PMC:7605643 / 20568-28625 JSONTXT

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T38","span":{"begin":5938,"end":5953},"obj":"Body_part"},{"id":"T39","span":{"begin":6693,"end":6718},"obj":"Body_part"},{"id":"T40","span":{"begin":7937,"end":7942},"obj":"Body_part"}],"attributes":[{"id":"A38","pred":"uberon_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/UBERON_0004134"},{"id":"A39","pred":"uberon_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/UBERON_0018229"},{"id":"A40","pred":"uberon_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"PubChem ID Compound Name Hub Nodes Pathways targeted\n121304016 Remdesivir CDK2, SRC, AURKA, ABL1, CDK1, MAPK1, MAPK14, TOP1, MTOR, CASP8, AURKB, CCNB1, PRKCA, PTK2, CDK5, SYK, MET, IGF1R, CASP3, PDGFRB, EIF4A1, PIK3CA, MAP3K5, CDK2, SRC Pathways in cancer, Relaxin signaling pathway, PI3K-Akt signaling pathway, Endocrine resistance, Phospholipase D signaling pathway, AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, MAPK pathway,Platelet activation, Chemokine signaling pathway, mTOR signaling pathway,FoxO signaling pathway,EGFR tyrosine kinase inhibitor resistance.\n6654 Alpha-pinene ESR1, AR, MAPK1, PTPN11, MAPK14, PTPN1, RARA, RXRA, NR3C1, PPARG, PTPN6, MAPK3, TOP1, ESR2, CDC25A, CD81, NCOA1, NOS2, TERT Th17 cell differentiation, VEGF signaling pathway, cAMP signaling pathway, Type 2 diabetes, Fat digestion and absorption, Neuroactive ligand-receptor interaction, Calcium signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, HIF-1 signaling pathway, IL-17 signaling pathway, Ras signaling pathway, Pathways in cancer\n7463 P-Cymene ESR1, HDAC1, AR, KDM1A, GSK3B, ESR2, ALB, KIF11, IGF1R, HTR3A, HTR2C, ALOX5, SHBG, CHRM3, AHR, PPARA Amphetamine addiction, Neuroactive ligand-receptor interaction, Calcium signaling pathway, Cocaine addiction, Alcoholism, Regulation of lipolysis in adipocytes, AGE-RAGE signaling pathway in diabetic complications, Inflammatory mediator regulation of TRP channels, c-GMP PkGsignaling pathway, NF-Κbsignaling pathway, IL-17 signaling pathway, cAMP signaling pathway\n10281 Thymoquinone GSK3B, PLK1, PARP1, PABPC1, NR3C1, MTNR1A, PTPN1, SOAT1, MTNR1B, XIAP, BRD4, PPARG, TOP2A, SYK, MAP2K1, IMPDH2, PTPN2, PGR, GLI1, MCL1, ALOX5 Neuroactive ligand-receptor interaction, Calcium signaling pathway, c-GMP PkGsignaling pathway, Alcoholism, Apoptosis, cAMP signaling pathway, lysosome, Influenza A, PI3K-AkT TNF signaling pathway, Pathways in cancer, NF-Κbsignaling pathway\n10364 Carvacrol ESR1, CDK2, HDAC1, AR, AURKA, AKT1, HDAC6, HDAC3, ADRB2, GAPDH, ESR2, ALB, MAPK8, CLK1,LDHA, PRKCA, LDHB, HDAC11, CCNA2, MAPK9, IGF1R Neuroactive ligand-receptor interaction, MAPK signaling pathway, Calcium signaling pathway, Relaxinsignaling pathway, Pathways in cancer, Alcoholism, PI3K-AkT TNF signaling pathway, Ras signaling pathway, Th17 cell differentiation, Influenza, Regulation of lipolysis in adipocytes, Endocrine and other factor- regulated calcium reabsorption, Adrenergic signaling in cardiomyocytes, Amphetamine addiction, VEGF signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Apoptosis, c-GMP PkGsignaling pathway, FOXO signaling pathway, Cocaine addiction\n11230 Terpinen-4-ol MAPK8, AR, JAK1, ESR1, JAK2, PTPN6, NR3C1, MAPK10, PPARA, PPARG, PTPN1, CHRM2, HTR2C, ESR2, CHRM4, HTR2A, DRD2, OPRK1, OPRD1, PGR, OPRM1, PARP1, MTNR1A Neuroactive ligand-receptor interaction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Th17 cell differentiation, Pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, cAMP signaling pathway, Tuberculosis, AMPK signaling pathway, Influenza, c-GMP PkGsignaling pathway, JAK-STAT pathway, Circadian rhythm, Relaxinsignaling pathway, Apoptosis- multiple species\n73296 alpha-Hederin GRB2, ITGA4, PPP1CA, SRC, AR, AURKA, PPP2CA, STAT3, CDK1, LGALS3, PTPN1, CASP8, XIAP, NCSTN, ATP1A1, ITGB1, PRKCD, IGF1R, CASP3, LGALS8, BCL2L1, MME, PSEN1, IMPDH2, HTR2C, IMPDH1, GLI1, HLA-A, ITGAV, ITGB3, PTPRA Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Rennin- angiotensin system, c-GMP PkGsignaling pathway, Pathways in cancer, PI3K-AkT TNF signaling pathway, Apoptosis, Autophagy, Complement and coagulation cascades, P53 signaling pathway, T-cell receptor signaling pathway, NF-Κbsignaling pathway, JAK-STAT pathway, Alcoholism, Chemokine signaling pathway, Tuberculosis, HIF-1 signaling pathway, MAPK signaling pathway\n95779 Thymohydroquinone HSP90AA1, HDAC1, AURKA, AKT1, PARP1, ERBB2, ABL1, HDAC6, CDK1, HDAC3, ADRB2, GAPDH, MTNR1A, MAPK14, ALB, PTPN1, MTNR1B, PRKCA, LDHA, NOS2, LDHB, BRAF Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, MAPK signaling pathway, Regulation of lipolysis in adipocytes, Oxytocin , Alcoholism, mTOR signaling pathway, PI3K-AkT TNF signaling pathway, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, VEGF signaling pathway, HIF-1 signaling pathway, Pathways in cancer, Natural killer cell mediated cytotoxicity, Tuberculosis, Colorectal cancer, Influenza A, Apoptosis, Amphetamine addiction, TNF signaling pathway, Hepatocellular carcinoma\n398941 Dithymoquinone HSP90AA1, SRC, AR, PRKDC, STAT3, NR3C1, MTNR1A, GAPDH, ESR2, ATM, MAPK8, TGFBR1, PTPN11, MTNR1B, EZR, NOS2, NCSTN, BRAF, CAPN1, PSEN1, CDC25A, PGR, PTK2B, ALOX5, PSEN2, OPRM1 Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, GABAergic synapse, Fluid shear stress and atherosclerosis, Apoptosis, Antigen processing and presentation, Chemokine signaling pathway, Morphine addiction, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, Cocaine addiction, Th17 cell differentiation, IL-17 signaling pathway, Alcoholism, c-GMP PkGsignaling pathway, Tuberculosis, Amphetamine addiction, Natural killer cell mediated cytotoxicity, TNF signaling pathway\n637563 trans-Anethole APP, EGF, RXPO1, ESR1 LRRK2 AR AURKA, RELA, PARP1, PRKDC, TUBB3, STAT3 MAPK14 KAT2B, PRKCA, NOS2, CDK5 KIF11, MAPT, JAK1, JAK2, CDC25B, TYK2 Nitrogen metabolism, Calcium signaling pathway, Primary immunodeficiency, TNF signaling pathway, T-cell receptor signaling pathway, Proximal tubule bicarbonate reclamation, Morphine addiction, IL-17 signaling pathway, NF-Κbsignaling pathway, Tuberculosis, VEGF signaling pathway, PI3K-AkT TNF signaling pathway, JAK-STAT pathway, Cocaine addiction, HIF-1 signaling pathway, Th17 cell differentiation, Pathways in cancer, Viral carcinogenesis\n11402337 Nigellicine HDAC1, EP300, AR, PPP1CA, CSNK2A1, RPA1, MAPK1, HDAC6, HSPA1A, CSNK2A2, MAP2K1, MCL1, TP53, NR4A1, ICAM1, TERT, EPRS, SORT1, FEN1, PGR Neuroactive ligand-receptor interaction, cAMP signaling pathway, Nitrogen metabolism, Apoptosis, Lysosome, TNF signaling pathway, NF-Κbsignaling pathway, Influenza A, Autophagy, Alcoholism, Rheumatoid arthritis, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, Renin- angiotensin system, FOXO signaling pathway, Transcriptional misregulation in cancer, c-GMP PkGsignaling pathway, Oxytocin signaling pathway, Viral carcinogenesis, Nitrogen metabolism\n136828302 Nigellidine ESR1, CDK2, VCP, AKT1, ERBB2, HTT, GSK3B, RAF1, PLK1, CDK1, CFTR, KIT, MTNR1A, ILK, PPARG, CCNA2, CCNB1, MTNR1B, PDGFRB, CCNE1, PRKACA, FGFR1, CDK5, PSEN1, OPRM1 Pathways in cancer, Neuroactive ligand-receptor interaction, Calcium signaling pathway, MAPK signaling pathway, Chemokine signaling pathway, c-GMP PkGsignaling pathway, Ras signaling pathway, HIF-1 signaling pathway, VEGF signaling pathway, Arachidonic acid metabolism, Autophagy, Apoptosis, FOXO signaling pathway, Tuberculosis, AGE-RAGE signaling pathway in diabetic complications, Morphine addiction, Cocaine addiction, T-cell receptor signaling pathway\n1796220 Longifolene ESR1, AR, ESR2, PTPN1, UBA2, NR1H3, SAE1, SHBG, PPARA, POLB, NR1I3, NR1H4, BCHE, AKR1B10, HSD11B1, SLC6A4, NCOA3, EP300, NCOA1, ACTB, ACHE, MED1, NCOR1 Steroid hormone mediated signaling pathway, response to oxygen- containing compound, lipid metabolic process, regulation of inflammatory response, regulation of cytokine mediated signaling pathway, regulation of innate immune process, blood circulation, regulation of insulin receptor signaling pathway, regulation of toll- like receptor signaling pathway"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T116","span":{"begin":516,"end":524},"obj":"Body_part"},{"id":"T117","span":{"begin":537,"end":546},"obj":"Body_part"},{"id":"T118","span":{"begin":617,"end":625},"obj":"Body_part"},{"id":"T119","span":{"begin":805,"end":809},"obj":"Body_part"},{"id":"T120","span":{"begin":1410,"end":1420},"obj":"Body_part"},{"id":"T121","span":{"begin":1933,"end":1941},"obj":"Body_part"},{"id":"T122","span":{"begin":2394,"end":2398},"obj":"Body_part"},{"id":"T123","span":{"begin":2454,"end":2464},"obj":"Body_part"},{"id":"T124","span":{"begin":2550,"end":2564},"obj":"Body_part"},{"id":"T125","span":{"begin":3053,"end":3057},"obj":"Body_part"},{"id":"T126","span":{"begin":3548,"end":3551},"obj":"Body_part"},{"id":"T127","span":{"begin":3890,"end":3894},"obj":"Body_part"},{"id":"T128","span":{"begin":3977,"end":3986},"obj":"Body_part"},{"id":"T129","span":{"begin":4444,"end":4454},"obj":"Body_part"},{"id":"T130","span":{"begin":4456,"end":4464},"obj":"Body_part"},{"id":"T131","span":{"begin":4678,"end":4697},"obj":"Body_part"},{"id":"T132","span":{"begin":4693,"end":4697},"obj":"Body_part"},{"id":"T133","span":{"begin":5207,"end":5214},"obj":"Body_part"},{"id":"T134","span":{"begin":5304,"end":5313},"obj":"Body_part"},{"id":"T135","span":{"begin":5451,"end":5455},"obj":"Body_part"},{"id":"T136","span":{"begin":5575,"end":5594},"obj":"Body_part"},{"id":"T137","span":{"begin":5590,"end":5594},"obj":"Body_part"},{"id":"T138","