PMC:7643666 / 6666-7481 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7643666","sourcedb":"PMC","sourceid":"7643666","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7643666","text":"2.1 Construction of homology models\nHomology models of residues 1–358 of Chiroptera ACE2 proteins and bat coronavirus spike protein were built using ExPASy SWISS-MODEL [23, 24]. The templates were chosen according to i) sequence similarity; ii) global model quality estimate (GMQE) value [24]. GMQE is a quality estimation method combining properties from the target–template alignment and the template search method. GMQE value is expressed as a number between 0 and 1: the higher the value, the higher the reliability; iii) qualitative model energy analysis (QMEAN) value [25, 26]. QMEAN is a composite estimator based on different geometrical properties that provide global and local absolute quality estimates based on one single model. The PDB models generated were used for the molecular docking calculation.","divisions":[{"label":"label","span":{"begin":0,"end":3}},{"label":"title","span":{"begin":5,"end":36}}],"tracks":[]}