PMC:7605643 / 37779-38142 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T196","span":{"begin":242,"end":249},"obj":"Body_part"}],"attributes":[{"id":"A196","pred":"fma_id","subj":"T196","obj":"http://purl.org/sig/ont/fma/fma9637"}],"text":"HIF1A activators may be used for relieving the symptoms of SARS-CoV-2 as it is responsible for the upregulation of glycolytic genes like phosphoglycerate kinase (PGK) and lactate dehydrogenase A (LDHA) under hypoxic conditions which help the tissues to adapt to oxygen deprived conditions and resort to anaerobic ATP formation (Hu et al., 2003; Lee et al., 2019)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T133","span":{"begin":59,"end":67},"obj":"Disease"}],"attributes":[{"id":"A133","pred":"mondo_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"HIF1A activators may be used for relieving the symptoms of SARS-CoV-2 as it is responsible for the upregulation of glycolytic genes like phosphoglycerate kinase (PGK) and lactate dehydrogenase A (LDHA) under hypoxic conditions which help the tissues to adapt to oxygen deprived conditions and resort to anaerobic ATP formation (Hu et al., 2003; Lee et al., 2019)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T423","span":{"begin":6,"end":16},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T424","span":{"begin":126,"end":131},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T425","span":{"begin":193,"end":194},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"HIF1A activators may be used for relieving the symptoms of SARS-CoV-2 as it is responsible for the upregulation of glycolytic genes like phosphoglycerate kinase (PGK) and lactate dehydrogenase A (LDHA) under hypoxic conditions which help the tissues to adapt to oxygen deprived conditions and resort to anaerobic ATP formation (Hu et al., 2003; Lee et al., 2019)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T359","span":{"begin":137,"end":153},"obj":"Chemical"},{"id":"T360","span":{"begin":171,"end":178},"obj":"Chemical"},{"id":"T361","span":{"begin":262,"end":268},"obj":"Chemical"},{"id":"T362","span":{"begin":313,"end":316},"obj":"Chemical"}],"attributes":[{"id":"A359","pred":"chebi_id","subj":"T359","obj":"http://purl.obolibrary.org/obo/CHEBI_61304"},{"id":"A360","pred":"chebi_id","subj":"T360","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A361","pred":"chebi_id","subj":"T361","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A362","pred":"chebi_id","subj":"T362","obj":"http://purl.obolibrary.org/obo/CHEBI_15422"},{"id":"A363","pred":"chebi_id","subj":"T362","obj":"http://purl.obolibrary.org/obo/CHEBI_30616"}],"text":"HIF1A activators may be used for relieving the symptoms of SARS-CoV-2 as it is responsible for the upregulation of glycolytic genes like phosphoglycerate kinase (PGK) and lactate dehydrogenase A (LDHA) under hypoxic conditions which help the tissues to adapt to oxygen deprived conditions and resort to anaerobic ATP formation (Hu et al., 2003; Lee et al., 2019)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T548","span":{"begin":313,"end":326},"obj":"http://purl.obolibrary.org/obo/GO_0006754"},{"id":"T549","span":{"begin":317,"end":326},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"HIF1A activators may be used for relieving the symptoms of SARS-CoV-2 as it is responsible for the upregulation of glycolytic genes like phosphoglycerate kinase (PGK) and lactate dehydrogenase A (LDHA) under hypoxic conditions which help the tissues to adapt to oxygen deprived conditions and resort to anaerobic ATP formation (Hu et al., 2003; Lee et al., 2019)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T217","span":{"begin":0,"end":363},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"HIF1A activators may be used for relieving the symptoms of SARS-CoV-2 as it is responsible for the upregulation of glycolytic genes like phosphoglycerate kinase (PGK) and lactate dehydrogenase A (LDHA) under hypoxic conditions which help the tissues to adapt to oxygen deprived conditions and resort to anaerobic ATP formation (Hu et al., 2003; Lee et al., 2019)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"852","span":{"begin":0,"end":5},"obj":"Gene"},{"id":"853","span":{"begin":171,"end":194},"obj":"Gene"},{"id":"854","span":{"begin":196,"end":200},"obj":"Gene"},{"id":"864","span":{"begin":59,"end":69},"obj":"Species"},{"id":"873","span":{"begin":262,"end":268},"obj":"Chemical"},{"id":"874","span":{"begin":313,"end":316},"obj":"Chemical"}],"attributes":[{"id":"A852","pred":"tao:has_database_id","subj":"852","obj":"Gene:3091"},{"id":"A853","pred":"tao:has_database_id","subj":"853","obj":"Gene:3939"},{"id":"A854","pred":"tao:has_database_id","subj":"854","obj":"Gene:3939"},{"id":"A864","pred":"tao:has_database_id","subj":"864","obj":"Tax:2697049"},{"id":"A873","pred":"tao:has_database_id","subj":"873","obj":"MESH:D010100"},{"id":"A874","pred":"tao:has_database_id","subj":"874","obj":"MESH:D000255"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"HIF1A activators may be used for relieving the symptoms of SARS-CoV-2 as it is responsible for the upregulation of glycolytic genes like phosphoglycerate kinase (PGK) and lactate dehydrogenase A (LDHA) under hypoxic conditions which help the tissues to adapt to oxygen deprived conditions and resort to anaerobic ATP formation (Hu et al., 2003; Lee et al., 2019)."}