span":{"begin":5905,"end":5909},"obj":"Body_part"},{"id":"T139","span":{"begin":6185,"end":6189},"obj":"Body_part"},{"id":"T140","span":{"begin":6504,"end":6512},"obj":"Body_part"},{"id":"T141","span":{"begin":6813,"end":6821},"obj":"Body_part"},{"id":"T142","span":{"begin":7182,"end":7191},"obj":"Body_part"},{"id":"T143","span":{"begin":7495,"end":7499},"obj":"Body_part"},{"id":"T144","span":{"begin":7702,"end":7717},"obj":"Body_part"},{"id":"T145","span":{"begin":7787,"end":7792},"obj":"Body_part"},{"id":"T146","span":{"begin":7863,"end":7871},"obj":"Body_part"},{"id":"T147","span":{"begin":7937,"end":7942},"obj":"Body_part"},{"id":"T148","span":{"begin":7970,"end":7977},"obj":"Body_part"}],"attributes":[{"id":"A116","pred":"fma_id","subj":"T116","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A117","pred":"fma_id","subj":"T117","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A118","pred":"fma_id","subj":"T118","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A119","pred":"fma_id","subj":"T119","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A120","pred":"fma_id","subj":"T120","obj":"http://purl.org/sig/ont/fma/fma63880"},{"id":"A121","pred":"fma_id","subj":"T121","obj":"http://purl.org/sig/ont/fma/fma63836"},{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A123","pred":"fma_id","subj":"T123","obj":"http://purl.org/sig/ont/fma/fma63880"},{"id":"A124","pred":"fma_id","subj":"T124","obj":"http://purl.org/sig/ont/fma/fma14067"},{"id":"A125","pred":"fma_id","subj":"T125","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A126","pred":"fma_id","subj":"T126","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A127","pred":"fma_id","subj":"T127","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A128","pred":"fma_id","subj":"T128","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A129","pred":"fma_id","subj":"T129","obj":"http://purl.org/sig/ont/fma/fma63880"},{"id":"A130","pred":"fma_id","subj":"T130","obj":"http://purl.org/sig/ont/fma/fma74647"},{"id":"A131","pred":"fma_id","subj":"T131","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A132","pred":"fma_id","subj":"T132","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A133","pred":"fma_id","subj":"T133","obj":"http://purl.org/sig/ont/fma/fma67408"},{"id":"A134","pred":"fma_id","subj":"T134","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A135","pred":"fma_id","subj":"T135","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A136","pred":"fma_id","subj":"T136","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A137","pred":"fma_id","subj":"T137","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A138","pred":"fma_id","subj":"T138","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A139","pred":"fma_id","subj":"T139","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A140","pred":"fma_id","subj":"T140","obj":"http://purl.org/sig/ont/fma/fma63836"},{"id":"A141","pred":"fma_id","subj":"T141","obj":"http://purl.org/sig/ont/fma/fma74647"},{"id":"A142","pred":"fma_id","subj":"T142","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A143","pred":"fma_id","subj":"T143","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A144","pred":"fma_id","subj":"T144","obj":"http://purl.org/sig/ont/fma/fma83353"},{"id":"A145","pred":"fma_id","subj":"T145","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A146","pred":"fma_id","subj":"T146","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A147","pred":"fma_id","subj":"T147","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A148","pred":"fma_id","subj":"T148","obj":"http://purl.org/sig/ont/fma/fma83365"}],"text":"PubChem ID Compound Name Hub Nodes Pathways targeted\n121304016 Remdesivir CDK2, SRC, AURKA, ABL1, CDK1, MAPK1, MAPK14, TOP1, MTOR, CASP8, AURKB, CCNB1, PRKCA, PTK2, CDK5, SYK, MET, IGF1R, CASP3, PDGFRB, EIF4A1, PIK3CA, MAP3K5, CDK2, SRC Pathways in cancer, Relaxin signaling pathway, PI3K-Akt signaling pathway, Endocrine resistance, Phospholipase D signaling pathway, AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, MAPK pathway,Platelet activation, Chemokine signaling pathway, mTOR signaling pathway,FoxO signaling pathway,EGFR tyrosine kinase inhibitor resistance.\n6654 Alpha-pinene ESR1, AR, MAPK1, PTPN11, MAPK14, PTPN1, RARA, RXRA, NR3C1, PPARG, PTPN6, MAPK3, TOP1, ESR2, CDC25A, CD81, NCOA1, NOS2, TERT Th17 cell differentiation, VEGF signaling pathway, cAMP signaling pathway, Type 2 diabetes, Fat digestion and absorption, Neuroactive ligand-receptor interaction, Calcium signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, HIF-1 signaling pathway, IL-17 signaling pathway, Ras signaling pathway, Pathways in cancer\n7463 P-Cymene ESR1, HDAC1, AR, KDM1A, GSK3B, ESR2, ALB, KIF11, IGF1R, HTR3A, HTR2C, ALOX5, SHBG, CHRM3, AHR, PPARA Amphetamine addiction, Neuroactive ligand-receptor interaction, Calcium signaling pathway, Cocaine addiction, Alcoholism, Regulation of lipolysis in adipocytes, AGE-RAGE signaling pathway in diabetic complications, Inflammatory mediator regulation of TRP channels, c-GMP PkGsignaling pathway, NF-Κbsignaling pathway, IL-17 signaling pathway, cAMP signaling pathway\n10281 Thymoquinone GSK3B, PLK1, PARP1, PABPC1, NR3C1, MTNR1A, PTPN1, SOAT1, MTNR1B, XIAP, BRD4, PPARG, TOP2A, SYK, MAP2K1, IMPDH2, PTPN2, PGR, GLI1, MCL1, ALOX5 Neuroactive ligand-receptor interaction, Calcium signaling pathway, c-GMP PkGsignaling pathway, Alcoholism, Apoptosis, cAMP signaling pathway, lysosome, Influenza A, PI3K-AkT TNF signaling pathway, Pathways in cancer, NF-Κbsignaling pathway\n10364 Carvacrol ESR1, CDK2, HDAC1, AR, AURKA, AKT1, HDAC6, HDAC3, ADRB2, GAPDH, ESR2, ALB, MAPK8, CLK1,LDHA, PRKCA, LDHB, HDAC11, CCNA2, MAPK9, IGF1R Neuroactive ligand-receptor interaction, MAPK signaling pathway, Calcium signaling pathway, Relaxinsignaling pathway, Pathways in cancer, Alcoholism, PI3K-AkT TNF signaling pathway, Ras signaling pathway, Th17 cell differentiation, Influenza, Regulation of lipolysis in adipocytes, Endocrine and other factor- regulated calcium reabsorption, Adrenergic signaling in cardiomyocytes, Amphetamine addiction, VEGF signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Apoptosis, c-GMP PkGsignaling pathway, FOXO signaling pathway, Cocaine addiction\n11230 Terpinen-4-ol MAPK8, AR, JAK1, ESR1, JAK2, PTPN6, NR3C1, MAPK10, PPARA, PPARG, PTPN1, CHRM2, HTR2C, ESR2, CHRM4, HTR2A, DRD2, OPRK1, OPRD1, PGR, OPRM1, PARP1, MTNR1A Neuroactive ligand-receptor interaction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Th17 cell differentiation, Pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, cAMP signaling pathway, Tuberculosis, AMPK signaling pathway, Influenza, c-GMP PkGsignaling pathway, JAK-STAT pathway, Circadian rhythm, Relaxinsignaling pathway, Apoptosis- multiple species\n73296 alpha-Hederin GRB2, ITGA4, PPP1CA, SRC, AR, AURKA, PPP2CA, STAT3, CDK1, LGALS3, PTPN1, CASP8, XIAP, NCSTN, ATP1A1, ITGB1, PRKCD, IGF1R, CASP3, LGALS8, BCL2L1, MME, PSEN1, IMPDH2, HTR2C, IMPDH1, GLI1, HLA-A, ITGAV, ITGB3, PTPRA Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Rennin- angiotensin system, c-GMP PkGsignaling pathway, Pathways in cancer, PI3K-AkT TNF signaling pathway, Apoptosis, Autophagy, Complement and coagulation cascades, P53 signaling pathway, T-cell receptor signaling pathway, NF-Κbsignaling pathway, JAK-STAT pathway, Alcoholism, Chemokine signaling pathway, Tuberculosis, HIF-1 signaling pathway, MAPK signaling pathway\n95779 Thymohydroquinone HSP90AA1, HDAC1, AURKA, AKT1, PARP1, ERBB2, ABL1, HDAC6, CDK1, HDAC3, ADRB2, GAPDH, MTNR1A, MAPK14, ALB, PTPN1, MTNR1B, PRKCA, LDHA, NOS2, LDHB, BRAF Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, MAPK signaling pathway, Regulation of lipolysis in adipocytes, Oxytocin , Alcoholism, mTOR signaling pathway, PI3K-AkT TNF signaling pathway, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, VEGF signaling pathway, HIF-1 signaling pathway, Pathways in cancer, Natural killer cell mediated cytotoxicity, Tuberculosis, Colorectal cancer, Influenza A, Apoptosis, Amphetamine addiction, TNF signaling pathway, Hepatocellular carcinoma\n398941 Dithymoquinone HSP90AA1, SRC, AR, PRKDC, STAT3, NR3C1, MTNR1A, GAPDH, ESR2, ATM, MAPK8, TGFBR1, PTPN11, MTNR1B, EZR, NOS2, NCSTN, BRAF, CAPN1, PSEN1, CDC25A, PGR, PTK2B, ALOX5, PSEN2, OPRM1 Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, GABAergic synapse, Fluid shear stress and atherosclerosis, Apoptosis, Antigen processing and presentation, Chemokine signaling pathway, Morphine addiction, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, Cocaine addiction, Th17 cell differentiation, IL-17 signaling pathway, Alcoholism, c-GMP PkGsignaling pathway, Tuberculosis, Amphetamine addiction, Natural killer cell mediated cytotoxicity, TNF signaling pathway\n637563 trans-Anethole APP, EGF, RXPO1, ESR1 LRRK2 AR AURKA, RELA, PARP1, PRKDC, TUBB3, STAT3 MAPK14 KAT2B, PRKCA, NOS2, CDK5 KIF11, MAPT, JAK1, JAK2, CDC25B, TYK2 Nitrogen metabolism, Calcium signaling pathway, Primary immunodeficiency, TNF signaling pathway, T-cell receptor signaling pathway, Proximal tubule bicarbonate reclamation, Morphine addiction, IL-17 signaling pathway, NF-Κbsignaling pathway, Tuberculosis, VEGF signaling pathway, PI3K-AkT TNF signaling pathway, JAK-STAT pathway, Cocaine addiction, HIF-1 signaling pathway, Th17 cell differentiation, Pathways in cancer, Viral carcinogenesis\n11402337 Nigellicine HDAC1, EP300, AR, PPP1CA, CSNK2A1, RPA1, MAPK1, HDAC6, HSPA1A, CSNK2A2, MAP2K1, MCL1, TP53, NR4A1, ICAM1, TERT, EPRS, SORT1, FEN1, PGR Neuroactive ligand-receptor