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PMC:7601109 / 64196-67092 JSONTXT

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LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T124 58-63 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T125 119-124 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T126 445-450 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T127 1340-1349 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T128 1390-1399 Body_part denotes hind limb http://purl.obolibrary.org/obo/UBERON_0002103
T129 1395-1399 Body_part denotes limb http://purl.obolibrary.org/obo/UBERON_0002101
T130 1418-1431 Body_part denotes soleus muscle http://purl.obolibrary.org/obo/UBERON_0001389
T131 1501-1510 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T132 1519-1528 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T133 1540-1549 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T134 1562-1571 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T135 1892-1905 Body_part denotes soleus muscle http://purl.obolibrary.org/obo/UBERON_0001389
T136 2020-2033 Body_part denotes blood vessels http://purl.obolibrary.org/obo/UBERON_0001981
T137 2020-2025 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T138 2026-2033 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T139 2041-2054 Body_part denotes gastrocnemius http://purl.obolibrary.org/obo/UBERON_0001388
T140 2462-2471 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T534 58-63 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T535 119-124 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T536 137-147 Body_part denotes quadriceps http://purl.org/sig/ont/fma/fma22428
T537 148-154 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T538 188-199 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T539 364-371 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T540 445-450 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T541 522-529 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T542 905-913 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T543 979-983 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T544 1045-1052 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T545 1340-1349 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T546 1390-1399 Body_part denotes hind limb http://purl.org/sig/ont/fma/fma7184
T547 1418-1431 Body_part denotes soleus muscle http://purl.org/sig/ont/fma/fma22542
T548 1501-1510 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T549 1519-1528 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T550 1540-1549 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T551 1562-1571 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T552 1575-1587 Body_part denotes muscle fiber http://purl.org/sig/ont/fma/fma67328
T553 1734-1748 Body_part denotes muscle-to-body http://purl.org/sig/ont/fma/fma297498
T554 1744-1748 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T555 1867-1884 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T556 1879-1884 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T557 1892-1905 Body_part denotes soleus muscle http://purl.org/sig/ont/fma/fma22542
T558 2020-2033 Body_part denotes blood vessels http://purl.org/sig/ont/fma/fma63183
T559 2020-2025 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T560 2041-2061 Body_part denotes gastrocnemius muscle http://purl.org/sig/ont/fma/fma22541
T561 2081-2087 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T562 2145-2154 Body_part denotes myoblasts http://purl.org/sig/ont/fma/fma70335
T563 2299-2316 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T564 2311-2316 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T565 2365-2382 Body_part denotes vascular networks http://purl.org/sig/ont/fma/fma69050
T566 2407-2413 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T567 2462-2471 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T568 2517-2523 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T569 2889-2895 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T116 711-724 Disease denotes hyperglycemia http://purl.obolibrary.org/obo/MONDO_0002909
T117 729-741 Disease denotes dyslipidemia http://purl.obolibrary.org/obo/MONDO_0002525
T118 2088-2094 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1031 58-63 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T1032 58-63 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T1033 119-124 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T1034 119-124 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T1035 148-154 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1036 148-154 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1037 148-154 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1038 148-154 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1039 364-371 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T1040 372-380 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1041 445-450 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T1042 445-450 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T1043 601-602 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1044 893-901 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1045 979-983 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1046 1010-1020 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T1047 1035-1044 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T1048 1195-1196 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1049 1395-1399 http://www.ebi.ac.uk/efo/EFO_0000876 denotes limb
T1050 1425-1431 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1051 1425-1431 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1052 1425-1431 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1053 1425-1431 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1054 1575-1581 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1055 1575-1581 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1056 1575-1581 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1057 1575-1581 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1058 1602-1603 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1059 1670-1680 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T1060 1734-1740 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1061 1734-1740 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1062 1734-1740 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1063 1734-1740 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1064 1767-1774 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T1065 1815-1822 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T1066 1867-1884 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T1067 1899-1905 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1068 1899-1905 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1069 1948-1955 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T1070 2020-2033 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessels
T1071 2020-2033 http://www.ebi.ac.uk/efo/EFO_0000817 denotes blood vessels
T1072 2055-2061 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1073 2055-2061 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1074 2055-2061 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1075 2055-2061 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1076 2081-2087 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1077 2081-2087 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1078 2081-2087 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1079 2081-2087 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1080 2139-2144 http://purl.obolibrary.org/obo/CLO_0050871 denotes C2C12
T1081 2228-2229 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1082 2299-2316 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T1083 2365-2382 http://purl.obolibrary.org/obo/UBERON_0002049 denotes vascular networks
T1084 2398-2413 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T1085 2398-2413 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T1086 2398-2413 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T1087 2508-2523 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T1088 2508-2523 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T1089 2508-2523 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T1090 2608-2616 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1091 2880-2895 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T1092 2880-2895 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T1093 2880-2895 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T37636 188-199 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T5272 188-193 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T91332 194-199 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T67914 364-371 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T46169 522-529 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T189 769-773 Chemical denotes CAPE http://purl.obolibrary.org/obo/CHEBI_8062
T17126 1045-1052 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T67499 2667-2670 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T3820 2723-2729 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T312 922-928 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T313 979-996 http://purl.obolibrary.org/obo/GO_0007050 denotes cell-cycle arrest
T314 1061-1065 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T315 1216-1239 http://purl.obolibrary.org/obo/GO_1903009 denotes proteasomal degradation
T316 1228-1239 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T317 2197-2212 http://purl.obolibrary.org/obo/GO_0010573 denotes VEGF production
T318 2272-2284 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T319 2631-2635 http://purl.obolibrary.org/obo/GO_0050405 denotes AMPK
T320 2631-2635 http://purl.obolibrary.org/obo/GO_0047322 denotes AMPK
T321 2631-2635 http://purl.obolibrary.org/obo/GO_0004691 denotes AMPK

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T66 711-724 Phenotype denotes hyperglycemia http://purl.obolibrary.org/obo/HP_0003074
T67 729-741 Phenotype denotes dyslipidemia http://purl.obolibrary.org/obo/HP_0003119
T68 1110-1117 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T383 0-244 Sentence denotes Mitchell and colleagues examined changes in microvascular blood volume, microvascular flow velocity, and microvascular blood flow in the quadriceps muscle following treatment with 15 g of amino acids in young and old subjects (20–70 years old).
