PMC:7601109 / 53668-53991 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T423","span":{"begin":282,"end":289},"obj":"Body_part"}],"attributes":[{"id":"A423","pred":"fma_id","subj":"T423","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Upon presence of growth factors, PI3k gets activated by IR substrate resulting in stimulation of a series of signaling cascades that involve activation of AKT, which leads to further activation of mTORC1. mTORC1 activates the phosphorylation of two main regulators of cap-dependent protein synthesis: S6K and eIF4E [2,140]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T824","span":{"begin":43,"end":52},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T825","span":{"begin":56,"end":58},"obj":"http://purl.obolibrary.org/obo/PR_000009064"},{"id":"T826","span":{"begin":97,"end":98},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T827","span":{"begin":109,"end":118},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T828","span":{"begin":141,"end":151},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T829","span":{"begin":183,"end":193},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T830","span":{"begin":212,"end":221},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Upon presence of growth factors, PI3k gets activated by IR substrate resulting in stimulation of a series of signaling cascades that involve activation of AKT, which leads to further activation of mTORC1. mTORC1 activates the phosphorylation of two main regulators of cap-dependent protein synthesis: S6K and eIF4E [2,140]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T62174","span":{"begin":56,"end":58},"obj":"Chemical"},{"id":"T78584","span":{"begin":282,"end":289},"obj":"Chemical"}],"attributes":[{"id":"A33147","pred":"chebi_id","subj":"T62174","obj":"http://purl.obolibrary.org/obo/CHEBI_74061"},{"id":"A83087","pred":"chebi_id","subj":"T78584","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Upon presence of growth factors, PI3k gets activated by IR substrate resulting in stimulation of a series of signaling cascades that involve activation of AKT, which leads to further activation of mTORC1. mTORC1 activates the phosphorylation of two main regulators of cap-dependent protein synthesis: S6K and eIF4E [2,140]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T241","span":{"begin":17,"end":23},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T242","span":{"begin":33,"end":37},"obj":"http://purl.obolibrary.org/obo/GO_0016303"},{"id":"T243","span":{"begin":109,"end":127},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T244","span":{"begin":109,"end":118},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T245","span":{"begin":212,"end":241},"obj":"http://purl.obolibrary.org/obo/GO_0042327"},{"id":"T246","span":{"begin":226,"end":241},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T247","span":{"begin":282,"end":299},"obj":"http://purl.obolibrary.org/obo/GO_0006412"},{"id":"T248","span":{"begin":290,"end":299},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"Upon presence of growth factors, PI3k gets activated by IR substrate resulting in stimulation of a series of signaling cascades that involve activation of AKT, which leads to further activation of mTORC1. mTORC1 activates the phosphorylation of two main regulators of cap-dependent protein synthesis: S6K and eIF4E [2,140]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T320","span":{"begin":0,"end":323},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Upon presence of growth factors, PI3k gets activated by IR substrate resulting in stimulation of a series of signaling cascades that involve activation of AKT, which leads to further activation of mTORC1. mTORC1 activates the phosphorylation of two main regulators of cap-dependent protein synthesis: S6K and eIF4E [2,140]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1291","span":{"begin":155,"end":158},"obj":"Gene"},{"id":"1292","span":{"begin":197,"end":203},"obj":"Gene"},{"id":"1293","span":{"begin":205,"end":211},"obj":"Gene"},{"id":"1294","span":{"begin":301,"end":304},"obj":"Gene"},{"id":"1295","span":{"begin":309,"end":314},"obj":"Gene"}],"attributes":[{"id":"A1291","pred":"tao:has_database_id","subj":"1291","obj":"Gene:24185"},{"id":"A1292","pred":"tao:has_database_id","subj":"1292","obj":"Gene:382056"},{"id":"A1293","pred":"tao:has_database_id","subj":"1293","obj":"Gene:382056"},{"id":"A1294","pred":"tao:has_database_id","subj":"1294","obj":"Gene:83840"},{"id":"A1295","pred":"tao:has_database_id","subj":"1295","obj":"Gene:117045"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Upon presence of growth factors, PI3k gets activated by IR substrate resulting in stimulation of a series of signaling cascades that involve activation of AKT, which leads to further activation of mTORC1. mTORC1 activates the phosphorylation of two main regulators of cap-dependent protein synthesis: S6K and eIF4E [2,140]."}