interaction, cAMP signaling pathway, Nitrogen metabolism, Apoptosis, Lysosome, TNF signaling pathway, NF-Κbsignaling pathway, Influenza A, Autophagy, Alcoholism, Rheumatoid arthritis, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, Renin- angiotensin system, FOXO signaling pathway, Transcriptional misregulation in cancer, c-GMP PkGsignaling pathway, Oxytocin signaling pathway, Viral carcinogenesis, Nitrogen metabolism\n136828302 Nigellidine ESR1, CDK2, VCP, AKT1, ERBB2, HTT, GSK3B, RAF1, PLK1, CDK1, CFTR, KIT, MTNR1A, ILK, PPARG, CCNA2, CCNB1, MTNR1B, PDGFRB, CCNE1, PRKACA, FGFR1, CDK5, PSEN1, OPRM1 Pathways in cancer, Neuroactive ligand-receptor interaction, Calcium signaling pathway, MAPK signaling pathway, Chemokine signaling pathway, c-GMP PkGsignaling pathway, Ras signaling pathway, HIF-1 signaling pathway, VEGF signaling pathway, Arachidonic acid metabolism, Autophagy, Apoptosis, FOXO signaling pathway, Tuberculosis, AGE-RAGE signaling pathway in diabetic complications, Morphine addiction, Cocaine addiction, T-cell receptor signaling pathway\n1796220 Longifolene ESR1, AR, ESR2, PTPN1, UBA2, NR1H3, SAE1, SHBG, PPARA, POLB, NR1I3, NR1H4, BCHE, AKR1B10, HSD11B1, SLC6A4, NCOA3, EP300, NCOA1, ACTB, ACHE, MED1, NCOR1 Steroid hormone mediated signaling pathway, response to oxygen- containing compound, lipid metabolic process, regulation of inflammatory response, regulation of cytokine mediated signaling pathway, regulation of innate immune process, blood circulation, regulation of insulin receptor signaling pathway, regulation of toll- like receptor signaling pathway"}

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ID Compound Name Hub Nodes Pathways targeted\n121304016 Remdesivir CDK2, SRC, AURKA, ABL1, CDK1, MAPK1, MAPK14, TOP1, MTOR, CASP8, AURKB, CCNB1, PRKCA, PTK2, CDK5, SYK, MET, IGF1R, CASP3, PDGFRB, EIF4A1, PIK3CA, MAP3K5, CDK2, SRC Pathways in cancer, Relaxin signaling pathway, PI3K-Akt signaling pathway, Endocrine resistance, Phospholipase D signaling pathway, AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, MAPK pathway,Platelet activation, Chemokine signaling pathway, mTOR signaling pathway,FoxO signaling pathway,EGFR tyrosine kinase inhibitor resistance.\n6654 Alpha-pinene ESR1, AR, MAPK1, PTPN11, MAPK14, PTPN1, RARA, RXRA, NR3C1, PPARG, PTPN6, MAPK3, TOP1, ESR2, CDC25A, CD81, NCOA1, NOS2, TERT Th17 cell differentiation, VEGF signaling pathway, cAMP signaling pathway, Type 2 diabetes, Fat digestion and absorption, Neuroactive ligand-receptor interaction, Calcium signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, HIF-1 signaling pathway, IL-17 signaling pathway, Ras signaling pathway, Pathways in cancer\n7463 P-Cymene ESR1, HDAC1, AR, KDM1A, GSK3B, ESR2, ALB, KIF11, IGF1R, HTR3A, HTR2C, ALOX5, SHBG, CHRM3, AHR, PPARA Amphetamine addiction, Neuroactive ligand-receptor interaction, Calcium signaling pathway, Cocaine addiction, Alcoholism, Regulation of lipolysis in adipocytes, AGE-RAGE signaling pathway in diabetic complications, Inflammatory mediator regulation of TRP channels, c-GMP PkGsignaling pathway, NF-Κbsignaling pathway, IL-17 signaling pathway, cAMP signaling pathway\n10281 Thymoquinone GSK3B, PLK1, PARP1, PABPC1, NR3C1, MTNR1A, PTPN1, SOAT1, MTNR1B, XIAP, BRD4, PPARG, TOP2A, SYK, MAP2K1, IMPDH2, PTPN2, PGR, GLI1, MCL1, ALOX5 Neuroactive ligand-receptor interaction, Calcium signaling pathway, c-GMP PkGsignaling pathway, Alcoholism, Apoptosis, cAMP signaling pathway, lysosome, Influenza A, PI3K-AkT TNF signaling pathway, Pathways in cancer, NF-Κbsignaling pathway\n10364 Carvacrol ESR1, CDK2, HDAC1, AR, AURKA, AKT1, HDAC6, HDAC3, ADRB2, GAPDH, ESR2, ALB, MAPK8, CLK1,LDHA, PRKCA, LDHB, HDAC11, CCNA2, MAPK9, IGF1R Neuroactive ligand-receptor interaction, MAPK signaling pathway, Calcium signaling pathway, Relaxinsignaling pathway, Pathways in cancer, Alcoholism, PI3K-AkT TNF signaling pathway, Ras signaling pathway, Th17 cell differentiation, Influenza, Regulation of lipolysis in adipocytes, Endocrine and other factor- regulated calcium reabsorption, Adrenergic signaling in cardiomyocytes, Amphetamine addiction, VEGF signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Apoptosis, c-GMP PkGsignaling pathway, FOXO signaling pathway, Cocaine addiction\n11230 Terpinen-4-ol MAPK8, AR, JAK1, ESR1, JAK2, PTPN6, NR3C1, MAPK10, PPARA, PPARG, PTPN1, CHRM2, HTR2C, ESR2, CHRM4, HTR2A, DRD2, OPRK1, OPRD1, PGR, OPRM1, PARP1, MTNR1A Neuroactive ligand-receptor interaction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Th17 cell differentiation, Pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, cAMP signaling pathway, Tuberculosis, AMPK signaling pathway, Influenza, c-GMP PkGsignaling pathway, JAK-STAT pathway, Circadian rhythm, Relaxinsignaling pathway, Apoptosis- multiple species\n73296 alpha-Hederin GRB2, ITGA4, PPP1CA, SRC, AR, AURKA, PPP2CA, STAT3, CDK1, LGALS3, PTPN1, CASP8, XIAP, NCSTN, ATP1A1, ITGB1, PRKCD, IGF1R, CASP3, LGALS8, BCL2L1, MME, PSEN1, IMPDH2, HTR2C, IMPDH1, GLI1, HLA-A, ITGAV, ITGB3, PTPRA Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Rennin- angiotensin system, c-GMP PkGsignaling pathway, Pathways in cancer, PI3K-AkT TNF signaling pathway, Apoptosis, Autophagy, Complement and coagulation cascades, P53 signaling pathway, T-cell receptor signaling pathway, NF-Κbsignaling pathway, JAK-STAT pathway, Alcoholism, Chemokine signaling pathway, Tuberculosis, HIF-1 signaling pathway, MAPK signaling pathway\n95779 Thymohydroquinone HSP90AA1, HDAC1, AURKA, AKT1, PARP1, ERBB2, ABL1, HDAC6, CDK1, HDAC3, ADRB2, GAPDH, MTNR1A, MAPK14, ALB, PTPN1, MTNR1B, PRKCA, LDHA, NOS2, LDHB, BRAF Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, MAPK signaling pathway, Regulation of lipolysis in adipocytes, Oxytocin , Alcoholism, mTOR signaling pathway, PI3K-AkT TNF signaling pathway, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, VEGF signaling pathway, HIF-1 signaling pathway, Pathways in cancer, Natural killer cell mediated cytotoxicity, Tuberculosis, Colorectal cancer, Influenza A, Apoptosis, Amphetamine addiction, TNF signaling pathway, Hepatocellular carcinoma\n398941 Dithymoquinone HSP90AA1, SRC, AR, PRKDC, STAT3, NR3C1, MTNR1A, GAPDH, ESR2, ATM, MAPK8, TGFBR1, PTPN11, MTNR1B, EZR, NOS2, NCSTN, BRAF, CAPN1, PSEN1, CDC25A, PGR, PTK2B, ALOX5, PSEN2, OPRM1 Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, GABAergic synapse, Fluid shear stress and atherosclerosis, Apoptosis, Antigen processing and presentation, Chemokine signaling pathway, Morphine addiction, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, Cocaine addiction, Th17 cell differentiation, IL-17 signaling pathway, Alcoholism, c-GMP PkGsignaling pathway, Tuberculosis, Amphetamine addiction, Natural killer cell mediated cytotoxicity, TNF signaling pathway\n637563 trans-Anethole APP, EGF, RXPO1, ESR1 LRRK2 AR AURKA, RELA, PARP1, PRKDC, TUBB3, STAT3 MAPK14 KAT2B, PRKCA, NOS2, CDK5 KIF11, MAPT, JAK1, JAK2, CDC25B, TYK2 Nitrogen metabolism, Calcium signaling pathway, Primary immunodeficiency, TNF signaling pathway, T-cell receptor signaling pathway, Proximal tubule bicarbonate reclamation, Morphine addiction, IL-17 signaling pathway, NF-Κbsignaling pathway, Tuberculosis, VEGF signaling pathway, PI3K-AkT TNF signaling pathway, JAK-STAT pathway, Cocaine addiction, HIF-1 signaling pathway, Th17 cell differentiation, Pathways in cancer, Viral carcinogenesis\n11402337 Nigellicine HDAC1, EP300, AR, PPP1CA, CSNK2A1, RPA1, MAPK1, HDAC6, HSPA1A, CSNK2A2, MAP2K1, MCL1, TP53, NR4A1, ICAM1, TERT, EPRS, SORT1, FEN1, PGR Neuroactive ligand-receptor interaction, cAMP signaling pathway, Nitrogen metabolism, Apoptosis, Lysosome, TNF signaling pathway, NF-Κbsignaling pathway, Influenza A, Autophagy, Alcoholism, Rheumatoid arthritis, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, Renin- angiotensin system, FOXO signaling pathway, Transcriptional misregulation in cancer, c-GMP PkGsignaling pathway, Oxytocin signaling pathway, Viral carcinogenesis, Nitrogen metabolism\n136828302 Nigellidine ESR1, CDK2, VCP, AKT1, ERBB2, HTT, GSK3B, RAF1, PLK1, CDK1, CFTR, KIT, MTNR1A, ILK, PPARG, CCNA2, CCNB1, MTNR1B, PDGFRB, CCNE1, PRKACA, FGFR1, CDK5, PSEN1, OPRM1 Pathways in cancer, Neuroactive ligand-receptor interaction, Calcium signaling pathway, MAPK signaling pathway, Chemokine signaling pathway, c-GMP PkGsignaling pathway, Ras signaling pathway, HIF-1 signaling pathway, VEGF signaling pathway, Arachidonic acid metabolism, Autophagy, Apoptosis, FOXO signaling pathway, Tuberculosis, AGE-RAGE signaling pathway in diabetic complications, Morphine addiction, Cocaine addiction, T-cell receptor signaling pathway\n1796220 Longifolene ESR1, AR, ESR2, PTPN1, UBA2, NR1H3, SAE1, SHBG, PPARA, POLB, NR1I3, NR1H4, BCHE, AKR1B10, HSD11B1, SLC6A4, NCOA3, EP300, NCOA1, ACTB, ACHE, MED1, NCOR1 Steroid hormone mediated signaling pathway, response to oxygen- containing compound, lipid metabolic process, regulation of inflammatory response, regulation of cytokine mediated signaling pathway, regulation of innate immune process, blood circulation, regulation of insulin receptor signaling pathway, regulation of toll- like receptor signaling pathway"}

