PMC:7605337 / 48983-49346 JSONTXT

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T333","span":{"begin":115,"end":124},"obj":"Disease"}],"attributes":[{"id":"A333","pred":"mondo_id","subj":"T333","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"These results are in fair agreement with experimental binding measurements with deep mutational scanning of RBD in nCOV-2019 where they used flow cytometry for different ACE2 concentrations to measure the dissociation constant KD.25 It was shown that mutations at K417, N487, T500, and G502 are detrimental for binding to ACE2, which agrees with the results here."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T160","span":{"begin":227,"end":229},"obj":"Chemical"}],"attributes":[{"id":"A160","pred":"chebi_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/CHEBI_73601"}],"text":"These results are in fair agreement with experimental binding measurements with deep mutational scanning of RBD in nCOV-2019 where they used flow cytometry for different ACE2 concentrations to measure the dissociation constant KD.25 It was shown that mutations at K417, N487, T500, and G502 are detrimental for binding to ACE2, which agrees with the results here."}

{"project":"LitCovid-sentences","denotations":[{"id":"T334","span":{"begin":0,"end":363},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"These results are in fair agreement with experimental binding measurements with deep mutational scanning of RBD in nCOV-2019 where they used flow cytometry for different ACE2 concentrations to measure the dissociation constant KD.25 It was shown that mutations at K417, N487, T500, and G502 are detrimental for binding to ACE2, which agrees with the results here."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1208","span":{"begin":170,"end":174},"obj":"Gene"},{"id":"1209","span":{"begin":322,"end":326},"obj":"Gene"},{"id":"1239","span":{"begin":115,"end":119},"obj":"Species"}],"attributes":[{"id":"A1208","pred":"tao:has_database_id","subj":"1208","obj":"Gene:59272"},{"id":"A1209","pred":"tao:has_database_id","subj":"1209","obj":"Gene:59272"},{"id":"A1239","pred":"tao:has_database_id","subj":"1239","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"These results are in fair agreement with experimental binding measurements with deep mutational scanning of RBD in nCOV-2019 where they used flow cytometry for different ACE2 concentrations to measure the dissociation constant KD.25 It was shown that mutations at K417, N487, T500, and G502 are detrimental for binding to ACE2, which agrees with the results here."}