PMC:7601109 / 53992-54331 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T424","span":{"begin":105,"end":115},"obj":"Body_part"},{"id":"T425","span":{"begin":131,"end":138},"obj":"Body_part"}],"attributes":[{"id":"A424","pred":"fma_id","subj":"T424","obj":"http://purl.org/sig/ont/fma/fma63832"},{"id":"A425","pred":"fma_id","subj":"T425","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"In addition, mTORC1 contributes to autophagy—a turnover process that involves clearance of dysfunctional organelles and long-lived protein aggregations with provision of energy and macromolecular precursors in return—by binding with AMPK resulting in phosphorylation of autophagy genes such as Unc51-like kinase 1 at different sites [140]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T831","span":{"begin":45,"end":46},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T832","span":{"begin":280,"end":285},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T833","span":{"begin":312,"end":316},"obj":"http://purl.obolibrary.org/obo/CLO_0001757"}],"text":"In addition, mTORC1 contributes to autophagy—a turnover process that involves clearance of dysfunctional organelles and long-lived protein aggregations with provision of energy and macromolecular precursors in return—by binding with AMPK resulting in phosphorylation of autophagy genes such as Unc51-like kinase 1 at different sites [140]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T52844","span":{"begin":131,"end":138},"obj":"Chemical"}],"attributes":[{"id":"A54251","pred":"chebi_id","subj":"T52844","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"In addition, mTORC1 contributes to autophagy—a turnover process that involves clearance of dysfunctional organelles and long-lived protein aggregations with provision of energy and macromolecular precursors in return—by binding with AMPK resulting in phosphorylation of autophagy genes such as Unc51-like kinase 1 at different sites [140]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T249","span":{"begin":35,"end":44},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T250","span":{"begin":35,"end":44},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T251","span":{"begin":233,"end":237},"obj":"http://purl.obolibrary.org/obo/GO_0050405"},{"id":"T252","span":{"begin":233,"end":237},"obj":"http://purl.obolibrary.org/obo/GO_0047322"},{"id":"T253","span":{"begin":233,"end":237},"obj":"http://purl.obolibrary.org/obo/GO_0004691"},{"id":"T254","span":{"begin":251,"end":266},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T255","span":{"begin":270,"end":279},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T256","span":{"begin":270,"end":279},"obj":"http://purl.obolibrary.org/obo/GO_0006914"}],"text":"In addition, mTORC1 contributes to autophagy—a turnover process that involves clearance of dysfunctional organelles and long-lived protein aggregations with provision of energy and macromolecular precursors in return—by binding with AMPK resulting in phosphorylation of autophagy genes such as Unc51-like kinase 1 at different sites [140]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T321","span":{"begin":0,"end":339},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In addition, mTORC1 contributes to autophagy—a turnover process that involves clearance of dysfunctional organelles and long-lived protein aggregations with provision of energy and macromolecular precursors in return—by binding with AMPK resulting in phosphorylation of autophagy genes such as Unc51-like kinase 1 at different sites [140]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1296","span":{"begin":13,"end":19},"obj":"Gene"},{"id":"1297","span":{"begin":233,"end":237},"obj":"Gene"},{"id":"1298","span":{"begin":294,"end":313},"obj":"Gene"}],"attributes":[{"id":"A1296","pred":"tao:has_database_id","subj":"1296","obj":"Gene:382056"},{"id":"A1297","pred":"tao:has_database_id","subj":"1297","obj":"Gene:78975"},{"id":"A1298","pred":"tao:has_database_id","subj":"1298","obj":"Gene:360827"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In addition, mTORC1 contributes to autophagy—a turnover process that involves clearance of dysfunctional organelles and long-lived protein aggregations with provision of energy and macromolecular precursors in return—by binding with AMPK resulting in phosphorylation of autophagy genes such as Unc51-like kinase 1 at different sites [140]."}