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PMC:7647877 / 10781-13161 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T200 172-179 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T201 212-229 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T202 224-229 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T203 237-248 Body_part denotes vasculature http://purl.org/sig/ont/fma/fma69050
T204 260-269 Body_part denotes epithelia http://purl.org/sig/ont/fma/fma9639
T205 277-282 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T206 284-293 Body_part denotes intestine http://purl.org/sig/ont/fma/fma7199
T207 295-300 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T208 302-307 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T209 312-318 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T210 342-346 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T211 416-420 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T212 612-615 Body_part denotes gut http://purl.org/sig/ont/fma/fma7199
T213 643-653 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T214 696-706 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T215 762-769 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T216 1029-1042 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T217 1558-1565 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T218 1665-1669 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T219 1813-1830 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T220 1825-1830 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T221 1864-1873 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T222 2019-2026 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T223 2063-2069 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T224 2143-2148 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T35 237-248 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049
T36 260-269 Body_part denotes epithelia http://purl.obolibrary.org/obo/UBERON_0000483
T37 284-293 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T38 295-300 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T39 302-307 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T40 312-318 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T41 1029-1042 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T42 1581-1587 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T43 2143-2148 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T47 20-28 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 156-164 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 320-328 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T50 539-574 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T51 545-574 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T52 576-580 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T53 682-691 Disease denotes diarrhoea http://purl.obolibrary.org/obo/MONDO_0001673
T54 696-719 Disease denotes intestinal inflammation http://purl.obolibrary.org/obo/MONDO_0002269
T55 707-719 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T56 732-740 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T57 752-756 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T58 885-897 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T59 938-946 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T60 949-958 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T61 1015-1023 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T62 1355-1362 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T63 1364-1387 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T64 1389-1397 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T65 1399-1425 Disease denotes neurodegenerative diseases http://purl.obolibrary.org/obo/MONDO_0005559
T66 1430-1436 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T67 1439-1451 Disease denotes malnutrition http://purl.obolibrary.org/obo/MONDO_0006873
T68 1643-1651 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 2214-2225 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T184 49-50 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T185 151-153 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T186 212-229 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T187 277-282 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T188 284-293 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestine
T189 284-293 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestine
T190 295-300 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T191 295-300 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T192 295-300 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T193 295-300 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T194 302-307 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T195 302-307 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T196 312-318 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T197 312-318 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T198 312-318 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T199 342-346 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T200 367-375 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T201 393-398 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T202 399-402 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T203 416-420 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T204 433-434 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T205 463-464 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T206 612-615 http://purl.obolibrary.org/obo/UBERON_0001007 denotes gut
T207 612-615 http://purl.obolibrary.org/obo/UBERON_0001555 denotes gut
T208 612-615 http://www.ebi.ac.uk/efo/EFO_0000834 denotes gut
T209 696-706 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T210 696-706 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T211 772-781 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T212 789-790 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T213 832-842 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T214 1029-1042 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T215 1043-1052 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T216 1108-1113 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T217 1510-1515 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T218 1520-1521 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T219 1581-1587 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T220 1665-1669 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T221 1726-1727 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T222 1813-1830 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T223 2045-2055 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T224 2121-2122 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T225 2143-2148 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T226 2143-2148 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T227 2159-2161 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T228 2231-2241 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T229 2328-2337 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T132 111-122 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T133 172-179 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T134 512-514 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T135 643-653 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T136 643-648 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T137 649-653 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T138 762-769 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T139 786-788 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T142 1198-1207 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T143 1701-1704 Chemical denotes Arg http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29952
T145 1705-1715 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T146 1735-1741 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T147 1749-1759 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T148 1895-1897 Chemical denotes B2 http://purl.obolibrary.org/obo/CHEBI_51707
T149 1964-1974 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T150 2019-2026 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T151 2063-2069 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T152 2302-2305 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T10 545-565 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T11 682-691 Phenotype denotes diarrhoea http://purl.obolibrary.org/obo/HP_0002014
T12 1355-1362 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T13 1364-1387 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T14 1399-1425 Phenotype denotes neurodegenerative diseases http://purl.obolibrary.org/obo/HP_0002180
T15 1430-1436 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T16 1439-1451 Phenotype denotes malnutrition http://purl.obolibrary.org/obo/HP_0004395
T17 2214-2225 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T63 351-362 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T64 367-382 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T65 635-666 http://purl.obolibrary.org/obo/GO_0015804 denotes neutral amino acid transporters
T66 707-719 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T67 846-850 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T68 885-897 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T69 1066-1090 http://purl.obolibrary.org/obo/GO_0002250 denotes adaptive immune response
T70 1075-1090 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T71 1466-1481 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T72 2130-2157 http://purl.obolibrary.org/obo/GO_0008217 denotes regulator of blood pressure
T73 2183-2195 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilation
T74 2197-2208 http://purl.obolibrary.org/obo/GO_0035815 denotes natriuresis
T75 2328-2337 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T69 0-155 Sentence denotes The access route of SARS-CoV-2 is represented by a hydrophobic pocket of the extracellular catalytic domain of Angiotensin-converting enzyme 2 (ACE2) [18].
