PMC:7643666 / 20522-21226 JSONTXT

{"project":"Zoonoses","denotations":[{"id":"T18","span":{"begin":420,"end":432},"obj":"Gene"}],"attributes":[{"id":"A18","pred":"tao:has_database_id","subj":"T18","obj":"Gene:43740568"}],"text":"Accordingly, performing in silico calculation based on multiple sequence alignment and homology modeling, molecular docking, and molecular dynamics, we identified Rhinolophus ferrumequinum as the best Chiroptera candidate to be the potential primary reservoir for the SARS-CoV-2 virus in Italy. The sequence alignment of Rhinolophus ferrumequinum ACE2 with hACE2 sequence indicated that most of the residues involved in SARS-CoV-2 S binding are conserved. Moreover, Rhinolophus ferrumequinum ACE2 shows the highest identity with the ACE2 proteins of wild and domestic species present in Italy (Figure 3B), indicating a potential role as a human-animals bridge infection in wild and domestic environments."}

{"project":"Covid19_manual_annotation_v2","denotations":[{"id":"T18","span":{"begin":420,"end":432},"obj":"Gene"}],"attributes":[{"id":"A18","pred":"tao:has_database_id","subj":"T18","obj":"Gene:43740568"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"BioProject","uri":"https://www.ncbi.nlm.nih.gov/bioproject/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"},{"prefix":"HP","uri":"https://hpo.jax.org/app/browse/term/HP:"},{"prefix":"BioSample","uri":"https://www.ncbi.nlm.nih.gov/biosample/"}],"text":"Accordingly, performing in silico calculation based on multiple sequence alignment and homology modeling, molecular docking, and molecular dynamics, we identified Rhinolophus ferrumequinum as the best Chiroptera candidate to be the potential primary reservoir for the SARS-CoV-2 virus in Italy. The sequence alignment of Rhinolophus ferrumequinum ACE2 with hACE2 sequence indicated that most of the residues involved in SARS-CoV-2 S binding are conserved. Moreover, Rhinolophus ferrumequinum ACE2 shows the highest identity with the ACE2 proteins of wild and domestic species present in Italy (Figure 3B), indicating a potential role as a human-animals bridge infection in wild and domestic environments."}