T384 245-381 Sentence denotes They detected improvements in all the 3 parameters only in young groups, and those effects were associated with proper insulin activity.
T385 382-550 Sentence denotes Thus, the authors suggested that refeeding effects on muscular blood supply may be hindered by dysfunctions in postprandial circulation and glucose dysregulation [157].
T386 551-751 Sentence denotes Bee products such as bee pollen and propolis have a potential to boost microcirculation and correct pathologies that contribute to vascular dysfunction such as hyperglycemia and dyslipidemia [36,155].
T387 752-936 Sentence denotes In this context, CAPE, one of the basic constituents of propolis, was reported to combat vascular damages by counteracting the proliferative activity of platelet-derived growth factor.
T388 937-1289 Sentence denotes The molecular mechanism involved inducing cell-cycle arrest in VSMCs via activation of p38mitogen-activated protein kinase (MAPK), which was associated with accumulation of hypoxia-inducible factor (HIF)-1α—mainly due to inhibition of HIF prolylhydroxylase, a key contributor to proteasomal degradation of HIF-1α—and subsequent induction of HO-1 [155].
T389 1290-1720 Sentence denotes In the same regard, supplementing rats undergoing capillary regression (resulting from two weeks of hind limb unloading) in the soleus muscle with two daily intragastric doses of propolis for two weeks restored capillary number, capillary structure, capillary volume, and capillary to muscle fiber ratio through a mechanism that involves inhibition of anti-angiogenic factors and activation of pro-angiogenic factors (e.g., VEGF).
T390 1721-1962 Sentence denotes The relative muscle-to-body weight in treated animals was higher than in the unloaded control animals, and the number of TUNEL-positive apoptotic endothelial cells in the soleus muscle was similar to that in the normal control animals [110].
T391 1963-2129 Sentence denotes Likewise, bee pollen (both neat and processed) increased blood vessels in the gastrocnemius muscle of rats undergoing muscle injury because of vigorous exercise [90].
T392 2130-2219 Sentence denotes Treating C2C12 myoblasts with propolis ethanolic extract increased VEGF production [108].
T393 2220-2383 Sentence denotes VEGF is a pro-angiogenic factor that contributes to angiogenesis by recruiting endothelial cells and promoting their differentiation to form new vascular networks.
T394 2384-2489 Sentence denotes VEGF protects skeletal muscle undergoing unloading against the progression of capillary regression [110].
T395 2490-2636 Sentence denotes Its expression in skeletal muscle and associated angiogenic response increase following exercise due to change in the activity of HIF-1α and AMPK.
T396 2637-2743 Sentence denotes It promotes the generation of ATP following mitochondrial biogenesis in order to meet oxygen demand [158].
T397 2744-2896 Sentence denotes Altogether, these reports signify that bee products and endurance exercise share common mechanisms to produce their vitality effects in skeletal muscle.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1530 1024-1059 Gene denotes p38mitogen-activated protein kinase Gene:81649
1531 1110-1143 Gene denotes hypoxia-inducible factor (HIF)-1α Gene:29560
1532 1243-1249 Gene denotes HIF-1α Gene:29560
1533 1278-1282 Gene denotes HO-1 Gene:24451
1534 1714-1718 Gene denotes VEGF Gene:83785
1535 2197-2201 Gene denotes VEGF Gene:83785
1536 2220-2224 Gene denotes VEGF Gene:83785
1537 2384-2388 Gene denotes VEGF Gene:83785
1538 2620-2626 Gene denotes HIF-1α Gene:29560
1539 2631-2635 Gene denotes AMPK Gene:78975
1540 364-371 Gene denotes insulin Gene:3630
1541 1324-1328 Species denotes rats Tax:10116
1542 2065-2069 Species denotes rats Tax:10116
1543 769-773 Chemical denotes CAPE MESH:C055494
1544 2667-2670 Chemical denotes ATP MESH:D000255
1545 2723-2729 Chemical denotes oxygen MESH:D010100
1546 137-154 Disease denotes quadriceps muscle MESH:D009135
1547 522-543 Disease denotes glucose dysregulation MESH:D021081
1548 682-702 Disease denotes vascular dysfunction MESH:D002561
1549 711-741 Disease denotes hyperglycemia and dyslipidemia MESH:D050171
1550 990-996 Disease denotes arrest MESH:D006323
1551 2081-2094 Disease denotes muscle injury MESH:D063806