PMC:7605337 / 4033-4736 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7605337","sourcedb":"PMC","sourceid":"7605337","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7605337","text":"The RBD of nCOV-2019 shares 72.8% sequence identity to SARS-COV RBD and the root mean squared deviation (RMSD) for the structure between the two proteins is 1.2Å, which shows the high structural similarity.4,8,9 Experimental binding affinity measurements using surface plasmon resonance (SPR) have shown that nCOV-2019 spike protein binds its receptor human angiotensin converter enzyme (ACE2) with 10 to 20 fold higher affinity than SARS-COV binding to ACE2.7 Based on the sequence similarity between RBD of nCOV-2019 and SARS-COV and also the tight binding between the RBD of nCOV-2019 and ACE2, it is most probable that nCOV-2019 uses this receptor on human cells to gain entry into the 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