PMC:7647877 / 12406-12762 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T218","span":{"begin":40,"end":44},"obj":"Body_part"},{"id":"T219","span":{"begin":188,"end":205},"obj":"Body_part"},{"id":"T220","span":{"begin":200,"end":205},"obj":"Body_part"},{"id":"T221","span":{"begin":239,"end":248},"obj":"Body_part"}],"attributes":[{"id":"A218","pred":"fma_id","subj":"T218","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A219","pred":"fma_id","subj":"T219","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A220","pred":"fma_id","subj":"T220","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A221","pred":"fma_id","subj":"T221","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"As noted earlier, SARS-CoV-2 enters the cell via ACE2; that inactivates des-Arg bradykinin, which is a potent ligand of the bradykinin receptor type 1 (BDKRB1).This receptor, localized on endothelial cells, is up-regulated by inflammatory cytokines, which is unlike the B2 receptor, that is constituently expressed and is the receptor for bradykinin (BDK)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T68","span":{"begin":18,"end":26},"obj":"Disease"}],"attributes":[{"id":"A68","pred":"mondo_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"As noted earlier, SARS-CoV-2 enters the cell via ACE2; that inactivates des-Arg bradykinin, which is a potent ligand of the bradykinin receptor type 1 (BDKRB1).This receptor, localized on endothelial cells, is up-regulated by inflammatory cytokines, which is unlike the B2 receptor, that is constituently expressed and is the receptor for bradykinin (BDK)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T220","span":{"begin":40,"end":44},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T221","span":{"begin":101,"end":102},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T222","span":{"begin":188,"end":205},"obj":"http://purl.obolibrary.org/obo/CL_0000115"}],"text":"As noted earlier, SARS-CoV-2 enters the cell via ACE2; that inactivates des-Arg bradykinin, which is a potent ligand of the bradykinin receptor type 1 (BDKRB1).This receptor, localized on endothelial cells, is up-regulated by inflammatory cytokines, which is unlike the B2 receptor, that is constituently expressed and is the receptor for bradykinin (BDK)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T143","span":{"begin":76,"end":79},"obj":"Chemical"},{"id":"T145","span":{"begin":80,"end":90},"obj":"Chemical"},{"id":"T146","span":{"begin":110,"end":116},"obj":"Chemical"},{"id":"T147","span":{"begin":124,"end":134},"obj":"Chemical"},{"id":"T148","span":{"begin":270,"end":272},"obj":"Chemical"},{"id":"T149","span":{"begin":339,"end":349},"obj":"Chemical"}],"attributes":[{"id":"A143","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_16467"},{"id":"A144","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_29952"},{"id":"A145","pred":"chebi_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/CHEBI_3165"},{"id":"A146","pred":"chebi_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A147","pred":"chebi_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/CHEBI_3165"},{"id":"A148","pred":"chebi_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/CHEBI_51707"},{"id":"A149","pred":"chebi_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/CHEBI_3165"}],"text":"As noted earlier, SARS-CoV-2 enters the cell via ACE2; that inactivates des-Arg bradykinin, which is a potent ligand of the bradykinin receptor type 1 (BDKRB1).This receptor, localized on endothelial cells, is up-regulated by inflammatory cytokines, which is unlike the B2 receptor, that is constituently expressed and is the receptor for bradykinin (BDK)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T78","span":{"begin":0,"end":356},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"As noted earlier, SARS-CoV-2 enters the cell via ACE2; that inactivates des-Arg bradykinin, which is a potent ligand of the bradykinin receptor type 1 (BDKRB1).This receptor, localized on endothelial cells, is up-regulated by inflammatory cytokines, which is unlike the B2 receptor, that is constituently expressed and is the receptor for bradykinin (BDK)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"331","span":{"begin":49,"end":53},"obj":"Gene"},{"id":"332","span":{"begin":80,"end":90},"obj":"Gene"},{"id":"333","span":{"begin":152,"end":158},"obj":"Gene"},{"id":"334","span":{"begin":270,"end":281},"obj":"Gene"},{"id":"335","span":{"begin":339,"end":349},"obj":"Gene"},{"id":"336","span":{"begin":351,"end":354},"obj":"Gene"},{"id":"347","span":{"begin":18,"end":28},"obj":"Species"}],"attributes":[{"id":"A331","pred":"tao:has_database_id","subj":"331","obj":"Gene:59272"},{"id":"A332","pred":"tao:has_database_id","subj":"332","obj":"Gene:3827"},{"id":"A333","pred":"tao:has_database_id","subj":"333","obj":"Gene:623"},{"id":"A334","pred":"tao:has_database_id","subj":"334","obj":"Gene:624"},{"id":"A335","pred":"tao:has_database_id","subj":"335","obj":"Gene:3827"},{"id":"A336","pred":"tao:has_database_id","subj":"336","obj":"Gene:3827"},{"id":"A347","pred":"tao:has_database_id","subj":"347","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"As noted earlier, SARS-CoV-2 enters the cell via ACE2; that inactivates des-Arg bradykinin, which is a potent ligand of the bradykinin receptor type 1 (BDKRB1).This receptor, localized on endothelial cells, is up-regulated by inflammatory cytokines, which is unlike the B2 receptor, that is constituently expressed and is the receptor for bradykinin (BDK)."}