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ID Compound Name Hub Nodes Pathways targeted\n121304016 Remdesivir CDK2, SRC, AURKA, ABL1, CDK1, MAPK1, MAPK14, TOP1, MTOR, CASP8, AURKB, CCNB1, PRKCA, PTK2, CDK5, SYK, MET, IGF1R, CASP3, PDGFRB, EIF4A1, PIK3CA, MAP3K5, CDK2, SRC Pathways in cancer, Relaxin signaling pathway, PI3K-Akt signaling pathway, Endocrine resistance, Phospholipase D signaling pathway, AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, MAPK pathway,Platelet activation, Chemokine signaling pathway, mTOR signaling pathway,FoxO signaling pathway,EGFR tyrosine kinase inhibitor resistance.\n6654 Alpha-pinene ESR1, AR, MAPK1, PTPN11, MAPK14, PTPN1, RARA, RXRA, NR3C1, PPARG, PTPN6, MAPK3, TOP1, ESR2, CDC25A, CD81, NCOA1, NOS2, TERT Th17 cell differentiation, VEGF signaling pathway, cAMP signaling pathway, Type 2 diabetes, Fat digestion and absorption, Neuroactive ligand-receptor interaction, Calcium signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, HIF-1 signaling pathway, IL-17 signaling pathway, Ras signaling pathway, Pathways in cancer\n7463 P-Cymene ESR1, HDAC1, AR, KDM1A, GSK3B, ESR2, ALB, KIF11, IGF1R, HTR3A, HTR2C, ALOX5, SHBG, CHRM3, AHR, PPARA Amphetamine addiction, Neuroactive ligand-receptor interaction, Calcium signaling pathway, Cocaine addiction, Alcoholism, Regulation of lipolysis in adipocytes, AGE-RAGE signaling pathway in diabetic complications, Inflammatory mediator regulation of TRP channels, c-GMP PkGsignaling pathway, NF-Κbsignaling pathway, IL-17 signaling pathway, cAMP signaling pathway\n10281 Thymoquinone GSK3B, PLK1, PARP1, PABPC1, NR3C1, MTNR1A, PTPN1, SOAT1, MTNR1B, XIAP, BRD4, PPARG, TOP2A, SYK, MAP2K1, IMPDH2, PTPN2, PGR, GLI1, MCL1, ALOX5 Neuroactive ligand-receptor interaction, Calcium signaling pathway, c-GMP PkGsignaling pathway, Alcoholism, Apoptosis, cAMP signaling pathway, lysosome, Influenza A, PI3K-AkT TNF signaling pathway, Pathways in cancer, NF-Κbsignaling pathway\n10364 Carvacrol ESR1, CDK2, HDAC1, AR, AURKA, AKT1, HDAC6, HDAC3, ADRB2, GAPDH, ESR2, ALB, MAPK8, CLK1,LDHA, PRKCA, LDHB, HDAC11, CCNA2, MAPK9, IGF1R Neuroactive ligand-receptor interaction, MAPK signaling pathway, Calcium signaling pathway, Relaxinsignaling pathway, Pathways in cancer, Alcoholism, PI3K-AkT TNF signaling pathway, Ras signaling pathway, Th17 cell differentiation, Influenza, Regulation of lipolysis in adipocytes, Endocrine and other factor- regulated calcium reabsorption, Adrenergic signaling in cardiomyocytes, Amphetamine addiction, VEGF signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Apoptosis, c-GMP PkGsignaling pathway, FOXO signaling pathway, Cocaine addiction\n11230 Terpinen-4-ol MAPK8, AR, JAK1, ESR1, JAK2, PTPN6, NR3C1, MAPK10, PPARA, PPARG, PTPN1, CHRM2, HTR2C, ESR2, CHRM4, HTR2A, DRD2, OPRK1, OPRD1, PGR, OPRM1, PARP1, MTNR1A Neuroactive ligand-receptor interaction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Th17 cell differentiation, Pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, cAMP signaling pathway, Tuberculosis, AMPK signaling pathway, Influenza, c-GMP PkGsignaling pathway, JAK-STAT pathway, Circadian rhythm, Relaxinsignaling pathway, Apoptosis- multiple species\n73296 alpha-Hederin GRB2, ITGA4, PPP1CA, SRC, AR, AURKA, PPP2CA, STAT3, CDK1, LGALS3, PTPN1, CASP8, XIAP, NCSTN, ATP1A1, ITGB1, PRKCD, IGF1R, CASP3, LGALS8, BCL2L1, MME, PSEN1, IMPDH2, HTR2C, IMPDH1, GLI1, HLA-A, ITGAV, ITGB3, PTPRA Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Rennin- angiotensin system, c-GMP PkGsignaling pathway, Pathways in cancer, PI3K-AkT TNF signaling pathway, Apoptosis, Autophagy, Complement and coagulation cascades, P53 signaling pathway, T-cell receptor signaling pathway, NF-Κbsignaling pathway, JAK-STAT pathway, Alcoholism, Chemokine signaling pathway, Tuberculosis, HIF-1 signaling pathway, MAPK signaling pathway\n95779 Thymohydroquinone HSP90AA1, HDAC1, AURKA, AKT1, PARP1, ERBB2, ABL1, HDAC6, CDK1, HDAC3, ADRB2, GAPDH, MTNR1A, MAPK14, ALB, PTPN1, MTNR1B, PRKCA, LDHA, NOS2, LDHB, BRAF Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, MAPK signaling pathway, Regulation of lipolysis in adipocytes, Oxytocin , Alcoholism, mTOR signaling pathway, PI3K-AkT TNF signaling pathway, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, VEGF signaling pathway, HIF-1 signaling pathway, Pathways in cancer, Natural killer cell mediated cytotoxicity, Tuberculosis, Colorectal cancer, Influenza A, Apoptosis, Amphetamine addiction, TNF signaling pathway, Hepatocellular carcinoma\n398941 Dithymoquinone HSP90AA1, SRC, AR, PRKDC, STAT3, NR3C1, MTNR1A, GAPDH, ESR2, ATM, MAPK8, TGFBR1, PTPN11, MTNR1B, EZR, NOS2, NCSTN, BRAF, CAPN1, PSEN1, CDC25A, PGR, PTK2B, ALOX5, PSEN2, OPRM1 Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, GABAergic synapse, Fluid shear stress and atherosclerosis, Apoptosis, Antigen processing and presentation, Chemokine signaling pathway, Morphine addiction, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, Cocaine addiction, Th17 cell differentiation, IL-17 signaling pathway, Alcoholism, c-GMP PkGsignaling pathway, Tuberculosis, Amphetamine addiction, Natural killer cell mediated cytotoxicity, TNF signaling pathway\n637563 trans-Anethole APP, EGF, RXPO1, ESR1 LRRK2 AR AURKA, RELA, PARP1, PRKDC, TUBB3, STAT3 MAPK14 KAT2B, PRKCA, NOS2, CDK5 KIF11, MAPT, JAK1, JAK2, CDC25B, TYK2 Nitrogen metabolism, Calcium signaling pathway, Primary immunodeficiency, TNF signaling pathway, T-cell receptor signaling pathway, Proximal tubule bicarbonate reclamation, Morphine addiction, IL-17 signaling pathway, NF-Κbsignaling pathway, Tuberculosis, VEGF signaling pathway, PI3K-AkT TNF signaling pathway, JAK-STAT pathway, Cocaine addiction, HIF-1 signaling pathway, Th17 cell differentiation, Pathways in cancer, Viral carcinogenesis\n11402337 Nigellicine HDAC1, EP300, AR, PPP1CA, CSNK2A1, RPA1, MAPK1, HDAC6, HSPA1A, CSNK2A2, MAP2K1, MCL1, TP53, NR4A1, ICAM1, TERT, EPRS, SORT1, FEN1, PGR Neuroactive ligand-receptor interaction, cAMP signaling pathway, Nitrogen metabolism, Apoptosis, Lysosome, TNF signaling pathway, NF-Κbsignaling pathway, Influenza A, Autophagy, Alcoholism, Rheumatoid arthritis, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, Renin- angiotensin system, FOXO signaling pathway, Transcriptional misregulation in cancer, c-GMP PkGsignaling pathway, Oxytocin signaling pathway, Viral carcinogenesis, Nitrogen metabolism\n136828302 Nigellidine ESR1, CDK2, VCP, AKT1, ERBB2, HTT, GSK3B, RAF1, PLK1, CDK1, CFTR, KIT, MTNR1A, ILK, PPARG, CCNA2, CCNB1, MTNR1B, PDGFRB, CCNE1, PRKACA, FGFR1, CDK5, PSEN1, OPRM1 Pathways in cancer, Neuroactive ligand-receptor interaction, Calcium signaling pathway, MAPK signaling pathway, Chemokine signaling pathway, c-GMP PkGsignaling pathway, Ras signaling pathway, HIF-1 signaling pathway, VEGF signaling pathway, Arachidonic acid metabolism, Autophagy, Apoptosis, FOXO signaling pathway, Tuberculosis, AGE-RAGE signaling pathway in diabetic complications, Morphine addiction, Cocaine addiction, T-cell receptor signaling pathway\n1796220 Longifolene ESR1, AR, ESR2, PTPN1, UBA2, NR1H3, SAE1, SHBG, PPARA, POLB, NR1I3, NR1H4, BCHE, AKR1B10, HSD11B1, SLC6A4, NCOA3, EP300, NCOA1, ACTB, ACHE, MED1, NCOR1 Steroid hormone mediated signaling pathway, response to oxygen- containing compound, lipid metabolic process, regulation of inflammatory response, regulation of cytokine mediated signaling pathway, regulation of innate immune process, blood circulation, regulation of insulin receptor signaling pathway, regulation of toll- like receptor signaling pathway"}

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Toll-like receptor signaling pathway, HIF-1 signaling pathway, IL-17 signaling pathway, Ras signaling pathway, Pathways in cancer\n7463 P-Cymene ESR1, HDAC1, AR, KDM1A, GSK3B, ESR2, ALB, KIF11, IGF1R, HTR3A, HTR2C, ALOX5, SHBG, CHRM3, AHR, PPARA Amphetamine addiction, Neuroactive ligand-receptor interaction, Calcium signaling pathway, Cocaine addiction, Alcoholism, Regulation of lipolysis in adipocytes, AGE-RAGE signaling pathway in diabetic complications, Inflammatory mediator regulation of TRP channels, c-GMP PkGsignaling pathway, NF-Κbsignaling pathway, IL-17 signaling pathway, cAMP signaling pathway\n10281 Thymoquinone GSK3B, PLK1, PARP1, PABPC1, NR3C1, MTNR1A, PTPN1, SOAT1, MTNR1B, XIAP, BRD4, PPARG, TOP2A, SYK, MAP2K1, IMPDH2, PTPN2, PGR, GLI1, MCL1, ALOX5 Neuroactive ligand-receptor interaction, Calcium signaling pathway, c-GMP PkGsignaling pathway, Alcoholism, Apoptosis, cAMP signaling pathway, lysosome, Influenza A, PI3K-AkT TNF signaling pathway, Pathways in cancer, NF-Κbsignaling pathway\n10364 Carvacrol ESR1, CDK2, HDAC1, AR, AURKA, AKT1, HDAC6, HDAC3, ADRB2, GAPDH, ESR2, ALB, MAPK8, CLK1,LDHA, PRKCA, LDHB, HDAC11, CCNA2, MAPK9, IGF1R Neuroactive ligand-receptor interaction, MAPK signaling pathway, Calcium signaling pathway, Relaxinsignaling pathway, Pathways in cancer, Alcoholism, PI3K-AkT TNF signaling pathway, Ras signaling pathway, Th17 cell differentiation, Influenza, Regulation of lipolysis in adipocytes, Endocrine and other factor- regulated calcium reabsorption, Adrenergic signaling in cardiomyocytes, Amphetamine addiction, VEGF signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Apoptosis, c-GMP PkGsignaling pathway, FOXO signaling pathway, Cocaine addiction\n11230 Terpinen-4-ol MAPK8, AR, JAK1, ESR1, JAK2, PTPN6, NR3C1, MAPK10, PPARA, PPARG, PTPN1, CHRM2, HTR2C, ESR2, CHRM4, HTR2A, DRD2, OPRK1, OPRD1, PGR, OPRM1, PARP1, MTNR1A Neuroactive ligand-receptor interaction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Th17 cell differentiation, Pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, cAMP signaling pathway, Tuberculosis, AMPK signaling pathway, Influenza, c-GMP PkGsignaling pathway, JAK-STAT pathway, Circadian rhythm, Relaxinsignaling pathway, Apoptosis- multiple species\n73296 alpha-Hederin