| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T265 |
0-139 |
Sentence |
denotes |
H-bond analysis was also performed for the mutant systems and the results for H-bonds with more than 40% consistency are shown in Table S3. |
| T266 |
140-247 |
Sentence |
denotes |
Few of the alanine substitutions increase the number of interfacial H-bonds between nCOV-2019 RBD and ACE2. |
| T267 |
248-350 |
Sentence |
denotes |
Interestingly, the ala-substitution at Y489A increased the number of H-bonds in the wild-type complex. |
| T268 |
351-527 |
Sentence |
denotes |
Mutation in some of the residues having consistent H-bonds in the wild type complex such as Q498A and Q493A, stunningly maintain the number of H-bonds in the wild-type complex. |
| T269 |
528-695 |
Sentence |
denotes |
This indicates that the plasticity in the network of H-bonds in RBM of nCOV-2019 can reshape the network and strengthen other H-bonds upon mutation in these locations. |
| T270 |
696-777 |
Sentence |
denotes |
However, few mutations decrease the number of H-bonds from the wild-type complex. |
| T271 |
778-897 |
Sentence |
denotes |
Alanine substitution at residue G502 has a significant effect on the network of H-bonds between nCOV-2019 and SARS-COV. |
| T272 |
898-989 |
Sentence |
denotes |
This residue locates at the end of L4 loop near two other important residues Q498 and T500. |
| T273 |
990-1041 |
Sentence |
denotes |
This mutation breaks the H-bonds at these residues. |
| T274 |
1042-1142 |
Sentence |
denotes |
Mutation K417A decreases the number of H-bonds to only 5 where the H-bond at residue Q498 is broken. |
| T275 |
1143-1277 |
Sentence |
denotes |
This indicates the delicate nature of the H-bond from residue Q498 which can easily be broken upon ala-substitution at other residues. |
| T276 |
1278-1373 |
Sentence |
denotes |
Furthermore, mutation N487 also decreases the number of H-bonds by breaking the H-bond at Q498. |
