PMC:7605337 / 43355-44193
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T62 | 366-373 | Body_part | denotes | alanine | http://purl.org/sig/ont/fma/fma82749 |
| T63 | 688-695 | Body_part | denotes | alanine | http://purl.org/sig/ont/fma/fma82749 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T296 | 24-33 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T297 | 38-42 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T298 | 311-315 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T299 | 586-595 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T300 | 600-604 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T271 | 180-181 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T272 | 204-205 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T273 | 391-392 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T274 | 417-420 | http://purl.obolibrary.org/obo/CLO_0003078 | denotes | FEL |
| T275 | 543-545 | http://purl.obolibrary.org/obo/CLO_0008933 | denotes | S5 |
| T276 | 834-836 | http://purl.obolibrary.org/obo/CLO_0008933 | denotes | S5 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T132 | 6-9 | Chemical | denotes | PCA | http://purl.obolibrary.org/obo/CHEBI_36751|http://purl.obolibrary.org/obo/CHEBI_62248 |
| T134 | 366-373 | Chemical | denotes | alanine | http://purl.obolibrary.org/obo/CHEBI_16449 |
| T135 | 485-487 | Chemical | denotes | S4 | http://purl.obolibrary.org/obo/CHEBI_29401 |
| T136 | 543-545 | Chemical | denotes | S5 | http://purl.obolibrary.org/obo/CHEBI_29386 |
| T137 | 581-584 | Chemical | denotes | PCA | http://purl.obolibrary.org/obo/CHEBI_36751|http://purl.obolibrary.org/obo/CHEBI_62248 |
| T139 | 688-695 | Chemical | denotes | alanine | http://purl.obolibrary.org/obo/CHEBI_16449 |
| T140 | 834-836 | Chemical | denotes | S5 | http://purl.obolibrary.org/obo/CHEBI_29386 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T296 | 0-238 | Sentence | denotes | Using PCA, the aFEL for nCOV-2019 and SARS-COV demonstrated that the former occupies only one low energy state whereas the latter forms two distinct low energy basins separated by a metastable state with a barrier of about 6–7.5 kcal/mol. |
| T297 | 239-354 | Sentence | denotes | This confirms that the level of binding for the RBD domain is weaker in SARS-COV due to the presence of two basins. |
| T298 | 355-489 | Sentence | denotes | Similarly, alanine-substitution for a few residues caused the FEL to degenerate into separate multiple low energy regions (Figure S4). |
| T299 | 490-668 | Sentence | denotes | Dominant motions in the RBD are visualized in Figure S5 using the first eigenvector of the PCA. nCOV-2019 and SARS-COV did not show any strong motion in the extended loop region. |
| T300 | 669-838 | Sentence | denotes | Porcupine plots of alanine-mutants demonstrated that mutant N487A shows large motion in the L1 region and Y449A, G447A, and E484A showed large motions in L3 (Figure S5). |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1067 | 24-28 | Species | denotes | nCOV | Tax:2697049 |
| 1068 | 38-46 | Species | denotes | SARS-COV | Tax:694009 |
| 1069 | 311-319 | Species | denotes | SARS-COV | Tax:694009 |
| 1070 | 586-590 | Species | denotes | nCOV | Tax:2697049 |
| 1071 | 600-608 | Species | denotes | SARS-COV | Tax:694009 |
| 1072 | 366-373 | Chemical | denotes | alanine | MESH:D000409 |
| 1073 | 688-695 | Chemical | denotes | alanine | MESH:D000409 |