GRB2, ITGA4, PPP1CA, SRC, AR, AURKA, PPP2CA, STAT3, CDK1, LGALS3, PTPN1, CASP8, XIAP, NCSTN, ATP1A1, ITGB1, PRKCD, IGF1R, CASP3, LGALS8, BCL2L1, MME, PSEN1, IMPDH2, HTR2C, IMPDH1, GLI1, HLA-A, ITGAV, ITGB3, PTPRA Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Rennin- angiotensin system, c-GMP PkGsignaling pathway, Pathways in cancer, PI3K-AkT TNF signaling pathway, Apoptosis, Autophagy, Complement and coagulation cascades, P53 signaling pathway, T-cell receptor signaling pathway, NF-Κbsignaling pathway, JAK-STAT pathway, Alcoholism, Chemokine signaling pathway, Tuberculosis, HIF-1 signaling pathway, MAPK signaling pathway\n95779 Thymohydroquinone HSP90AA1, HDAC1, AURKA, AKT1, PARP1, ERBB2, ABL1, HDAC6, CDK1, HDAC3, ADRB2, GAPDH, MTNR1A, MAPK14, ALB, PTPN1, MTNR1B, PRKCA, LDHA, NOS2, LDHB, BRAF Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, MAPK signaling pathway, Regulation of lipolysis in adipocytes, Oxytocin , Alcoholism, mTOR signaling pathway, PI3K-AkT TNF signaling pathway, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, VEGF signaling pathway, HIF-1 signaling pathway, Pathways in cancer, Natural killer cell mediated cytotoxicity, Tuberculosis, Colorectal cancer, Influenza A, Apoptosis, Amphetamine addiction, TNF signaling pathway, Hepatocellular carcinoma\n398941 Dithymoquinone HSP90AA1, SRC, AR, PRKDC, STAT3, NR3C1, MTNR1A, GAPDH, ESR2, ATM, MAPK8, TGFBR1, PTPN11, MTNR1B, EZR, NOS2, NCSTN, BRAF, CAPN1, PSEN1, CDC25A, PGR, PTK2B, ALOX5, PSEN2, OPRM1 Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, GABAergic synapse, Fluid shear stress and atherosclerosis, Apoptosis, Antigen processing and presentation, Chemokine signaling pathway, Morphine addiction, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, Cocaine addiction, Th17 cell differentiation, IL-17 signaling pathway, Alcoholism, c-GMP PkGsignaling pathway, Tuberculosis, Amphetamine addiction, Natural killer cell mediated cytotoxicity, TNF signaling pathway\n637563 trans-Anethole APP, EGF, RXPO1, ESR1 LRRK2 AR AURKA, RELA, PARP1, PRKDC, TUBB3, STAT3 MAPK14 KAT2B, PRKCA, NOS2, CDK5 KIF11, MAPT, JAK1, JAK2, CDC25B, TYK2 Nitrogen metabolism, Calcium signaling pathway, Primary immunodeficiency, TNF signaling pathway, T-cell receptor signaling pathway, Proximal tubule bicarbonate reclamation, Morphine addiction, IL-17 signaling pathway, NF-Κbsignaling pathway, Tuberculosis, VEGF signaling pathway, PI3K-AkT TNF signaling pathway, JAK-STAT pathway, Cocaine addiction, HIF-1 signaling pathway, Th17 cell differentiation, Pathways in cancer, Viral carcinogenesis\n11402337 Nigellicine HDAC1, EP300, AR, PPP1CA, CSNK2A1, RPA1, MAPK1, HDAC6, HSPA1A, CSNK2A2, MAP2K1, MCL1, TP53, NR4A1, ICAM1, TERT, EPRS, SORT1, FEN1, PGR Neuroactive ligand-receptor interaction, cAMP signaling pathway, Nitrogen metabolism, Apoptosis, Lysosome, TNF signaling pathway, NF-Κbsignaling pathway, Influenza A, Autophagy, Alcoholism, Rheumatoid arthritis, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, Renin- angiotensin system, FOXO signaling pathway, Transcriptional misregulation in cancer, c-GMP PkGsignaling pathway, Oxytocin signaling pathway, Viral carcinogenesis, Nitrogen metabolism\n136828302 Nigellidine ESR1, CDK2, VCP, AKT1, ERBB2, HTT, GSK3B, RAF1, PLK1, CDK1, CFTR, KIT, MTNR1A, ILK, PPARG, CCNA2, CCNB1, MTNR1B, PDGFRB, CCNE1, PRKACA, FGFR1, CDK5, PSEN1, OPRM1 Pathways in cancer, Neuroactive ligand-receptor interaction, Calcium signaling pathway, MAPK signaling pathway, Chemokine signaling pathway, c-GMP PkGsignaling pathway, Ras signaling pathway, HIF-1 signaling pathway, VEGF signaling pathway, Arachidonic acid metabolism, Autophagy, Apoptosis, FOXO signaling pathway, Tuberculosis, AGE-RAGE signaling pathway in diabetic complications, Morphine addiction, Cocaine addiction, T-cell receptor signaling pathway\n1796220 Longifolene ESR1, AR, ESR2, PTPN1, UBA2, NR1H3, SAE1, SHBG, PPARA, POLB, NR1I3, NR1H4, BCHE, AKR1B10, HSD11B1, SLC6A4, NCOA3, EP300, NCOA1, ACTB, ACHE, MED1, NCOR1 Steroid hormone mediated signaling pathway, response to oxygen- containing compound, lipid metabolic process, regulation of inflammatory response, regulation of cytokine mediated signaling pathway, regulation of innate immune process, blood circulation, regulation of insulin receptor signaling pathway, regulation of toll- like receptor signaling pathway"}

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ID Compound Name Hub Nodes Pathways targeted\n121304016 Remdesivir CDK2, SRC, AURKA, ABL1, CDK1, MAPK1, MAPK14, TOP1, MTOR, CASP8, AURKB, CCNB1, PRKCA, PTK2, CDK5, SYK, MET, IGF1R, CASP3, PDGFRB, EIF4A1, PIK3CA, MAP3K5, CDK2, SRC Pathways in cancer, Relaxin signaling pathway, PI3K-Akt signaling pathway, Endocrine resistance, Phospholipase D signaling pathway, AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, MAPK pathway,Platelet activation, Chemokine signaling pathway, mTOR signaling pathway,FoxO signaling pathway,EGFR tyrosine kinase inhibitor resistance.\n6654 Alpha-pinene ESR1, AR, MAPK1, PTPN11, MAPK14, PTPN1, RARA, RXRA, NR3C1, PPARG, PTPN6, MAPK3, TOP1, ESR2, CDC25A, CD81, NCOA1, NOS2, TERT Th17 cell differentiation, VEGF signaling pathway, cAMP signaling pathway, Type 2 diabetes, Fat digestion and absorption, Neuroactive ligand-receptor interaction, Calcium signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, HIF-1 signaling pathway, IL-17 signaling pathway, Ras signaling pathway, Pathways in cancer\n7463 P-Cymene ESR1, HDAC1, AR, KDM1A, GSK3B, ESR2, ALB, KIF11, IGF1R, HTR3A, HTR2C, ALOX5, SHBG, CHRM3, AHR, PPARA Amphetamine addiction, Neuroactive ligand-receptor interaction, Calcium signaling pathway, Cocaine addiction, Alcoholism, Regulation of lipolysis in adipocytes, AGE-RAGE signaling pathway in diabetic complications, Inflammatory mediator regulation of TRP channels, c-GMP PkGsignaling pathway, NF-Κbsignaling pathway, IL-17 signaling pathway, cAMP signaling pathway\n10281 Thymoquinone GSK3B, PLK1, PARP1, PABPC1, NR3C1, MTNR1A, PTPN1, SOAT1, MTNR1B, XIAP, BRD4, PPARG, TOP2A, SYK, MAP2K1, IMPDH2, PTPN2, PGR, GLI1, MCL1, ALOX5 Neuroactive ligand-receptor interaction, Calcium signaling pathway, c-GMP PkGsignaling pathway, Alcoholism, Apoptosis, cAMP signaling pathway, lysosome, Influenza A, PI3K-AkT TNF signaling pathway, Pathways in cancer, NF-Κbsignaling pathway\n10364 Carvacrol ESR1, CDK2, HDAC1, AR, AURKA, AKT1, HDAC6, HDAC3, ADRB2, GAPDH, ESR2, ALB, MAPK8, CLK1,LDHA, PRKCA, LDHB, HDAC11, CCNA2, MAPK9, IGF1R Neuroactive ligand-receptor interaction, MAPK signaling pathway, Calcium signaling pathway, Relaxinsignaling pathway, Pathways in cancer, Alcoholism, PI3K-AkT TNF signaling pathway, Ras signaling pathway, Th17 cell differentiation, Influenza, Regulation of lipolysis in adipocytes, Endocrine and other factor- regulated calcium reabsorption, Adrenergic signaling in cardiomyocytes, Amphetamine addiction, VEGF signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Apoptosis, c-GMP PkGsignaling pathway, FOXO signaling pathway, Cocaine addiction\n11230 Terpinen-4-ol MAPK8, AR, JAK1, ESR1, JAK2, PTPN6, NR3C1, MAPK10, PPARA, PPARG, PTPN1, CHRM2, HTR2C, ESR2, CHRM4, HTR2A, DRD2, OPRK1, OPRD1, PGR, OPRM1, PARP1, MTNR1A Neuroactive ligand-receptor interaction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Th17 cell differentiation, Pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, cAMP signaling pathway, Tuberculosis, AMPK signaling pathway, Influenza, c-GMP PkGsignaling pathway, JAK-STAT pathway, Circadian rhythm, Relaxinsignaling pathway, Apoptosis- multiple species\n73296 alpha-Hederin GRB2, ITGA4, PPP1CA, SRC, AR, AURKA, PPP2CA, STAT3, CDK1, LGALS3, PTPN1, CASP8, XIAP, NCSTN, ATP1A1, ITGB1, PRKCD, IGF1R, CASP3, LGALS8, BCL2L1, MME, PSEN1, IMPDH2, HTR2C, IMPDH1, GLI1, HLA-A, ITGAV, ITGB3, PTPRA Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Rennin- angiotensin system, c-GMP PkGsignaling pathway, Pathways in cancer, PI3K-AkT TNF signaling pathway, Apoptosis, Autophagy, Complement and coagulation cascades, P53 signaling pathway, T-cell receptor signaling pathway, NF-Κbsignaling pathway, JAK-STAT pathway, Alcoholism, Chemokine signaling pathway, Tuberculosis, HIF-1 signaling pathway, MAPK signaling pathway\n95779 Thymohydroquinone HSP90AA1, HDAC1, AURKA, AKT1, PARP1, ERBB2, ABL1, HDAC6, CDK1, HDAC3, ADRB2, GAPDH, MTNR1A, MAPK14, ALB, PTPN1, MTNR1B, PRKCA, LDHA, NOS2, LDHB, BRAF Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, MAPK signaling pathway, Regulation of lipolysis in adipocytes, Oxytocin , Alcoholism, mTOR signaling pathway, PI3K-AkT TNF signaling pathway, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, VEGF signaling pathway, HIF-1 signaling pathway, Pathways in cancer, Natural killer cell mediated cytotoxicity, Tuberculosis, Colorectal cancer, Influenza A, Apoptosis, Amphetamine addiction, TNF signaling pathway, Hepatocellular carcinoma\n398941 Dithymoquinone HSP90AA1, SRC, AR, PRKDC, STAT3, NR3C1, MTNR1A, GAPDH, ESR2, ATM, MAPK8, TGFBR1, PTPN11, MTNR1B, EZR, NOS2, NCSTN, BRAF, CAPN1, PSEN1, CDC25A, PGR, PTK2B, ALOX5, PSEN2, OPRM1 Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, GABAergic synapse, Fluid shear stress and atherosclerosis, Apoptosis, Antigen processing and presentation, Chemokine signaling pathway, Morphine addiction, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, Cocaine addiction, Th17 cell differentiation, IL-17 signaling pathway, Alcoholism, c-GMP PkGsignaling pathway, Tuberculosis, Amphetamine addiction, Natural killer cell mediated cytotoxicity, TNF signaling pathway\n637563 trans-Anethole APP, EGF, RXPO1, ESR1 LRRK2 AR AURKA, RELA, PARP1, PRKDC, TUBB3, STAT3 