PMC:7601109 / 82960-83763 JSONTXT

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T161","span":{"begin":392,"end":397},"obj":"Body_part"},{"id":"T162","span":{"begin":659,"end":664},"obj":"Body_part"}],"attributes":[{"id":"A161","pred":"uberon_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A162","pred":"uberon_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"Despite the details illustrated in this review, many questions remain unanswered. The most important question among all is which bee product or bee component can produce the best benefits against skeletal muscle senescence and under which circumstances? Sarcopenia is the result of several interrelated factors such as neuromuscular dysfunction, oxidative stress, metabolic alterations, poor blood supply, hormonal deficiencies (e.g., sex hormones), chronic inflammation, and lifestyle choices (e.g., physical inactivity and unhealthy diet) [21]. The effect of bee products on some of these factors are underaddressed (e.g., neuromuscular dysfunction, muscle blood supply, and gut microbiome) while some other have not been explored yet (e.g., sex steroids and their association with muscular function)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T735","span":{"begin":205,"end":211},"obj":"Body_part"},{"id":"T736","span":{"begin":392,"end":397},"obj":"Body_part"},{"id":"T737","span":{"begin":439,"end":447},"obj":"Body_part"},{"id":"T738","span":{"begin":652,"end":658},"obj":"Body_part"},{"id":"T739","span":{"begin":659,"end":664},"obj":"Body_part"},{"id":"T740","span":{"begin":677,"end":680},"obj":"Body_part"}],"attributes":[{"id":"A735","pred":"fma_id","subj":"T735","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A736","pred":"fma_id","subj":"T736","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A737","pred":"fma_id","subj":"T737","obj":"http://purl.org/sig/ont/fma/fma12278"},{"id":"A738","pred":"fma_id","subj":"T738","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A739","pred":"fma_id","subj":"T739","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A740","pred":"fma_id","subj":"T740","obj":"http://purl.org/sig/ont/fma/fma7199"}],"text":"Despite the details illustrated in this review, many questions remain unanswered. The most important question among all is which bee product or bee component can produce the best benefits against skeletal muscle senescence and under which circumstances? Sarcopenia is the result of several interrelated factors such as neuromuscular dysfunction, oxidative stress, metabolic alterations, poor blood supply, hormonal deficiencies (e.g., sex hormones), chronic inflammation, and lifestyle choices (e.g., physical inactivity and unhealthy diet) [21]. The effect of bee products on some of these factors are underaddressed (e.g., neuromuscular dysfunction, muscle blood supply, and gut microbiome) while some other have not been explored yet (e.g., sex steroids and their association with muscular function)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T138","span":{"begin":254,"end":264},"obj":"Disease"},{"id":"T139","span":{"begin":458,"end":470},"obj":"Disease"}],"attributes":[{"id":"A138","pred":"mondo_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/MONDO_0006516"},{"id":"A139","pred":"mondo_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"Despite the details illustrated in this review, many questions remain unanswered. The most important question among all is which bee product or bee component can produce the best benefits against skeletal muscle senescence and under which circumstances? Sarcopenia is the result of several interrelated factors such as neuromuscular dysfunction, oxidative stress, metabolic alterations, poor blood supply, hormonal deficiencies (e.g., sex hormones), chronic inflammation, and lifestyle choices (e.g., physical inactivity and unhealthy diet) [21]. The effect of bee products on some of these factors are underaddressed (e.g., neuromuscular dysfunction, muscle blood supply, and gut microbiome) while some other have not been explored yet (e.g., sex steroids and their association with muscular function)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1466","span":{"begin":196,"end":211},"obj":"http://purl.obolibrary.org/obo/UBERON_0001134"},{"id":"T1467","span":{"begin":196,"end":211},"obj":"http://purl.obolibrary.org/obo/UBERON_0014892"},{"id":"T1468","span":{"begin":196,"end":211},"obj":"http://www.ebi.ac.uk/efo/EFO_0000888"},{"id":"T1469","span":{"begin":392,"end":397},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T1470","span":{"begin":392,"end":397},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T1471","span":{"begin":652,"end":658},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1472","span":{"begin":652,"end":658},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1473","span":{"begin":652,"end":658},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1474","span":{"begin":652,"end":658},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1475","span":{"begin":659,"end":664},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T1476","span":{"begin":659,"end":664},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T1477","span":{"begin":677,"end":680},"obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"T1478","span":{"begin":677,"end":680},"obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"T1479","span":{"begin":677,"end":680},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"}],"text":"Despite the details illustrated in this review, many questions remain unanswered. The most important question among all is which bee product or bee component can produce the best benefits against skeletal muscle senescence and under which circumstances? Sarcopenia is the result of several interrelated factors such as neuromuscular dysfunction, oxidative stress, metabolic alterations, poor blood supply, hormonal deficiencies (e.g., sex hormones), chronic inflammation, and lifestyle choices (e.g., physical inactivity and unhealthy diet) [21]. The effect of bee products on some of these factors are underaddressed (e.g., neuromuscular dysfunction, muscle blood supply, and gut microbiome) while some other have not been explored yet (e.g., sex steroids and their association with muscular