PMC:7646269 / 2112-3363 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7646269","sourcedb":"PMC","sourceid":"7646269","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7646269","text":"2 PATIENTS AND METHODS\nWe performed a retrospective chart review of all COVID‐19‐infected patients with Aspergillus isolates in respiratory samples during 21 March and 22 April 2020 at Mount Sinai Beth Israel, an acute care hospital in New York City. We collected longitudinal clinical data, including fraction of inspired oxygen (FiO2) and vital signs, laboratory and microbiology data, treatment, and outcomes. Serial chest radiographs and computed tomography (CT) scans were reviewed. Glucocorticoid dose was converted into an equivalent dose of prednisone. Fever was defined as a temperature of ≥100.4 Fahrenheit. We used the clinical algorithm for ICU patients to classify pulmonary aspergillosis as either putative IPA or colonisation (AspICU algorithm). 7 As per the clinical algorithm, persistent fever was defined as fever persisting despite at least 3 days of antibiotic therapy or recrudescent fever while on antibiotics without other apparent cause. Worsening respiratory status was defined by an increase in FiO2 requirement on mechanical ventilation, or worsening respiratory failure led to invasive mechanical ventilation. Study approval was obtained from the institutional review board of the Icahn School of Medicine at Mount 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