PMC:7605643 / 7001-9284
Annnotations
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T14 | 70-85 | Body_part | denotes | attachment site | http://purl.obolibrary.org/obo/UBERON_4200047 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T27 | 112-119 | Body_part | denotes | Protein | http://purl.org/sig/ont/fma/fma67257 |
| T28 | 167-174 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T29 | 280-287 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T30 | 417-424 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T31 | 496-504 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T32 | 829-837 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T33 | 897-904 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T28 | 90-98 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T29 | 2059-2061 | Disease | denotes | XP | http://purl.obolibrary.org/obo/MONDO_0019600 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T63 | 104-110 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
| T64 | 211-216 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T65 | 252-257 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T66 | 434-435 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T67 | 1270-1273 | http://purl.obolibrary.org/obo/CLO_0050167 | denotes | LLC |
| T68 | 1285-1287 | http://purl.obolibrary.org/obo/CLO_0009877 | denotes | NY |
| T69 | 1494-1499 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T70 | 1801-1804 | http://purl.obolibrary.org/obo/CLO_0050167 | denotes | LLC |
| T71 | 1816-1818 | http://purl.obolibrary.org/obo/CLO_0009877 | denotes | NY |
| T72 | 1973-1976 | http://purl.obolibrary.org/obo/CLO_0050167 | denotes | LLC |
| T73 | 1988-1990 | http://purl.obolibrary.org/obo/CLO_0009877 | denotes | NY |
| T74 | 2146-2149 | http://purl.obolibrary.org/obo/CLO_0050167 | denotes | LLC |
| T75 | 2161-2163 | http://purl.obolibrary.org/obo/CLO_0009877 | denotes | NY |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T41 | 112-119 | Chemical | denotes | Protein | http://purl.obolibrary.org/obo/CHEBI_16541 |
| T42 | 167-174 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T43 | 280-287 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T44 | 417-424 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T45 | 496-504 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T46 | 829-837 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T47 | 897-904 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T48 | 1108-1115 | Chemical | denotes | ligands | http://purl.obolibrary.org/obo/CHEBI_52214 |
| T49 | 1285-1287 | Chemical | denotes | NY | http://purl.obolibrary.org/obo/CHEBI_73427 |
| T50 | 1816-1818 | Chemical | denotes | NY | http://purl.obolibrary.org/obo/CHEBI_73427 |
| T51 | 1869-1876 | Chemical | denotes | ligands | http://purl.obolibrary.org/obo/CHEBI_52214 |
| T52 | 1988-1990 | Chemical | denotes | NY | http://purl.obolibrary.org/obo/CHEBI_73427 |
| T53 | 2161-2163 | Chemical | denotes | NY | http://purl.obolibrary.org/obo/CHEBI_73427 |
| T54 | 2231-2237 | Chemical | denotes | ligand | http://purl.obolibrary.org/obo/CHEBI_52214 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T12 | 1338-1348 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | Metabolism |
| T13 | 1353-1362 | http://purl.obolibrary.org/obo/GO_0007588 | denotes | Excretion |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T49 | 0-7 | Sentence | denotes | Methods |
| T50 | 9-48 | Sentence | denotes | ACE2 interaction network and hypothesis |
| T51 | 49-111 | Sentence | denotes | ACE2 is the proposed attachment site for SARS-CoV-2 in humans. |
| T52 | 112-265 | Sentence | denotes | Protein interaction studies were conducted around this protein to understand how the attachment of virus with ACE2 affects the pathology in human system. |
