolic pathophysiology are considering leptin and leptin receptor as markers of inflammation and immune activation in the context of innate-adaptive system [45].
T137 5035-5142 Sentence denotes In the light of above mentioned, leptin represents a connection between metabolism and the immune response.
T138 5143-5254 Sentence denotes Its dysregulatory activity would have serious consequences during an eventual infection, such as COVID-19 [46].
T139 5255-5425 Sentence denotes By altering the metabolic setting, hyperleptinemia and insulin resistance in obesity disrupt T-cell function, resulting in a suppressed T-cell response to infection [47].
T140 5426-5615 Sentence denotes This metabolic condition compromises the immune response and leads patients to morbidity and mortality from SARS-CoV-2 infection, coupled with the lack of containing viral replication [46].
T141 5616-5744 Sentence denotes The pivotal role of IL-6 in mediating the acute phase response seems to interest the strategical treatment in COVID-19 patients.
T142 5745-5995 Sentence denotes Researches are still in progress and it would be intriguing to investigate whether people with obesity and higher circulating IL-6 levels, compared with lean controls, respond more favourably to IL-6 inhibition strategies in SARS-CoV-2 pandemic [43].
T143 5996-6100 Sentence denotes TNF-α is a pyrogen cytokine released in the acute phase of inflammation by macrophages and immune cells.
T144 6101-6222 Sentence denotes It is well known that during influenzae and viral infections, the expression of TNF-α in lung epithelial cells is higher.
T145 6223-6338 Sentence denotes In patients with COVID-19 and obesity, the IL-6 and TNF-α high serum levels are negatively associated with T-cells.
T146 6339-6433 Sentence denotes On the contrary, T cell levels are restored by reducing concentrations of both IL-6 and TNF-α.
T147 6434-6546 Sentence denotes These findings suggested that these cytokines could represent important targets of anti-COVID-19 therapies [48].
T148 6547-6643 Sentence denotes Infectious diseases, like COVID-19, are characterized by an increased production of adiponectin.
T149 6644-6945 Sentence denotes In fact, it seems that adiponectin can reduce innate and adaptive immune cell proliferation and polarization on two fronts: acting on the production blockage of pro-inflammatory cytokines such as TNF-α, IL-2, and IL-6, and enhancing the secretion of anti-inflammatory cytokines such as IL-10 [49, 50].
T150 6946-7046 Sentence denotes It seems interesting the possibility to improve the action of adiponectin through diet intervention.
T151 7047-7185 Sentence denotes A healthy lifestyle and a Mediterranean diet seem to ameliorate adiponectin levels in human, working on omega-3 biochemical pathways [51].
T152 7186-7314 Sentence denotes Finally, in light of the above, a possible COVID-19 therapy would combine drug therapy with a personalized immunonutrition [48].
T153 7315-7496 Sentence denotes Whereas healthy adipose tissue is essential to achieve a metabolic health status, sick inflamed fat leads to metabolic pathways dysregulation and different chronic pathologies [52].
T154 7497-7853 Sentence denotes According to what mentioned above and considering the endocrine and inflammatory role of the adipose tissue, it is necessary to classify obesity on the basis of body fat composition and distribution [53], rather than simply anthropometric measurements, e.g. Body Mass Index (BMI) classification, that could lead to a large error and misclassification [54].
T155 7854-8135 Sentence denotes As different phenotypes of obesity can be diagnosed according to percentage of total bodyfat mass (PBF), associated with an early inflammatory status, and high oxidative stress level [55], to identify obese subjects at risk of COVID-19 it is necessary to evaluate body composition.
T156 8136-8282 Sentence denotes Moreover, obesity and adiposopathy contribute to the pathways related to appetite regulation, fat storage and alteration of intestinal microbiota.
T157 8283-8389 Sentence denotes Dysbiosis of gut microbiota can influence the onset and progression of chronic degenerative diseases [56].
T158 8390-8491 Sentence denotes The impact of these metabolic abnormalities has undergone intense investigation over the past decade.
T159 8492-8650 Sentence denotes Although that, it is still not clear how the immune system and host defense are influenced by the pro-inflammatory and excess energy milieu of the obese [57].
T160 8651-8825 Sentence denotes There is strong evidence in literature indicating that abundant adiposity negatively impacts on immune system functionality and host defense in individuals with obesity [57].
T161 8826-8960 Sentence denotes In people with obesity, the caloric balance surplus is not directly proportional to the high nutritional food components quality [53].
T162 8961-9137 Sentence denotes Hence, the overfed malnourished patient may be compared to the underfed malnourishment, because malnutrition is considered the primary cause of immunodeficiency worldwide [58].
T163 9138-9235 Sentence denotes Chronic diseases, such as obesity, have been recognized as virulence factors for severe COVID-19.
T164 9236-9361 Sentence denotes These morbidities are usually coupled to protein-energy malnutrition, which is demonstrated to impair immune cell activation.
T165 9362-9462 Sentence denotes This process allows longer viral persistence and increased dealing of pro-inflammatory factors [59].
