PMC:7601109 / 54926-56279
Annnotations
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T85 | 365-369 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
| T86 | 692-697 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T432 | 55-61 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T433 | 72-77 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T434 | 225-231 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T435 | 242-247 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T436 | 365-369 | Body_part | denotes | hand | http://purl.org/sig/ont/fma/fma9712 |
| T437 | 489-494 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T438 | 566-571 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T439 | 692-697 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T440 | 832-838 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T441 | 938-943 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T442 | 1069-1074 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T443 | 1150-1155 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T444 | 1231-1237 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T445 | 1302-1310 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T446 | 1329-1335 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T100 | 320-330 | Disease | denotes | sarcopenia | http://purl.obolibrary.org/obo/MONDO_0006516 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T852 | 55-61 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T853 | 55-61 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T854 | 55-61 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T855 | 55-61 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T856 | 62-77 | http://purl.obolibrary.org/obo/CL_0000514 | denotes | satellite cells |
| T857 | 92-93 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T858 | 225-231 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T859 | 225-231 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T860 | 225-231 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T861 | 225-231 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T862 | 232-247 | http://purl.obolibrary.org/obo/CL_0000514 | denotes | satellite cells |
| T863 | 251-252 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T864 | 285-288 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T865 | 479-494 | http://purl.obolibrary.org/obo/CL_0000514 | denotes | satellite cells |
| T866 | 556-571 | http://purl.obolibrary.org/obo/CL_0000514 | denotes | satellite cells |
| T867 | 576-586 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T868 | 594-603 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T869 | 617-625 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T870 | 646-656 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T871 | 727-728 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T872 | 749-759 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T873 | 771-780 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T874 | 812-813 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T875 | 832-838 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T876 | 832-838 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T877 | 832-838 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T878 | 832-838 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T879 | 928-943 | http://purl.obolibrary.org/obo/CL_0000514 | denotes | satellite cells |
| T880 | 949-957 | http://purl.obolibrary.org/obo/CL_0002372 | denotes | myotubes |
| T881 | 1024-1033 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T882 | 1038-1047 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T883 | 1059-1074 | http://purl.obolibrary.org/obo/CL_0000514 | denotes | satellite cells |
| T884 | 1150-1155 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T885 | 1187-1195 | http://purl.obolibrary.org/obo/CL_0002372 | denotes | myotubes |
| T886 | 1231-1237 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T887 | 1231-1237 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T888 | 1231-1237 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T889 | 1231-1237 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T890 | 1329-1335 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T891 | 1329-1335 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T892 | 1329-1335 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T893 | 1329-1335 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T12144 | 406-417 | Chemical | denotes | royal jelly | http://purl.obolibrary.org/obo/CHEBI_78665 |
| T48139 | 1302-1310 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T266 | 185-195 | http://purl.obolibrary.org/obo/GO_0042692 | denotes | myogenesis |
| T267 | 185-195 | http://purl.obolibrary.org/obo/GO_0007519 | denotes | myogenesis |
| T268 | 590-603 | http://purl.obolibrary.org/obo/GO_0043491 | denotes | AKT signaling |
| T269 | 594-603 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T270 | 771-789 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathways |
| T271 | 771-780 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T272 | 839-845 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T273 | 1038-1055 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathway |
| T274 | 1038-1047 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T275 | 1150-1181 | http://purl.obolibrary.org/obo/GO_0030154 | denotes | cells and their differentiation |
| T276 | 1280-1289 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T277 | 1336-1347 | http://purl.obolibrary.org/obo/GO_0006508 | denotes | proteolysis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T327 | 0-171 | Sentence | denotes | Reduction of the number and functional capacity of the muscle satellite cells is considered a core contributor to the development of age-related muscular dysfunction [96]. |
| T328 | 172-351 | Sentence | denotes | Induction of myogenesis via in vivo reprogramming of muscle satellite cells is a currently studied strategy that has not been successfully used for sarcopenia treatment yet [143]. |
| T329 | 352-612 | Sentence | denotes | On the other hand, treating sarcopenic rats with both royal jelly and pRJ was reported to increase the number of Pax7-positive satellite cells in vivo and in vitro (pRJ only). pRJ induced self-renewal of satellite cells via activation of AKT signaling [96,97]. |
| T330 | 613-714 | Sentence | denotes | AKT activity was associated with activation of IGF-1 as indicated by increased serum levels of IGF-1. |
| T331 | 715-1008 | Sentence | denotes | IGF-1 plays a crucial rule in the activation of various signaling pathways; it is believed to be a major mediator of muscle growth and repair that functions by stimulating the proliferation and differentiation of satellite cells into myotubes, albeit the exact mechanism is not clear yet [96]. |
| T332 | 1009-1243 | Sentence | denotes | Similarly, pRJ activated AKT-signaling pathway in satellite cells culture, which was associated with increased proliferation of myosatellite cells and their differentiation into myotubes—an effect that is contradictory to muscle loss. |
| T333 | 1244-1353 | Sentence | denotes | AKT is thought to contribute to the synthesis of muscular proteins and inhibition of muscle proteolysis [96]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1325 | 465-469 | Gene | denotes | Pax7 | Gene:500574 |
| 1326 | 590-593 | Gene | denotes | AKT | Gene:24185 |
| 1327 | 613-616 | Gene | denotes | AKT | Gene:24185 |
| 1328 | 660-665 | Gene | denotes | IGF-1 | Gene:24482 |
| 1329 | 708-713 | Gene | denotes | IGF-1 | Gene:24482 |
| 1330 | 715-720 | Gene | denotes | IGF-1 | Gene:24482 |
| 1331 | 1034-1037 | Gene | denotes | AKT | Gene:24185 |
| 1332 | 1244-1247 | Gene | denotes | AKT | Gene:24185 |
| 1333 | 133-136 | Gene | denotes | age | Gene:81759 |
| 1334 | 391-395 | Species | denotes | rats | Tax:10116 |
| 1335 | 406-417 | Chemical | denotes | royal jelly | MESH:C058787 |
| 1336 | 422-425 | Chemical | denotes | pRJ | |
| 1337 | 145-165 | Disease | denotes | muscular dysfunction | MESH:D018908 |
| 1338 | 320-330 | Disease | denotes | sarcopenia | MESH:D055948 |
| 1339 | 1231-1242 | Disease | denotes | muscle loss | MESH:D009135 |