PMC:7605337 / 25856-26557 JSONTXT

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T159","span":{"begin":134,"end":143},"obj":"Disease"},{"id":"T160","span":{"begin":388,"end":392},"obj":"Disease"}],"attributes":[{"id":"A159","pred":"mondo_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A160","pred":"mondo_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"In each system, the first eigenvector was used to construct the porcupine plots to visualize the most dominant movements (Figure S5). nCOV-2019 showed a small motion in L3 and the core region and the extended loop region are very rigid showing small cones in the porcupine plot. The core structure of the RBD remains dormant as the cones are blue in most of the regions (Figure S5-A). In SARS-COV, the C-terminal region shows large motions (Figure S5-B). Mutation N487A showed a large motion in L1 (Figure S5-C). Mutations Y449A, G447A, and E484A demonstrate large motions in L3 (Figure S5). Overall, these plots show the involvement of these residues in the dynamic stability of the RBD/ACE2 complex."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T174","span":{"begin":129,"end":131},"obj":"http://purl.obolibrary.org/obo/CLO_0008933"},{"id":"T175","span":{"begin":151,"end":152},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T176","span":{"begin":378,"end":380},"obj":"http://purl.obolibrary.org/obo/CLO_0008933"},{"id":"T177","span":{"begin":381,"end":382},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T178","span":{"begin":448,"end":450},"obj":"http://purl.obolibrary.org/obo/CLO_0008933"},{"id":"T179","span":{"begin":451,"end":452},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T180","span":{"begin":477,"end":478},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T181","span":{"begin":506,"end":508},"obj":"http://purl.obolibrary.org/obo/CLO_0008933"},{"id":"T182","span":{"begin":587,"end":589},"obj":"http://purl.obolibrary.org/obo/CLO_0008933"}],"text":"In each system, the first eigenvector was used to construct the porcupine plots to visualize the most dominant movements (Figure S5). nCOV-2019 showed a small motion in L3 and the core region and the extended loop region are very rigid showing small cones in the porcupine plot. The core structure of the RBD remains dormant as the cones are blue in most of the regions (Figure S5-A). In SARS-COV, the C-terminal region shows large motions (Figure S5-B). Mutation N487A showed a large motion in L1 (Figure S5-C). Mutations Y449A, G447A, and E484A demonstrate large motions in L3 (Figure S5). Overall, these plots show the involvement of these residues in the dynamic stability of the RBD/ACE2 complex."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T91","span":{"begin":129,"end":131},"obj":"Chemical"},{"id":"T92","span":{"begin":378,"end":380},"obj":"Chemical"},{"id":"T93","span":{"begin":448,"end":450},"obj":"Chemical"},{"id":"T94","span":{"begin":506,"end":508},"obj":"Chemical"},{"id":"T95","span":{"begin":587,"end":589},"obj":"Chemical"}],"attributes":[{"id":"A91","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_29386"},{"id":"A92","pred":"chebi_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/CHEBI_29386"},{"id":"A93","pred":"chebi_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/CHEBI_29386"},{"id":"A94","pred":"chebi_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/CHEBI_29386"},{"id":"A95","pred":"chebi_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/CHEBI_29386"}],"text":"In each system, the first eigenvector was used to construct the porcupine plots to visualize the most dominant movements (Figure S5). nCOV-2019 showed a small motion in L3 and the core region and the extended loop region are very rigid showing small cones in the porcupine plot. The core structure of the RBD remains dormant as the cones are blue in most of the regions (Figure S5-A). In SARS-COV, the C-terminal region shows large motions (Figure S5-B). Mutation N487A showed a large motion in L1 (Figure S5-C). Mutations Y449A, G447A, and E484A demonstrate large motions in L3 (Figure S5). Overall, these plots show the involvement of these residues in the dynamic stability of the RBD/ACE2 complex."}

{"project":"LitCovid-sentences","denotations":[{"id":"T156","span":{"begin":0,"end":278},"obj":"Sentence"},{"id":"T157","span":{"begin":279,"end":384},"obj":"Sentence"},{"id":"T158","span":{"begin":385,"end":454},"obj":"Sentence"},{"id":"T159","span":{"begin":455,"end":512},"obj":"Sentence"},{"id":"T160","span":{"begin":513,"end":591},"obj":"Sentence"},{"id":"T161","span":{"begin":592,"end":701},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In each system, the first eigenvector was used to construct the porcupine plots to visualize the most dominant movements (Figure S5). nCOV-2019 showed a small motion in L3 and the core region and the extended loop region are very rigid showing small cones in the porcupine plot. The core structure of the RBD remains dormant as the cones are blue in most of the regions (Figure S5-A). In SARS-COV, the C-terminal region shows large motions (Figure S5-B). Mutation N487A showed a large motion in L1 (Figure S5-C). Mutations Y449A, G447A, and E484A demonstrate large motions in L3 (Figure S5). Overall, these plots show the involvement of these residues in the dynamic stability of the RBD/ACE2 complex."}

{"project":"LitCovid-PubTator","denotations":[{"id":"549","span":{"begin":688,"end":692},"obj":"Gene"},{"id":"550","span":{"begin":134,"end":138},"obj":"Species"},{"id":"551","span":{"begin":388,"end":396},"obj":"Species"}],"attributes":[{"id":"A549","pred":"tao:has_database_id","subj":"549","obj":"Gene:59272"},{"id":"A550","pred":"tao:has_database_id","subj":"550","obj":"Tax:2697049"},{"id":"A551","pred":"tao:has_database_id","subj":"551","obj":"Tax:694009"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In each system, the first eigenvector was used to construct the porcupine plots to visualize the most dominant movements (Figure S5). nCOV-2019 showed a small motion in L3 and the core region and the extended loop region are very rigid showing small cones in the porcupine plot. The core structure of the RBD remains dormant as the cones are blue in most of the regions (Figure S5-A). In SARS-COV, the C-terminal region shows large motions (Figure S5-B). Mutation N487A showed a large motion in L1 (Figure S5-C). Mutations Y449A, G447A, and E484A demonstrate large motions in L3 (Figure S5). Overall, these plots show the involvement of these residues in the dynamic stability of the RBD/ACE2 complex."}