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PMC:7605643 / 278-2032 JSONTXT

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LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1078-1102 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T2 1104-1110 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T3 1136-1141 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T4 1155-1167 Body_part denotes blood vessel http://purl.obolibrary.org/obo/UBERON_0001981
T5 1155-1160 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T6 1161-1167 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T7 1576-1589 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 794-801 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T2 1104-1110 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T3 1136-1141 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T4 1155-1167 Body_part denotes blood vessel http://purl.org/sig/ont/fma/fma63183
T5 1442-1451 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T6 1576-1589 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T4 0-8 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 370-378 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 405-413 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 506-514 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 700-704 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T9 711-720 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T10 1051-1055 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T11 1537-1549 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T12 1708-1716 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T2 652-657 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T3 724-730 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T4 1104-1110 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T5 1104-1110 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T6 1104-1110 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T7 1136-1141 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T8 1136-1141 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T9 1155-1167 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessel
T10 1155-1167 http://www.ebi.ac.uk/efo/EFO_0000817 denotes blood vessel
T11 1464-1473 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T12 1576-1589 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T13 1733-1734 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 234-243 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T2 245-261 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T3 598-609 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T4 610-612 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T5 794-801 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T6 1084-1095 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T7 1425-1427 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T9 1432-1435 Chemical denotes AGE http://purl.obolibrary.org/obo/CHEBI_84123
T10 1456-1463 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 1122-1153 http://purl.obolibrary.org/obo/GO_1903522 denotes regulation of blood circulation
T2 1122-1132 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T3 1136-1153 http://purl.obolibrary.org/obo/GO_0008015 denotes blood circulation
T4 1456-1473 http://purl.obolibrary.org/obo/GO_0019722 denotes calcium signaling
T5 1464-1473 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6 1537-1549 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T7 0-193 Sentence denotes COVID-19, emerged at the end of 2019 have dramatically threatened the health, economy, and social mobility of people around the world and till date no medication is available for its treatment.
T8 194-414 Sentence denotes An amazing herb, Nigella sativa, having antiviral, antihypertensive, anti- diarrhoeal, analgesics, and anti-bacterial properties, needs to be explored for its efficacy against SARS-CoV-2, the causative agent of COVID-19.
T9 415-540 Sentence denotes In-silico studies were carried out to understand the role of its bioactive constituents in COVID-19 treatment and prevention.
T10 541-658 Sentence denotes Firstly, the disease network was prepared by using ACE2 (Angiotensin-II receptor), as it is the entry site for virus.
T11 659-731 Sentence denotes It was used to decipher the mechanism of SARS-COV-2 infection in humans.
T12 732-837 Sentence denotes Second, the target receptors for N. sativa were predicted and protein interaction studies were conducted.
T13 838-927 Sentence denotes Further, docking studies were also performed to analyse it for treatment purpose as well.
T14 928-1182 Sentence denotes This study concludes that pathways undertaken by N. sativa bioactive constituents were similar to the pathways followed in SARS-COV-2 pathology, like renin-angiotensin system, kidney functions, regulation of blood circulation, blood vessel diameter, etc.
T15 1183-1334 Sentence denotes Also, in docking studies, the constituents of N. sativa, α-hederin, Thymohydroquinone and Thymoquinone were observed to be efficiently binding to ACE2.
T16 1335-1611 Sentence denotes Also, the bioactive phytoconstituents are involved in molecular pathways like HIF1, VEGF, IL-17, AGE-RAGE, chemokine and calcium signaling pathways which can be majorly helpful in combating hypoxia and inflammation caused due to compromised immune system and oxidative stress.
T17 1612-1754 Sentence denotes Therefore, N. sativa standardized extract having the above phytoconstituents could be useful in COVID-19 and hence opens a new treatment line.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1525-1532 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T2 1594-1610 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
32 592-596 Gene denotes ACE2 Gene:59272
33 1078-1083 Gene denotes renin Gene:5972
34 1329-1333 Gene denotes ACE2 Gene:59272
35 1419-1423 Gene denotes VEGF Gene:83785
36 110-116 Species denotes people Tax:9606
37 370-380 Species denotes SARS-CoV-2 Tax:2697049
38 724-730 Species denotes humans Tax:9606
39 765-774 Species denotes N. sativa Tax:555479
40 977-986 Species denotes N. sativa Tax:555479
41 1051-1061 Species denotes SARS-COV-2 Tax:2697049
42 1229-1238 Species denotes N. sativa Tax:555479
43 1623-1632 Species denotes N. sativa Tax:555479
44 211-218 Species denotes Nigella Tax:555479
45 1240-1249 Chemical denotes α-hederin MESH:C010177
46 1251-1268 Chemical denotes Thymohydroquinone MESH:C003465
47 1273-1285 Chemical denotes Thymoquinone MESH:C003466
48 1456-1463 Chemical denotes calcium MESH:D002118
49 0-8 Disease denotes COVID-19 MESH:C000657245
50 405-413 Disease denotes COVID-19 MESH:C000657245
51 506-514 Disease denotes COVID-19 MESH:C000657245
52 700-720 Disease denotes SARS-COV-2 infection MESH:C000657245
53 1525-1532 Disease denotes hypoxia MESH:D000860
54 1537-1549 Disease denotes inflammation MESH:D007249
55 1708-1716 Disease denotes COVID-19 MESH:C000657245