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PMC:7640975 / 47027-48606 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T407 30-35 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T408 159-167 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T409 672-679 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T410 697-702 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T411 828-833 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T412 852-856 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T413 904-909 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T414 998-1009 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T415 1090-1095 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T416 1346-1351 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T417 1368-1376 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T418 1415-1423 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T419 1497-1505 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T420 1570-1578 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T77 235-250 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T78 241-250 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T79 501-517 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T80 708-717 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T81 959-968 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T82 1044-1053 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T83 1254-1263 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T84 1551-1554 Disease denotes NS6 http://purl.obolibrary.org/obo/MONDO_0013186
T85 1556-1559 Disease denotes NS7 http://purl.obolibrary.org/obo/MONDO_0013379

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T513 30-35 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T514 40-47 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T515 141-146 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T516 257-258 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T517 387-389 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T518 583-585 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T519 615-618 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T520 619-626 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T521 697-702 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T522 763-765 http://purl.obolibrary.org/obo/CL_0000453 denotes LC
T523 766-768 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T524 769-771 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T525 828-833 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T526 852-862 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines
T527 873-875 http://purl.obolibrary.org/obo/CLO_0009141 denotes ST
T528 873-875 http://purl.obolibrary.org/obo/CLO_0050980 denotes ST
T529 877-880 http://purl.obolibrary.org/obo/CLO_0050167 denotes LLC
T530 881-884 http://purl.obolibrary.org/obo/CLO_0050105 denotes PK1
T531 886-891 http://purl.obolibrary.org/obo/CLO_0050908 denotes PK-15
T532 897-903 http://purl.obolibrary.org/obo/CLO_0006963 denotes IPI-2I
T533 904-909 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T534 1090-1095 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T535 1285-1286 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T536 1346-1351 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T537 1527-1535 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T538 1551-1554 http://purl.obolibrary.org/obo/OGG_3000004893 denotes NS6
T539 1556-1559 http://purl.obolibrary.org/obo/CLO_0008201 denotes NS7

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T430 159-167 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T431 341-350 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T432 387-389 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T433 672-679 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T434 763-765 Chemical denotes LC http://purl.obolibrary.org/obo/CHEBI_73582
T435 766-768 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T436 769-771 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T437 873-875 Chemical denotes ST http://purl.obolibrary.org/obo/CHEBI_141393
T438 886-888 Chemical denotes PK http://purl.obolibrary.org/obo/CHEBI_74792
T439 1368-1376 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T440 1415-1423 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T441 1497-1505 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T442 1570-1578 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T219 235-250 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T220 501-517 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T303 0-727 Sentence denotes The interactions between host cells and viruses are highly complex, which usually involves numerous alterations in the expression of diverse genes, mRNAs, and proteins.36,37 Deciphering the laws behind these changes over the course of viral infection plays a vital role in elucidating the pathogenic mechanisms and in developing efficacious antiviral strategies.37 Over the past decade, MS-based proteomic techniques have contributed significantly to uncovering more factors and mechanisms related to viral infections and the corresponding host cellular pathophysiological processes.18 However, no research to date has focused on differential proteomic analysis of global protein profiles in host cells upon infection by PDCoV.
T304 728-834 Sentence denotes In this study, iTRAQ combined with LC-MS/MS was used to identify the DEPs in PDCoV-infected IPEC-J2 cells.
T305 835-1272 Sentence denotes Although various cell lines including ST, LLC-PK1, PK-15, and IPI-2I cells have been shown to be highly permissive to PDCoV infection,17,34,38 considering porcine enterocytes are the natural targets for PDCoV infection in vivo,8,9 we chose to use IPEC-J2 cells for the proteomic analysis with the goal of obtaining experimental data that could better reflect the physiological state of pigs and the true state of PDCoV infection in vivo.
T306 1273-1457 Sentence denotes Ultimately, a total of 78 DEPs were identified in PDCoV-infected IPEC-J2 cells, among which 23 proteins were significantly upregulated and 55 proteins were significantly downregulated.
T307 1458-1579 Sentence denotes Moreover, we also identified six viral proteins including the spike, membrane, nucleocapsid, NS6, NS7, and Nsp5 proteins.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
852 1551-1554 Gene denotes NS6 Gene:4893
853 1556-1559 Gene denotes NS7 Gene:673
854 1565-1569 Gene denotes Nsp5 Gene:92521
855 1221-1225 Species denotes pigs Tax:9823
856 990-997 Species denotes porcine Tax:28344
857 235-250 Disease denotes viral infection MESH:D001102
858 501-517 Disease denotes viral infections MESH:D001102
859 708-717 Disease denotes infection MESH:D007239
860 805-819 Disease denotes PDCoV-infected MESH:D007239
861 959-968 Disease denotes infection MESH:D007239
862 1038-1053 Disease denotes PDCoV infection MESH:D007239
863 1248-1263 Disease denotes PDCoV infection MESH:D007239
864 1323-1337 Disease denotes PDCoV-infected MESH:D007239
865 820-827 CellLine denotes IPEC-J2 CVCL:2246
866 1082-1089 CellLine denotes IPEC-J2 CVCL:2246
867 1338-1345 CellLine denotes IPEC-J2 CVCL:2246