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PMC:7640975 / 60882-62534 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T504 378-383 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T505 798-803 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T506 966-976 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T507 1271-1276 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T508 1403-1408 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T116 101-148 Disease denotes severe acute respiratory syndrome coronavirus-2 http://purl.obolibrary.org/obo/MONDO_0100096
T117 101-134 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T118 150-158 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T119 185-209 Disease denotes Coronavirus Disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T120 211-219 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T121 398-406 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T122 409-418 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T123 522-530 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T124 533-542 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T125 703-711 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T126 819-827 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T127 830-839 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T128 1009-1024 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T129 1015-1024 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T130 1147-1155 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T131 1250-1258 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T132 1378-1386 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T677 234-237 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T678 244-245 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T679 373-377 http://purl.obolibrary.org/obo/CLO_0009989 denotes Huh7
T680 378-383 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T681 462-471 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T682 632-641 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T683 791-797 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco-2
T684 791-797 http://purl.obolibrary.org/obo/CLO_0051943 denotes Caco-2
T685 791-797 http://purl.obolibrary.org/obo/CLO_0051958 denotes Caco-2
T686 791-797 http://purl.obolibrary.org/obo/CLO_0051960 denotes Caco-2
T687 798-803 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T688 1055-1061 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T689 1264-1270 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco-2
T690 1264-1270 http://purl.obolibrary.org/obo/CLO_0051943 denotes Caco-2
T691 1264-1270 http://purl.obolibrary.org/obo/CLO_0051958 denotes Caco-2
T692 1264-1270 http://purl.obolibrary.org/obo/CLO_0051960 denotes Caco-2
T693 1271-1276 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T694 1403-1408 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T695 1445-1454 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T49991 594-603 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T37870 604-611 Chemical denotes MK-2206 http://purl.obolibrary.org/obo/CHEBI_67271
T94018 604-606 Chemical denotes MK http://purl.obolibrary.org/obo/CHEBI_74706
T27802 943-949 Chemical denotes carbon http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415
T71 966-976 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T59320 1078-1088 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T47204 1090-1103 Chemical denotes cycloheximide http://purl.obolibrary.org/obo/CHEBI_27641
T76342 1108-1115 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T73678 1191-1206 Chemical denotes pharmaceuticals http://purl.obolibrary.org/obo/CHEBI_52217
T90954 1480-1489 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T83300 1595-1600 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T10537 1631-1640 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T381 462-480 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T382 462-471 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T383 632-649 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T384 632-641 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T385 906-917 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T386 933-941 http://purl.obolibrary.org/obo/GO_0045292 denotes splicing
T387 950-960 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T388 966-987 http://purl.obolibrary.org/obo/GO_0009117 denotes nucleotide metabolism
T389 977-987 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T390 1009-1024 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T391 1066-1077 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T392 1445-1463 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T393 1445-1454 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T394 1507-1532 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibit viral replication
T395 1515-1532 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T396 1515-1532 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T346 0-285 Sentence denotes Of note, it is of great significance to compare our proteomics data with those of the newly emergent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2),78,79 which caused the Coronavirus Disease 2019 (COVID-19) Pandemic and has posed a serious global public health emergency.
T347 286-714 Sentence denotes Recently, Appelberg et al. conducted an integrative proteo-transcriptomics analysis of Huh7 cells responding to SARS-CoV-2 infection, and identified ErbB, HIF-1, mTOR, and TNF signaling pathways that were significantly regulated during SARS-CoV-2 infection in vitro.78 They further demonstrated that the Akt inhibitor MK-2206, targeting the mTOR signaling pathway, was able to significantly reduce the replication of SARS-CoV-2.
T348 715-1277 Sentence denotes Moreover, another recent study investigated the translatome and proteome of Caco-2 cells in response to SARS-CoV-2 infection in vitro, and discovered that several cellular pathways linked to translation, proteostasis, splicing, carbon metabolism, and nucleotide metabolism were reshaped during viral infection.79 On this basis, the authors tested two translation inhibitors, cycloheximide and emetine, for their ability to suppress SARS-CoV-2 replication, and found that both pharmaceuticals significantly decreased the replication of SARS-CoV-2 in Caco-2 cells.
T349 1278-1652 Sentence denotes Undoubtedly, by comparing the similarities and differences of cellular proteomes between PDCoV- and SARS-CoV-2-infected host cells, it is possible to find some common signaling pathways and key adaptor molecules that function to inhibit viral replication, and thus provide valuable clues for screening of therapeutic drugs for PDCoV and designing novel antiviral strategies.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1219 435-439 Gene denotes ErbB Gene:1956
1220 441-446 Gene denotes HIF-1 Gene:3091
1221 448-452 Gene denotes mTOR Gene:2475
1222 458-461 Gene denotes TNF Gene:7124
1223 590-593 Gene denotes Akt Gene:207
1224 627-631 Gene denotes mTOR Gene:2475
1225 101-148 Species denotes severe acute respiratory syndrome coronavirus-2 Tax:2697049
1226 150-160 Species denotes SARS-CoV-2 Tax:2697049
1227 703-713 Species denotes SARS-CoV-2 Tax:2697049
1228 1147-1157 Species denotes SARS-CoV-2 Tax:2697049
1229 1250-1260 Species denotes SARS-CoV-2 Tax:2697049
1230 604-611 Chemical denotes MK-2206 MESH:C548887
1231 943-949 Chemical denotes carbon MESH:D002244
1232 1090-1103 Chemical denotes cycloheximide MESH:D003513
1233 1108-1115 Chemical denotes emetine MESH:D004640
1234 185-209 Disease denotes Coronavirus Disease 2019 MESH:C000657245
1235 211-219 Disease denotes COVID-19 MESH:C000657245
1236 398-418 Disease denotes SARS-CoV-2 infection MESH:C000657245
1237 522-542 Disease denotes SARS-CoV-2 infection MESH:C000657245
1238 819-839 Disease denotes SARS-CoV-2 infection MESH:C000657245
1239 1009-1024 Disease denotes viral infection MESH:D001102
1240 1378-1397 Disease denotes SARS-CoV-2-infected MESH:C000657245
1241 373-377 CellLine denotes Huh7 CVCL:0336
1242 791-797 CellLine denotes Caco-2 CVCL:0025
1243 1264-1270 CellLine denotes Caco-2 CVCL:0025