PMC:7640975 / 56293-57738
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T479 | 150-155 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T480 | 479-483 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T481 | 626-631 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T482 | 644-651 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T483 | 1330-1335 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T104 | 815-823 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
| T105 | 828-834 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T621 | 26-35 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T622 | 65-74 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T623 | 114-123 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T624 | 150-155 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T625 | 223-232 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T626 | 294-295 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T627 | 383-392 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activated |
| T628 | 479-483 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T629 | 536-545 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T630 | 701-713 | http://purl.obolibrary.org/obo/OBI_0000245 | denotes | organization |
| T631 | 748-751 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T632 | 869-878 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T633 | 1045-1046 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T634 | 1068-1077 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T635 | 1237-1246 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T636 | 1330-1335 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T637 | 1390-1400 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T638 | 1427-1436 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T79790 | 626-631 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T7173 | 644-651 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T15 | 828-834 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T289 | 26-43 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathway |
| T290 | 26-35 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T291 | 65-83 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathways |
| T292 | 65-74 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T293 | 85-89 | http://purl.obolibrary.org/obo/GO_0016303 | denotes | PI3K |
| T294 | 186-206 | http://purl.obolibrary.org/obo/GO_0010506 | denotes | regulating autophagy |
| T295 | 197-206 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T296 | 197-206 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T297 | 214-218 | http://purl.obolibrary.org/obo/GO_0016303 | denotes | PI3K |
| T298 | 219-232 | http://purl.obolibrary.org/obo/GO_0043491 | denotes | AKT signaling |
| T299 | 223-232 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T300 | 429-447 | http://purl.obolibrary.org/obo/GO_0009987 | denotes | cellular processes |
| T301 | 468-477 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T302 | 468-477 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T303 | 479-489 | http://purl.obolibrary.org/obo/GO_0007049 | denotes | cell cycle |
| T304 | 536-553 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathway |
| T305 | 536-545 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T306 | 644-661 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | protein synthesis |
| T307 | 652-661 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T308 | 663-686 | http://purl.obolibrary.org/obo/GO_0010506 | denotes | regulation of autophagy |
| T309 | 663-673 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T310 | 677-686 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T311 | 677-686 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T312 | 860-864 | http://purl.obolibrary.org/obo/GO_0016303 | denotes | PI3K |
| T313 | 865-878 | http://purl.obolibrary.org/obo/GO_0043491 | denotes | AKT signaling |
| T314 | 869-878 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T315 | 915-944 | http://purl.obolibrary.org/obo/GO_0010508 | denotes | positively regulate autophagy |
| T316 | 926-944 | http://purl.obolibrary.org/obo/GO_0010506 | denotes | regulate autophagy |
| T317 | 935-944 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T318 | 935-944 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T319 | 1018-1027 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T320 | 1018-1027 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T321 | 1054-1058 | http://purl.obolibrary.org/obo/GO_0016303 | denotes | PI3K |
| T322 | 1068-1085 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathway |
| T323 | 1068-1077 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T324 | 1137-1168 | http://purl.obolibrary.org/obo/GO_0010507 | denotes | negatively regulating autophagy |
| T325 | 1148-1168 | http://purl.obolibrary.org/obo/GO_0010506 | denotes | regulating autophagy |
| T326 | 1159-1168 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T327 | 1159-1168 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T328 | 1219-1223 | http://purl.obolibrary.org/obo/GO_0016303 | denotes | PI3K |
| T329 | 1237-1255 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathways |
| T330 | 1237-1246 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T331 | 1413-1417 | http://purl.obolibrary.org/obo/GO_0016303 | denotes | PI3K |
| T332 | 1427-1444 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathway |
| T333 | 1427-1436 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T335 | 0-1445 | Sentence | denotes | Except for the RIG-I-like signaling pathway, two multifunctional signaling pathways, PI3K-AKT and mTOR, were also activated in PDCoV-infected IPEC-J2 cells, both of which participate in regulating autophagy.60 The PI3K-AKT signaling pathway could be triggered by numerous factors and regulates a variety of fundamental cellular functions, for instance, proliferation and survival.61 Activated AKT subsequently modulates numerous cellular processes, including cellular autophagy, cell cycle progression and cellular survival.62 The mTOR signaling pathway is involved in regulating diverse basic biological processes, including lipid biogenesis, protein synthesis, regulation of autophagy, cytoskeletal organization and so on,63,64 whose dysfunction has been associated with the pathophysiology of many diseases like diabetes and cancer.65 Although the mTOR and PI3K-AKT signaling pathways are able to negatively and positively regulate autophagy, respectively, in an independent manner,60,66−68 they usually coregulate autophagy via merging into a single PI3K-AKT-mTOR signaling pathway, which serves as one of the classical pathways for negatively regulating autophagy.69,70 From the KEGG analysis, we noticed that the PI3K-AKT and mTOR signaling pathways were respectively upregulated and downregulated in PDCoV-infected IPEC-J2 cells, which are the two important indicators of autophagic activation through the PI3K-AKT-mTOR signaling pathway. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1103 | 15-20 | Gene | denotes | RIG-I | Gene:23586 |
| 1104 | 90-93 | Gene | denotes | AKT | Gene:207 |
| 1105 | 98-102 | Gene | denotes | mTOR | Gene:2475 |
| 1106 | 219-222 | Gene | denotes | AKT | Gene:100126861 |
| 1107 | 393-396 | Gene | denotes | AKT | Gene:100126861 |
| 1108 | 531-535 | Gene | denotes | mTOR | Gene:100127359 |
| 1109 | 851-855 | Gene | denotes | mTOR | Gene:2475 |
| 1110 | 865-868 | Gene | denotes | AKT | Gene:207 |
| 1111 | 1059-1062 | Gene | denotes | AKT | Gene:207 |
| 1112 | 1063-1067 | Gene | denotes | mTOR | Gene:2475 |
| 1113 | 1224-1227 | Gene | denotes | AKT | Gene:207 |
| 1114 | 1232-1236 | Gene | denotes | mTOR | Gene:2475 |
| 1115 | 1418-1421 | Gene | denotes | AKT | Gene:100126861 |
| 1116 | 1422-1426 | Gene | denotes | mTOR | Gene:100127359 |
| 1119 | 1114-1123 | Species | denotes | classical | Tax:11096 |
| 1120 | 626-631 | Chemical | denotes | lipid | MESH:D008055 |
| 1121 | 127-141 | Disease | denotes | PDCoV-infected | MESH:D007239 |
| 1122 | 736-747 | Disease | denotes | dysfunction | MESH:D009461 |
| 1123 | 815-823 | Disease | denotes | diabetes | MESH:D003920 |
| 1124 | 828-834 | Disease | denotes | cancer | MESH:D009369 |
| 1125 | 1307-1321 | Disease | denotes | PDCoV-infected | MESH:D007239 |
| 1129 | 142-149 | CellLine | denotes | IPEC-J2 | CVCL:2246 |
| 1130 | 1322-1329 | CellLine | denotes | IPEC-J2 | CVCL:2246 |