PMC:7640975 / 17368-19151
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T114 | 112-116 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
T115 | 235-238 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T116 | 280-285 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T117 | 336-339 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T118 | 433-436 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T119 | 672-677 | Body_part | denotes | actin | http://purl.org/sig/ont/fma/fma67843 |
T120 | 696-700 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
T121 | 814-819 | Body_part | denotes | actin | http://purl.org/sig/ont/fma/fma67843 |
T122 | 1143-1148 | Body_part | denotes | actin | http://purl.org/sig/ont/fma/fma67843 |
T123 | 1615-1620 | Body_part | denotes | actin | http://purl.org/sig/ont/fma/fma67843 |
T124 | 1760-1765 | Body_part | denotes | actin | http://purl.org/sig/ont/fma/fma67843 |
T125 | 1776-1780 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T232 | 280-285 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T233 | 446-447 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T234 | 590-591 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T235 | 681-682 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T236 | 696-700 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
T237 | 820-825 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
T238 | 1261-1265 | http://purl.obolibrary.org/obo/CLO_0001564 | denotes | a 20 |
T239 | 1261-1265 | http://purl.obolibrary.org/obo/CLO_0050194 | denotes | a 20 |
T240 | 1482-1483 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T241 | 1776-1780 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T133 | 1406-1411 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T32 | 85-100 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
T33 | 476-485 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | Synthesis |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T91 | 0-38 | Sentence | denotes | 2.9 Quantitative Real-Time PCR (qPCR) |
T92 | 39-219 | Sentence | denotes | To verify the DEPs identified by iTRAQ at the transcriptional level, the mRNA of two representative DEPs, the downregulated ANAPC7 and the upregulated IFIT1, were detected by qPCR. |
T93 | 220-371 | Sentence | denotes | Total cellular RNA of both PDCoV- and mock-infected IPEC-J2 cells was extracted using the TaKaRa MiniBEST universal RNA extraction kit (Dalian, China). |
T94 | 372-552 | Sentence | denotes | The first strand cDNA was synthesized using 2 μg of cellular RNA and with a RevertAid First Strand cDNA Synthesis Kit (Thermo Scientific) following the manufacturer’s instructions. |
T95 | 553-701 | Sentence | denotes | The qPCR assays were conducted using a TaKaRa SYBR Premix Ex Taq kit on an ABI 7500 real-time PCR machine along with β-actin as a housekeeping gene. |
T96 | 702-906 | Sentence | denotes | The primers used for the qPCR assay were designed based on the NCBI reference sequences for ANAPC7, IFIT1 and β-actin genes under GenBank accession numbers NM_016238, HQ679904 and NM_001101, respectively. |
T97 | 907-982 | Sentence | denotes | The information for the designed primers was as following: ANAPC7 (Forward: |
T98 | 983-1019 | Sentence | denotes | 5′-CTTTGCTGAGGAACGCACTG-3′, Reverse: |
T99 | 1020-1064 | Sentence | denotes | 5′-TCCATGTCGTCCACATCCTC-3′); IFIT1 (Forward: |
T100 | 1065-1106 | Sentence | denotes | 5′-GAAGATTTAACCCAACAAGAACATA-3′, Reverse: |
T101 | 1107-1158 | Sentence | denotes | 5′-CTTTCGATACGTAAGGTAATACAGC-3′); β-actin (Forward: |
T102 | 1159-1195 | Sentence | denotes | 5′-TCCCTGGAGAAGAGCTACGA-3′, Reverse: |
T103 | 1196-1224 | Sentence | denotes | 5′-AGCACTGTGTTGGCGTACAG-3′). |
T104 | 1225-1434 | Sentence | denotes | The qPCR assays were carried out in a 20-μL reaction volume comprised 10 μL of TaKaRa SYBR Premix Ex Taq, 0.4 μL of each forward and reverse primer (10 μM), 7.2 μL of nuclease-free water, and 2 μL of template. |
T105 | 1435-1671 | Sentence | denotes | The qPCR amplifications were carried out using a thermal profile with an initial step at 95 °C for 2 min, followed by 40 cycles of 95 °C for 10 s, 60 °C for 10 s (for ANAPC7 and β-actin) or 55 °C for 10 s (for IFIT1) and 72 °C for 40 s. |
T106 | 1672-1783 | Sentence | denotes | Fold-change values were calculated in term of the 2–ΔΔCt method and normalized to the β-actin reference gene.33 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
293 | 163-169 | Gene | denotes | ANAPC7 | Gene:51434 |
294 | 190-195 | Gene | denotes | IFIT1 | Gene:3434 |
295 | 670-677 | Gene | denotes | β-actin | Gene:728378 |
296 | 794-800 | Gene | denotes | ANAPC7 | Gene:51434 |
297 | 802-807 | Gene | denotes | IFIT1 | Gene:3434 |
298 | 812-819 | Gene | denotes | β-actin | Gene:728378 |
299 | 966-972 | Gene | denotes | ANAPC7 | Gene:51434 |
300 | 1049-1054 | Gene | denotes | IFIT1 | Gene:3434 |
301 | 1141-1148 | Gene | denotes | β-actin | Gene:728378 |
302 | 1602-1608 | Gene | denotes | ANAPC7 | Gene:51434 |
303 | 1613-1620 | Gene | denotes | β-actin | Gene:728378 |
304 | 1645-1650 | Gene | denotes | IFIT1 | Gene:3434 |
305 | 486-489 | Gene | denotes | Kit | Gene:396810 |
306 | 618-621 | Gene | denotes | kit | Gene:396810 |
307 | 351-354 | Gene | denotes | kit | Gene:396810 |
308 | 1758-1765 | Gene | denotes | β-actin | Gene:728378 |
309 | 1406-1411 | Chemical | denotes | water | MESH:D014867 |
310 | 263-271 | Disease | denotes | infected | MESH:D007239 |
311 | 272-279 | CellLine | denotes | IPEC-J2 | CVCL:2246 |