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PMC:7601109 / 48533-50159 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T360 45-51 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T361 105-116 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T362 129-135 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T363 239-249 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T364 341-347 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T365 410-421 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T366 434-440 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T367 516-523 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T368 557-564 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T369 596-607 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T370 689-696 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T371 778-789 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T372 865-876 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T373 1009-1020 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T374 1083-1089 Body_part denotes valine http://purl.org/sig/ont/fma/fma82766
T375 1129-1140 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T376 1308-1315 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T377 1334-1343 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T378 1441-1447 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T379 1489-1498 Body_part denotes ribosomal http://purl.org/sig/ont/fma/fma66867
T380 1499-1507 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T381 1573-1580 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T96 45-59 Disease denotes muscle wasting http://purl.obolibrary.org/obo/MONDO_0004323

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T702 36-51 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T703 36-51 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T704 36-51 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T705 120-135 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T706 120-135 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T707 120-135 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T708 165-173 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T709 189-199 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T710 332-347 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T711 332-347 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T712 332-347 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T713 425-440 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T714 425-440 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T715 425-440 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T716 497-498 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T717 537-538 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T718 689-696 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T719 726-735 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T720 837-845 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T721 905-913 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T722 958-963 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T723 1167-1177 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T724 1334-1343 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T725 1432-1447 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T726 1432-1447 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T727 1432-1447 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T728 1455-1465 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T729 1528-1538 http://purl.obolibrary.org/obo/NCBITaxon_2759 denotes eukaryotic
T730 1605-1610 http://purl.obolibrary.org/obo/CLO_0053406 denotes 4eBP1

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T28371 105-116 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T5751 105-110 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T11752 111-116 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T4 239-249 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T45057 239-244 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T61372 245-249 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T55344 410-421 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T27259 410-415 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T13669 416-421 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T64550 499-507 Chemical denotes nutrient http://purl.obolibrary.org/obo/CHEBI_33284
T23687 516-523 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T46508 557-564 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T21569 596-607 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T62121 596-601 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T73912 602-607 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T74297 624-627 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T27922 689-696 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T59193 778-789 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T94290 778-783 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T58757 784-789 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T30204 865-876 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T8531 865-870 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T19387 871-876 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T6863 1009-1020 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T39885 1009-1014 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T30308 1015-1020 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T76570 1048-1059 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T62196 1083-1089 Chemical denotes valine http://purl.obolibrary.org/obo/CHEBI_27266
T30 1129-1140 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T25391 1129-1134 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T36795 1135-1140 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T93939 1197-1209 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T31798 1204-1209 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T98156 1499-1507 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T92500 1573-1580 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T205 200-220 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T206 200-213 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T207 499-515 http://purl.obolibrary.org/obo/GO_0009594 denotes nutrient sensing
T208 544-575 http://purl.obolibrary.org/obo/GO_0051246 denotes regulator of protein metabolism
T209 557-575 http://purl.obolibrary.org/obo/GO_0019538 denotes protein metabolism
T210 565-575 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T211 667-673 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T212 726-735 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T213 807-813 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T214 1539-1561 http://purl.obolibrary.org/obo/GO_0006413 denotes translation initiation
T215 1539-1550 http://purl.obolibrary.org/obo/GO_0006412 denotes translation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T47 45-59 Phenotype denotes muscle wasting http://purl.obolibrary.org/obo/HP_0003202
T48 644-660 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T291 0-267 Sentence denotes Research indicates that age-related skeletal muscle wasting results mainly from insufficient delivery of amino acids to skeletal muscle due to dysregulations in the activity of mTORC1- and activating transcription factor-4 (ATF4)-mediated amino acid sensing pathways.
T292 268-576 Sentence denotes Meanwhile, interventions that ameliorate age-related damages in skeletal muscle operate primarily by reversing alterations in the delivery of amino acids to skeletal muscle via upregulation of mTORC1 and/or ATF4 [139]. mTORC1 is a nutrient sensing protein that acts as a core regulator of protein metabolism.
T293 577-744 Sentence denotes It is sensitive to amino acids, energy status (ATP), stress (e.g., oxidative stress), and growth factors (e.g., insulin), which all can regulate its signaling [2,136].
T294 745-853 Sentence denotes Nevertheless, bioavailability of amino acids is necessary for growth factors to effectively activate mTORC1.
T295 854-927 Sentence denotes Even more, amino acids on their own can adequately activate mTORC1 [136].
T296 928-1274 Sentence denotes Evidence from preclinical and human studies confirms that ingestion of essential amino acids (similar to those found in royal jelly and bee pollen such as valine) increases cellular bioavailability of amino acids, which is associated with activation of the endothelial nitric oxide synthase (eNOs) pathway. eNOs further upregulates mTORC1 kinase.
T297 1275-1626 Sentence denotes Translocation of mTORC1 from the cytosol to the surface of lysosomes is associated with improved mitochondrial biogenesis and cellular oxidative capacity in skeletal muscle due to activation of its substrates: P70 ribosomal proteins S6 kinase (S6K) and eukaryotic translation initiation 4E-binding protein 1 (eIF4E, also known as 4eBP1) [120,135,136].

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1174 177-183 Gene denotes mTORC1 Gene:382056
1175 189-222 Gene denotes activating transcription factor-4 Gene:79255
1176 224-228 Gene denotes ATF4 Gene:79255
1177 461-467 Gene denotes mTORC1 Gene:382056
1178 475-479 Gene denotes ATF4 Gene:79255
1179 487-493 Gene denotes mTORC1 Gene:382056
1180 689-696 Gene denotes insulin Gene:3630
1181 846-852 Gene denotes mTORC1 Gene:382056
1182 914-920 Gene denotes mTORC1 Gene:382056
1183 1185-1218 Gene denotes endothelial nitric oxide synthase Gene:4846
1184 1220-1224 Gene denotes eNOs Gene:4846
1185 1260-1266 Gene denotes mTORC1 Gene:382056
1186 1292-1298 Gene denotes mTORC1 Gene:382056
1187 1508-1517 Gene denotes S6 kinase Gene:83840
1188 1519-1522 Gene denotes S6K Gene:83840
1189 1584-1589 Gene denotes eIF4E Gene:117045
1190 1605-1610 Gene denotes 4eBP1 Gene:116636
1191 1235-1239 Gene denotes eNOs Gene:4846
1192 309-312 Gene denotes age Gene:81759
1193 24-27 Gene denotes age Gene:81759
1194 958-963 Species denotes human Tax:9606
1195 999-1020 Chemical denotes essential amino acids MESH:D000601
1196 1083-1089 Chemical denotes valine MESH:D014633
1197 45-59 Disease denotes muscle wasting MESH:D009133