MAPK14 KAT2B, PRKCA, NOS2, CDK5 KIF11, MAPT, JAK1, JAK2, CDC25B, TYK2 Nitrogen metabolism, Calcium signaling pathway, Primary immunodeficiency, TNF signaling pathway, T-cell receptor signaling pathway, Proximal tubule bicarbonate reclamation, Morphine addiction, IL-17 signaling pathway, NF-Κbsignaling pathway, Tuberculosis, VEGF signaling pathway, PI3K-AkT TNF signaling pathway, JAK-STAT pathway, Cocaine addiction, HIF-1 signaling pathway, Th17 cell differentiation, Pathways in cancer, Viral carcinogenesis\n11402337 Nigellicine HDAC1, EP300, AR, PPP1CA, CSNK2A1, RPA1, MAPK1, HDAC6, HSPA1A, CSNK2A2, MAP2K1, MCL1, TP53, NR4A1, ICAM1, TERT, EPRS, SORT1, FEN1, PGR Neuroactive ligand-receptor interaction, cAMP signaling pathway, Nitrogen metabolism, Apoptosis, Lysosome, TNF signaling pathway, NF-Κbsignaling pathway, Influenza A, Autophagy, Alcoholism, Rheumatoid arthritis, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, Renin- angiotensin system, FOXO signaling pathway, Transcriptional misregulation in cancer, c-GMP PkGsignaling pathway, Oxytocin signaling pathway, Viral carcinogenesis, Nitrogen metabolism\n136828302 Nigellidine ESR1, CDK2, VCP, AKT1, ERBB2, HTT, GSK3B, RAF1, PLK1, CDK1, CFTR, KIT, MTNR1A, ILK, PPARG, CCNA2, CCNB1, MTNR1B, PDGFRB, CCNE1, PRKACA, FGFR1, CDK5, PSEN1, OPRM1 Pathways in cancer, Neuroactive ligand-receptor interaction, Calcium signaling pathway, MAPK signaling pathway, Chemokine signaling pathway, c-GMP PkGsignaling pathway, Ras signaling pathway, HIF-1 signaling pathway, VEGF signaling pathway, Arachidonic acid metabolism, Autophagy, Apoptosis, FOXO signaling pathway, Tuberculosis, AGE-RAGE signaling pathway in diabetic complications, Morphine addiction, Cocaine addiction, T-cell receptor signaling pathway\n1796220 Longifolene ESR1, AR, ESR2, PTPN1, UBA2, NR1H3, SAE1, SHBG, PPARA, POLB, NR1I3, NR1H4, BCHE, AKR1B10, HSD11B1, SLC6A4, NCOA3, EP300, NCOA1, ACTB, ACHE, MED1, NCOR1 Steroid hormone mediated signaling pathway, response to oxygen- containing compound, lipid metabolic process, regulation of inflammatory response, regulation of cytokine mediated signaling pathway, regulation of innate immune process, blood circulation, regulation of insulin receptor signaling pathway, regulation of toll- like receptor signaling pathway"}

{"project":"LitCovid-sentences","denotations":[{"id":"T139","span":{"begin":0,"end":55},"obj":"Sentence"},{"id":"T140","span":{"begin":56,"end":654},"obj":"Sentence"},{"id":"T141","span":{"begin":655,"end":1142},"obj":"Sentence"},{"id":"T142","span":{"begin":1143,"end":1625},"obj":"Sentence"},{"id":"T143","span":{"begin":1626,"end":2030},"obj":"Sentence"},{"id":"T144","span":{"begin":2031,"end":2754},"obj":"Sentence"},{"id":"T145","span":{"begin":2755,"end":3339},"obj":"Sentence"},{"id":"T146","span":{"begin":3340,"end":4067},"obj":"Sentence"},{"id":"T147","span":{"begin":4068,"end":4848},"obj":"Sentence"},{"id":"T148","span":{"begin":4849,"end":5639},"obj":"Sentence"},{"id":"T149","span":{"begin":5640,"end":6247},"obj":"Sentence"},{"id":"T150","span":{"begin":6248,"end":6882},"obj":"Sentence"},{"id":"T151","span":{"begin":6883,"end":7526},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"PubChem ID Compound Name Hub Nodes Pathways targeted\n121304016 Remdesivir CDK2, SRC, AURKA, ABL1, CDK1, MAPK1, MAPK14, TOP1, MTOR, CASP8, AURKB, CCNB1, PRKCA, PTK2, CDK5, SYK, MET, IGF1R, CASP3, PDGFRB, EIF4A1, PIK3CA, MAP3K5, CDK2, SRC Pathways in cancer, Relaxin signaling pathway, PI3K-Akt signaling pathway, Endocrine resistance, Phospholipase D signaling pathway, AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, MAPK pathway,Platelet activation, Chemokine signaling pathway, mTOR signaling pathway,FoxO signaling pathway,EGFR tyrosine kinase inhibitor resistance.\n6654 Alpha-pinene ESR1, AR, MAPK1, PTPN11, MAPK14, PTPN1, RARA, RXRA, NR3C1, PPARG, PTPN6, MAPK3, TOP1, ESR2, CDC25A, CD81, NCOA1, NOS2, TERT Th17 cell differentiation, VEGF signaling pathway, cAMP signaling pathway, Type 2 diabetes, Fat digestion and absorption, Neuroactive ligand-receptor interaction, Calcium signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, HIF-1 signaling pathway, IL-17 signaling pathway, Ras signaling pathway, Pathways in cancer\n7463 P-Cymene ESR1, HDAC1, AR, KDM1A, GSK3B, ESR2, ALB, KIF11, IGF1R, HTR3A, HTR2C, ALOX5, SHBG, CHRM3, AHR, PPARA Amphetamine addiction, Neuroactive ligand-receptor interaction, Calcium signaling pathway, Cocaine addiction, Alcoholism, Regulation of lipolysis in adipocytes, AGE-RAGE signaling pathway in diabetic complications, Inflammatory mediator regulation of TRP channels, c-GMP PkGsignaling pathway, NF-Κbsignaling pathway, IL-17 signaling pathway, cAMP signaling pathway\n10281 Thymoquinone GSK3B, PLK1, PARP1, PABPC1, NR3C1, MTNR1A, PTPN1, SOAT1, MTNR1B, XIAP, BRD4, PPARG, TOP2A, SYK, MAP2K1, IMPDH2, PTPN2, PGR, GLI1, MCL1, ALOX5 Neuroactive ligand-receptor interaction, Calcium signaling pathway, c-GMP PkGsignaling pathway, Alcoholism, Apoptosis, cAMP signaling pathway, lysosome, Influenza A, PI3K-AkT TNF signaling pathway, Pathways in cancer, NF-Κbsignaling pathway\n10364 Carvacrol ESR1, CDK2, HDAC1, AR, AURKA, AKT1, HDAC6, HDAC3, ADRB2, GAPDH, ESR2, ALB, MAPK8, CLK1,LDHA, PRKCA, LDHB, HDAC11, CCNA2, MAPK9, IGF1R Neuroactive ligand-receptor interaction, MAPK signaling pathway, Calcium signaling pathway, Relaxinsignaling pathway, Pathways in cancer, Alcoholism, PI3K-AkT TNF signaling pathway, Ras signaling pathway, Th17 cell differentiation, Influenza, Regulation of lipolysis in adipocytes, Endocrine and other factor- regulated calcium reabsorption, Adrenergic signaling in cardiomyocytes, Amphetamine addiction, VEGF signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Apoptosis, c-GMP PkGsignaling pathway, FOXO signaling pathway, Cocaine addiction\n11230 Terpinen-4-ol MAPK8, AR, JAK1, ESR1, JAK2, PTPN6, NR3C1, MAPK10, PPARA, PPARG, PTPN1, CHRM2, HTR2C, ESR2, CHRM4, HTR2A, DRD2, OPRK1, OPRD1, PGR, OPRM1, PARP1, MTNR1A Neuroactive ligand-receptor interaction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Th17 cell differentiation, Pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, cAMP signaling pathway, Tuberculosis, AMPK signaling pathway, Influenza, c-GMP PkGsignaling pathway, JAK-STAT pathway, Circadian rhythm, Relaxinsignaling pathway, Apoptosis- multiple species\n73296 alpha-Hederin GRB2, ITGA4, PPP1CA, SRC, AR, AURKA, PPP2CA, STAT3, CDK1, LGALS3, PTPN1, CASP8, XIAP, NCSTN, ATP1A1, ITGB1, PRKCD, IGF1R, CASP3, LGALS8, BCL2L1, MME, PSEN1, IMPDH2, HTR2C, IMPDH1, GLI1, HLA-A, ITGAV, ITGB3, PTPRA Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Rennin- angiotensin system, c-GMP PkGsignaling pathway, Pathways in cancer, PI3K-AkT TNF signaling pathway, Apoptosis, Autophagy, Complement and coagulation cascades, P53 signaling pathway, T-cell receptor signaling pathway, NF-Κbsignaling pathway, JAK-STAT pathway, Alcoholism, Chemokine signaling pathway, Tuberculosis, HIF-1 signaling pathway, MAPK signaling pathway\n95779 Thymohydroquinone HSP90AA1, HDAC1, AURKA, AKT1, PARP1, ERBB2, ABL1, HDAC6, CDK1, HDAC3, ADRB2, GAPDH, MTNR1A, MAPK14, ALB, PTPN1, MTNR1B, PRKCA, LDHA, NOS2, LDHB, BRAF Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, MAPK signaling pathway, Regulation of lipolysis in adipocytes, Oxytocin , Alcoholism, mTOR signaling pathway, PI3K-AkT TNF signaling pathway, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, VEGF signaling pathway, HIF-1 signaling pathway, Pathways in cancer, Natural killer cell mediated cytotoxicity, Tuberculosis, Colorectal cancer, Influenza A, Apoptosis, Amphetamine addiction, TNF signaling pathway, Hepatocellular carcinoma\n398941 Dithymoquinone HSP90AA1, SRC, AR, PRKDC, STAT3, NR3C1, MTNR1A, GAPDH, ESR2, ATM, MAPK8, TGFBR1, PTPN11, MTNR1B, EZR, NOS2, NCSTN, BRAF, CAPN1, PSEN1, CDC25A, PGR, PTK2B, ALOX5, PSEN2, OPRM1 Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, GABAergic synapse, Fluid shear stress and atherosclerosis, Apoptosis, Antigen processing and presentation, Chemokine signaling pathway, Morphine addiction, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, Cocaine addiction, Th17 cell differentiation, IL-17 signaling pathway, Alcoholism, c-GMP PkGsignaling pathway, Tuberculosis, Amphetamine addiction, Natural killer cell mediated cytotoxicity, TNF signaling pathway\n637563 trans-Anethole APP, EGF, RXPO1, ESR1 LRRK2 AR AURKA, RELA, PARP1, PRKDC, TUBB3, STAT3 MAPK14 KAT2B, PRKCA, NOS2, CDK5 KIF11, MAPT, JAK1, JAK2, CDC25B, TYK2 Nitrogen metabolism, Calcium signaling pathway, Primary immunodeficiency, TNF signaling pathway, T-cell receptor signaling pathway, Proximal tubule bicarbonate reclamation, Morphine addiction, IL-17 signaling pathway, NF-Κbsignaling pathway, Tuberculosis, VEGF signaling pathway, PI3K-AkT TNF signaling pathway, JAK-STAT pathway, Cocaine addiction, HIF-1 signaling pathway, Th17 cell differentiation, Pathways in cancer, Viral carcinogenesis\n11402337 Nigellicine HDAC1, EP300, AR, PPP1CA, CSNK2A1, RPA1, MAPK1, HDAC6, HSPA1A, CSNK2A2, MAP2K1, MCL1, TP53, NR4A1, ICAM1, TERT, EPRS, SORT1, FEN1, PGR Neuroactive ligand-receptor interaction, cAMP signaling pathway, Nitrogen metabolism, Apoptosis, Lysosome, TNF signaling pathway, NF-Κbsignaling pathway, Influenza A, Autophagy, Alcoholism, Rheumatoid arthritis, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, Renin- angiotensin system, FOXO signaling pathway, Transcriptional misregulation in cancer, c-GMP PkGsignaling pathway, Oxytocin signaling pathway, Viral carcinogenesis, Nitrogen metabolism\n136828302 