PMC:7646269 / 12592-13492
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7646269","sourcedb":"PMC","sourceid":"7646269","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7646269","text":"Early diagnosis of IPA is critical but challenging in mechanically ventilated patients with COVID‐19. Bronchoscopy and transbronchial biopsy are rarely performed given the risk of complications and transmission of the virus. Further, pneumonia due to SARS‐CoV‐2 may obscure the radiological findings of IPA. Consolidation is commonly seen in both COVID‐19 and superimposing pulmonary aspergillosis, and any new radiological signs could be obscured by background bilateral ground‐glass opacities. Systemic inflammatory markers are almost always elevated with severe COVID‐19, which make them less useful to diagnose secondary fungal infection. While it has been suggested that a low procalcitonin level may indicate a high likelihood for invasive fungal infection in critically ill patients with clinical signs of sepsis, 9 the procalcitonin level was elevated in only two patients with putative 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