T166 9463-9573 Sentence denotes This will allow you to make a personalized emergency intervention, in all the subjects suffering from obesity.
T167 9574-9706 Sentence denotes In the onset of COVID-19 era, the nutritional approach might be managed in two different strategies, considering the disease status.
T168 9707-9938 Sentence denotes In a severe phase of COVID-19 in a patient with obesity, immunonutrition would be fundamental to support the immune response and protein synthesis, and, at the same time, to reduce inflammation caused by the pathological condition.
T169 9939-10094 Sentence denotes The organism fights both the acute inflammatory state triggered by COVID-19 and, in addition, the latent chronic inflammation due to the obesity condition.
T170 10095-10299 Sentence denotes This latter is employed in the case of malnourished surgical patients, where immunonutrition significantly reduced the risk of acquired infections, wound complications, and length of stay at the hospital.
T171 10300-10443 Sentence denotes In this context, immunomodulating diets (IMDs) have been demonstrated to improve immune system response and modulate inflammation cascade [60].
T172 10444-10672 Sentence denotes Furthermore, the nutritional approach should be firstly preventive to reduce the large number of complications linked to obesity condition; and, secondly, could be predictive to act on the etiopathogenesis of SARS-CoV-2 disease.
T173 10673-10786 Sentence denotes In the current pandemic panorama, the connection between nutrition science and virology takes a predictable turn.
T174 10787-10886 Sentence denotes It is worth that nutritional innovation must correlate all the previously treated clinical aspects.
T175 10887-11178 Sentence denotes By referring to WHO guidelines, it is fundamental to follow healthy eating habits and lifestyle to achieve an optimal health status supporting immune cells system, and to switch from an unhealthy condition of dysbiosis to a healthy condition of eubiosis and modulating systemic inflammation.
T176 11179-11298 Sentence denotes This is essentially possible pursuing a balanced diet based on the Mediterranean concept and staying physically active.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
529 20-27 Disease denotes obesity MESH:D009765
543 1056-1062 Species denotes People Tax:9606
544 78-85 Disease denotes obesity MESH:D009765
545 361-373 Disease denotes inflammation MESH:D007249
546 471-478 Disease denotes obesity MESH:D009765
547 590-602 Disease denotes hypothalamic MESH:D007027
548 618-637 Disease denotes endocrine disorders MESH:D004700
549 1153-1160 Disease denotes obesity MESH:D009765
550 1219-1235 Disease denotes chronic diseases MESH:D002908
551 1247-1269 Disease denotes cardiovascular disease MESH:D002318
552 1274-1282 Disease denotes diabetes MESH:D003920
553 1302-1310 Disease denotes Covid-19 MESH:C000657245
554 1366-1386 Disease denotes SARS-CoV-2 infection MESH:C000657245
555 1436-1445 Disease denotes mortality MESH:D003643
563 1463-1475 Disease denotes Adiposopathy
564 1522-1529 Disease denotes obesity MESH:D009765
565 1811-1828 Disease denotes metabolic disease MESH:D008659
566 1832-1849 Disease denotes adverse endocrine MESH:D004700
567 2017-2034 Disease denotes dysfunctional fat MESH:D005218
568 2108-2119 Disease denotes hypertrophy MESH:D006984
569 2332-2351 Disease denotes metabolic disorders MESH:D008659
578 2644-2651 Gene denotes insulin Gene:3630
579 2795-2802 Disease denotes obesity MESH:D009765
580 2804-2816 Disease denotes inflammation MESH:D007249
581 2838-2849 Disease denotes hypertrophy MESH:D006984
582 2856-2861 Disease denotes death MESH:D003643
583 2863-2871 Disease denotes fibrosis MESH:D005355
584 2876-2897 Disease denotes metabolic dysfunction MESH:D008659
585 3146-3153 Disease denotes obesity MESH:D009765
599 4077-4083 Gene denotes Leptin Gene:3952
600 4085-4096 Gene denotes adiponectin Gene:9370
601 4098-4102 Gene denotes IL-6 Gene:3569
602 4107-4112 Gene denotes TNF-α Gene:7124
603 4149-4156 Gene denotes insulin Gene:3630
604 3206-3213 Disease denotes obesity MESH:D009765
605 3453-3465 Disease denotes inflammation MESH:D007249
606 3758-3765 Disease denotes obesity MESH:D009765
607 3769-3777 Disease denotes COVID-19 MESH:C000657245
608 3995-4002 Disease denotes obesity MESH:D009765
609 4007-4015 Disease denotes COVID-19 MESH:C000657245
