PMC:7643666 / 4994-5606 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7643666","sourcedb":"PMC","sourceid":"7643666","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7643666","text":"Analogously to many viruses [20], infection of SARS-CoV-2 occurs through the binding of viral surface glycoprotein, spike (S) protein, to the angiotensin-converting enzyme 2 (ACE2) [1, 21]. ACE2 is expressed in several cell types, including type II pneumocytes, myocardial cells, cholangiocytes, enterocytes, and oral mucosal epithelium [22]. According to a structural biology view, infection of SARS-CoV-2 depends on an optimal interaction of S protein with the ACE2 receptor. Therefore, species where ACE2 can efficaciously interact with SARS-CoV-2 S protein can be considered valuable reservoirs of the virus.","tracks":[{"project":"Zoonoses","denotations":[{"id":"T4","span":{"begin":540,"end":552},"obj":"Gene"}],"attributes":[{"id":"A4","pred":"tao:has_database_id","subj":"T4","obj":"Gene:43740568"},{"subj":"T4","pred":"source","obj":"Zoonoses"}]},{"project":"Covid19_manual_annotation_v2","denotations":[{"id":"T4","span":{"begin":540,"end":552},"obj":"Gene"}],"attributes":[{"id":"A4","pred":"tao:has_database_id","subj":"T4","obj":"Gene:43740568"},{"subj":"T4","pred":"source","obj":"Covid19_manual_annotation_v2"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"BioProject","uri":"https://www.ncbi.nlm.nih.gov/bioproject/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"},{"prefix":"HP","uri":"https://hpo.jax.org/app/browse/term/HP:"},{"prefix":"BioSample","uri":"https://www.ncbi.nlm.nih.gov/biosample/"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Zoonoses","color":"#ecc393","default":true},{"id":"Covid19_manual_annotation_v2","color":"#a993ec"}]}]}}