PMC:7643666 / 10419-11717 JSONTXT

{"project":"Zoonoses","denotations":[{"id":"T22","span":{"begin":122,"end":125},"obj":"Phenomena"},{"id":"T6","span":{"begin":23,"end":35},"obj":"Gene"},{"id":"T7","span":{"begin":229,"end":241},"obj":"Gene"}],"attributes":[{"id":"A22","pred":"tao:has_database_id","subj":"T22","obj":"MESH:D000072417"},{"id":"A6","pred":"tao:has_database_id","subj":"T6","obj":"Gene:43740568"},{"id":"A7","pred":"tao:has_database_id","subj":"T7","obj":"Gene:43740568"}],"text":"2.6 Analysis of human SARS-CoV-2 S and spike protein of Bat coronavirus Rp3\nSequence alignment was carried out using the RBD (residues 339–490) of bat coronavirus Rp3/2004 S protein (UniProt ID: Q3I5J5), and residues 336–518 of SARS-CoV-2 S protein (UniProt ID: P0DTC2). The alignment was carried out using Clustal Omega [35, 36] (see Table 1).\nTable 1 ACE2 sequences of wild and domestic species present in Italy with their UniProt codes and the percentage of identity with human and ACE2 of Chiroptera species present in Italy.\nWild and domestic species present in Italy UniProt ID % Identity with hACE2 % Identity with M. daubentonii ACE2 % Identity with R. ferrumequinum (E2DHI2) ACE2 % Identity with R. ferrumequinum (B6ZGN7) ACE2\nEquus caballus (Horse) F6V9L3 84.72 82.40 84.36 84.92\nFelis catus (Cat) Q56H28 83.06 80.44 82.12 82.68\nOryctolagus cuniculus (Rabbit) G1TEF4 83.90 81.84 79.33 79.89\nUrsus arctos horribilis (Grizzly bear) A0A3Q7TE16 82.22 78.49 80.16 80.73\nCanis lupus familiaris (Dog) A0A5F4BS93 80.56 77.65 78.49 79.05\nVulpes vulpes (Red fox) A0A3Q7RAT9 80.27 77.93 79.05 79.61\nMus musculus (Mouse) Q8R0I0 80.83 78.61 78.71 79.33\nSus scrofa (Pig) K7GLM4 80.55 77.34 77.93 78.49\nBostaurus (Cattle) Q58DD0 78.67 76.19 78.49 79.05\nOvis aries (Sheep) W5PSB6 79.10 75.98 78.27 78.83"}

{"project":"Covid19_manual_annotation_v2","denotations":[{"id":"T6","span":{"begin":23,"end":35},"obj":"Gene"},{"id":"T7","span":{"begin":229,"end":241},"obj":"Gene"},{"id":"T22","span":{"begin":122,"end":125},"obj":"Phenomena"}],"attributes":[{"id":"A6","pred":"tao:has_database_id","subj":"T6","obj":"Gene:43740568"},{"id":"A7","pred":"tao:has_database_id","subj":"T7","obj":"Gene:43740568"},{"id":"A22","pred":"tao:has_database_id","subj":"T22","obj":"MESH:D000072417"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"BioProject","uri":"https://www.ncbi.nlm.nih.gov/bioproject/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"},{"prefix":"HP","uri":"https://hpo.jax.org/app/browse/term/HP:"},{"prefix":"BioSample","uri":"https://www.ncbi.nlm.nih.gov/biosample/"}],"text":"2.6 Analysis of human SARS-CoV-2 S and spike protein of Bat coronavirus Rp3\nSequence alignment was carried out using the RBD (residues 339–490) of bat coronavirus Rp3/2004 S protein (UniProt ID: Q3I5J5), and residues 336–518 of SARS-CoV-2 S protein (UniProt ID: P0DTC2). The alignment was carried out using Clustal Omega [35, 36] (see Table 1).\nTable 1 ACE2 sequences of wild and domestic species present in Italy with their UniProt codes and the percentage of identity with human and ACE2 of Chiroptera species present in Italy.\nWild and domestic species present in Italy UniProt ID % Identity with hACE2 % Identity with M. daubentonii ACE2 % Identity with R. ferrumequinum (E2DHI2) ACE2 % Identity with R. ferrumequinum (B6ZGN7) ACE2\nEquus caballus (Horse) F6V9L3 84.72 82.40 84.36 84.92\nFelis catus (Cat) Q56H28 83.06 80.44 82.12 82.68\nOryctolagus cuniculus (Rabbit) G1TEF4 83.90 81.84 79.33 79.89\nUrsus arctos horribilis (Grizzly bear) A0A3Q7TE16 82.22 78.49 80.16 80.73\nCanis lupus familiaris (Dog) A0A5F4BS93 80.56 77.65 78.49 79.05\nVulpes vulpes (Red fox) A0A3Q7RAT9 80.27 77.93 79.05 79.61\nMus musculus (Mouse) Q8R0I0 80.83 78.61 78.71 79.33\nSus scrofa (Pig) K7GLM4 80.55 77.34 77.93 78.49\nBostaurus (Cattle) Q58DD0 78.67 76.19 78.49 79.05\nOvis aries (Sheep) W5PSB6 79.10 75.98 78.27 78.83"}