Nigellidine ESR1, CDK2, VCP, AKT1, ERBB2, HTT, GSK3B, RAF1, PLK1, CDK1, CFTR, KIT, MTNR1A, ILK, PPARG, CCNA2, CCNB1, MTNR1B, PDGFRB, CCNE1, PRKACA, FGFR1, CDK5, PSEN1, OPRM1 Pathways in cancer, Neuroactive ligand-receptor interaction, Calcium signaling pathway, MAPK signaling pathway, Chemokine signaling pathway, c-GMP PkGsignaling pathway, Ras signaling pathway, HIF-1 signaling pathway, VEGF signaling pathway, Arachidonic acid metabolism, Autophagy, Apoptosis, FOXO signaling pathway, Tuberculosis, AGE-RAGE signaling pathway in diabetic complications, Morphine addiction, Cocaine addiction, T-cell receptor signaling pathway\n1796220 Longifolene ESR1, AR, ESR2, PTPN1, UBA2, NR1H3, SAE1, SHBG, PPARA, POLB, NR1I3, NR1H4, BCHE, AKR1B10, HSD11B1, SLC6A4, NCOA3, EP300, NCOA1, ACTB, ACHE, MED1, NCOR1 Steroid hormone mediated signaling pathway, response to oxygen- containing compound, lipid metabolic process, regulation of inflammatory response, regulation of cytokine mediated signaling pathway, regulation of innate immune process, blood circulation, regulation of insulin receptor signaling pathway, regulation of toll- like receptor signaling pathway"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T12","span":{"begin":255,"end":261},"obj":"Phenotype"},{"id":"T13","span":{"begin":875,"end":890},"obj":"Phenotype"},{"id":"T14","span":{"begin":1136,"end":1142},"obj":"Phenotype"},{"id":"T15","span":{"begin":1371,"end":1381},"obj":"Phenotype"},{"id":"T16","span":{"begin":1886,"end":1896},"obj":"Phenotype"},{"id":"T17","span":{"begin":2000,"end":2006},"obj":"Phenotype"},{"id":"T18","span":{"begin":2314,"end":2320},"obj":"Phenotype"},{"id":"T19","span":{"begin":2322,"end":2332},"obj":"Phenotype"},{"id":"T20","span":{"begin":3087,"end":3093},"obj":"Phenotype"},{"id":"T21","span":{"begin":3766,"end":3772},"obj":"Phenotype"},{"id":"T22","span":{"begin":3965,"end":3975},"obj":"Phenotype"},{"id":"T23","span":{"begin":4467,"end":4477},"obj":"Phenotype"},{"id":"T24","span":{"begin":4670,"end":4676},"obj":"Phenotype"},{"id":"T25","span":{"begin":4746,"end":4752},"obj":"Phenotype"},{"id":"T26","span":{"begin":4824,"end":4848},"obj":"Phenotype"},{"id":"T27","span":{"begin":5239,"end":5254},"obj":"Phenotype"},{"id":"T28","span":{"begin":5498,"end":5508},"obj":"Phenotype"},{"id":"T29","span":{"begin":5862,"end":5878},"obj":"Phenotype"},{"id":"T30","span":{"begin":6219,"end":6225},"obj":"Phenotype"},{"id":"T31","span":{"begin":6585,"end":6595},"obj":"Phenotype"},{"id":"T32","span":{"begin":6597,"end":6617},"obj":"Phenotype"},{"id":"T33","span":{"begin":6777,"end":6783},"obj":"Phenotype"},{"id":"T34","span":{"begin":7082,"end":7088},"obj":"Phenotype"}],"attributes":[{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A13","pred":"hp_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/HP_0005978"},{"id":"A14","pred":"hp_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0030955"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0030955"},{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0030955"},{"id":"A20","pred":"hp_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A21","pred":"hp_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A22","pred":"hp_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/HP_0030955"},{"id":"A23","pred":"hp_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/HP_0030955"},{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0001402"},{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0002621"},{"id":"A28","pred":"hp_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/HP_0030955"},{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0002721"},{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0030955"},{"id":"A32","pred":"hp_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/HP_0001370"},{"id":"A33","pred":"hp_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A34","pred":"hp_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"PubChem ID Compound Name Hub Nodes Pathways targeted\n121304016 Remdesivir CDK2, SRC, AURKA, ABL1, CDK1, MAPK1, MAPK14, TOP1, MTOR, CASP8, AURKB, CCNB1, PRKCA, PTK2, CDK5, SYK, MET, IGF1R, CASP3, PDGFRB, EIF4A1, PIK3CA, MAP3K5, CDK2, SRC Pathways in cancer, Relaxin signaling pathway, PI3K-Akt signaling pathway, Endocrine resistance, Phospholipase D signaling pathway, AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, MAPK pathway,Platelet activation, Chemokine signaling pathway, mTOR signaling pathway,FoxO signaling pathway,EGFR tyrosine kinase inhibitor resistance.\n6654 Alpha-pinene ESR1, AR, MAPK1, PTPN11, MAPK14, PTPN1, RARA, RXRA, NR3C1, PPARG, PTPN6, MAPK3, TOP1, ESR2, CDC25A, CD81, NCOA1, NOS2, TERT Th17 cell differentiation, VEGF signaling pathway, cAMP signaling pathway, Type 2 diabetes, Fat digestion and absorption, Neuroactive ligand-receptor interaction, Calcium signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, HIF-1 signaling pathway, IL-17 signaling pathway, Ras signaling pathway, Pathways in cancer\n7463 P-Cymene ESR1, HDAC1, AR, KDM1A, GSK3B, ESR2, ALB, KIF11, IGF1R, HTR3A, HTR2C, ALOX5, SHBG, CHRM3, AHR, PPARA Amphetamine addiction, Neuroactive ligand-receptor interaction, Calcium signaling pathway, Cocaine addiction, Alcoholism, Regulation of lipolysis in adipocytes, AGE-RAGE signaling pathway in diabetic complications, Inflammatory mediator regulation of TRP channels, c-GMP PkGsignaling pathway, NF-Κbsignaling pathway, IL-17 signaling pathway, cAMP signaling pathway\n10281 Thymoquinone GSK3B, PLK1, PARP1, PABPC1, NR3C1, MTNR1A, PTPN1, SOAT1, MTNR1B, XIAP, BRD4, PPARG, TOP2A, SYK, MAP2K1, IMPDH2, PTPN2, PGR, GLI1, MCL1, ALOX5 Neuroactive ligand-receptor interaction, Calcium signaling pathway, c-GMP PkGsignaling pathway, Alcoholism, Apoptosis, cAMP signaling pathway, lysosome, Influenza A, PI3K-AkT TNF signaling pathway, Pathways in cancer, NF-Κbsignaling pathway\n10364 Carvacrol ESR1, CDK2, HDAC1, AR, AURKA, AKT1, HDAC6, HDAC3, ADRB2, GAPDH, ESR2, ALB, MAPK8, CLK1,LDHA, PRKCA, LDHB, HDAC11, CCNA2, MAPK9, IGF1R Neuroactive ligand-receptor interaction, MAPK signaling pathway, Calcium signaling pathway, Relaxinsignaling pathway, Pathways in cancer, Alcoholism, PI3K-AkT TNF signaling pathway, Ras signaling pathway, Th17 cell differentiation, Influenza, Regulation of lipolysis in adipocytes, Endocrine and other factor- regulated calcium reabsorption, Adrenergic signaling in cardiomyocytes, Amphetamine addiction, VEGF signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Apoptosis, c-GMP PkGsignaling pathway, FOXO signaling pathway, Cocaine addiction\n11230 Terpinen-4-ol MAPK8, AR, JAK1, ESR1, JAK2, PTPN6, NR3C1, MAPK10, PPARA, PPARG, PTPN1, CHRM2, HTR2C, ESR2, CHRM4, HTR2A, DRD2, OPRK1, OPRD1, PGR, OPRM1, PARP1, MTNR1A Neuroactive ligand-receptor interaction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Th17 cell differentiation, Pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, cAMP signaling pathway, Tuberculosis, AMPK signaling pathway, Influenza, c-GMP PkGsignaling pathway, JAK-STAT pathway, Circadian rhythm, Relaxinsignaling pathway, Apoptosis- multiple species\n73296 alpha-Hederin GRB2, ITGA4, PPP1CA, SRC, AR, AURKA, PPP2CA, STAT3, CDK1, LGALS3, PTPN1, CASP8, XIAP, NCSTN, ATP1A1, ITGB1, PRKCD, IGF1R, CASP3, LGALS8, BCL2L1, MME, PSEN1, IMPDH2, HTR2C, IMPDH1, GLI1, HLA-A, ITGAV, ITGB3, PTPRA Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Rennin- angiotensin system, c-GMP PkGsignaling pathway, Pathways in cancer, PI3K-AkT TNF signaling pathway, Apoptosis, Autophagy, Complement and coagulation cascades, P53 signaling pathway, T-cell receptor signaling pathway, NF-Κbsignaling pathway, JAK-STAT pathway, Alcoholism, Chemokine signaling pathway, Tuberculosis, HIF-1 signaling pathway, MAPK signaling pathway\n95779 Thymohydroquinone HSP90AA1, HDAC1, AURKA, AKT1, PARP1, ERBB2, ABL1, HDAC6, CDK1, HDAC3, ADRB2, GAPDH, MTNR1A, MAPK14, ALB, PTPN1, MTNR1B, PRKCA, LDHA, NOS2, LDHB, BRAF Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, MAPK signaling pathway, Regulation of lipolysis in adipocytes, Oxytocin , Alcoholism, mTOR signaling pathway, PI3K-AkT TNF signaling pathway, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, VEGF signaling pathway, HIF-1 signaling pathway, Pathways in cancer, Natural killer cell mediated cytotoxicity, Tuberculosis, Colorectal cancer, Influenza A, Apoptosis, Amphetamine addiction, TNF signaling pathway, Hepatocellular carcinoma\n398941 Dithymoquinone HSP90AA1, SRC, AR, PRKDC, STAT3, NR3C1, MTNR1A, GAPDH, ESR2, ATM, MAPK8, TGFBR1, PTPN11, MTNR1B, EZR, NOS2, NCSTN, BRAF, CAPN1, PSEN1, CDC25A, PGR, PTK2B, ALOX5, PSEN2, OPRM1 Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, GABAergic synapse, Fluid shear stress and atherosclerosis, Apoptosis, Antigen processing and presentation, Chemokine signaling pathway, Morphine addiction, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, Cocaine addiction, Th17 cell differentiation, IL-17 signaling pathway, Alcoholism, c-GMP PkGsignaling pathway, Tuberculosis, Amphetamine addiction, Natural killer cell mediated cytotoxicity, TNF signaling pathway\n637563 trans-Anethole APP, EGF, RXPO1, ESR1 LRRK2 AR AURKA, RELA, PARP1, PRKDC, TUBB3, STAT3 MAPK14 KAT2B, PRKCA, NOS2, CDK5 KIF11, MAPT, JAK1, JAK2, CDC25B, TYK2 Nitrogen metabolism, Calcium signaling pathway, Primary immunodeficiency, TNF signaling pathway, T-cell receptor signaling pathway, Proximal tubule bicarbonate reclamation, Morphine addiction, IL-17 signaling pathway, NF-Κbsignaling pathway, Tuberculosis, VEGF signaling pathway, PI3K-AkT TNF signaling pathway, JAK-STAT pathway, Cocaine