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PMC:7605337 / 7288-8239 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T30 179-187 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T31 498-505 Body_part denotes alanine http://purl.org/sig/ont/fma/fma82749
T32 620-625 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T33 727-739 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T54 114-129 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T55 120-129 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T56 268-277 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T57 333-337 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T58 684-688 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T59 747-751 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T60 825-829 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T67 74-82 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human or
T68 100-101 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T69 614-625 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T70 764-766 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T71 767-769 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T72 902-903 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73 930-931 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T29 179-187 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T30 498-505 Chemical denotes alanine http://purl.obolibrary.org/obo/CHEBI_16449
T31 727-739 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 114-129 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T38 0-951 Sentence denotes It was demonstrated that these mutations were viral adaptations to either human or civet ACE2.14,16 A pseudotyped viral infection assay of the interaction between different spike proteins and ACE2 confirmed the correlation between high affinity mutants and their high infection.16 Further investigation of RBD residues in binding of SARS-COV and ACE2 was performed through ala-scanning mutagenesis, which resulted in identification of residues that reduce binding affinity to ACE2 upon mutation to alanine.17 RBD mutations have also been identified in MERS-COV, which affected their affinity to receptor (DPP4) on human cells.14 Multiple monoclonal antibodies have been developed for SARS since 2002 that neutralized the spike glycoprotein on the SARS-COV surface.18−22 However, multiple escape mutations exist in the RBD of SARS-COV that affect neutralization with antibodies, which led to the use of a cocktail of antibodies as a robust treatment.23

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
211 89-93 Gene denotes ACE2 Gene:59272
212 192-196 Gene denotes ACE2 Gene:59272
213 346-350 Gene denotes ACE2 Gene:59272
214 476-480 Gene denotes ACE2 Gene:59272
215 605-609 Gene denotes DPP4 Gene:1803
217 173-178 Gene denotes spike Gene:43740568
231 74-79 Species denotes human Tax:9606
232 333-341 Species denotes SARS-COV Tax:694009
233 552-560 Species denotes MERS-COV Tax:1335626
234 614-619 Species denotes human Tax:9606
235 747-755 Species denotes SARS-COV Tax:694009
236 825-833 Species denotes SARS-COV Tax:694009
238 373-376 Chemical denotes ala MESH:D000409
239 498-505 Chemical denotes alanine MESH:D000409
240 114-129 Disease denotes viral infection MESH:D001102
241 268-277 Disease denotes infection MESH:D007239