PMC:7605337 / 9414-10228
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T36 | 275-282 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T72 | 163-172 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T73 | 570-579 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T74 | 672-681 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T76 | 133-134 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T37 | 275-282 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T47 | 0-99 | Sentence | denotes | It is not known whether these mutations are linked to the severity of coronavirus in these regions. |
| T48 | 100-323 | Sentence | denotes | Starr and co-workers25 performed a deep mutational scanning of nCOV-2019 RBD and used flow cytometry to measure the effect of single mutations on the expression of the folded protein as well as its binding affinity to ACE2. |
| T49 | 324-464 | Sentence | denotes | They showed that RBD is very tolerant to these mutations to maintain its expression level as well as binding affinity to ACE2 in most cases. |
| T50 | 465-580 | Sentence | denotes | According to their results, most natural mutations exert similar binding affinities to ACE2 as wild-type nCOV-2019. |
| T51 | 581-814 | Sentence | denotes | Furthermore, they showed that mutations at critical positions at the RBD-ACE2 interface at nCOV-2019 such as residues Q493 and Q498 do not reduce the binding affinity to ACE2 which shows the substantial plasticity of the interface.25 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 265 | 318-322 | Gene | denotes | ACE2 | Gene:59272 |
| 266 | 445-449 | Gene | denotes | ACE2 | Gene:59272 |
| 267 | 552-556 | Gene | denotes | ACE2 | Gene:59272 |
| 268 | 654-658 | Gene | denotes | ACE2 | Gene:59272 |
| 269 | 751-755 | Gene | denotes | ACE2 | Gene:59272 |
| 270 | 70-81 | Species | denotes | coronavirus | Tax:11118 |
| 271 | 163-167 | Species | denotes | nCOV | Tax:2697049 |
| 272 | 570-574 | Species | denotes | nCOV | Tax:2697049 |
| 273 | 672-676 | Species | denotes | nCOV | Tax:2697049 |