PMC:7605337 / 28572-29876
Annnotations
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T176 | 51-55 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T177 | 61-70 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T178 | 364-373 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T179 | 436-440 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T180 | 602-611 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T181 | 616-620 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T182 | 696-705 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T183 | 738-742 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T184 | 874-883 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T185 | 915-919 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T186 | 925-934 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T187 | 1019-1023 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T188 | 1103-1107 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T189 | 1162-1171 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T190 | 1264-1273 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T191 | 1283-1287 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T193 | 140-142 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T194 | 374-377 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T195 | 378-379 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T196 | 445-448 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T197 | 449-450 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T198 | 803-804 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T199 | 948-949 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T181 | 0-504 | Sentence | denotes | The binding energetics between ACE2 and the RBD of SARS-COV, nCOV-2019, and all its mutant complexes were investigated by the MMPBSA method.48 The binding energy was partitioned into its individual components including: electrostatic, van der Waals, polar solvation, and SASA to identify important factors affecting the interface of RBD and ACE2 in all complexes. nCOV-2019 has a total binding energy of −50.22 ± 1.93 kcal/mol, whereas SARS-COV has a much higher binding energy of −18.79 ± 1.53 kcal/mol. |
| T182 | 505-747 | Sentence | denotes | Decomposition of binding energy to its components show that the most striking difference between nCOV-2019 and SARS-COV is the electrostatic contribution which is −746.69 ± 2.66 kcal/mol for nCOV-2019 and −600.14 ± 7.65 kcal/mol for SARS-COV. |
| T183 | 748-1052 | Sentence | denotes | This high electrostatic contribution is compensated by a large polar solvation free energy which is 797.30 ± 3.12kcal/mol for nCOV-2019 and 659.61 ± 8.98 kcal/mol for SARS-COV. nCOV-2019 also possess a higher van der Waals (vdw) contribution (−89.93 ± 0.46 kcal/mol than SARS-COV (−70.07 ± 1.22 kcal/mol. |
| T184 | 1053-1172 | Sentence | denotes | Furthermore, the SASA contribution to binding for SARS-COV was −8.30 ± 0.15 kcal/mol and −10.58 kcal/mol for nCOV-2019. |
| T185 | 1173-1304 | Sentence | denotes | Both hydrophobic and electrostatic interactions play major roles in the higher affinity of nCOV-2019 RBD than SARS-COV RBD to ACE2. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 633 | 31-35 | Gene | denotes | ACE2 | Gene:59272 |
| 634 | 341-345 | Gene | denotes | ACE2 | Gene:59272 |
| 635 | 1299-1303 | Gene | denotes | ACE2 | Gene:59272 |
| 636 | 51-59 | Species | denotes | SARS-COV | Tax:694009 |
| 637 | 61-65 | Species | denotes | nCOV | Tax:2697049 |
| 638 | 364-368 | Species | denotes | nCOV | Tax:2697049 |
| 639 | 436-444 | Species | denotes | SARS-COV | Tax:694009 |
| 640 | 602-606 | Species | denotes | nCOV | Tax:2697049 |
| 641 | 616-624 | Species | denotes | SARS-COV | Tax:694009 |
| 642 | 696-700 | Species | denotes | nCOV | Tax:2697049 |
| 643 | 738-746 | Species | denotes | SARS-COV | Tax:694009 |
| 644 | 874-878 | Species | denotes | nCOV | Tax:2697049 |
| 645 | 915-923 | Species | denotes | SARS-COV | Tax:694009 |
| 646 | 925-929 | Species | denotes | nCOV | Tax:2697049 |
| 647 | 1019-1027 | Species | denotes | SARS-COV | Tax:694009 |
| 648 | 1103-1111 | Species | denotes | SARS-COV | Tax:694009 |
| 649 | 1162-1166 | Species | denotes | nCOV | Tax:2697049 |
| 650 | 1264-1268 | Species | denotes | nCOV | Tax:2697049 |
| 651 | 1283-1291 | Species | denotes | SARS-COV | Tax:694009 |