PMC:7605337 / 571-1122 JSONTXT

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T3","span":{"begin":93,"end":102},"obj":"Disease"},{"id":"T4","span":{"begin":184,"end":217},"obj":"Disease"},{"id":"T5","span":{"begin":231,"end":235},"obj":"Disease"},{"id":"T6","span":{"begin":354,"end":363},"obj":"Disease"}],"attributes":[{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"ensin converter enzyme (ACE2). Our goal is to provide a detailed structural mechanism of how nCOV-2019 recognizes and establishes contacts with ACE2 and its difference with an earlier severe acute respiratory syndrome coronavirus (SARS-COV) in 2002 via extensive molecular dynamics (MD) simulations. Numerous mutations have been identified in the RBD of nCOV-2019 strains isolated from humans in different parts of the world. In this study, we investigated the effect of these mutations as well as other Ala-scanning mutations on the stability of the "}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T4","span":{"begin":54,"end":55},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T5","span":{"begin":283,"end":285},"obj":"http://purl.obolibrary.org/obo/CLO_0007622"},{"id":"T6","span":{"begin":386,"end":392},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}],"text":"ensin converter enzyme (ACE2). Our goal is to provide a detailed structural mechanism of how nCOV-2019 recognizes and establishes contacts with ACE2 and its difference with an earlier severe acute respiratory syndrome coronavirus (SARS-COV) in 2002 via extensive molecular dynamics (MD) simulations. Numerous mutations have been identified in the RBD of nCOV-2019 strains isolated from humans in different parts of the world. In this study, we investigated the effect of these mutations as well as other Ala-scanning mutations on the stability of the "}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T5","span":{"begin":283,"end":285},"obj":"Chemical"},{"id":"T6","span":{"begin":504,"end":507},"obj":"Chemical"}],"attributes":[{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_74699"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_16977"},{"id":"A7","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_46217"}],"text":"ensin converter enzyme (ACE2). Our goal is to provide a detailed structural mechanism of how nCOV-2019 recognizes and establishes contacts with ACE2 and its difference with an earlier severe acute respiratory syndrome coronavirus (SARS-COV) in 2002 via extensive molecular dynamics (MD) simulations. Numerous mutations have been identified in the RBD of nCOV-2019 strains isolated from humans in different parts of the world. In this study, we investigated the effect of these mutations as well as other Ala-scanning mutations on the stability of the "}

{"project":"LitCovid-sentences","denotations":[{"id":"T5","span":{"begin":31,"end":299},"obj":"Sentence"},{"id":"T6","span":{"begin":300,"end":425},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ensin converter enzyme (ACE2). Our goal is to provide a detailed structural mechanism of how nCOV-2019 recognizes and establishes contacts with ACE2 and its difference with an earlier severe acute respiratory syndrome coronavirus (SARS-COV) in 2002 via extensive molecular dynamics (MD) simulations. Numerous mutations have been identified in the RBD of nCOV-2019 strains isolated from humans in different parts of the world. In this study, we investigated the effect of these mutations as well as other Ala-scanning mutations on the stability of the "}

{"project":"LitCovid-PubTator","denotations":[{"id":"21","span":{"begin":24,"end":28},"obj":"Gene"},{"id":"22","span":{"begin":144,"end":148},"obj":"Gene"},{"id":"31","span":{"begin":93,"end":97},"obj":"Species"},{"id":"32","span":{"begin":184,"end":229},"obj":"Species"},{"id":"33","span":{"begin":231,"end":239},"obj":"Species"},{"id":"34","span":{"begin":354,"end":358},"obj":"Species"},{"id":"35","span":{"begin":386,"end":392},"obj":"Species"},{"id":"38","span":{"begin":504,"end":507},"obj":"Chemical"}],"attributes":[{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"Gene:59272"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Gene:59272"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"Tax:2697049"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"Tax:694009"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"Tax:694009"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"Tax:2697049"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"Tax:9606"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"MESH:D000409"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ensin converter enzyme (ACE2). Our goal is to provide a detailed structural mechanism of how nCOV-2019 recognizes and establishes contacts with ACE2 and its difference with an earlier severe acute respiratory syndrome coronavirus (SARS-COV) in 2002 via extensive molecular dynamics (MD) simulations. Numerous mutations have been identified in the RBD of nCOV-2019 strains isolated from humans in different parts of the world. In this study, we investigated the effect of these mutations as well as other Ala-scanning mutations on the stability of the "}