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PMC:7640975 / 54283-56292 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T468 143-152 Body_part denotes cytosolic http://purl.org/sig/ont/fma/fma66836
T469 239-242 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T470 583-591 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T471 697-702 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T472 719-727 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T473 1002-1007 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T474 1201-1206 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T475 1240-1245 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T476 1511-1516 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T477 1881-1888 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T478 1979-1982 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T100 805-821 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T101 904-913 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T102 1013-1022 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T103 1889-1892 Disease denotes NS6 http://purl.obolibrary.org/obo/MONDO_0013186

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T594 18-27 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T595 97-106 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T596 304-312 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T597 324-333 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T598 440-448 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T599 632-635 http://purl.obolibrary.org/obo/CLO_0009915 denotes Mx1
T600 697-702 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T601 957-966 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T602 981-990 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T603 1002-1007 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T604 1063-1064 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T605 1151-1160 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T606 1173-1182 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T607 1201-1206 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T608 1220-1221 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T609 1240-1245 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T610 1247-1257 http://purl.obolibrary.org/obo/CLO_0008447 denotes PK-15, was
T611 1247-1257 http://purl.obolibrary.org/obo/CLO_0008448 denotes PK-15, was
T612 1247-1252 http://purl.obolibrary.org/obo/CLO_0050908 denotes PK-15
T613 1331-1334 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T614 1503-1516 http://purl.obolibrary.org/obo/CLO_0052497 denotes LLC-PK1 cells
T615 1596-1597 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T616 1656-1664 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T617 1761-1767 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T618 1783-1792 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T619 1839-1847 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T620 1889-1892 http://purl.obolibrary.org/obo/OGG_3000004893 denotes NS6

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T84303 371-374 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T2647 395-398 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T3272 399-408 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T35749 422-425 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T79198 485-494 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T25165 583-591 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T75260 719-727 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T20380 746-749 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T14676 953-956 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T50278 1247-1249 Chemical denotes PK http://purl.obolibrary.org/obo/CHEBI_74792
T42745 1483-1486 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T54 1881-1888 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T38201 1917-1920 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T41383 1963-1982 Chemical denotes double-stranded RNA http://purl.obolibrary.org/obo/CHEBI_67208

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T269 18-36 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T270 18-27 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T271 67-71 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T272 87-96 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T273 87-96 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T274 97-115 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T275 97-106 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T276 324-342 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling cascades
T277 324-333 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T278 495-508 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T279 805-821 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T280 957-975 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T281 957-966 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T282 1151-1168 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T283 1151-1160 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T284 1399-1414 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T285 1535-1550 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T286 1639-1664 http://purl.obolibrary.org/obo/GO_0004521 denotes endoribonuclease activity
T287 1796-1809 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T288 1830-1847 http://purl.obolibrary.org/obo/GO_0008233 denotes protease activity

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T329 0-116 Sentence denotes Other interesting signaling pathways included RIG-I-like receptor, PI3K-AKT, mTOR, and autophagy signaling pathways.
T330 117-703 Sentence denotes As an important family of cytosolic pattern recognition receptors, RIG-I is responsible for sensing of the invading viral RNA by recognizing its pathogen-associated molecular patterns to activate downstream signaling cascades, and thereby produce type I IFN.53,54 The generated IFN molecules then bind to IFN receptors and activate numerous ISGs, which exert critical antiviral innate immune functions either directly or indirectly.55 In our study, five upregulated proteins encoded by ISGs, including ISG15, OAS1, Mx1, IFIT1, and IFIT3, were identified in PDCoV-infected IPEC-J2 cells.
T331 704-914 Sentence denotes Although these proteins related to type I IFN induction have been reported to participate in diverse viral infections,22,56 most of them were identified for the first time to be associated with PDCoV infection.
T332 915-1032 Sentence denotes These data suggest that the canonical IFN signaling pathways were activated in IPEC-J2 cells upon infection by PDCoV.
T333 1033-1415 Sentence denotes This was further confirmed by a recent transcriptome-level study which also demonstrated that the RIG-I-like receptor signaling pathway was activated in PDCoV-infected cells, even though a different type of cells, PK-15, was used.17 Nevertheless, there is increasing evidence suggesting that PDCoV has evolved multiple escape strategies to interfere with the host’s innate immunity.
T334 1416-2009 Sentence denotes For example, the nsp15 of PDCoV was found to be able to antagonize IFN-β production in LLC-PK1 cells by disrupting the phosphorylation and nuclear translocation of nuclear factor-κB p65 subunit, which is independent of its endoribonuclease activity.57 The Nsp5 of PDCoV was demonstrated to suppress the production of type I IFNs by cleaving the signal transducer and activator of transcription 2, depending on its protease activity.58 Moreover, the PDCoV accessory protein NS6 was shown to antagonize IFN-β production by disrupting the binding of double-stranded RNA to RIG-I/MDA5 receptors.59

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1052 72-75 Gene denotes AKT Gene:207
1053 77-81 Gene denotes mTOR Gene:2475
1054 184-189 Gene denotes RIG-I Gene:23586
1055 619-624 Gene denotes ISG15 Gene:9636
1056 626-630 Gene denotes OAS1 Gene:4938
1057 632-635 Gene denotes Mx1 Gene:4599
1058 637-642 Gene denotes IFIT1 Gene:3434
1059 648-653 Gene denotes IFIT3 Gene:3437
1060 1483-1488 Gene denotes IFN-β Gene:3439
1061 1672-1676 Gene denotes Nsp5 Gene:92521
1062 1761-1811 Gene denotes signal transducer and activator of transcription 2 Gene:6773
1063 1889-1892 Gene denotes NS6 Gene:4893
1064 1917-1922 Gene denotes IFN-β Gene:3439
1065 1986-1991 Gene denotes RIG-I Gene:23586
1066 1992-1996 Gene denotes MDA5 Gene:64135
1067 674-688 Disease denotes PDCoV-infected MESH:D007239
1068 805-821 Disease denotes viral infections MESH:D001102
1069 898-913 Disease denotes PDCoV infection MESH:D007239
1070 1013-1022 Disease denotes infection MESH:D007239
1071 1186-1200 Disease denotes PDCoV-infected MESH:D007239
1072 689-696 CellLine denotes IPEC-J2 CVCL:2246
1073 994-1001 CellLine denotes IPEC-J2 CVCL:2246