function)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T88164","span":{"begin":435,"end":447},"obj":"Chemical"},{"id":"T356","span":{"begin":439,"end":447},"obj":"Chemical"},{"id":"T47352","span":{"begin":748,"end":756},"obj":"Chemical"}],"attributes":[{"id":"A55672","pred":"chebi_id","subj":"T88164","obj":"http://purl.obolibrary.org/obo/CHEBI_50112"},{"id":"A39862","pred":"chebi_id","subj":"T356","obj":"http://purl.obolibrary.org/obo/CHEBI_24621"},{"id":"A49036","pred":"chebi_id","subj":"T47352","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"}],"text":"Despite the details illustrated in this review, many questions remain unanswered. The most important question among all is which bee product or bee component can produce the best benefits against skeletal muscle senescence and under which circumstances? Sarcopenia is the result of several interrelated factors such as neuromuscular dysfunction, oxidative stress, metabolic alterations, poor blood supply, hormonal deficiencies (e.g., sex hormones), chronic inflammation, and lifestyle choices (e.g., physical inactivity and unhealthy diet) [21]. The effect of bee products on some of these factors are underaddressed (e.g., neuromuscular dysfunction, muscle blood supply, and gut microbiome) while some other have not been explored yet (e.g., sex steroids and their association with muscular function)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T393","span":{"begin":458,"end":470},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Despite the details illustrated in this review, many questions remain unanswered. The most important question among all is which bee product or bee component can produce the best benefits against skeletal muscle senescence and under which circumstances? Sarcopenia is the result of several interrelated factors such as neuromuscular dysfunction, oxidative stress, metabolic alterations, poor blood supply, hormonal deficiencies (e.g., sex hormones), chronic inflammation, and lifestyle choices (e.g., physical inactivity and unhealthy diet) [21]. The effect of bee products on some of these factors are underaddressed (e.g., neuromuscular dysfunction, muscle blood supply, and gut microbiome) while some other have not been explored yet (e.g., sex steroids and their association with muscular function)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T85","span":{"begin":346,"end":362},"obj":"Phenotype"}],"attributes":[{"id":"A85","pred":"hp_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/HP_0025464"}],"text":"Despite the details illustrated in this review, many questions remain unanswered. The most important question among all is which bee product or bee component can produce the best benefits against skeletal muscle senescence and under which circumstances? Sarcopenia is the result of several interrelated factors such as neuromuscular dysfunction, oxidative stress, metabolic alterations, poor blood supply, hormonal deficiencies (e.g., sex hormones), chronic inflammation, and lifestyle choices (e.g., physical inactivity and unhealthy diet) [21]. The effect of bee products on some of these factors are underaddressed (e.g., neuromuscular dysfunction, muscle blood supply, and gut microbiome) while some other have not been explored yet (e.g., sex steroids and their association with muscular function)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T488","span":{"begin":0,"end":81},"obj":"Sentence"},{"id":"T489","span":{"begin":82,"end":253},"obj":"Sentence"},{"id":"T490","span":{"begin":254,"end":546},"obj":"Sentence"},{"id":"T491","span":{"begin":547,"end":803},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Despite the details illustrated in this review, many questions remain unanswered. The most important question among all is which bee product or bee component can produce the best benefits against skeletal muscle senescence and under which circumstances? Sarcopenia is the result of several interrelated factors such as neuromuscular dysfunction, oxidative stress, metabolic alterations, poor blood supply, hormonal deficiencies (e.g., sex hormones), chronic inflammation, and lifestyle choices (e.g., physical inactivity and unhealthy diet) [21]. The effect of bee products on some of these factors are underaddressed (e.g., neuromuscular dysfunction, muscle blood supply, and gut microbiome) while some other have not been explored yet (e.g., sex steroids and their association with muscular function)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1843","span":{"begin":677,"end":691},"obj":"Species"},{"id":"1844","span":{"begin":748,"end":756},"obj":"Chemical"},{"id":"1845","span":{"begin":254,"end":264},"obj":"Disease"},{"id":"1846","span":{"begin":319,"end":344},"obj":"Disease"},{"id":"1847","span":{"begin":406,"end":427},"obj":"Disease"},{"id":"1848","span":{"begin":458,"end":470},"obj":"Disease"},{"id":"1849","span":{"begin":625,"end":650},"obj":"Disease"}],"attributes":[{"id":"A1843","pred":"tao:has_database_id","subj":"1843","obj":"Tax:749906"},{"id":"A1844","pred":"tao:has_database_id","subj":"1844","obj":"MESH:D013256"},{"id":"A1845","pred":"tao:has_database_id","subj":"1845","obj":"MESH:D055948"},{"id":"A1846","pred":"tao:has_database_id","subj":"1846","obj":"MESH:D009468"},{"id":"A1847","pred":"tao:has_database_id","subj":"1847","obj":"MESH:C565870"},{"id":"A1848","pred":"tao:has_database_id","subj":"1848","obj":"MESH:D007249"},{"id":"A1849","pred":"tao:has_database_id","subj":"1849","obj":"MESH:D009468"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Despite the details illustrated in this review, many questions remain unanswered. The most important question among all is which bee product or bee component can produce the best benefits against skeletal muscle senescence and under which circumstances? Sarcopenia is the result of several interrelated factors such as neuromuscular dysfunction, oxidative stress, metabolic alterations, poor blood supply, hormonal deficiencies (e.g., sex hormones), chronic inflammation, and lifestyle choices (e.g., physical inactivity and unhealthy diet) [21]. The effect of bee products on some of these factors are underaddressed (e.g., neuromuscular dysfunction, muscle blood supply, and gut microbiome) while some other have not been explored yet (e.g., sex steroids and their association with muscular function)."}