> top > docs > PMC:7605337 > spans > 5941-8239 > annotations

PMC:7605337 / 5941-8239 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T30 1526-1534 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T31 1845-1852 Body_part denotes alanine http://purl.org/sig/ont/fma/fma82749
T32 1967-1972 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T33 2074-2086 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T39 31-35 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T40 50-54 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T41 90-99 Disease denotes nCOV-2019 http://purl.obolibrary.org/obo/MONDO_0100096
T42 187-196 Disease denotes nCOV-2019 http://purl.obolibrary.org/obo/MONDO_0100096
T43 201-205 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T44 257-261 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T45 312-316 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T46 327-331 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T47 685-689 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T48 778-782 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T49 836-840 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T50 924-928 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T51 996-1000 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T52 1044-1048 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T53 1265-1269 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T54 1461-1476 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T55 1467-1476 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T56 1615-1624 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T57 1680-1684 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T58 2031-2035 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T59 2094-2098 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T60 2172-2176 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T57 43-48 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T58 142-143 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T59 374-381 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T60 461-466 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T61 858-859 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T62 883-888 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T63 893-898 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T64 902-907 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T65 1063-1069 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T66 1149-1152 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T67 1421-1429 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human or
T68 1447-1448 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T69 1961-1972 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T70 2111-2113 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T71 2114-2116 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T72 2249-2250 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73 2277-2278 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T25 556-560 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T27 620-624 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T29 1526-1534 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T30 1845-1852 Chemical denotes alanine http://purl.obolibrary.org/obo/CHEBI_16449
T31 2074-2086 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 1461-1476 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T31 0-132 Sentence denotes The sequence alignment between SARS-COV in human, SARS civet, Bat RaTG13 coronavirus, and nCOV-2019 in the RBM is shown in Figure 2.
T32 133-210 Sentence denotes There is a 50% sequence similarity between the RBM of nCOV-2019 and SARS-COV.
T33 211-382 Sentence denotes RBM mutations played an important role in the SARS epidemic in 2002.3,12 Two mutations in the RBM of SARS-2002 from SARS-Civet were observed from strains of these viruses.
T34 383-424 Sentence denotes These two mutations were K479N and S487T.
T35 425-529 Sentence denotes These two residues are close to the virus binding hotspots in ACE2 including hotspot-31 and hotspot-353.
T36 530-658 Sentence denotes Hotspot-31 centers on the salt-bridge between K31-E35 and hotspot-353 are centered on the salt-bridge between K353-E358 on ACE2.
T37 659-1346 Sentence denotes Residues K479 and S487 in SARS-Civet are in close proximity with these hotspots and mutations at these residues caused SARS to bind ACE2 with significantly higher affinity than SARS-civet and played a major role in civet-to-human and human-to-human transmission of SARS coronavirus in 2002.3,13−15 Numerous mutations in the interface of SARS-COV RBD and ACE2 from different strains of SARS isolated from humans in 2002 have been identified and the effect of these mutations on binding ACE2 has been investigated by SPR.14,16 Two identified RBD mutations (Y442F and L472F) increased the binding affinity of SARS-COV to ACE2 and two mutations (N479K, T487S) decreased the binding affinity.
T38 1347-2298 Sentence denotes It was demonstrated that these mutations were viral adaptations to either human or civet ACE2.14,16 A pseudotyped viral infection assay of the interaction between different spike proteins and ACE2 confirmed the correlation between high affinity mutants and their high infection.16 Further investigation of RBD residues in binding of SARS-COV and ACE2 was performed through ala-scanning mutagenesis, which resulted in identification of residues that reduce binding affinity to ACE2 upon mutation to alanine.17 RBD mutations have also been identified in MERS-COV, which affected their affinity to receptor (DPP4) on human cells.14 Multiple monoclonal antibodies have been developed for SARS since 2002 that neutralized the spike glycoprotein on the SARS-COV surface.18−22 However, multiple escape mutations exist in the RBD of SARS-COV that affect neutralization with antibodies, which led to the use of a cocktail of antibodies as a robust treatment.23

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
205 487-491 Gene denotes ACE2 Gene:59272
206 653-657 Gene denotes ACE2 Gene:59272
207 791-795 Gene denotes ACE2 Gene:59272
208 1013-1017 Gene denotes ACE2 Gene:59272
209 1144-1148 Gene denotes ACE2 Gene:59272
210 1277-1281 Gene denotes ACE2 Gene:59272
211 1436-1440 Gene denotes ACE2 Gene:59272
212 1539-1543 Gene denotes ACE2 Gene:59272
213 1693-1697 Gene denotes ACE2 Gene:59272
214 1823-1827 Gene denotes ACE2 Gene:59272
215 1952-1956 Gene denotes DPP4 Gene:1803
216 576-579 Gene denotes K31 Gene:3881
217 1520-1525 Gene denotes spike Gene:43740568
218 31-39 Species denotes SARS-COV Tax:694009
219 43-48 Species denotes human Tax:9606
220 73-84 Species denotes coronavirus Tax:11118
221 90-94 Species denotes nCOV Tax:2697049
222 187-191 Species denotes nCOV Tax:2697049
223 201-209 Species denotes SARS-COV Tax:694009
224 883-888 Species denotes human Tax:9606
225 893-898 Species denotes human Tax:9606
226 902-907 Species denotes human Tax:9606
227 924-940 Species denotes SARS coronavirus Tax:694009
228 996-1004 Species denotes SARS-COV Tax:694009
229 1063-1069 Species denotes humans Tax:9606
230 1265-1273 Species denotes SARS-COV Tax:694009
231 1421-1426 Species denotes human Tax:9606
232 1680-1688 Species denotes SARS-COV Tax:694009
233 1899-1907 Species denotes MERS-COV Tax:1335626
234 1961-1966 Species denotes human Tax:9606
235 2094-2102 Species denotes SARS-COV Tax:694009
236 2172-2180 Species denotes SARS-COV Tax:694009
237 640-644 Chemical denotes K353
238 1720-1723 Chemical denotes ala MESH:D000409
239 1845-1852 Chemical denotes alanine MESH:D000409
240 1461-1476 Disease denotes viral infection MESH:D001102
241 1615-1624 Disease denotes infection MESH:D007239