PMC:7640975 / 149-1658
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T4 | 117-133 | Body_part | denotes | small intestinal | http://purl.org/sig/ont/fma/fma7200 |
| T5 | 134-150 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T6 | 145-150 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T7 | 181-186 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T8 | 423-431 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T9 | 465-470 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T10 | 538-546 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T11 | 830-837 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T12 | 1210-1223 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T13 | 1225-1241 | Body_part | denotes | digestive system | http://purl.org/sig/ont/fma/fma7152 |
| T14 | 1316-1320 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T15 | 1419-1424 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 117-133 | Body_part | denotes | small intestinal | http://purl.obolibrary.org/obo/UBERON_0002108 |
| T2 | 1210-1223 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
| T3 | 1225-1241 | Body_part | denotes | digestive system | http://purl.obolibrary.org/obo/UBERON_0001007 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 99-107 | Disease | denotes | diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T2 | 196-205 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T8 | 117-133 | http://purl.obolibrary.org/obo/UBERON_0002108 | denotes | small intestinal |
| T9 | 134-144 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T10 | 145-150 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T11 | 181-186 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T12 | 284-292 | http://purl.obolibrary.org/obo/CLO_0007225 | denotes | labeling |
| T13 | 352-354 | http://purl.obolibrary.org/obo/CL_0000453 | denotes | LC |
| T14 | 355-357 | http://purl.obolibrary.org/obo/CLO_0007874 | denotes | MS |
| T15 | 358-360 | http://purl.obolibrary.org/obo/CLO_0007874 | denotes | MS |
| T16 | 465-470 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T17 | 472-473 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T18 | 1101-1102 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T19 | 1182-1191 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T20 | 1210-1223 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T21 | 1225-1241 | http://purl.obolibrary.org/obo/UBERON_0001007 | denotes | digestive system |
| T22 | 1225-1241 | http://www.ebi.ac.uk/efo/EFO_0000793 | denotes | digestive system |
| T23 | 1243-1249 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T24 | 1316-1320 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T25 | 1327-1336 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T26 | 1419-1424 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T4 | 352-354 | Chemical | denotes | LC | http://purl.obolibrary.org/obo/CHEBI_73582 |
| T5 | 355-357 | Chemical | denotes | MS | http://purl.obolibrary.org/obo/CHEBI_73613 |
| T6 | 358-360 | Chemical | denotes | MS | http://purl.obolibrary.org/obo/CHEBI_73613 |
| T7 | 423-431 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T8 | 538-546 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T9 | 811-821 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T10 | 830-837 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 99-107 | Phenotype | denotes | diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 749-757 | http://purl.obolibrary.org/obo/GO_0051322 | denotes | anaphase |
| T2 | 1182-1200 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathways |
| T3 | 1182-1191 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T4 | 1243-1262 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signal transduction |
| T5 | 1250-1262 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | transduction |
| T6 | 1291-1295 | http://purl.obolibrary.org/obo/GO_0016303 | denotes | PI3K |
| T7 | 1301-1310 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T8 | 1301-1310 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T9 | 1316-1326 | http://purl.obolibrary.org/obo/GO_0007049 | denotes | cell cycle |
| T10 | 1327-1345 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathways |
| T11 | 1327-1336 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T12 | 1496-1508 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 0-108 | Sentence | denotes | Porcine deltacoronavirus (PDCoV) is an emergent enteropathogenic coronavirus associated with swine diarrhea. |
| T4 | 109-214 | Sentence | denotes | Porcine small intestinal epithelial cells (IPEC) are the primary target cells of PDCoV infection in vivo. |
| T5 | 215-471 | Sentence | denotes | Here, isobaric tags for relative and absolute quantification (iTRAQ) labeling coupled to liquid chromatography–tandem mass spectrometry (LC-MS/MS) was used to quantitatively identify differentially expressed proteins (DEPs) in PDCoV-infected IPEC-J2 cells. |
| T6 | 472-586 | Sentence | denotes | A total of 78 DEPs, including 23 upregulated and 55 downregulated proteins, were identified at 24 h postinfection. |
| T7 | 587-656 | Sentence | denotes | The data are available via ProteomeXchange with identifier PXD019975. |
| T8 | 657-1012 | Sentence | denotes | To ensure reliability of the proteomics data, two randomly selected DEPs, the downregulated anaphase-promoting complex subunit 7 (ANAPC7) and upregulated interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), were verified by real-time PCR and Western blot, and the results of which indicate that the proteomics data were reliable and valid. |
| T9 | 1013-1346 | Sentence | denotes | Bioinformatics analyses, including GO, COG, KEGG, and STRING, further demonstrated that a majority of the DEPs are involved in numerous crucial biological processes and signaling pathways, such as immune system, digestive system, signal transduction, RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. |
| T10 | 1347-1509 | Sentence | denotes | Altogether, this is the first study on proteomes of PDCoV-infected host cells, which shall provide valuable clues for further investigation of PDCoV pathogenesis. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 21 | 749-785 | Gene | denotes | anaphase-promoting complex subunit 7 | Gene:51434 |
| 22 | 787-793 | Gene | denotes | ANAPC7 | Gene:51434 |
| 23 | 811-870 | Gene | denotes | interferon-induced protein with tetratricopeptide repeats 1 | Gene:3434 |
| 24 | 872-877 | Gene | denotes | IFIT1 | Gene:3434 |
| 25 | 1285-1289 | Gene | denotes | mTOR | Gene:2475 |
| 26 | 1296-1299 | Gene | denotes | AKT | Gene:207 |
| 27 | 0-24 | Species | denotes | Porcine deltacoronavirus | Tax:1586324 |
| 28 | 65-76 | Species | denotes | coronavirus | Tax:11118 |
| 29 | 93-98 | Species | denotes | swine | Tax:9823 |
| 30 | 109-116 | Species | denotes | Porcine | Tax:28344 |
| 31 | 99-107 | Disease | denotes | diarrhea | MESH:D003967 |
| 32 | 196-205 | Disease | denotes | infection | MESH:D007239 |
| 33 | 442-456 | Disease | denotes | PDCoV-infected | MESH:D007239 |
| 34 | 1399-1413 | Disease | denotes | PDCoV-infected | MESH:D007239 |
| 35 | 457-464 | CellLine | denotes | IPEC-J2 | CVCL:2246 |