addiction, HIF-1 signaling pathway, Th17 cell differentiation, Pathways in cancer, Viral carcinogenesis\n11402337 Nigellicine HDAC1, EP300, AR, PPP1CA, CSNK2A1, RPA1, MAPK1, HDAC6, HSPA1A, CSNK2A2, MAP2K1, MCL1, TP53, NR4A1, ICAM1, TERT, EPRS, SORT1, FEN1, PGR Neuroactive ligand-receptor interaction, cAMP signaling pathway, Nitrogen metabolism, Apoptosis, Lysosome, TNF signaling pathway, NF-Κbsignaling pathway, Influenza A, Autophagy, Alcoholism, Rheumatoid arthritis, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, Renin- angiotensin system, FOXO signaling pathway, Transcriptional misregulation in cancer, c-GMP PkGsignaling pathway, Oxytocin signaling pathway, Viral carcinogenesis, Nitrogen metabolism\n136828302 Nigellidine ESR1, CDK2, VCP, AKT1, ERBB2, HTT, GSK3B, RAF1, PLK1, CDK1, CFTR, KIT, MTNR1A, ILK, PPARG, CCNA2, CCNB1, MTNR1B, PDGFRB, CCNE1, PRKACA, FGFR1, CDK5, PSEN1, OPRM1 Pathways in cancer, Neuroactive ligand-receptor interaction, Calcium signaling pathway, MAPK signaling pathway, Chemokine signaling pathway, c-GMP PkGsignaling pathway, Ras signaling pathway, HIF-1 signaling pathway, VEGF signaling pathway, Arachidonic acid metabolism, Autophagy, Apoptosis, FOXO signaling pathway, Tuberculosis, AGE-RAGE signaling pathway in diabetic complications, Morphine addiction, Cocaine addiction, T-cell receptor signaling pathway\n1796220 Longifolene ESR1, AR, ESR2, PTPN1, UBA2, NR1H3, SAE1, SHBG, PPARA, POLB, NR1I3, NR1H4, BCHE, AKR1B10, HSD11B1, SLC6A4, NCOA3, EP300, NCOA1, ACTB, ACHE, MED1, NCOR1 Steroid hormone mediated signaling pathway, response to oxygen- containing compound, lipid metabolic process, regulation of inflammatory response, regulation of cytokine mediated signaling pathway, regulation of innate immune process, blood circulation, regulation of insulin receptor signaling pathway, regulation of toll- like receptor signaling pathway"}

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ID Compound Name Hub Nodes Pathways targeted\n121304016 Remdesivir CDK2, SRC, AURKA, ABL1, CDK1, MAPK1, MAPK14, TOP1, MTOR, CASP8, AURKB, CCNB1, PRKCA, PTK2, CDK5, SYK, MET, IGF1R, CASP3, PDGFRB, EIF4A1, PIK3CA, MAP3K5, CDK2, SRC Pathways in cancer, Relaxin signaling pathway, PI3K-Akt signaling pathway, Endocrine resistance, Phospholipase D signaling pathway, AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, MAPK pathway,Platelet activation, Chemokine signaling pathway, mTOR signaling pathway,FoxO signaling pathway,EGFR tyrosine kinase inhibitor resistance.\n6654 Alpha-pinene ESR1, AR, MAPK1, PTPN11, MAPK14, PTPN1, RARA, RXRA, NR3C1, PPARG, PTPN6, MAPK3, TOP1, ESR2, CDC25A, CD81, NCOA1, NOS2, TERT Th17 cell differentiation, VEGF signaling pathway, cAMP signaling pathway, Type 2 diabetes, Fat digestion and absorption, Neuroactive ligand-receptor interaction, Calcium signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, HIF-1 signaling pathway, IL-17 signaling pathway, Ras signaling pathway, Pathways in cancer\n7463 P-Cymene ESR1, HDAC1, AR, KDM1A, GSK3B, ESR2, ALB, KIF11, IGF1R, HTR3A, HTR2C, ALOX5, SHBG, CHRM3, AHR, PPARA Amphetamine addiction, Neuroactive ligand-receptor interaction, Calcium signaling pathway, Cocaine addiction, Alcoholism, Regulation of lipolysis in adipocytes, AGE-RAGE signaling pathway in diabetic complications, Inflammatory mediator regulation of TRP channels, c-GMP PkGsignaling pathway, NF-Κbsignaling pathway, IL-17 signaling pathway, cAMP signaling pathway\n10281 Thymoquinone GSK3B, PLK1, PARP1, PABPC1, NR3C1, MTNR1A, PTPN1, SOAT1, MTNR1B, XIAP, BRD4, PPARG, TOP2A, SYK, MAP2K1, IMPDH2, PTPN2, PGR, GLI1, MCL1, ALOX5 Neuroactive ligand-receptor interaction, Calcium signaling pathway, c-GMP PkGsignaling pathway, Alcoholism, Apoptosis, cAMP signaling pathway, lysosome, Influenza A, PI3K-AkT TNF signaling pathway, Pathways in cancer, NF-Κbsignaling pathway\n10364 Carvacrol ESR1, CDK2, HDAC1, AR, AURKA, AKT1, HDAC6, HDAC3, ADRB2, GAPDH, ESR2, ALB, MAPK8, CLK1,LDHA, PRKCA, LDHB, HDAC11, CCNA2, MAPK9, IGF1R Neuroactive ligand-receptor interaction, MAPK signaling pathway, Calcium signaling pathway, Relaxinsignaling pathway, Pathways in cancer, Alcoholism, PI3K-AkT TNF signaling pathway, Ras signaling pathway, Th17 cell differentiation, Influenza, Regulation of lipolysis in adipocytes, Endocrine and other factor- regulated calcium reabsorption, Adrenergic signaling in cardiomyocytes, Amphetamine addiction, VEGF signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Apoptosis, c-GMP PkGsignaling pathway, FOXO signaling pathway, Cocaine addiction\n11230 Terpinen-4-ol MAPK8, AR, JAK1, ESR1, JAK2, PTPN6, NR3C1, MAPK10, PPARA, PPARG, PTPN1, CHRM2, HTR2C, ESR2, CHRM4, HTR2A, DRD2, OPRK1, OPRD1, PGR, OPRM1, PARP1, MTNR1A Neuroactive ligand-receptor interaction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Th17 cell differentiation, Pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, cAMP signaling pathway, Tuberculosis, AMPK signaling pathway, Influenza, c-GMP PkGsignaling pathway, JAK-STAT pathway, Circadian rhythm, Relaxinsignaling pathway, Apoptosis- multiple species\n73296 alpha-Hederin GRB2, ITGA4, PPP1CA, SRC, AR, AURKA, PPP2CA, STAT3, CDK1, LGALS3, PTPN1, CASP8, XIAP, NCSTN, ATP1A1, ITGB1, PRKCD, IGF1R, CASP3, LGALS8, BCL2L1, MME, PSEN1, IMPDH2, HTR2C, IMPDH1, GLI1, HLA-A, ITGAV, ITGB3, PTPRA Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Rennin- angiotensin system, c-GMP PkGsignaling pathway, Pathways in cancer, PI3K-AkT TNF signaling pathway, Apoptosis, Autophagy, Complement and coagulation cascades, P53 signaling pathway, T-cell receptor signaling pathway, NF-Κbsignaling pathway, JAK-STAT pathway, Alcoholism, Chemokine signaling pathway, Tuberculosis, HIF-1 signaling pathway, MAPK signaling pathway\n95779 Thymohydroquinone HSP90AA1, HDAC1, AURKA, AKT1, PARP1, ERBB2, ABL1, HDAC6, CDK1, HDAC3, ADRB2, GAPDH, MTNR1A, MAPK14, ALB, PTPN1, MTNR1B, PRKCA, LDHA, NOS2, LDHB, BRAF Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, MAPK signaling pathway, Regulation of lipolysis in adipocytes, Oxytocin , Alcoholism, mTOR signaling pathway, PI3K-AkT TNF signaling pathway, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, VEGF signaling pathway, HIF-1 signaling pathway, Pathways in cancer, Natural killer cell mediated cytotoxicity, Tuberculosis, Colorectal cancer, Influenza A, Apoptosis, Amphetamine addiction, TNF signaling pathway, Hepatocellular carcinoma\n398941 Dithymoquinone HSP90AA1, SRC, AR, PRKDC, STAT3, NR3C1, MTNR1A, GAPDH, ESR2, ATM, MAPK8, TGFBR1, PTPN11, MTNR1B, EZR, NOS2, NCSTN, BRAF, CAPN1, PSEN1, CDC25A, PGR, PTK2B, ALOX5, PSEN2, OPRM1 Neuroactive ligand-receptor interaction, Calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Relaxinsignaling pathway, GABAergic synapse, Fluid shear stress and atherosclerosis, Apoptosis, Antigen processing and presentation, Chemokine signaling pathway, Morphine addiction, FOXO signaling pathway, Inflammatory mediator regulation of TRP channels, Cocaine addiction, Th17 cell differentiation, IL-17 signaling pathway, Alcoholism, c-GMP PkGsignaling pathway, Tuberculosis, Amphetamine addiction, Natural killer cell mediated cytotoxicity, TNF signaling pathway\n637563 trans-Anethole APP, EGF, RXPO1, ESR1 LRRK2 AR AURKA, RELA, PARP1, PRKDC, TUBB3, STAT3 MAPK14 KAT2B, PRKCA, NOS2, CDK5 KIF11, MAPT, JAK1, JAK2, CDC25B, TYK2 Nitrogen metabolism, Calcium signaling pathway, Primary immunodeficiency, TNF signaling pathway, T-cell receptor signaling pathway, Proximal tubule bicarbonate reclamation, Morphine addiction, IL-17 signaling pathway, NF-Κbsignaling pathway, Tuberculosis, VEGF signaling pathway, PI3K-AkT TNF signaling pathway, JAK-STAT pathway, Cocaine addiction, HIF-1 signaling pathway, Th17 cell differentiation, Pathways in cancer, Viral carcinogenesis\n11402337 Nigellicine HDAC1, EP300, AR, PPP1CA, CSNK2A1, RPA1, MAPK1, HDAC6, HSPA1A, CSNK2A2, MAP2K1, MCL1, TP53, NR4A1, ICAM1, TERT, EPRS, SORT1, FEN1, PGR Neuroactive ligand-receptor interaction, cAMP signaling pathway, Nitrogen metabolism, Apoptosis, Lysosome, TNF signaling pathway, NF-Κbsignaling pathway, Influenza A, Autophagy, Alcoholism, Rheumatoid arthritis, HIF-1 signaling pathway, IL-17 signaling pathway, VEGF signaling pathway, Renin- angiotensin system, FOXO signaling pathway, Transcriptional misregulation in cancer, c-GMP PkGsignaling pathway, Oxytocin signaling pathway, Viral carcinogenesis, Nitrogen metabolism\n136828302 Nigellidine ESR1, CDK2, VCP, AKT1, ERBB2, HTT, GSK3B, RAF1, PLK1, CDK1, CFTR, KIT, MTNR1A, ILK, PPARG, CCNA2, CCNB1, MTNR1B, PDGFRB, CCNE1, PRKACA, FGFR1, CDK5, PSEN1, OPRM1 Pathways in cancer, Neuroactive ligand-receptor interaction, Calcium signaling pathway, MAPK signaling pathway, Chemokine signaling pathway, c-GMP PkGsignaling pathway, Ras signaling pathway, HIF-1 signaling pathway, VEGF signaling pathway, Arachidonic acid metabolism, Autophagy, Apoptosis, FOXO signaling pathway, Tuberculosis, AGE-RAGE signaling pathway in diabetic complications, Morphine addiction, Cocaine addiction, T-cell receptor signaling pathway\n1796220 Longifolene ESR1, AR, ESR2, PTPN1, UBA2, NR1H3, SAE1, SHBG, PPARA, POLB, NR1I3, NR1H4, BCHE, AKR1B10, HSD11B1, SLC6A4, NCOA3, EP300, NCOA1, ACTB, ACHE, MED1, NCOR1 Steroid hormone mediated signaling pathway, response to oxygen- containing compound, lipid metabolic process, regulation of inflammatory response, regulation of cytokine mediated signaling pathway, regulation of innate immune process, blood circulation, regulation of insulin receptor signaling pathway, regulation of toll- like receptor signaling pathway"}