610 4173-4192 Disease denotes metabolic disorders MESH:D008659
611 4209-4216 Disease denotes obesity MESH:D009765
615 4223-4229 Gene denotes Leptin Gene:3952
616 4539-4554 Gene denotes Leptin receptor Gene:3953
617 4667-4673 Gene denotes leptin Gene:3952
624 4912-4918 Gene denotes leptin Gene:3952
625 4923-4938 Gene denotes leptin receptor Gene:3953
626 5068-5074 Gene denotes leptin Gene:3952
627 4953-4965 Disease denotes inflammation MESH:D007249
628 5221-5230 Disease denotes infection MESH:D007239
629 5240-5248 Disease denotes COVID-19 MESH:C000657245
634 5310-5317 Gene denotes insulin Gene:3630
635 5290-5305 Disease denotes hyperleptinemia
636 5332-5347 Disease denotes obesity disrupt MESH:D009765
637 5410-5419 Disease denotes infection MESH:D007239
641 5493-5501 Species denotes patients Tax:9606
642 5519-5528 Disease denotes mortality MESH:D003643
643 5534-5554 Disease denotes SARS-CoV-2 infection MESH:C000657245
652 5636-5640 Gene denotes IL-6 Gene:3569
653 5871-5875 Gene denotes IL-6 Gene:3569
654 5940-5944 Gene denotes IL-6 Gene:3569
655 5735-5743 Species denotes patients Tax:9606
656 5828-5834 Species denotes people Tax:9606
657 5970-5980 Species denotes SARS-CoV-2 Tax:2697049
658 5726-5734 Disease denotes COVID-19 MESH:C000657245
659 5840-5847 Disease denotes obesity MESH:D009765
672 5996-6001 Gene denotes TNF-α Gene:7124
673 6181-6186 Gene denotes TNF-α Gene:7124
674 6266-6270 Gene denotes IL-6 Gene:3569
675 6275-6280 Gene denotes TNF-α Gene:7124
676 6418-6422 Gene denotes IL-6 Gene:3569
677 6427-6432 Gene denotes TNF-α Gene:7124
678 6226-6234 Species denotes patients Tax:9606
679 6055-6067 Disease denotes inflammation MESH:D007249
680 6145-6161 Disease denotes viral infections MESH:D001102
681 6240-6248 Disease denotes COVID-19 MESH:C000657245
682 6253-6260 Disease denotes obesity MESH:D009765
683 6522-6530 Disease denotes COVID-19 MESH:C000657245
692 6631-6642 Gene denotes adiponectin Gene:9370
693 6667-6678 Gene denotes adiponectin Gene:9370
694 6840-6845 Gene denotes TNF-α Gene:7124
695 6847-6851 Gene denotes IL-2 Gene:3558
696 6857-6861 Gene denotes IL-6 Gene:3569
697 6930-6935 Gene denotes IL-10 Gene:3586
698 6547-6566 Disease denotes Infectious diseases MESH:D003141
699 6573-6581 Disease denotes COVID-19 MESH:C000657245
705 7008-7019 Gene denotes adiponectin Gene:9370
706 7111-7122 Gene denotes adiponectin Gene:9370
707 7133-7138 Species denotes human Tax:9606
708 7151-7158 Chemical denotes omega-3 MESH:D015525
709 7229-7237 Disease denotes COVID-19 MESH:C000657245
711 7634-7641 Disease denotes obesity MESH:D009765
715 7881-7888 Disease denotes obesity MESH:D009765
716 8055-8060 Disease denotes obese MESH:D009765
717 8081-8089 Disease denotes COVID-19 MESH:C000657245
721 8146-8170 Disease denotes obesity and adiposopathy MESH:D009765
722 8283-8292 Disease denotes Dysbiosis MESH:D064806
723 8362-8383 Disease denotes degenerative diseases MESH:D019636
726 8410-8433 Disease denotes metabolic abnormalities MESH:D008659
727 8639-8644 Disease denotes obese MESH:D009765
729 8812-8819 Disease denotes obesity MESH:D009765
732 8829-8835 Species denotes people Tax:9606
733 8841-8848 Disease denotes obesity MESH:D009765
739 8993-9000 Species denotes patient Tax:9606
740 9105-9121 Disease denotes immunodeficiency MESH:D007153
741 9138-9154 Disease denotes Chronic diseases MESH:D002908
742 9164-9171 Disease denotes obesity MESH:D009765
743 9226-9234 Disease denotes COVID-19 MESH:C000657245
745 9565-9572 Disease denotes obesity MESH:D009765
760 9742-9749 Species denotes patient Tax:9606
761 10156-10164 Species denotes patients Tax:9606
762 9590-9598 Disease denotes COVID-19 MESH:C000657245
763 9728-9736 Disease denotes COVID-19 MESH:C000657245
764 9755-9762 Disease denotes obesity MESH:D009765
765 9888-9900 Disease denotes inflammation MESH:D007249
766 10006-10014 Disease denotes COVID-19 MESH:C000657245
767 10052-10064 Disease denotes inflammation MESH:D007249
768 10076-10083 Disease denotes obesity MESH:D009765
769 10231-10241 Disease denotes infections MESH:D007239
770 10341-10345 Disease denotes IMDs
771 10417-10429 Disease denotes inflammation MESH:D007249
772 10565-10572 Disease denotes obesity MESH:D009765
773 10653-10671 Disease denotes SARS-CoV-2 disease MESH:C000657245
776 11096-11105 Disease denotes dysbiosis MESH:D064806
777 11165-11177 Disease denotes inflammation MESH:D007249