T70 156-319 Sentence denotes SARS-CoV peak S protein trimers bind ACE2, expressed in endothelial cells of the vasculature and in the epithelia of the lungs, intestine, heart, brain and kidney.
T71 320-383 Sentence denotes SARS-CoV-2 enters the cell for endocytosis and membrane fusion.
T72 384-587 Sentence denotes Once the virus has infected the cell, it follows a downregulation of ACE2 with a consequent local increase in the levels of Ang II, and the development of acute respiratory distress syndrome (ARDS) [19].
T73 588-741 Sentence denotes The role of ACE2 in the gut, for expression of neutral amino acid transporters, could explain diarrhoea and intestinal inflammation observed in COVID-19.
T74 742-923 Sentence denotes Moreover, SARS-CoV2 protein E activates the NFκB inflammatory pathway with the consequent activation of MAPK p38, resulting in exacerbation of inflammation and immunopathology [20].
T75 924-1193 Sentence denotes Following the SARS-CoV-2 infection, in the incubation stage and in the non-serious form of COVID-19, the immune system activates the specific adaptive immune response to eliminate the virus, which should be sufficient to block viral propagation and disease progression.
T76 1194-1304 Sentence denotes The antiviral system functions well in the presence of general good health and an adequate genetic background.
T77 1305-1624 Sentence denotes However, the presence of concomitant pathologies (obesity, cardiovascular diseases, diabetes, neurodegenerative diseases and cancer), malnutrition, and impaired immune response determine the spread of the virus and a massive destruction of the affected tissues, especially in organs that have high ACE2 expression [21].
T78 1625-1981 Sentence denotes As noted earlier, SARS-CoV-2 enters the cell via ACE2; that inactivates des-Arg bradykinin, which is a potent ligand of the bradykinin receptor type 1 (BDKRB1).This receptor, localized on endothelial cells, is up-regulated by inflammatory cytokines, which is unlike the B2 receptor, that is constituently expressed and is the receptor for bradykinin (BDK).
T79 1982-2265 Sentence denotes BDK is produced from an inactive pre-protein kininogen through activation by the serine protease kallikrein; in addition, it is considered a potent regulator of blood pressure [22], because it induces vasodilation, natriuresis, and hypotension upon activation of the BDKRB2 receptor.
T80 2266-2380 Sentence denotes BDK is strongly integrated with the RAS, and the BDK receptor signaling is increased by angiotensin’s action [23].

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
323 111-142 Gene denotes Angiotensin-converting enzyme 2 Gene:59272
324 144-148 Gene denotes ACE2 Gene:59272
325 193-197 Gene denotes ACE2 Gene:59272
326 453-457 Gene denotes ACE2 Gene:59272
327 508-511 Gene denotes Ang Gene:283
328 600-604 Gene denotes ACE2 Gene:59272
329 786-790 Gene denotes NFκB Gene:4790
330 1603-1607 Gene denotes ACE2 Gene:59272
331 1674-1678 Gene denotes ACE2 Gene:59272
332 1705-1715 Gene denotes bradykinin Gene:3827
333 1777-1783 Gene denotes BDKRB1 Gene:623
334 1895-1906 Gene denotes B2 receptor Gene:624
335 1964-1974 Gene denotes bradykinin Gene:3827
336 1976-1979 Gene denotes BDK Gene:3827
337 1982-1985 Gene denotes BDK Gene:3827
338 2079-2089 Gene denotes kallikrein Gene:9622
339 2249-2255 Gene denotes BDKRB2 Gene:624
340 2266-2269 Gene denotes BDK Gene:3827
341 770-771 Gene denotes E Gene:43740570
342 367-375 Gene denotes membrane Gene:43740571
343 20-30 Species denotes SARS-CoV-2 Tax:2697049
344 156-164 Species denotes SARS-CoV Tax:694009
345 320-330 Species denotes SARS-CoV-2 Tax:2697049
346 752-761 Species denotes SARS-CoV2 Tax:2697049
347 1643-1653 Species denotes SARS-CoV-2 Tax:2697049
348 2063-2069 Chemical denotes serine MESH:D012694
349 403-411 Disease denotes infected MESH:D007239
350 539-574 Disease denotes acute respiratory distress syndrome MESH:D012128
351 576-580 Disease denotes ARDS MESH:D012128
352 682-691 Disease denotes diarrhoea MESH:D003967
353 696-719 Disease denotes intestinal inflammation MESH:D007249
354 732-740 Disease denotes COVID-19 MESH:C000657245
355 885-897 Disease denotes inflammation MESH:D007249
356 943-958 Disease denotes CoV-2 infection MESH:C000657245
357 1015-1023 Disease denotes COVID-19 MESH:C000657245
358 1355-1362 Disease denotes obesity MESH:D009765
359 1364-1387 Disease denotes cardiovascular diseases MESH:D002318
360 1389-1397 Disease denotes diabetes MESH:D003920
361 1399-1425 Disease denotes neurodegenerative diseases MESH:D019636
362 1430-1436 Disease denotes cancer MESH:D009369
363 2214-2225 Disease denotes hypotension MESH:D007022