| T53 | 266-425 | Sentence | denotes | Computational protein-interaction analysis provides the knowledge about the indirect and probable interactions which might be occurring with the query protein. |
| T54 | 426-527 | Sentence | denotes | This is a very useful approach for predicting the new interactions of proteins in the in-vivo system. |
| T55 | 528-611 | Sentence | denotes | Cytoscape v3.7.2 (Shannon et al., 2003) was used to design the interaction network. |
| T56 | 612-733 | Sentence | denotes | BiNGO plugin was used for the analysis and prediction of overrepresented pathways in master network (Maere et al., 2005). |
| T57 | 734-850 | Sentence | denotes | Overrepresented pathways are the set of pathways which are collectively taken-up by the set of proteins under study. |
| T58 | 851-918 | Sentence | denotes | This helps in understanding the final fate of protein-interactions. |
| T59 | 920-965 | Sentence | denotes | Pharmaco-networking of N. sativa constituents |
| T60 | 966-1041 | Sentence | denotes | Literature mining was done to find the different constituents of N. sativa. |
| T61 | 1042-1148 | Sentence | denotes | Their PubChem IDs (Kim, et al.) were retrieved, and constituents (ligands) were downloaded in .SDF format. |
| T62 | 1149-1247 | Sentence | denotes | QikProp v6.3 (rel 13) was used to perform computational ADME analysis (Schrödinger Release 2020-1: |
| T63 | 1248-1295 | Sentence | denotes | QikProp, Schrödinger, LLC, New York, NY, 2020). |
| T64 | 1296-1363 | Sentence | denotes | ADME stands for Absorption, Distribution, Metabolism and Excretion. |
| T65 | 1364-1426 | Sentence | denotes | It was performed to predict the druggability of the compounds. |
| T66 | 1427-1568 | Sentence | denotes | Further, receptors were predicted for constituents of N. sativa in human system by using Swiss target prediction tool (Gfeller et al., 2014). |
| T67 | 1569-1665 | Sentence | denotes | These receptors were additionally used to analyse their mode of action via interaction analysis. |
| T68 | 1667-1682 | Sentence | denotes | Docking studies |
| T69 | 1683-1778 | Sentence | denotes | ACE2 was downloaded from PDB database in Maestro v12.3 environment (Schrödinger Release 2020-1: |
| T70 | 1779-1860 | Sentence | denotes | Maestro, Schrödinger, LLC, New York, NY, 2020) and prepared for docking analysis. |
| T71 | 1861-1950 | Sentence | denotes | All the ligands of N. sativa were processed by using LigPrep (Schrödinger Release 2020-1: |
| T72 | 1951-2041 | Sentence | denotes | LigPrep, Schrödinger, LLC, New York, NY, 2020) to generate all the possible stereoisomers. |
| T73 | 2042-2125 | Sentence | denotes | Extra-Precision (XP) docking was performed using Glide (Schrödinger Release 2020-1: |
| T74 | 2126-2171 | Sentence | denotes | Glide, Schrödinger, LLC, New York, NY, 2020). |
| T75 | 2172-2283 | Sentence | denotes | Docking analysis was performed to analyse the best binding ligand from N. sativa constituents to ACE2 receptor. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 181 | 9-13 | Gene | denotes | ACE2 | Gene:59272 |
| 187 | 49-53 | Gene | denotes | ACE2 | Gene:59272 |
| 188 | 222-226 | Gene | denotes | ACE2 | Gene:59272 |
| 189 | 90-100 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 190 | 104-110 | Species | denotes | humans | Tax:9606 |
| 191 | 252-257 | Species | denotes | human | Tax:9606 |
| 193 | 943-952 | Species | denotes | N. sativa | Tax:555479 |
| 198 | 1031-1040 | Species | denotes | N. sativa | Tax:555479 |
| 199 | 1481-1490 | Species | denotes | N. sativa | Tax:555479 |
| 200 | 1494-1499 | Species | denotes | human | Tax:9606 |
| 201 | 1296-1300 | Chemical | denotes | ADME | |
| 206 | 1683-1687 | Gene | denotes | ACE2 | Gene:59272 |
| 207 | 2269-2273 | Gene | denotes | ACE2 | Gene:59272 |
| 208 | 1880-1889 | Species | denotes | N. sativa | Tax:555479 |
| 209 | 2243-2252 | Species | denotes | N. sativa | Tax:555479 |